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Corcept Therapeutics Inc. (CORT)
NASDAQ:CORT

Corcept Therapeutics (CORT) AI Stock Analysis

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CORT

Corcept Therapeutics

(NASDAQ:CORT)

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Neutral 67 (OpenAI - 5.2)
Rating:67Neutral
Price Target:
$40.00
▲(9.65% Upside)
Action:ReiteratedDate:02/25/26
The score is supported by strong financial quality (rapid revenue growth, very high gross margins, and a low-debt balance sheet) and a generally constructive earnings outlook with meaningful pipeline catalysts. It is constrained by clearly bearish technicals (price far below key moving averages with negative MACD), premium valuation (P/E ~41.7), and elevated regulatory/legal risks highlighted on the earnings call (CRL and patent ruling) alongside 2025 margin and cash-flow softening.
Positive Factors
Revenue Growth & High Gross Margins
Sustained top-line growth with exceptionally high gross margins indicates durable demand and strong unit economics for Korlym. High margins support cash generation and reinvestment in trials and commercialization, giving the company long-term funding flexibility even amid episodic pressures.
Conservative Balance Sheet & Cash
A low-leverage balance sheet and a sizeable cash position provide financial flexibility to fund ongoing trials, regulatory interactions, and operational scaling. The ability to repurchase shares while retaining cash suggests capital allocation discipline and a buffer against execution or regulatory delays.
Robust Clinical Proof and Upcoming Catalysts
Positive pivotal data in ROSELLA is a structural value driver: a clear survival benefit strengthens relacorilant's regulatory case in oncology and supports label expansion. Multiple additional mid/late-stage readouts through 2027 create durable catalyst cadence and potential new revenue streams beyond Korlym.
Negative Factors
FDA Complete Response Letter for Relacorilant
The CRL introduces structural regulatory uncertainty and likely requires additional clinical or safety data, delaying U.S. commercialization for a meaningful indication. Protracted regulatory review increases development costs and pushes out revenue diversification timelines for relacorilant.
Appellate Setback in Korlym Patent Case
The adverse appellate ruling raises the prospect of generic entry or broader generic access, which would structurally erode Korlym's revenue base. As Korlym is the flagship revenue driver, weakened exclusivity increases long-term sales risk and heightens the importance of successful pipeline commercialization.
Profitability Compression & Weaker Cash Conversion
Material decline in net margin and weaker operating cash conversion signals rising operating costs or timing headwinds. If margins and cash conversion remain depressed, the company will face reduced internal funding for trials and commercialization, increasing dependency on external capital or more aggressive allocation tradeoffs.

Corcept Therapeutics (CORT) vs. SPDR S&P 500 ETF (SPY)

Corcept Therapeutics Business Overview & Revenue Model

Company DescriptionCorcept Therapeutics Incorporated discovers, develops, and commercializes drugs for the treatment of severe metabolic, oncologic, and neuropsychiatric disorders in the United States. The company offers Korlym (mifepristone) tablets as a once-daily oral medication for the treatment of hyperglycemia secondary to hypercortisolism in adult patients with endogenous Cushing's syndrome, who have type 2 diabetes mellitus or glucose intolerance, and have failed surgery or are not candidates for surgery. It is developing relacorilant to treat patients with Cushing's syndrome; and nab-paclitaxel in combination with relacorilant, which has completed Phase II clinical trial to treat patients with advanced ovarian tumors, as well as for the treatment of cortisol excess. The company is also developing selective cortisol modulator to treat patients with metastatic castration-resistant prostate cancer; selective cortisol modulator for the treatment of antipsychotic-induced weight gain and other disorders; and FKBP5 gene expression assays. Corcept Therapeutics Incorporated was incorporated in 1998 and is headquartered in Menlo Park, California.
How the Company Makes MoneyCorcept Therapeutics generates revenue primarily through the sale of its flagship product, Korlym, which is prescribed for patients with Cushing's syndrome. The company also engages in research collaborations and partnerships that may provide additional funding and resources for the development of new therapies. Revenue is driven by both direct sales to healthcare providers and reimbursement from insurance companies. Additionally, Corcept's focus on expanding the indications for its existing products and developing new treatments contributes to its potential revenue growth, as successful clinical trials can lead to new market opportunities.

