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Jazz Pharmaceuticals
(NASDAQ:JAZZ)
Jazz Pharmaceuticals (JAZZ) vs. SPDR S&P 500 ETF (SPY)
Jazz Pharmaceuticals Business Overview & Revenue Model
Jazz Pharmaceuticals Key Performance Indicators (KPIs)
Highlights revenue generated from neuroscience products, indicating the company's strength and focus in treating neurological disorders, and potential growth in this specialized market.
Main Street DataJazz Pharmaceuticals Earnings Call Summary
Jazz Pharmaceuticals Financial Statement Overview
| Breakdown | TTM | Dec 2024 | Dec 2023 | Dec 2022 | Dec 2021 | Dec 2020 |
|---|---|---|---|---|---|---|
Income Statement | ||||||
| Total Revenue | 4.09B | 4.07B | 3.83B | 3.66B | 3.09B | 2.36B |
| Gross Profit | 3.63B | 3.62B | 3.40B | 3.12B | 2.65B | 2.21B |
| EBITDA | 447.10M | 1.52B | 1.45B | 1.47B | 1.03B | 1.04B |
| Net Income | -404.84M | 560.12M | 414.83M | -224.06M | -328.95M | 238.62M |
Balance Sheet | ||||||
| Total Assets | 10.94B | 12.01B | 11.39B | 10.84B | 12.30B | 6.54B |
| Cash, Cash Equivalents and Short-Term Investments | 1.67B | 2.99B | 1.63B | 881.48M | 591.45M | 2.13B |
| Total Debt | 5.43B | 6.16B | 5.79B | 5.81B | 6.15B | 2.25B |
| Total Liabilities | 7.24B | 7.92B | 7.66B | 7.75B | 8.33B | 2.88B |
| Stockholders Equity | 3.71B | 4.09B | 3.74B | 3.09B | 3.97B | 3.66B |
Cash Flow | ||||||
| Free Cash Flow | 1.27B | 1.35B | 1.07B | 773.78M | 732.98M | 520.39M |
| Operating Cash Flow | 1.32B | 1.40B | 1.09B | 1.27B | 778.51M | 899.65M |
| Investing Cash Flow | -789.15M | -508.19M | -163.06M | -446.23M | -5.21B | -1.01B |
| Financing Cash Flow | -699.84M | 20.52M | -305.25M | -529.49M | 3.97B | 528.07M |
Jazz Pharmaceuticals Technical Analysis
Jazz Pharmaceuticals Risk Analysis
Jazz Pharmaceuticals Peers Comparison
Name | Overall Rating | Market Cap | P/E Ratio | ROE | Dividend Yield | Revenue Growth | EPS Growth |
|---|---|---|---|---|---|---|---|
75 Outperform | $7.77B | 15.28 | 179.14% | ― | 34.97% | 71.10% | |
70 Outperform | $8.28B | 69.95 | 21.42% | ― | 25.71% | 4.48% | |
65 Neutral | $8.34B | ― | -10.84% | ― | 4.52% | -205.13% | |
64 Neutral | $9.74B | 136.16 | 3.68% | 0.50% | 5.23% | -56.70% | |
61 Neutral | $12.11B | ― | -15.84% | ― | -85.32% | -111.82% | |
52 Neutral | $10.10B | ― | -46.61% | ― | -100.00% | -23.49% | |
51 Neutral | $7.86B | -0.30 | -43.30% | 2.27% | 22.53% | -2.21% |
Jazz Pharmaceuticals Corporate Events
On October 21, 2025, Jazz Pharmaceuticals and its subsidiaries reached a global settlement agreement with Avadel Pharmaceuticals to resolve all disputes, including ongoing patent infringement litigation. As part of the settlement, Jazz will grant Avadel licenses for its Lumryz product, while Avadel will pay royalties to Jazz and refrain from marketing certain products until 2028. Jazz will pay Avadel $90 million and waive certain royalties, expecting a pre-tax charge of approximately $90 million in Q3 2025. The agreement aims to dismiss pending legal proceedings and includes mutual releases of claims.
The most recent analyst rating on (JAZZ) stock is a Buy with a $180.00 price target. To see the full list of analyst forecasts on Jazz Pharmaceuticals stock, see the JAZZ Stock Forecast page.
