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Esperion (ESPR)
NASDAQ:ESPR
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Esperion (ESPR) AI Stock Analysis

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ESPR

Esperion

(NASDAQ:ESPR)

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Neutral 59 (OpenAI - 4o)
Rating:59Neutral
Price Target:
$3.00
▲(3.45% Upside)
Esperion's stock score is primarily influenced by its robust earnings call performance, indicating strong revenue growth and strategic achievements. However, significant financial challenges, including negative equity and ongoing losses, weigh heavily on the overall score. The technical analysis shows positive momentum, but valuation concerns due to a negative P/E ratio and lack of dividend yield further impact the score.
Positive Factors
Revenue Growth
The consistent revenue growth indicates strong market demand and effective sales strategies, which are crucial for long-term financial health and expansion.
International Expansion
Growth in international markets through partnerships enhances revenue streams and diversifies market risks, supporting sustainable business growth.
Patent Protection
Extended patent protection secures market exclusivity, allowing Esperion to maintain pricing power and revenue from its key products.
Negative Factors
Negative Equity
Negative equity indicates financial instability, posing risks to long-term viability and limiting the company's ability to raise capital.
Cash Flow Challenges
Negative cash flow can hinder operational capabilities and investment in growth opportunities, affecting long-term sustainability.
Profitability Issues
Ongoing profitability issues suggest operational inefficiencies, which may impact the company's ability to achieve sustainable growth and investor confidence.

Esperion (ESPR) vs. SPDR S&P 500 ETF (SPY)

Esperion Business Overview & Revenue Model

Company DescriptionEsperion Therapeutics, Inc., a pharmaceutical company, develops and commercializes medicines for the treatment of patients with elevated low density lipoprotein cholesterol. Its lead product candidates are NEXLETOL (bempedoic acid) and NEXLIZET (bempedoic acid and ezetimibe) tablets for the treatment of patients with atherosclerotic cardiovascular disease or heterozygous familial hypercholesterolemia. The company has a license and collaboration agreement with Daiichi Sankyo Europe GmbH; and Serometrix to in-license its oral, small molecule PCSK9 inhibitor program. Esperion Therapeutics, Inc. was incorporated in 2008 and is headquartered in Ann Arbor, Michigan.
How the Company Makes MoneyEsperion generates revenue primarily through the sale of its pharmaceutical products, particularly bempedoic acid, which is marketed under the brand name Nexletol. The company earns revenue by selling these products to healthcare providers and pharmacies, which in turn sell them to patients. Additionally, Esperion may receive royalties and milestone payments from partnerships and collaborations with larger pharmaceutical companies that have been established to enhance distribution and marketing efforts. Such partnerships can also facilitate access to broader markets and boost sales. Furthermore, the company may benefit from government and private health insurance reimbursements that cover the cost of its therapies, contributing significantly to its overall revenue.

Esperion Earnings Call Summary

Earnings Call Date:Aug 11, 2025
(Q2-2025)
|
% Change Since: |
Next Earnings Date:Nov 06, 2025
Earnings Call Sentiment Positive
The earnings call highlighted Esperion's robust financial performance with significant revenue growth and strategic achievements, such as achieving operating income for the first time and strong international partnerships. While there were some concerns about collaboration revenue and milestone payments, the positive aspects of the company's growth and strategic initiatives significantly outweigh the challenges.
Q2-2025 Updates
Positive Updates
Record Revenue Growth
Esperion reported a 12% year-over-year increase in total revenue for Q2 2025, reaching $82.4 million. U.S. net product sales saw a 42% increase year-over-year to $40.3 million.
First Operating Income
Esperion achieved its first quarter of operating income from ongoing business, amounting to approximately $15 million, signaling a transition towards sustainable profitability by Q1 2026.
Significant Increase in Prescriptions
Esperion reported double-digit sequential growth in prescriptions, with a 10% increase in total retail prescription equivalents from Q1 2025.
Strong International Performance
Royalty revenue from Daiichi Sankyo Europe increased 30% from Q1 2025, and the company surpassed the 500,000 patient mark in Europe.
Successful Marketing Campaigns
The 'Can't take a statin? Make NEXLIZET happen' campaign drove significant brand awareness, with 650,000 visits to the consumer website and 600,000 click-throughs to the physician site.
Intellectual Property Settlements
Esperion reached settlement agreements with three generic manufacturers to delay the marketing of generic NEXLETOL in the U.S. until 2040.
Negative Updates
Collaboration Revenue Decline
Collaboration revenue decreased by 7% compared to the same period in 2024, primarily due to a settlement milestone in the prior year, although this was offset by a 105% increase when excluding the milestone.
Uncertainty in Milestone Payments
Concerns were raised regarding the timing and conditions of milestone payments from Otsuka Pharmaceuticals, though management expressed confidence in achieving the full amount.
Company Guidance
During Esperion's Second Quarter 2025 earnings call, the company reported strong financial performance, highlighted by a 42% year-over-year increase in U.S. net product revenue, reaching $40.3 million, and a total revenue growth of 12% year-over-year to $82.4 million. This period marked their first quarter of operating income from ongoing business, approximately $15 million, and a sequential quarterly revenue growth of 15%. Esperion emphasized the robust adoption of their products NEXLETOL and NEXLIZET, driven by effective marketing strategies and favorable reimbursement landscapes, which led to over 80% approval rates among targeted prescribers. The company also noted significant gains in digital engagement, with 38% of prescriptions prompted by digital-only interactions. Their international partnerships contributed to the revenue, with a 30% increase in royalty revenue from Daiichi Sankyo Europe. Looking ahead, Esperion is optimistic about transitioning to sustainable profitability by the first quarter of 2026 and anticipates continued growth fueled by both domestic and international market expansions.

