Castle Biosciences (CSTL) AI Stock Analysis

• Market Cap: $587.26M
• Dividend Yield: N/A
• Average Volume (3M): 421.34K
• Price to Earnings (P/E): 30.6
• Beta (1Y): 0.68
• Revenue Growth: 38.43%
• EPS Growth: 86.19%
• Country: US
• Employees: 784
• Sector: Healthcare
• Sector Strength: 47
• Industry: Medical - Diagnostics & Research
• EPS (TTM): -0.90
• Shares Outstanding: 28,872,314
• 10 Day Avg. Volume: 495,179
• 30 Day Avg. Volume: 421,338
• PEG Ratio: -0.08
• Price to Book (P/B): 1.54
• Price to Sales (P/S): 0.00
• P/FCF Ratio: -12.97
• Enterprise Value/Market Cap: 0.86
• Enterprise Value/Revenue: 0.39
• Enterprise Value/Gross Profit: 1.69
• Enterprise Value/Ebitda: 4.59
• 1Y Price Target: $35.83
• Price Target Upside: 76.16% Upside
• Rating Consensus: Strong Buy
• Number of Analyst Covering: 6

• Rating: 73 Outperform
• Price Target: $21.00 ▲(3.24%Upside)

Castle Biosciences demonstrates strong financial performance and promising earnings call highlights, offset by valuation concerns due to a negative P/E ratio. The stock shows short-term bullish technical indicators but is challenged by longer-term trends.

Positive Factors

Collaboration Opportunities

Castle Biosciences enters a collaboration and license agreement with SciBase Holding AB to develop a diagnostic test for atopic dermatitis.

Financial Performance

Castle reported 4Q24 revenues of $86.3M, well ahead of consensus of $80.4M and estimate of $82.3M.

Growth Potential

Triple-digit growth in CSTL's TissueCypher marked a highlight, indicating strong demand and market success.

Negative Factors

Growth Challenges

There is material risk to the company executing on its growth strategy.

Reimbursement Uncertainty

There is uncertainty regarding the SCC reimbursement status, which could impact CSTL's profitability.

Revenue Concerns

CSTL will no longer benefit from DDx-SCC revenue.

Castle Biosciences Business Overview & Revenue Model

Company Description

Castle Biosciences, Inc. (CSTL) is a leading diagnostics company specializing in the development and commercialization of innovative diagnostic and prognostic tests for dermatologic cancers and other complex diseases. The company focuses on providing clinicians with actionable genomic information to improve treatment decisions and patient outcomes. Its flagship products include proprietary multi-gene expression profile tests that help in the management of melanoma, cutaneous squamous cell carcinoma, and other skin conditions.

How the Company Makes Money

Castle Biosciences generates revenue primarily through the sale of its proprietary diagnostic tests to healthcare providers, hospitals, and laboratories. The company earns money by charging fees for each test conducted, which are reimbursed by insurance companies, Medicare, and other third-party payers. Key revenue streams include their DecisionDx-Melanoma test, DecisionDx-SCC, and DecisionDx-UM, among others. Castle Biosciences also forms strategic partnerships with biopharmaceutical companies to collaborate on the development of new tests and to expand its product offerings. The company's growth is driven by the adoption of its tests, expansion into new markets, and ongoing research and development efforts to enhance its test portfolio.

Castle Biosciences Financial Statement Overview

Summary

Castle Biosciences demonstrates substantial financial improvement across all fronts, with strong revenue growth, improved profitability, and cash flow recovery. The company's low debt levels and strong equity base provide stability, while the positive cash flow metrics underscore efficient operational management. These factors position the company well for future growth and resilience.

Income Statement

Castle Biosciences shows strong revenue growth with a 51.1% increase from 2023 to 2024, indicating robust market demand. Gross Profit Margin is stable at approximately 100%, demonstrating effective cost management. Net Profit Margin improved significantly to 5.5% in 2024 from a negative margin in 2023, reflecting enhanced profitability. Both EBIT and EBITDA Margins turned positive, indicating improved operational efficiency.

Balance Sheet

The company maintains a healthy Equity Ratio of 85.8%, suggesting a strong capital structure with low reliance on debt. The Debt-to-Equity Ratio is favorable at 0.06, indicating low financial leverage. Return on Equity improved to 4.0% in 2024, a positive turnaround from previous losses, showing better returns on shareholder investments.

