CompetitionA crowded bispecific therapy field with multiple competitors showing strong responses increases the risk that the drug will struggle to achieve best-in-class status and capture market share.
Development Timeline RiskClinical setbacks, delays, or being behind a competitor on topline readout could narrow the opportunity to secure a first-to-market advantage and amplify downside risk.
Safety And TolerabilityConcerns that the TGFβ component may add little efficacy while heightening safety risks, including anemia, bleeding, and cardiovascular events, could impair treatment persistence and regulatory outcomes.