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Esperion (ESPR)
NASDAQ:ESPR
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Esperion (ESPR) AI Stock Analysis

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ESPR

Esperion

(NASDAQ:ESPR)

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Neutral 51 (OpenAI - 4o)
Rating:51Neutral
Price Target:
$3.00
▲(7.53% Upside)
Esperion's overall stock score is driven by significant financial challenges, including negative equity and profitability issues, which are partially offset by strong revenue growth and strategic initiatives highlighted in the earnings call. The technical analysis suggests a neutral trend, while valuation remains a concern due to ongoing losses.
Positive Factors
Revenue Growth
Strong revenue growth indicates successful execution of commercial strategies and expanding market presence, supporting long-term business sustainability.
Strategic Partnerships
These agreements protect product exclusivity, securing long-term revenue streams and enhancing competitive positioning in the market.
International Expansion
International partnerships expand market reach and diversify revenue sources, reducing reliance on domestic markets and enhancing global presence.
Negative Factors
Financial Stability
Negative equity and high leverage pose significant financial risks, potentially limiting future investment and operational flexibility.
Profitability Challenges
Ongoing profitability issues highlight operational inefficiencies, which could hinder long-term growth and necessitate strategic adjustments.
Cash Flow Issues
Negative cash flow indicates potential liquidity constraints, affecting the company's ability to fund operations and invest in growth opportunities.

Esperion (ESPR) vs. SPDR S&P 500 ETF (SPY)

Esperion Business Overview & Revenue Model

Company DescriptionEsperion Therapeutics, Inc., a pharmaceutical company, develops and commercializes medicines for the treatment of patients with elevated low density lipoprotein cholesterol. Its lead product candidates are NEXLETOL (bempedoic acid) and NEXLIZET (bempedoic acid and ezetimibe) tablets for the treatment of patients with atherosclerotic cardiovascular disease or heterozygous familial hypercholesterolemia. The company has a license and collaboration agreement with Daiichi Sankyo Europe GmbH; and Serometrix to in-license its oral, small molecule PCSK9 inhibitor program. Esperion Therapeutics, Inc. was incorporated in 2008 and is headquartered in Ann Arbor, Michigan.
How the Company Makes MoneyEsperion generates revenue primarily through the sale of its pharmaceutical products, particularly bempedoic acid, which is marketed under the brand name Nexletol. The company earns revenue by selling these products to healthcare providers and pharmacies, which in turn sell them to patients. Additionally, Esperion may receive royalties and milestone payments from partnerships and collaborations with larger pharmaceutical companies that have been established to enhance distribution and marketing efforts. Such partnerships can also facilitate access to broader markets and boost sales. Furthermore, the company may benefit from government and private health insurance reimbursements that cover the cost of its therapies, contributing significantly to its overall revenue.

Esperion Earnings Call Summary

Earnings Call Date:Nov 06, 2025
(Q3-2025)
|
% Change Since: |
Next Earnings Date:Feb 24, 2026
Earnings Call Sentiment Positive
The earnings call reflected strong revenue growth, successful strategic initiatives, and international expansion. However, increased operating expenses and onetime financial impacts were noted as challenges. Overall, the highlights of growth and strategic progress outweigh the lowlights.
Q3-2025 Updates
Positive Updates
Record Revenue Growth
Total revenue for Q3 2025 grew 69% year-over-year to $87.3 million, with U.S. net product revenue increasing 31% year-over-year to $40.7 million.
Commercial Strategy Success
Esperion achieved nearly double-digit sequential quarterly prescription growth. Their strategic marketing initiatives, such as the 'Can’t take a statin? Make NEXLIZET happen!' campaign, have significantly increased brand awareness and prescriber engagement.
Strategic Partnerships and Approvals
Esperion finalized agreements with 4 generic manufacturers, ensuring no market entry of generic versions of NEXLETOL and NEXLIZET before April 2040. Additionally, bempedoic acid was included in the ESC/EAS guidelines, with U.S. guidelines expected to follow in early 2026.
International Expansion
Partnerships with Daiichi Sankyo Europe and Otsuka Pharmaceutical have shown strong growth, with significant market shares in Europe and upcoming launch in Japan. Royalty revenue from DSE increased 21% sequentially to $16.4 million.
Pipeline Advancements
Nomination of ESP-2001 as a preclinical development candidate for primary sclerosing cholangitis, with plans to initiate first-in-human clinical studies in 2026.
Negative Updates
Increased Operating Expenses
Research and development expenses increased by 36% to $14.1 million, and selling, general and administrative expenses rose by 5% to $41.8 million, primarily due to legal costs and media expenses.
Reimbursement Challenges
Despite a 9% increase in total retail prescription equivalents, U.S. revenues were relatively flat due to onetime investments in Medicare plans and a new e-voucher program affecting short-term financials.
Company Guidance
During the third quarter of 2025, Esperion reported a total revenue increase of 69% year-over-year, reaching $87.3 million. U.S. net product revenue grew by 31% to $40.7 million, while collaboration revenue surged by 128% to $46.7 million. The company achieved a 9% sequential increase in total retail prescription equivalents and a 7% rise in the number of healthcare professionals prescribing their products, expanding their prescriber base to over 30,000 practitioners. Esperion finalized agreements with four generic manufacturers, ensuring no market entry of generic NEXLETOL and NEXLIZET before April 2040, safeguarding the long-term value of their franchise. The inclusion of bempedoic acid in the 2025 ESC/EAS guidelines further validated its clinical benefits, with expectations for similar recognition in U.S. guidelines by early 2026. Additionally, the company reported an 87% Medicare coverage approval rate, with out-of-pocket costs reduced to $29 for a 30-day supply, and an 86% commercial coverage approval rate, with costs at $36. Internationally, they saw a 21% sequential increase in third-quarter royalty revenue from Daiichi Sankyo Europe, and Otsuka Pharmaceutical in Japan received preliminary pricing approval for NEXLETOL, indicating potential milestone payments upon final pricing approval.