Cash Flow

Castle Biosciences' Free Cash Flow turned positive in 2024, indicating improved cash management and operational efficiency. The significant Free Cash Flow Growth Rate from a negative base in 2023 highlights a strong recovery. The Operating Cash Flow to Net Income Ratio is robust at 3.56, reflecting effective cash generation from operations.

Breakdown	TTM	Dec 2024	Dec 2023	Dec 2022	Dec 2021	Dec 2020
Income Statement
Total Revenue	347.08M	332.07M	219.79M	137.04M	94.08M	62.65M
Gross Profit	298.06M	271.86M	174.81M	105.03M	78.26M	52.96M
EBITDA	37.27M	38.14M	-45.02M	-58.34M	-36.60M	-7.09M
Net Income	-5.07M	18.25M	-57.47M	-67.14M	-31.29M	-10.28M
Balance Sheet
Total Assets	501.71M	531.24M	453.34M	447.33M	462.57M	439.33M
Cash, Cash Equivalents and Short-Term Investments	275.15M	293.13M	243.10M	258.63M	329.63M	409.85M
Total Debt	25.84M	26.34M	15.34M	13.31M	8.08M	0.00
Total Liabilities	61.41M	75.40M	62.07M	48.18M	50.83M	23.64M
Stockholders Equity	440.31M	455.83M	391.27M	399.15M	411.74M	415.69M
Cash Flow
Free Cash Flow	41.75M	36.54M	-19.25M	-47.29M	-22.47M	5.11M
Operating Cash Flow	65.67M	64.87M	-5.63M	-41.66M	-18.98M	9.87M
Investing Cash Flow	-52.87M	-50.14M	-16.18M	-166.54M	-66.66M	-4.75M
Financing Cash Flow	-6.06M	6.14M	-2.30M	1.51M	5.42M	305.89M

Castle Biosciences Technical Analysis

• Technical Analysis Sentiment: Neutral
• Last Price: 20.34
• 50DMA: Positive
• 100DMA: Negative
• 200DMA: Negative
• MACD: Negative
• RSI: Neutral
• STOCH: Negative

Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For CSTL, the sentiment is Neutral. The current price of 20.34 is above the 20-day moving average (MA) of 18.87, above the 50-day MA of 18.18, and below the 200-day MA of 24.90, indicating a neutral trend. The MACD of 0.69 indicates Negative momentum. The RSI at 63.99 is Neutral, neither overbought nor oversold. The STOCH value of 85.48 is Negative, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Neutral sentiment for CSTL.

Castle Biosciences Peers Comparison

Name	Overall Rating	Market Cap	P/E Ratio	ROE	Dividend Yield	Revenue Growth	EPS Growth
CSTL	73 Outperform	$587.26M	30.59	-1.20%	―	38.43%	86.19%
GRAL	70 Neutral	$1.77B	―	-62.22%	―	30.47%	-26.63%
PSNL	60 Neutral	$580.30M	―	-51.25%	―	15.57%	31.82%
LAB	55 Neutral	$489.97M	―	-25.73%	―	33.86%	64.34%
FLGT	52 Neutral	$606.13M	―	-3.61%	―	1.71%	76.00%
Sector *	51 Neutral	$7.55B	0.30	-61.90%	2.27%	17.11%	1.58%
MYGN	45 Neutral	$509.74M	―	-13.84%	―	7.38%	60.45%

Castle Biosciences Corporate Events

Castle Biosciences Holds Annual Stockholders Meeting

On May 22, 2025, Castle Biosciences held its annual meeting of stockholders, where key decisions were made. Stockholders elected three Class III Directors to serve until 2028, ratified KPMG LLP as the independent accounting firm for 2025, approved executive compensation, and amended the company’s certificate of incorporation to limit officer liability. These decisions reflect the company’s ongoing efforts to strengthen governance and operational frameworks.

The most recent analyst rating on (CSTL) stock is a Buy with a $34.00 price target. To see the full list of analyst forecasts on Castle Biosciences stock, see the CSTL Stock Forecast page.

Castle Biosciences Reports 21% Revenue Increase in Q1 2025

On May 5, 2025, Castle Biosciences reported a 21% increase in Q1 2025 revenue to $88 million compared to the same period in 2024, driven by a 33% rise in test reports for core products. The company raised its full-year revenue guidance to $287-297 million, reflecting strong growth and successful execution in its test portfolio. A significant milestone was achieved with over 200,000 orders for DecisionDx-Melanoma, which has been shown to improve patient survival rates. The company also announced the discontinuation of the IDgenetix test offering, effective May 2025, impacting its financials with a net loss of $25.8 million for the quarter.