Esperion Financial Statement Overview

Summary
Esperion shows strong revenue growth but faces significant challenges with profitability and financial stability. The negative equity and high leverage are concerning, and cash flow remains negative despite some improvements.
Income Statement
45
Neutral
Esperion has shown significant revenue growth from 2023 to 2024, with a Revenue Growth Rate of 185.6%. However, the company is still facing challenges with profitability as indicated by the negative Net Profit Margin of -15.6% in 2024. The Gross Profit Margin improved to 79.3%, but the negative EBIT and EBITDA margins reflect ongoing operational challenges.
Balance Sheet
30
Negative
The balance sheet reveals a concerning negative Stockholders' Equity of -$388.7 million, indicating financial instability. The Debt-to-Equity Ratio is not calculable due to negative equity, highlighting high leverage. The Equity Ratio is also negative, suggesting that liabilities exceed assets, which poses a significant risk.
Cash Flow
40
Negative
Esperion's cash flow situation is challenging, with a negative Free Cash Flow of -$23.97 million in 2024. The Operating Cash Flow to Net Income Ratio is negative, indicating cash flow issues relative to net losses. However, the company has managed to reduce its negative Free Cash Flow compared to previous years, showing some improvement.
BreakdownTTMDec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income Statement
Total Revenue268.13M332.31M116.33M75.47M78.45M227.55M
Gross Profit173.06M263.71M73.07M48.51M64.23M225.16M
EBITDA-24.59M7.57M-150.11M-176.35M-222.14M-120.33M
Net Income-96.09M-51.74M-209.25M-287.82M-318.82M-166.19M
Balance Sheet
Total Assets347.08M343.82M205.80M247.94M381.59M353.26M
Cash, Cash Equivalents and Short-Term Investments86.06M144.76M82.25M124.78M208.89M304.96M
Total Debt146.45M591.21M540.95M260.95M260.20M185.41M
Total Liabilities780.59M732.54M660.79M571.72M578.53M449.39M
Stockholders Equity-433.51M-388.72M-454.99M-1.34B-1.11B-838.82M
Cash Flow
Free Cash Flow-124.49M-23.97M-135.49M-174.83M-263.81M-98.55M
Operating Cash Flow-124.33M-23.65M-135.49M-174.83M-263.81M-85.18M
Investing Cash Flow-167.00K-317.00K42.50M8.10M-50.48M21.36M
Financing Cash Flow21.25M86.48M50.46M32.61M268.22M201.72M

Esperion Technical Analysis

Technical Analysis Sentiment
Positive
Last Price2.90
Price Trends
50DMA
2.58
Positive
100DMA
1.96
Positive
200DMA
1.69
Positive
Market Momentum
MACD
0.05
Positive
RSI
57.77
Neutral
STOCH
67.51
Neutral
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For ESPR, the sentiment is Positive. The current price of 2.9 is above the 20-day moving average (MA) of 2.77, above the 50-day MA of 2.58, and above the 200-day MA of 1.69, indicating a bullish trend. The MACD of 0.05 indicates Positive momentum. The RSI at 57.77 is Neutral, neither overbought nor oversold. The STOCH value of 67.51 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Positive sentiment for ESPR.

