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Jazz Pharmaceuticals (JAZZ)
NASDAQ:JAZZ
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Jazz Pharmaceuticals (JAZZ) AI Stock Analysis

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JAZZ

Jazz Pharmaceuticals

(NASDAQ:JAZZ)

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Outperform 72 (OpenAI - 5.2)
Rating:72Outperform
Price Target:
$251.00
▲(23.39% Upside)
Action:Reiterated
Date:05/09/26
The score is driven primarily by strong cash-flow generation and sustained high gross margins, supporting financial resilience despite volatile net income. Technicals are constructive with a strong uptrend, though overbought signals raise short-term risk. Valuation appears reasonable with a ~10 P/E, and the latest earnings call was broadly positive with reaffirmed guidance, tempered by expected H2 sleep-market competition and some margin/mix pressure.
Positive Factors
Cash Generation
Consistent, large operating and free cash flow provides durable financial flexibility for R&D, commercialization, and debt servicing. Over a 2–6 month horizon this supports continued pipeline funding, commercialization of new launches, and optionality for M&A or buybacks despite volatile reported earnings.
Negative Factors
Elevated Absolute Debt
Despite improved leverage metrics, a ~$5.4B absolute debt load constrains strategic flexibility and increases sensitivity to earnings volatility. Over the medium term this limits free capital for acquisitions or aggressive share returns and raises refinancing and interest-rate exposure risk.
Read all positive and negative factors
Positive Factors
Negative Factors
Cash Generation
Consistent, large operating and free cash flow provides durable financial flexibility for R&D, commercialization, and debt servicing. Over a 2–6 month horizon this supports continued pipeline funding, commercialization of new launches, and optionality for M&A or buybacks despite volatile reported earnings.
Read all positive factors

Jazz Pharmaceuticals Key Performance Indicators (KPIs)

Any
Any
Neroscience Revenue Breakdown
Neroscience Revenue Breakdown
Highlights revenue generated from neuroscience products, indicating the company's strength and focus in treating neurological disorders, and potential growth in this specialized market.
Chart InsightsJazz’s portfolio has re-centered: legacy Xyrem has collapsed (patent/generic impact) while Xywav has rapidly scaled to replace that oxybate business, becoming the primary revenue driver. Epidiolex is a steady, growing second pillar. Minor assets (Sativex) and Sunosi are immaterial or absent, increasing concentration risk; near-term upside depends on Xywav/Epidiolex market durability, pricing dynamics, and any competitive or regulatory threats to those two franchises.
Data provided by:The Fly

Jazz Pharmaceuticals (JAZZ) vs. SPDR S&P 500 ETF (SPY)

Jazz Pharmaceuticals Business Overview & Revenue Model

Company Description
Jazz Pharmaceuticals plc, a biopharmaceutical company, identifies, develops, and commercializes pharmaceutical products for various unmet medical needs in the United States, Europe, and internationally. The company has a portfolio of products and ...
How the Company Makes Money
Jazz Pharmaceuticals primarily makes money by selling prescription medicines, with revenue recognized from product sales to wholesalers, specialty pharmacies, hospitals, and other healthcare channels (net of rebates, discounts, returns, and other ...

Jazz Pharmaceuticals Earnings Call Summary

Earnings Call Date:May 05, 2026
(Q1-2026)
|
% Change Since: |
Next Earnings Date:Aug 11, 2026
Earnings Call Sentiment Positive
The call conveyed strong commercial execution and substantial pipeline/regulatory progress that drove record Q1 revenue, robust product-level growth (notably oncology, Xywav and Epidiolex), solid cash generation and clear near-term catalysts (zanidatumab PDUFA, multiple interim readouts). Headline growth was partially boosted by an extra shipping week and FX effects, and management highlighted expected competitive dynamics in sleep and areas of margin and policy uncertainty. Overall, the positives (record revenue, high growth rates, cash strength, promising pivotal data and imminent regulatory milestones) outweigh the outlined risks and uncertainties.
Positive Updates
Record First-Quarter Revenue and Strong Top-Line Growth
Reported highest-ever Q1 total revenues of approximately $1.07–$1.10 billion, representing more than 19% year-over-year growth; non-GAAP adjusted EPS of $6.34 and reaffirmation of full-year 2026 revenue guidance of $4.25 billion to $4.5 billion.
Negative Updates
Anticipated Competitive Pressure in Oxybate/Sleep Market
Management expects increased competition in H2 2026 including growth of high-sodium generics and potential entry of daytime wake-promoting agents, and expects declines in Xyrem and high-sodium authorized generic revenues as generics build volumes.
Read all updates
Q1-2026 Updates
Negative
Record First-Quarter Revenue and Strong Top-Line Growth
Reported highest-ever Q1 total revenues of approximately $1.07–$1.10 billion, representing more than 19% year-over-year growth; non-GAAP adjusted EPS of $6.34 and reaffirmation of full-year 2026 revenue guidance of $4.25 billion to $4.5 billion.
Read all positive updates
Company Guidance
Jazz reaffirmed full‑year 2026 non‑GAAP guidance of $4.25–$4.50 billion in revenue after a very strong start: Q1 record revenue of ~$1.07B (reported as $1.1B) and >19% YoY growth, non‑GAAP adjusted EPS of $6.34, and operating cash flow of $408M, with $2.9B in cash and investments at quarter‑end. Management said Q1 growth was led by oncology (+45%), Xywav (+18% to $408M; ~16,600 patients, ~425 net adds), Epidiolex (+15% to $250M; volume +16%), Zepzelca (+60% to $101M), Midevo ($41M; ~500 patients treated) and ZYHERA ($13M); Q1 benefitted from 13 shipping weeks (+~2 ppt) and FX (+~1.5 ppt). They noted a slight non‑GAAP gross margin decline, SG&A down ~$164M (but up ~$8M ex‑litigation), R&D up ~$13M, a modestly lower non‑GAAP tax rate, and reiterated assumptions of 2H headwinds in sleep (generic high‑sodium oxybates and potential new wake‑promoters), declining Xyrem/authorized‑generic revenues, and reduced second‑line Zepzelca use.