Corcept Therapeutics Key Performance Indicators (KPIs)

Any
Any
Research & Development Expense Breakdown
Research & Development Expense Breakdown
Allocation of R&D spending across programs and trial stages reveals how Corcept is prioritizing its pipeline—whether cash is focused on late‑stage clinical trials that could produce near‑term approvals and revenue, or on early discovery that points to longer‑term growth. Changes in the mix and absolute R&D spend also signal the company’s cash burn and financing needs, the surface area for regulatory and clinical risk, and how management balances short‑term commercial support with long‑term drug development.
Chart InsightsCorcept has materially reallocated R&D toward hypercortisolism and oncology: hypercortisolism spend surges into 2024–25 consistent with relacorilant’s imminent PDUFA dates and commercialization prep, while oncology investment also rises, reflecting new trials. By contrast, pre‑clinical/early‑stage spending has been cut sharply in 2025, signaling prioritization of late‑stage programs. Rising unallocated and stock‑based comp suggest higher commercialization and retention costs. That mix explains why revenue grew but net income fell—management is front‑loading investment to capture the multibillion relacorilant opportunity, at the expense of near‑term margins and increased litigation and commercialization risks.
Data provided by:The Fly

Corcept Therapeutics Earnings Call Summary

Earnings Call Date:Feb 24, 2026
(Q4-2025)
|
Next Earnings Date:May 06, 2026
Earnings Call Sentiment Neutral
The call presented a mix of strong commercial momentum, robust clinical successes across multiple programs (notably ROSELLA and DAZALS), clear revenue growth and higher guidance, and resolved operational capacity with an improving commercial outlook. These positives are tempered by a significant regulatory setback for relacorilant in Cushing's syndrome, a Federal Circuit loss in the generic patent dispute, meaningful net income decline, and prior pharmacy-related supply disruptions. The pipeline and upcoming readouts provide multiple near-term catalysts, while regulatory and legal risks require attention.
Q4-2025 Updates
Positive Updates
Revenue Growth and 2026 Guidance
Full-year 2025 revenue was $761 million, up from $675 million in 2024 (≈+12.8%). Company provided 2026 revenue guidance of $900 million to $1 billion.
Strong Cash Position and Capital Actions
Cash and investments at December 31, 2025 were $532 million; 2025 included $245 million of share repurchases under the repurchase program.
Commercial Demand Expansion for Cushing's Products
Record number of new prescriptions in 2025: new prescriptions increased 61% year-over-year; tablets delivered increased 37% year-over-year despite capacity constraints, and monthly new patient starts improving after pharmacy transition.
CATALYST Trial — Diabetes Population Findings
Prevalence phase screened 1,000 uncontrolled diabetes patients and found 24% had hypercortisolism; treatment phase (n=136) showed Korlym reduced mean HbA1c by 1.47% vs 0.17% for placebo (absolute delta ≈1.30%), plus large decreases in weight and waist circumference.
ROSELLA Phase III — Positive Oncology Outcomes
In platinum-resistant ovarian cancer, relacorilant plus nab‑paclitaxel reduced risk of death by 35% (HR 0.65, p=0.0004), with median overall survival extended by 4.1 months and up to 8 months longer at the 75th percentile; met both dual primary endpoints and full data to be presented at SGO.
DAZALS (ALS) Phase II — Large Mortality Signal
In DAZALS, patients receiving 300 mg dazucorilant for 1 year showed an 84% reduction in risk of death vs placebo (p=0.0009); company initiating dose-titration work to address tolerability and plans pivotal trial later this year.
Ongoing Pipeline Momentum and Upcoming Readouts
MONARCH Phase IIb (MASH) fully enrolled (175 patients) with results expected by year-end; MOMENTUM results (resistant hypertension prevalence/treatment) to be announced next month; multiple oncology and combination studies ongoing with anticipated data through 2027.
Resolved Pharmacy Capacity Transition
Completed transition to new specialty pharmacy (Curant) with final patient files received; company reports improving fulfillment metrics, on track for a monthly record for new patient starts and greater capacity/scalability going forward.
Negative Updates
FDA Complete Response Letter for Relacorilant in Cushing's Syndrome
FDA declined approval for relacorilant in Cushing's syndrome despite GRACE meeting its primary endpoint (p=0.02); cited liver enzyme elevations among issues. Company plans an April meeting with FDA to determine next steps (resubmission, appeal, or new study).
Federal Circuit Ruling Against Patent Case Versus Teva
Federal Circuit ruled against Corcept in lawsuit to stop Teva marketing a generic Korlym; company believes the court erred and plans to appeal, creating potential competitive pressure on Korlym sales.
Net Income Decline
Net income for full-year 2025 was $99.7 million versus $141.2 million in 2024, a decline of roughly 29.4%, reflecting lower profitability year-over-year.
Commercial Supply Disruption Impacted Deliveries
Operational capacity limitations at prior pharmacy vendor caused a mismatch between a 61% increase in new prescriptions and only a 37% increase in tablets sold, indicating lost or delayed supply fulfillment during the transition period.
Authorized Generic (AG) Price Pressure
AG channel represented ~75% of business at year-end and ~78% currently; AG net price is about a 30% discount to WAC, and company expects AG-related pricing pressure to be essentially stabilized but built into 2026 assumptions.
Tolerability Issues in DAZALS Leading to Discontinuations
DAZALS discontinuations were primarily due to nonserious gastrointestinal distress; company is conducting a dose-titration study to mitigate GI tolerability before proceeding to a pivotal trial.
Company Guidance
Management guided 2026 revenue of $900 million to $1.0 billion (2025 revenue was $761M vs $675M in 2024), said most of the guide is driven by the Cushing’s business (oncology is a small portion), and reported 2025 net income of $99.7M and cash & investments of $532M (after $245M of stock repurchases in 2025). Commercial metrics: tablets delivered +37% vs 2024 while new prescriptions were +61% (tablet growth was constrained by a pharmacy transition), about 75% of volume ended the year flowing through the AG at roughly a 30% discount to WAC (about 78% currently), and February was on track for a monthly record of new patient starts. Clinical/regulatory milestones and trial metrics cited include a relacorilant oncology PDUFA of July 11; ROSELLA OS hazard ratio 0.65 (35% reduction in risk of death, p=0.0004) with median OS +4.1 months (75th‑percentile +8 months); GRACE primary endpoint p=0.02; CATALYST screened 1,000 patients (24% had hypercortisolism), randomized 136 with Korlym showing −1.47% HbA1c vs −0.17% placebo at 24 weeks; DAZALS (n=249) reported an 84% reduction in risk of death at 300 mg (p=0.0009); MONARCH Phase IIb (n=175) is fully enrolled with results by year‑end; and management reiterated a longer‑term objective of Cushing’s revenue of at least $2 billion annually by the end of the decade.

