Competitive TimingA competitor is ahead on topline results, creating a first‑mover advantage that could constrain market share and commercial positioning.
Outcome‑driven Trial RiskInvestment outcomes depend heavily on key clinical trial readouts, exposing the stock to material downside from negative results, delays, or failure to secure regulatory approvals.
Safety And Mechanism RiskConcerns that the TGF‑beta trap contributes little to efficacy raise downside risk tied to TGF‑beta–mediated safety issues such as anemia, bleeding, skin events, and cardiovascular toxicity that could hurt treatment persistence.