Jazz Pharmaceuticals Financial Statement Overview

Summary
Strong cash generation (operating cash flow and free cash flow remain robust) and durable gross margins support financial flexibility. Offsetting this, earnings quality is volatile (large loss in 2025 and only near break-even TTM) and the company still carries substantial absolute debt despite improved leverage metrics.
Income Statement
58
Neutral
Balance Sheet
62
Positive
Cash Flow
78
Positive
BreakdownTTMDec 2025Dec 2024Dec 2023Dec 2022Dec 2021
Income Statement
Total Revenue4.44B4.27B4.07B3.83B3.66B3.09B
Gross Profit3.73B3.76B3.62B3.40B3.12B2.65B
EBITDA395.43M108.46M1.52B1.45B1.47B1.03B
Net Income29.49M-356.15M560.12M414.83M-224.06M-328.95M
Balance Sheet
Total Assets11.86B11.66B12.01B11.39B10.84B12.30B
Cash, Cash Equivalents and Short-Term Investments2.87B2.44B2.99B1.63B881.48M591.45M
Total Debt5.42B5.42B6.16B5.79B5.81B6.15B
Total Liabilities7.33B7.34B7.92B7.66B7.75B8.33B
Stockholders Equity4.53B4.32B4.09B3.74B3.09B3.97B
Cash Flow
Free Cash Flow1.25B1.30B1.35B1.07B773.78M732.98M
Operating Cash Flow1.33B1.36B1.40B1.09B1.27B778.51M
Investing Cash Flow-1.22B-1.51B-508.19M-163.06M-446.23M-5.21B
Financing Cash Flow-138.41M-873.38M20.52M-305.25M-529.49M3.97B

Jazz Pharmaceuticals Technical Analysis

Technical Analysis Sentiment
Positive
Last Price203.42
Price Trends
50DMA
183.03
Positive
100DMA
175.90
Positive
200DMA
151.89
Positive
Market Momentum
MACD
5.06
Negative
RSI
67.75
Neutral
STOCH
84.25
Negative
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For JAZZ, the sentiment is Positive. The current price of 203.42 is above the 20-day moving average (MA) of 190.96, above the 50-day MA of 183.03, and above the 200-day MA of 151.89, indicating a bullish trend. The MACD of 5.06 indicates Negative momentum. The RSI at 67.75 is Neutral, neither overbought nor oversold. The STOCH value of 84.25 is Negative, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Positive sentiment for JAZZ.

Jazz Pharmaceuticals Risk Analysis

Jazz Pharmaceuticals disclosed 47 risk factors in its most recent earnings report. Jazz Pharmaceuticals reported the most risks in the "Legal & Regulatory" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks

Jazz Pharmaceuticals Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
73
Outperform
$5.49B-33.737.50%12.20%-64.76%
73
Outperform
$8.41B12.7292.67%39.12%-24.20%
72
Outperform
$14.30B9.980.71%9.20%-94.01%
63
Neutral
$30.98B-10.61-83.22%-76.93%
62
Neutral
$7.42B39.895.49%0.54%0.17%-15.73%
61
Neutral
$21.03B-14.22-18.32%-86.36%-751.06%
51
Neutral
$7.86B-0.30-43.30%2.27%22.53%-2.21%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
JAZZ
Jazz Pharmaceuticals
232.33
126.26
119.03%
CORT
Corcept Therapeutics
57.08
-16.28
-22.19%
HALO
Halozyme
70.03
21.08
43.06%
TECH
Bio-Techne
44.89
-3.07
-6.40%
RVMD
Revolution Medicines
149.94
110.50
280.17%
ROIV
Roivant Sciences
29.22
18.46
171.56%
Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: May 09, 2026