Corcept Therapeutics Financial Statement Overview

Summary
Strong top-line growth (2025 revenue $761M vs $675M) and exceptionally high gross margins (~98%+) support quality, and the balance sheet is very conservative (debt-to-equity ~0.9%) with sizable equity. Offsetting this, 2025 profitability compressed materially (net margin ~12.9% vs ~20.7% in 2024) and free cash flow fell year-over-year with weaker cash conversion (OCF ~0.85x net income).
Income Statement
78
Positive
Revenue has grown strongly over the period, accelerating in 2025 (annual revenue up from $675M to $761M), supporting a solid growth profile. Profitability remains positive with very high gross margins (~98%+), but operating and net profitability have compressed meaningfully versus 2021–2024 (net margin down to ~12.9% in 2025 from ~20.7% in 2024), indicating higher operating costs and/or elevated expenses weighing on earnings power.
Balance Sheet
92
Very Positive
The balance sheet is conservatively positioned with minimal leverage (debt-to-equity ~0.9% in 2025) and a large equity base (~$648M) supporting financial flexibility. Returns on equity are healthy (mid-teens in 2025) but have trended down from the low-20% range in 2022–2024, consistent with the recent profitability compression.
Cash Flow
74
Positive
Cash generation is solid with operating cash flow of ~$142M and free cash flow of ~$142M in 2025, and free cash flow closely tracks net income (near 1.0x), suggesting good earnings quality. However, cash flow has weakened year-over-year (free cash flow down ~12.8% in 2025) and operating cash flow no longer fully covers net income in 2025 (~0.85x), pointing to some working-capital or timing headwinds versus prior years.
BreakdownTTMDec 2025Dec 2024Dec 2023Dec 2022Dec 2021
Income Statement
Total Revenue741.17M761.41M675.04M482.38M401.86M365.98M
Gross Profit727.78M748.43M664.16M475.89M396.47M360.70M
EBITDA72.46M68.35M138.29M108.32M113.89M127.95M
Net Income105.19M98.17M139.73M106.14M101.42M112.51M
Balance Sheet
Total Assets823.61M836.65M840.55M621.52M583.43M423.76M
Cash, Cash Equivalents and Short-Term Investments421.68M372.15M383.33M368.22M431.67M223.53M
Total Debt6.36M6.11M6.94M151.00K1.14M526.00K
Total Liabilities191.71M188.85M160.96M114.81M81.59M47.95M
Stockholders Equity631.90M647.80M679.59M506.70M501.84M375.81M
Cash Flow
Free Cash Flow162.57M141.78M195.90M126.90M119.91M167.42M
Operating Cash Flow162.85M142.00M198.07M127.04M120.32M167.89M
Investing Cash Flow17.24M69.76M-177.60M90.91M-114.33M136.13M
Financing Cash Flow-193.71M-220.37M-28.35M-148.72M-17.28M-302.59M