Jazz Pharmaceuticals has recently completed a clinical study titled ‘A Phase 1b/2, 2-part Open-label Study to Assess the Safety and Antitumor Activity of Zanidatamab in Combination With ALX148 in Advanced HER2-expressing Cancer.’ The study aimed to evaluate the safety and effectiveness of combining zanidatamab with evorpacept (ALX148) in treating patients with advanced HER2-expressing cancers. This study is significant as it explores new treatment avenues for cancers that express the HER2 protein, potentially offering new hope for patients with limited options.
Jazz Pharmaceuticals recently updated its Phase 2 clinical study on ZW25 (zanidatamab) combined with chemotherapy for HER2-expressing gastrointestinal cancers. The study aims to assess the safety and efficacy of this treatment in patients with gastroesophageal adenocarcinoma, biliary tract cancer, and colorectal cancer. This research is significant as it targets difficult-to-treat cancers with limited options.
Study Overview: Jazz Pharmaceuticals is conducting an observational study titled Observational Pregnancy Surveillance Program of Patients Exposed to Epidiolex/Epidyolex During Pregnancy. The study aims to assess the risk of pregnancy and maternal complications, as well as other events of interest, on the developing fetus, neonate, and infant up to 12 months of life. This research is significant as it seeks to provide crucial insights into the safety of Epidiolex/Epidyolex during pregnancy.
Jazz Pharmaceuticals is conducting a study titled ‘Observational, Prospective, Multicenter Study of Epidyolex® (Cannabidiol CBD 100 mg/ml) Oral Solution, as Adjunctive Treatment for Seizures Associated With Lennox- Gastaut Syndrome (LGS), Dravet Syndrome (DS) and Tuberous Sclerosis Complex (TSC)’. The study aims to observe the effects of Epidyolex® on seizures in patients with LGS, DS, and TSC in Italy, highlighting its potential to improve patient outcomes in these challenging conditions.
Jazz Pharmaceuticals is conducting a Phase 3 study titled A Study Comparing the Efficacy and Safety of Zanidatamab to Trastuzumab, Each in Combination With Physician’s Choice Chemotherapy, for the Treatment of Participants With Metastatic HER2-positive Breast Cancer. The study aims to evaluate the effectiveness and safety of zanidatamab combined with chemotherapy compared to trastuzumab with chemotherapy in patients with metastatic HER2-positive breast cancer who have not responded to previous treatments. This study is significant as it explores new treatment options for a challenging cancer type.
Jazz Pharmaceuticals is currently conducting a clinical study titled ‘An Open-label Randomized Trial of the Efficacy and Safety of Zanidatamab With Standard-of-care Therapy Against Standard-of-care Therapy Alone for Advanced HER2-positive Biliary Tract Cancer.’ The study aims to evaluate the effectiveness and safety of Zanidatamab, in combination with Cisplatin and Gemcitabine, with or without a PD-1/L1 inhibitor, as a first-line treatment for HER2-positive biliary tract cancer. This study holds significant potential for improving treatment options for this aggressive cancer type.
Jazz Pharmaceuticals is conducting a study titled An Open-label Randomized Trial of the Efficacy and Safety of Zanidatamab With Standard-of-care Therapy Against Standard-of-care Therapy Alone for Advanced HER2-positive Biliary Tract Cancer. The study aims to evaluate the efficacy and safety of Zanidatamab combined with CisGem (Cisplatin and Gemcitabine) and possibly a PD-1/L1 inhibitor, compared to standard care alone, for treating advanced HER2-positive biliary tract cancer.
Jazz Pharmaceuticals is conducting a pivotal study titled ‘An Open-label Randomized Trial of the Efficacy and Safety of Zanidatamab With Standard-of-care Therapy Against Standard-of-care Therapy Alone for Advanced HER2-positive Biliary Tract Cancer.’ The study aims to evaluate the effectiveness and safety of Zanidatamab combined with standard treatments, including Cisplatin and Gemcitabine, with or without a PD-1/L1 inhibitor, for patients with advanced HER2-positive biliary tract cancer. This research is significant as it could offer a new first-line treatment option for this challenging cancer type.