Esperion Financial Statement Overview

Summary
Esperion's financial performance is challenged by significant profitability and financial stability issues. Despite strong revenue growth, the company faces negative net profit margins and negative equity, indicating high financial risk and leverage.
Income Statement
45
Neutral
Esperion has shown significant revenue growth from 2023 to 2024, with a Revenue Growth Rate of 185.6%. However, the company is still facing challenges with profitability as indicated by the negative Net Profit Margin of -15.6% in 2024. The Gross Profit Margin improved to 79.3%, but the negative EBIT and EBITDA margins reflect ongoing operational challenges.
Balance Sheet
30
Negative
The balance sheet reveals a concerning negative Stockholders' Equity of -$388.7 million, indicating financial instability. The Debt-to-Equity Ratio is not calculable due to negative equity, highlighting high leverage. The Equity Ratio is also negative, suggesting that liabilities exceed assets, which poses a significant risk.
Cash Flow
40
Negative
Esperion's cash flow situation is challenging, with a negative Free Cash Flow of -$23.97 million in 2024. The Operating Cash Flow to Net Income Ratio is negative, indicating cash flow issues relative to net losses. However, the company has managed to reduce its negative Free Cash Flow compared to previous years, showing some improvement.
BreakdownTTMDec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income Statement
Total Revenue303.80M332.31M116.33M75.47M78.45M227.55M
Gross Profit162.67M263.71M73.07M48.51M64.23M225.16M
EBITDA-27.34M7.57M-150.11M-176.35M-222.14M-120.33M
Net Income-105.83M-51.74M-209.25M-233.66M-269.11M-143.55M
Balance Sheet
Total Assets364.02M343.82M205.80M247.94M381.59M353.26M
Cash, Cash Equivalents and Short-Term Investments92.45M144.76M82.25M166.86M259.33M304.96M
Total Debt600.99M591.21M540.95M260.95M260.20M185.41M
Total Liabilities815.38M732.54M660.79M571.72M578.53M449.39M
Stockholders Equity-451.36M-388.72M-454.99M-323.78M-196.94M-96.13M
Cash Flow
Free Cash Flow-93.29M-23.97M-135.49M-174.83M-263.81M-98.55M
Operating Cash Flow-93.29M-23.65M-135.49M-174.83M-263.81M-85.18M
Investing Cash Flow0.00-317.00K42.50M8.10M-50.48M21.36M
Financing Cash Flow41.02M86.48M50.46M32.61M268.22M201.72M

Esperion Technical Analysis

Technical Analysis Sentiment
Neutral
Last Price2.79
Price Trends
50DMA
2.78
Positive
100DMA
2.26
Positive
200DMA
1.76
Positive
Market Momentum
MACD
0.04
Positive
RSI
48.96
Neutral
STOCH
45.12
Neutral
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For ESPR, the sentiment is Neutral. The current price of 2.79 is below the 20-day moving average (MA) of 2.86, above the 50-day MA of 2.78, and above the 200-day MA of 1.76, indicating a neutral trend. The MACD of 0.04 indicates Positive momentum. The RSI at 48.96 is Neutral, neither overbought nor oversold. The STOCH value of 45.12 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Neutral sentiment for ESPR.