Corcept Therapeutics Technical Analysis

Technical Analysis Sentiment
Negative
Last Price36.48
Price Trends
50DMA
50.23
Negative
100DMA
64.29
Negative
200DMA
68.46
Negative
Market Momentum
MACD
-3.28
Negative
RSI
38.02
Neutral
STOCH
53.40
Neutral
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For CORT, the sentiment is Negative. The current price of 36.48 is below the 20-day moving average (MA) of 39.95, below the 50-day MA of 50.23, and below the 200-day MA of 68.46, indicating a bearish trend. The MACD of -3.28 indicates Negative momentum. The RSI at 38.02 is Neutral, neither overbought nor oversold. The STOCH value of 53.40 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Negative sentiment for CORT.

Corcept Therapeutics Risk Analysis

Corcept Therapeutics disclosed 28 risk factors in its most recent earnings report. Corcept Therapeutics reported the most risks in the "Finance & Corporate" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks

Corcept Therapeutics Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
73
Outperform
$10.56B-28.64-9.06%4.14%-179.96%
67
Neutral
$3.84B41.6816.47%17.92%-26.13%
55
Neutral
$20.27B-20.23-60.76%-100.00%-44.24%
53
Neutral
$6.58B-31.79-240.36%54.92%28.47%
52
Neutral
$8.69B-46.00-275.50%65.83%28.50%
51
Neutral
$7.86B-0.30-43.30%2.27%22.53%-2.21%
50
Neutral
$3.60B-14.93-22.60%74.91%31.54%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
CORT
Corcept Therapeutics
36.48
-24.75
-40.42%
JAZZ
Jazz Pharmaceuticals
173.83
34.16
24.46%
AXSM
Axsome Therapeutics
169.95
42.86
33.72%
RYTM
Rhythm Pharmaceuticals
98.65
47.62
93.32%
RVMD
Revolution Medicines
104.83
63.49
153.58%
LEGN
Legend Biotech
19.50
-17.51
-47.31%

Corcept Therapeutics Corporate Events

Business Operations and StrategyStock BuybackFinancial Disclosures
Corcept Therapeutics Posts Strong 2025 Results, Issues Optimistic Outlook
Positive
Feb 24, 2026

On February 24, 2026, Corcept Therapeutics reported audited fourth-quarter and full-year 2025 results, with revenue rising to $202.1 million in the quarter and $761.4 million for the year, driven by stronger demand in its Cushing’s syndrome business despite supply and pharmacy transition constraints. Full-year 2025 net income declined to $99.7 million from $141.2 million in 2024, cash and investments fell to $532.4 million as the company spent $245.9 million on share repurchases, and management issued 2026 revenue guidance of $900 million to $1 billion, signaling confidence in long-term growth.