Jazz Pharmaceuticals’ recent earnings call reflected a strong sentiment of optimism mixed with challenges. The company reported robust revenue growth driven by its neuroscience assets and strategic pipeline developments, particularly in oncology. However, it also faced declines in oncology sales and inventory dynamics affecting Epidiolex, alongside a significant financial loss due to acquisition charges. Despite these hurdles, Jazz remains optimistic about future growth, anticipating several regulatory and commercial milestones.
Jazz Pharmaceuticals plc is a global biopharmaceutical company based in Dublin, Ireland, known for its focus on developing life-changing medicines for serious diseases, particularly in the fields of sleep disorders, epilepsy, and oncology.
Jazz Pharmaceuticals is conducting a Phase 3 study titled ‘A Study Comparing the Efficacy and Safety of Zanidatamab to Trastuzumab, Each in Combination With Physician’s Choice Chemotherapy, for the Treatment of Participants With Metastatic HER2-positive Breast Cancer.’ The study aims to evaluate the efficacy and safety of zanidatamab combined with chemotherapy compared to trastuzumab combined with chemotherapy for patients with metastatic HER2-positive breast cancer who have not responded to previous treatments.
Study Overview: Jazz Pharmaceuticals is conducting a Phase 3 study titled A Randomized, Multicenter, Phase 3 Study of Zanidatamab in Combination With Chemotherapy With or Without Tislelizumab in Subjects With HER2-positive Unresectable Locally Advanced or Metastatic Gastroesophageal Adenocarcinoma (GEA). The study aims to evaluate the safety and efficacy of zanidatamab, with or without tislelizumab, compared to trastuzumab in treating advanced HER2-positive stomach and esophageal cancers. This study is significant as it explores potentially more effective treatment options for these aggressive cancers.
Jazz Pharmaceuticals is currently conducting a study titled ‘An Open-label Randomized Trial of the Efficacy and Safety of Zanidatamab With Standard-of-care Therapy Against Standard-of-care Therapy Alone for Advanced HER2-positive Biliary Tract Cancer.’ The study aims to assess the effectiveness and safety of Zanidatamab, combined with CisGem (Cisplatin and Gemcitabine), with or without a PD-1/L1 inhibitor, as a first-line treatment for HER2-positive biliary tract cancer. This research is significant as it explores potential advancements in treatment options for this aggressive cancer type.
Study Overview: Jazz Pharmaceuticals is conducting a Phase 3 study titled A Randomized, Multicenter, Phase 3 Study of Zanidatamab in Combination With Chemotherapy With or Without Tislelizumab in Subjects With HER2-positive Unresectable Locally Advanced or Metastatic Gastroesophageal Adenocarcinoma (GEA). The study aims to evaluate the safety and efficacy of zanidatamab, in combination with chemotherapy, with or without tislelizumab, compared to trastuzumab with chemotherapy, in treating advanced HER2-positive gastric and esophageal cancers.
On July 24, 2025, Jazz Pharmaceuticals held its annual general meeting of shareholders in Dublin, Ireland, where four key proposals were voted on. The shareholders elected four directors to serve until 2028, ratified KPMG as independent auditors, approved executive compensation, and granted the board authority to issue shares without pre-emption rights, indicating strong shareholder support for the company’s strategic decisions.
The most recent analyst rating on (JAZZ) stock is a Buy with a $183.00 price target. To see the full list of analyst forecasts on Jazz Pharmaceuticals stock, see the JAZZ Stock Forecast page.
Jazz Pharmaceuticals, in collaboration with Hoffmann-La Roche, is conducting a Phase III clinical study titled ‘A Phase III, Randomized, Open-Label, Multicenter Study of Lurbinectedin in Combination With Atezolizumab Compared With Atezolizumab as Maintenance Therapy in Participants With Extensive-Stage Small-Cell Lung Cancer (ES-SCLC).’ The study aims to evaluate the efficacy of lurbinectedin combined with atezolizumab versus atezolizumab alone as maintenance therapy for ES-SCLC patients who have responded to initial treatment with carboplatin, etoposide, and atezolizumab.