Esperion Risk Analysis

Esperion disclosed 69 risk factors in its most recent earnings report. Esperion reported the most risks in the "Finance & Corporate" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 1 New Risks

Esperion Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
72
Outperform
$582.87M7.0939.94%-0.85%-13.50%
67
Neutral
$519.42M7.6413.92%-29.91%
60
Neutral
$651.06M0.30%2.24%-67.56%
51
Neutral
$7.86B-0.30-43.30%2.27%22.53%-2.21%
51
Neutral
$666.99M2.83%13.61%
49
Neutral
$439.48M15.10%0.18%
49
Neutral
$417.15M-7.82%1.76%18.31%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
ESPR
Esperion
2.79
0.32
12.96%
EBS
Emergent Biosolutions
9.89
0.49
5.21%
SIGA
SIGA Technologies
5.91
0.23
4.05%
ORGO
Organogenesis Holdings
5.13
1.11
27.61%
EOLS
Evolus
6.78
-6.26
-48.01%
SNDL
SNDL
1.62
-0.36
-18.18%

Esperion Corporate Events

Esperion Therapeutics Reports Strong Q3 Revenue Growth
Nov 7, 2025

Esperion Therapeutics, Inc. is a commercial-stage biopharmaceutical company focused on developing and marketing non-statin medicines for cardiovascular disease, with a unique emphasis on patients with elevated LDL-C levels who are statin intolerant.

Esperion Therapeutics Reports Strong Q3 Growth Amid Challenges
Nov 7, 2025

The latest earnings call from Esperion Therapeutics painted a picture of robust growth and strategic achievements, despite some financial hurdles. The company reported strong revenue growth, driven by successful strategic initiatives and international expansion. While increased operating expenses and onetime financial impacts were noted, the overall sentiment leaned towards optimism, with growth and strategic progress taking center stage.

Business Operations and StrategyExecutive/Board Changes
Esperion Appoints New Chief Commercial Officer
Positive
Nov 4, 2025

On November 4, 2025, Esperion Therapeutics announced the appointment of John B. Harlow, Jr. as the new Chief Commercial Officer, effective November 17, 2025. Harlow, who previously served as Chief Commercial Officer at Melinta Therapeutics, brings extensive experience in driving commercial strategies and enhancing sales and marketing performance. His appointment is expected to play a crucial role in expanding the adoption of Esperion’s cardiovascular risk reduction therapies and increasing the company’s global presence. Harlow’s leadership is anticipated to accelerate the delivery of innovative therapies to patients worldwide, furthering Esperion’s growth and market impact.

The most recent analyst rating on (ESPR) stock is a Hold with a $3.00 price target. To see the full list of analyst forecasts on Esperion stock, see the ESPR Stock Forecast page.

Business Operations and StrategyPrivate Placements and Financing
Esperion Announces Public Offering to Raise $70.2 Million
Neutral
Oct 8, 2025

On October 7, 2025, Esperion Therapeutics announced an underwritten public offering of 30,000,000 shares of its common stock at $2.50 per share, with an option for underwriters to purchase an additional 4,500,000 shares. The offering is expected to close around October 9, 2025, and aims to raise approximately $70.2 million, or $80.7 million if the option is fully exercised. The proceeds will primarily fund the commercialization of NEXLETOL and NEXLIZET, research and development, and general corporate purposes. This move is part of Esperion’s strategy to strengthen its financial position and support its ongoing operations and growth initiatives.

The most recent analyst rating on (ESPR) stock is a Buy with a $16.00 price target. To see the full list of analyst forecasts on Esperion stock, see the ESPR Stock Forecast page.

Business Operations and StrategyFinancial DisclosuresProduct-Related Announcements
Esperion Announces Strategic Expansion Plans for Bempedoic Acid
Positive
Oct 7, 2025

On October 7, 2025, Esperion Therapeutics announced an updated corporate presentation outlining their strategic plans to expand the Bempedoic Acid franchise globally. The company has secured key ANDA settlements extending exclusivity until April 19, 2040, and is implementing a balanced engagement strategy to boost physician adoption. Esperion aims to transition into a cash-generating pharmaceutical company by advancing its development pipeline and exploring potential acquisitions. The company reported its first quarter of operating income from ongoing business in Q2 2025, driven by increased product adoption and geographic expansion, supporting its profitability objectives.

The most recent analyst rating on (ESPR) stock is a Buy with a $16.00 price target. To see the full list of analyst forecasts on Esperion stock, see the ESPR Stock Forecast page.

Esperion Delays Q2 2025 Financial Report Filing
Aug 11, 2025

Esperion Therapeutics, Inc. has announced a delay in filing its Form 10-Q (Quarter Report) for the financial period ending June 30, 2025. The primary reason for the delay is the company’s need for additional time to complete its financial closing procedures, following the identification and correction of errors in its earnings release. Esperion expects to file the report no later than five calendar days after the prescribed due date. The company has not indicated any significant changes in financial results from the previous year. Ongoing compliance efforts are being managed by CEO Sheldon L. Koenig, who has signed the notification.

The most recent analyst rating on (ESPR) stock is a Buy with a $16.00 price target. To see the full list of analyst forecasts on Esperion stock, see the ESPR Stock Forecast page.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Nov 11, 2025