Quarterly Revenue and Raised Guidance
Revenue of $164.9 million in Q1 2026 versus $157.2 million a year earlier, an increase of approximately 4.9%. Company raised 2026 revenue guidance to $950 million–$1.05 billion.
Strong Cash Position
Cash and investments of $515 million as of March 31, 2026 providing runway for ongoing commercial and development programs.
Record Commercial Demand for Endocrinology Franchise
All-time highs in number of new prescriptions, number of prescribers and total patients receiving medications; record new patient starts in March and again in April, indicating accelerating demand.
CATALYST and MOMENTUM Clinical Findings Driving Market Expansion
CATALYST: 24% of patients with resistant diabetes had hypercortisolism; treatment with Korlym produced substantial reductions in HbA1c, weight and waist circumference (published in Diabetes Care, Dec 2025; referenced in AACE guidance Mar 2026). MOMENTUM: 27% of patients with resistant hypertension had hypercortisolism (presented at ACC). Management expects these studies to materially increase screening and treatment demand and projects Cushing's syndrome business to grow to at least $2 billion annually by decade-end.
Lifyorli FDA Approval and Compelling ROSELLA Results
FDA approved Lifyorli for platinum-resistant ovarian cancer 3.5 months ahead of PDUFA. ROSELLA pivotal trial met both primary endpoints: Lifyorli + nab-paclitaxel reduced risk of death by 35% (hazard ratio 0.65; p=0.0004). No biomarker required. Results published in The Lancet.
Rapid Commercial Launch Traction for Lifyorli
Product available within 5 days of approval; within ~36 days into launch, prescriptions written by over 200 physicians across community oncology, gynecology and academic centers; included as a preferred regimen in NCCN guidelines 15 days after approval. Management projects Lifyorli to exceed $1 billion annual U.S. revenue by decade-end.
Promising ALS and MASH Development Data
DAZALS (dazucorilant) in ALS: 300 mg showed an 84% reduction in risk of death at 1 year (p=0.0009) and 87% reduction at 2 years (p<0.0001). Company plans pivotal Phase III starting later this year with survival as primary endpoint. Miricorilant for MASH: Phase IIb MONARCH fully enrolled (175 patients) with results expected by year-end; earlier Phase Ib showed rapid liver fat reduction and fibrosis marker improvement.
Active Oncology Development Portfolio Beyond Lifyorli
Relacorilant NDA in Cushing's syndrome under FDA discussion; BELLA trial (relacorilant + nab‑paclitaxel + bevacizumab) first-arm results due by year-end. Additional relacorilant and nenocorilant studies (including Phase Ib with nivolumab) ongoing with multiple readouts planned through next year.