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Upstream Bio, Inc. (UPB)
NASDAQ:UPB
Total Valuation
Upstream Bio, Inc. has a market cap or net worth of $1.50B. The enterprise value is $643.43M.
Market Cap$1.50B
Enterprise Value$643.43M
Share Statistics
Upstream Bio, Inc. has 54,038,590 shares outstanding. The number of shares has decreased by -2.65% in one year.
Shares Outstanding54,038,590
Owned by Insiders8.43%
Owned by Institutions42.78%
Financial Efficiency
Upstream Bio, Inc.’s return on equity (ROE) is -0.13 and return on invested capital (ROIC) is -16.46%.
Return on Equity (ROE)-0.13
Return on Assets (ROA)-0.13
Return on Invested Capital (ROIC)-16.46%
Return on Capital Employed (ROCE)-0.17
Revenue Per Employee45.58K
Profits Per Employee-1.21M
Employee Count52
Asset Turnover<0.01
Inventory Turnover0.00
Valuation Ratios
The current PE Ratio of Upstream Bio, Inc. is ―. Upstream Bio, Inc.’s PEG ratio is -0.32.
PE Ratio―
PS Ratio356.14
PB Ratio1.80
Price to Fair Value1.80
Price to FCF-14.14
Price to Operating Cash Flow-11.30
PEG Ratio-0.32
Income Statement
In the last 12 months, Upstream Bio, Inc. had revenue of 2.37M and earned -62.81M in profits. Earnings per share was -1.49.
Revenue2.37M
Gross Profit2.37M
Operating Income-77.76M
Pretax Income-62.81M
Net Income-62.81M
EBITDA-77.67M
Earnings Per Share (EPS)-1.49
Cash Flow
In the last 12 months, operating cash flow was -122.26M and capital expenditures -185.00K, giving a free cash flow of -122.44M billion.
Operating Cash Flow-122.26M
Free Cash Flow-122.44M
Free Cash Flow per Share-2.27
Dividends & Yields
Upstream Bio, Inc. pays an annual dividend of ―, resulting in a dividend yield of ―
Dividend Per Share―
Dividend Yield―
Payout RatioN/A
Free Cash Flow Yield―
Earnings Yield―
Stock Price Statistics
Beta0.83
52-Week Price Change34.59%
50-Day Moving Average24.01
200-Day Moving Average14.87
Relative Strength Index (RSI)55.30
Average Volume (3m)388.50K
Important Dates
Upstream Bio, Inc. upcoming earnings date is Mar 18, 2026, Before Open (Confirmed).
Last Earnings DateNov 6, 2025
Next Earnings DateMar 18, 2026
Ex-Dividend Date―
Financial Position
Upstream Bio, Inc. as a current ratio of 44.63, with Debt / Equity ratio of 0.38%
Current Ratio44.63
Quick Ratio44.63
Debt to Market Cap<0.01
Net Debt to EBITDA4.17
Interest Coverage Ratio0.00
Taxes
In the past 12 months, Upstream Bio, Inc. has paid 0.00 in taxes.
Income Tax0.00
Effective Tax Rate0.00
Enterprise Valuation
Upstream Bio, Inc. EV to EBITDA ratio is -6.69, with an EV/FCF ratio of -8.71.
EV to Sales219.41
EV to EBITDA-6.69
EV to Free Cash Flow-8.71
EV to Operating Cash Flow-8.79
Balance Sheet
Upstream Bio, Inc. has $372.43M in cash and marketable securities with $1.42M in debt, giving a net cash position of $371.01M billion.
Cash & Marketable Securities$372.43M
Total Debt$1.42M
Net Cash$371.01M
Net Cash Per Share$6.87
Tangible Book Value Per Share$9.15
Margins
Gross margin is 100.00%, with operating margin of -3281.18%, and net profit margin of -2650.04%.
Gross Margin100.00%
Operating Margin-3281.18%
Pretax Margin-2650.04%
Net Profit Margin-2650.04%
EBITDA Margin-3277.43%
EBIT Margin-3281.18%
Analyst Forecast
The average price target for Upstream Bio, Inc. is $52.67, which is 11.43% higher than the current price. The consensus rating is Strong Buy
Price Target$52.67
Price Target Upside95.29% Upside
Analyst ConsensusStrong Buy
Analyst Count7
Revenue Growth Forecast―
EPS Growth Forecast―