Transformational Acquisition of Corstasis / Enbumyst
Announced planned acquisition of Corstasis Therapeutics to gain global rights to Enbumyst (FDA-approved intranasal diuretic) and a subcutaneous pipeline; transaction expected to close in Q2 2026 and provides entry into a >$4 billion U.S. outpatient heart failure market with immediate cross-selling synergies.
Record Quarterly and Annual Revenue Growth
Fourth quarter 2025 total revenue was $168.4 million, an increase of 144% year-over-year, driven by stronger product sales and collaboration payments.
Strong U.S. Bempedoic Acid Commercial Performance
U.S. net product revenue for Q4 was $43.7 million, up ~38% versus Q4 2024; retail prescription equivalents grew 34% and the number of unique HCPs prescribing NEXLETOL/NEXLIZET increased nearly 25%.
Large Collaboration and Milestone Contribution
Collaboration revenue in Q4 was $124.7 million versus $37.6 million prior-year (+232%), driven partly by a one-time $90 million payment from Otsuka tied to regulatory approval and favorable NHI pricing.
International Expansion Momentum
Daiichi Sankyo Europe increased Q4 royalty revenue by 51% year-over-year, expanded access to 30 countries and, with partners, has treated over 700,000 patients to date; Otsuka launched NEXLETOL in Japan with favorable national health insurance pricing and early reception exceeding expectations.
Stronger Balance Sheet and Debt Reduction
Ended 2025 with $167.9 million in cash and cash equivalents and paid off $55 million of debt by retiring the 2025 convertible note stub, supporting planned integration and launches.
Pipeline Progress and New Development Candidate
Nominated ESP-2001 as next development candidate for primary sclerosing cholangitis (PSC); advancing IND-enabling studies with clinical entry planned by year-end.
Triple Combination Programs Targeting High LDL Reductions
Advancing two triple combination programs (bempedoic acid + ezetimibe + low‑dose statins) with plans to complete clinical/regulatory requirements to commercialize in 2027; published data suggest potential LDL reductions up to ~70%.
Operational Readiness for Guideline and Market Opportunities
Prepared cross-functional plans for anticipated U.S. dyslipidemia guideline inclusion and ACC timing; management reports ~90% commercial and Medicare coverage and readiness to leverage guideline-driven awareness.
Controlled Post-Acquisition Post-Market Requirements
Corstasis Enbumyst has some small post‑marketing (PMR) study obligations that management expects to be minimal and included in updated expense guidance.