The company highlighted significant clinical and regulatory momentum, including ongoing engagement with the FDA following a Complete Response Letter for relacorilant in Cushing’s syndrome and active review of its NDA for relacorilant plus nab-paclitaxel in platinum-resistant ovarian cancer, supported by Phase 3 ROSELLA data showing a 35 percent reduction in risk of death. Across oncology, MASH and ALS, Corcept is advancing multiple mid- and late-stage trials — including the MONARCH Phase 2b MASH study, BELLA and other solid tumor programs, and a planned Phase 3 dazucorilant ALS trial — positioning the company for potential new indications that could broaden its revenue base and reinforce its standing in cortisol-modulating therapies.

The most recent analyst rating on (CORT) stock is a Buy with a $67.00 price target. To see the full list of analyst forecasts on Corcept Therapeutics stock, see the CORT Stock Forecast page.

Business Operations and StrategyLegal Proceedings
Corcept Faces Appellate Setback in Korlym Patent Dispute
Negative
Feb 19, 2026

On February 19, 2026, Corcept Therapeutics announced that the U.S. Court of Appeals for the Federal Circuit ruled Teva Pharmaceuticals’ marketing of a generic version of Korlym does not infringe two Corcept patents covering methods of safely co-administering Korlym with CYP3A4-inhibiting drugs commonly used by patients with Cushing’s syndrome. The decision upholds a December 2023 verdict from the Federal District Court for the District of New Jersey, potentially clearing a key legal hurdle for Teva’s generic Korlym product and raising competitive and revenue implications for Corcept’s flagship hypercortisolism therapy.

Corcept’s chief executive officer, Joseph K. Belanoff, M.D., expressed disappointment with the ruling, emphasizing that the asserted patents protect treatment methods relied on daily by physicians treating Cushing’s syndrome. He stated that the company will vigorously defend its intellectual property rights and is evaluating options for further judicial review, signaling an ongoing legal strategy as Corcept seeks to protect market exclusivity and manage the impact of generic competition on its Korlym franchise.

The most recent analyst rating on (CORT) stock is a Buy with a $100.00 price target. To see the full list of analyst forecasts on Corcept Therapeutics stock, see the CORT Stock Forecast page.

Business Operations and StrategyProduct-Related Announcements
Corcept Therapeutics Phase 3 ROSELLA Trial Achieves Survival Benefit
Positive
Jan 22, 2026

On January 22, 2026, Corcept Therapeutics reported that its pivotal Phase 3 ROSELLA trial of relacorilant plus nab-paclitaxel in patients with platinum-resistant ovarian cancer met its overall survival primary endpoint, with the combination reducing the risk of death by 35% versus nab-paclitaxel alone and extending median overall survival to 16.0 months from 11.9 months, without adding safety burden compared with chemotherapy alone. The trial, which previously met its progression-free survival primary endpoint and enrolled 381 patients across multiple regions, strengthens relacorilant’s clinical profile as an oral, biomarker-agnostic therapy that could reshape the treatment landscape for platinum-resistant ovarian cancer and supports Corcept’s ongoing regulatory reviews in the U.S. and Europe, as well as its broader development strategy for relacorilant and other cortisol modulators in solid tumors and hypercortisolism.

The most recent analyst rating on (CORT) stock is a Buy with a $90.00 price target. To see the full list of analyst forecasts on Corcept Therapeutics stock, see the CORT Stock Forecast page.

Business Operations and StrategyProduct-Related AnnouncementsRegulatory Filings and Compliance
Corcept Therapeutics Faces FDA Setback for Relacorilant Approval
Negative
Dec 31, 2025

On December 31, 2025, Corcept Therapeutics announced that the U.S. Food and Drug Administration issued a Complete Response Letter for its New Drug Application seeking approval of relacorilant to treat patients with hypertension secondary to hypercortisolism, despite the agency acknowledging that the pivotal GRACE trial met its primary endpoint and that the GRADIENT trial provided confirmatory evidence. The FDA concluded it could not yet make a favorable benefit-risk assessment without additional evidence of effectiveness, a setback that delays U.S. commercialization of relacorilant in hypercortisolism even as the company continues to advance the drug for other indications, including platinum-resistant ovarian cancer, where it has an FDA PDUFA decision date set for July 11, 2026 and a marketing application under review in Europe.

The most recent analyst rating on (CORT) stock is a Hold with a $95.00 price target. To see the full list of analyst forecasts on Corcept Therapeutics stock, see the CORT Stock Forecast page.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Feb 25, 2026