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UPB Stock Chart & Stats
$6.41
>-$0.01(-0.16%)
At close: 4:00 PM EDT
$6.41
>-$0.01(-0.16%)
Day’s Range― - ―
52-Week Range$5.85 - $33.68
Previous Close$6.3
Volume459.48K
Average Volume (3M)586.81K
Market Cap
$378.47M
Enterprise Value$117.26
Total Cash (Recent Filing)$261.31M
Total Debt (Recent Filing)$954.00K
Price to Earnings (P/E)―
Beta1.21
Next Earnings
Nov 05, 2026EPS Estimate
-0.73Next Dividend Ex-DateN/A
Dividend YieldN/A
Share Statistics
EPS (TTM)-2.90
Shares Outstanding54,771,040
10 Day Avg. Volume463,820
30 Day Avg. Volume586,814
Financial Highlights & Ratios
PEG Ratio-0.13
Price to Book (P/B)4.30
Price to Sales (P/S)512.30
P/FCF Ratio-10.97
Enterprise Value/Market Cap<0.01
Enterprise Value/Revenue<0.01
Enterprise Value/Gross Profit<0.01
Enterprise Value/Ebitda>-0.01
Forecast
1Y Price Target
$32.80Price Target Upside411.70% Upside
Rating ConsensusStrong Buy
Number of Analyst Covering6
EPS Forecast (FY)-2.88
Revenue Forecast (FY)$2.78M
Bulls Say, Bears Say
Bulls Say
Balance Sheet StrengthVery low leverage and meaningful positive equity (~$271M) provide durable financial flexibility for an R&D-intensive biotech. This reduces near-term liquidity risk, supports continued clinical spending without immediate distress, and increases optionality for partnerships or staged financing.
Advancing Clinical Program (Phase 3 Readiness)Progressing toward Phase 3 with scheduled FDA end-of-Phase-2 interactions and >500 trial participants materially de-risks development versus earlier stages. Compelling Phase 2 results and CMC/device progress improve the company’s odds of regulatory success and future commercialization options over the coming months.
Governance And Oversight ContinuityRecent board elections and ratification of PricewaterhouseCoopers reinforce governance continuity and external oversight. Stable governance and a reputable auditor support credible financial reporting, regulatory interactions, and institutional partner confidence during critical late-stage development.
Bears Say
High Cash BurnSustained negative operating and free cash flow of roughly -$136M TTM indicates material runway pressure. The company will likely need external funding or significant spending reductions in the medium term, raising dilution or refinancing risk that can alter strategic flexibility.
Very Small And Declining RevenueWith revenue near $3.2M TTM and recent decline, current commercial receipts are insufficient to offset R&D and G&A. Until a product reaches market or licensing generates material revenue, the firm’s operating model remains dependent on external capital, limiting earnings resiliency.
Deep Negative Profitability And Weak ReturnsLarge recurring net losses (~-$156.5M TTM) and a deeply negative ROE (~-44%) signal that current operations erode shareholder capital. Continued negative profitability can deplete equity over time absent funding or successful commercialization, constraining long-term value creation.
UPB FAQ
What was Upstream Bio, Inc.’s price range in the past 12 months?
Upstream Bio, Inc. lowest stock price was $5.85 and its highest was $33.68 in the past 12 months.
What is Upstream Bio, Inc.’s market cap?
Upstream Bio, Inc.’s market cap is $378.47M.
When is Upstream Bio, Inc.’s upcoming earnings report date?
Upstream Bio, Inc.’s upcoming earnings report date is Nov 05, 2026 which is in 82 days.
How were Upstream Bio, Inc.’s earnings last quarter?
Upstream Bio, Inc. released its earnings results on Aug 11, 2026. The company reported -$0.73 earnings per share for the quarter, missing the consensus estimate of -$0.726 by -$0.004.
Is Upstream Bio, Inc. overvalued?
According to Wall Street analysts Upstream Bio, Inc.’s price is currently Undervalued.
Does Upstream Bio, Inc. pay dividends?
Upstream Bio, Inc. does not currently pay dividends.
What is Upstream Bio, Inc.’s EPS estimate?
Upstream Bio, Inc.’s EPS estimate is -0.73.
How many shares outstanding does Upstream Bio, Inc. have?
Upstream Bio, Inc. has 54,771,040 shares outstanding.
What happened to Upstream Bio, Inc.’s price movement after its last earnings report?
Upstream Bio, Inc. reported an EPS of -$0.73 in its last earnings report, missing expectations of -$0.726. Following the earnings report the stock price went down -4.704%.
Which hedge fund is a major shareholder of Upstream Bio, Inc.?
Currently, no hedge funds are holding shares in UPB
What is the TipRanks Smart Score and how is it calculated?
Smart Score combines eight research factors - such as analyst recommendations, hedge fund trends, and technical indicators - to measure a stock’s outlook. These signals are unified into a single score that reflects bullish or bearish momentum. See detailed methodology
Upstream Bio, Inc. Stock Smart Score
Neutral
1
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9
10
Analyst Consensus
Strong Buy
Average Price Target:
$32.80 (411.70% Upside)
$32.80 (411.70% Upside)
Blogger Sentiment
Bullish
UPB Sentiment 75%
Sector Average ―
Sector Average ―
Hedge Fund Trend
Decreased
By 1.2M Shares
Last Quarter.
Last Quarter.
Insider Transactions
Sold Shares
Worth $25.2K over
the Last 3 Months
the Last 3 Months
Crowd Wisdom
Very Negative
Last 7 Days ▼ 1.4%
Last 30 Days ▼ 2.2%
Last 30 Days ▼ 2.2%
News Sentiment
Very Bullish
Bullish news 100%
Bearish news 0%
Bearish news 0%
Technicals
SMA
Negative
20 days / 200 days
Momentum
-51.98%
12-Months-Change
Fundamentals
Return on Equity
―
Trailing 12-Months
Asset Growth
-33.14%
Trailing 12-Months
Company Description
Upstream Bio, Inc.
Upstream Bio, Inc. is a biotechnology company in the clinical development stage, dedicated to innovating therapies for inflammatory conditions, particularly those affecting the severe respiratory system. Its pipeline notably features verekitug, a monoclonal antibody designed to selectively target and suppress the thymic stromal lymphopoietin receptor. Beyond this, the company is actively developing treatments for severe asthma, chronic rhinosinusitis with nasal polyps, and chronic obstructive pulmonary disease. Established in 2021, Upstream Bio maintains its operational base in Waltham, Massachusetts.
UPB Stock 12 Month Forecast
Average Price Target
$32.80
▲(411.70% Upside)
Technical Analysis
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Ownership Overview
8.63% Insiders
21.61% Mutual Funds
30.65% Other Institutional Investors
30.14% Public Companies and
Individual Investors