Esperion Risk Analysis

Esperion disclosed 69 risk factors in its most recent earnings report. Esperion reported the most risks in the "Finance & Corporate" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks

Esperion Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
$604.35M7.3443.61%3.86%-2.60%
$519.64M3.9530.24%-22.74%
$627.70M-3.48%36.57%
$7.86B-0.30-43.30%2.27%22.53%-2.21%
$576.58M-8.30%0.70%15.62%
$540.41M-2.64%-4.21%7.78%
$439.21M-9999.00%17.15%-7.23%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
ESPR
Esperion
2.90
0.77
36.15%
EBS
Emergent Biosolutions
9.69
0.02
0.21%
SIGA
SIGA Technologies
8.43
2.07
32.55%
ORGO
Organogenesis Holdings
4.28
1.33
45.08%
EOLS
Evolus
7.22
-9.05
-55.62%
SNDL
SNDL
2.24
0.03
1.36%

Esperion Corporate Events

Business Operations and StrategyPrivate Placements and Financing
Esperion Announces Public Offering to Raise $70.2 Million
Neutral
Oct 8, 2025

On October 7, 2025, Esperion Therapeutics announced an underwritten public offering of 30,000,000 shares of its common stock at $2.50 per share, with an option for underwriters to purchase an additional 4,500,000 shares. The offering is expected to close around October 9, 2025, and aims to raise approximately $70.2 million, or $80.7 million if the option is fully exercised. The proceeds will primarily fund the commercialization of NEXLETOL and NEXLIZET, research and development, and general corporate purposes. This move is part of Esperion’s strategy to strengthen its financial position and support its ongoing operations and growth initiatives.

The most recent analyst rating on (ESPR) stock is a Buy with a $16.00 price target. To see the full list of analyst forecasts on Esperion stock, see the ESPR Stock Forecast page.

Business Operations and StrategyFinancial DisclosuresProduct-Related Announcements
Esperion Announces Strategic Expansion Plans for Bempedoic Acid
Positive
Oct 7, 2025

On October 7, 2025, Esperion Therapeutics announced an updated corporate presentation outlining their strategic plans to expand the Bempedoic Acid franchise globally. The company has secured key ANDA settlements extending exclusivity until April 19, 2040, and is implementing a balanced engagement strategy to boost physician adoption. Esperion aims to transition into a cash-generating pharmaceutical company by advancing its development pipeline and exploring potential acquisitions. The company reported its first quarter of operating income from ongoing business in Q2 2025, driven by increased product adoption and geographic expansion, supporting its profitability objectives.

The most recent analyst rating on (ESPR) stock is a Buy with a $16.00 price target. To see the full list of analyst forecasts on Esperion stock, see the ESPR Stock Forecast page.

Esperion Delays Q2 2025 Financial Report Filing
Aug 11, 2025

Esperion Therapeutics, Inc. has announced a delay in filing its Form 10-Q (Quarter Report) for the financial period ending June 30, 2025. The primary reason for the delay is the company’s need for additional time to complete its financial closing procedures, following the identification and correction of errors in its earnings release. Esperion expects to file the report no later than five calendar days after the prescribed due date. The company has not indicated any significant changes in financial results from the previous year. Ongoing compliance efforts are being managed by CEO Sheldon L. Koenig, who has signed the notification.

The most recent analyst rating on (ESPR) stock is a Buy with a $16.00 price target. To see the full list of analyst forecasts on Esperion stock, see the ESPR Stock Forecast page.

Esperion Therapeutics Reports Strong Q2 2025 Growth
Aug 6, 2025

Esperion Therapeutics, Inc. is a biopharmaceutical company focused on developing and commercializing oral, non-statin medications for cardiovascular disease prevention, particularly for patients with elevated LDL cholesterol levels. In its second quarter of 2025, Esperion reported a 12% year-over-year increase in total revenue, reaching $82.4 million, with U.S. net product revenue growing by 42% to $40.3 million. The company also achieved its first quarter of operating income from ongoing operations, marking a significant milestone in its financial performance. Key highlights include settlement agreements preventing generic versions of its drug NEXLETOL from entering the market before 2040 and strategic expansions in international markets, including Japan and Europe. Esperion’s research and development expenses decreased by 37% compared to the previous year, and the company reduced its net loss significantly from $61.9 million in Q2 2024 to $4.8 million in Q2 2025. Looking ahead, Esperion anticipates achieving sustainable profitability by the first quarter of 2026, driven by continued revenue growth and strategic market expansions.

Esperion Therapeutics’ Earnings Call Highlights Growth
Aug 6, 2025

Esperion Therapeutics’ recent earnings call exuded a positive sentiment, underscored by robust growth in U.S. sales and successful marketing strategies. The company demonstrated significant progress in international markets, with strategic initiatives driving increased revenue and market penetration. Despite a slight dip in collaboration revenue, the overall positive developments and promising future prospects were the focal points of the discussion.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Oct 23, 2025