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TransMedics Group Inc (TMDX)
NASDAQ:TMDX
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TransMedics Group (TMDX) AI Stock Analysis

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TMDX

TransMedics Group

(NASDAQ:TMDX)

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Outperform 78 (OpenAI - 4o)
Rating:78Outperform
Price Target:
$149.00
▲(14.16% Upside)
TransMedics Group's strong financial performance and positive earnings call are the primary drivers of its high score. The company's robust revenue growth, profitability, and strategic initiatives underscore its potential for sustained growth. However, high valuation and technical indicators suggesting overbought conditions present risks. Investors should monitor leverage levels and market dynamics closely.
Positive Factors
Revenue Growth
The strong revenue growth indicates robust demand for TransMedics' products, enhancing its market position and supporting long-term financial stability.
Cash Generation
Strong cash generation and a healthy cash reserve provide financial flexibility for future investments and strategic initiatives, reinforcing business resilience.
FDA Approval
FDA approval for new products can drive future growth by expanding the product portfolio and enhancing the company's competitive edge in the medical device sector.
Negative Factors
Increasing Liabilities
Rising liabilities could pressure the company's financial health, limiting its ability to invest in growth opportunities and manage economic downturns effectively.
Seasonality Impact
Seasonal fluctuations may lead to inconsistent financial performance, complicating long-term planning and potentially affecting investor confidence.
Competitive Market Noise
Competitive pressures and market noise can hinder market share growth and create challenges in maintaining a strong brand image, affecting long-term strategic positioning.

TransMedics Group (TMDX) vs. SPDR S&P 500 ETF (SPY)

TransMedics Group Business Overview & Revenue Model

Company DescriptionTransMedics Group, Inc., a commercial-stage medical technology company, engages in transforming organ transplant therapy for end-stage organ failure patients in the United States and internationally. The company offers Organ Care System (OCS), a portable organ perfusion, optimization, and monitoring system that utilizes its proprietary and customized technology to replicate near-physiologic conditions for donor organs outside of the human body. Its Organ Care System includes OCS LUNG for the preservation of standard criteria donor lungs for double-lung transplantation; OCS Heart, a technology for extracorporeal perfusion and preservation of donor hearts; and OCS Liver for the preservation of donor livers. The company was founded in 1998 and is headquartered in Andover, Massachusetts.
How the Company Makes MoneyTransMedics generates revenue primarily through the sale of its Organ Care Systems and related disposable products used in the organ preservation and transplantation process. The company earns revenue by leasing the OCS devices to hospitals and transplant centers, which includes a fee for each organ transported using the system. Additionally, TMDX benefits from recurring revenues through the sale of disposables that accompany the use of the OCS, such as perfusion kits and other single-use components. Strategic partnerships with hospitals, transplant programs, and organ procurement organizations also contribute to the company’s growth and revenue, as they expand the network of facilities adopting TransMedics' innovative technology.

TransMedics Group Key Performance Indicators (KPIs)

Any
Any
Revenue by Organ
Revenue by Organ
Details revenue generated from different organ transplant solutions, indicating which areas are most lucrative and where there might be potential for expansion or increased market share.
Chart InsightsTransMedics is experiencing robust growth across its organ segments, with liver revenue showing the most significant increase, reflecting strategic success in this area. Despite challenges in the lung perfusion market, the company’s overall revenue trajectory remains strong, supported by FDA approvals for lung and heart programs. The raised full-year revenue guidance and strategic focus on expanding the NOP model internationally highlight management's confidence in sustained growth. However, investors should be mindful of potential seasonal impacts in Q3 and ongoing challenges in the lung segment.
Data provided by:Main Street Data

TransMedics Group Earnings Call Summary

Earnings Call Date:Jul 30, 2025
(Q2-2025)
|
% Change Since: |
Next Earnings Date:Oct 29, 2025
Earnings Call Sentiment Positive
The earnings call reflected a strong financial performance with significant revenue and profit growth, successful FDA approvals, and raised guidance. However, there were challenges including a decline in OUS revenue and anticipated seasonality impacts, alongside addressing competitive noise. Overall, the positive highlights significantly outweighed the lowlights.
Q2-2025 Updates
Positive Updates
Record Revenue Growth
Total revenue for 2Q 2025 was $157.4 million, representing approximately 38% growth year-over-year and approximately 10% sequential growth from 1Q 2025.
Strong Operating Profit and Cash Generation
Operating profit of approximately $36.6 million in 2Q, representing more than 23% of total revenue, and strong cash generation with over $400 million in cash at the end of 2Q.
Growth in Transplant Logistics Revenue
Transplant logistics service revenue for 2Q was $29.8 million, representing 56% year-over-year and 14% sequential growth.
FDA Conditional Approval for OCS Lung IDE
Received FDA conditional approval for the OCS Lung IDE in July, with plans to begin trial initiation activities soon.
Raised Full Year 2025 Revenue Guidance
Raised full year 2025 revenue guidance to between $585 million and $605 million, representing approximately 35% growth over full year 2024.
Negative Updates
Decline in OUS Revenue
OUS revenue was $4 million, down 12% from Q2 of 2024, though up 2% sequentially.
Seasonality Impact on Performance
Expected minor and transient seasonality in Q3 performance, similar to the previous year, which could impact sequential growth.
Challenges with Competitive Commentary and Market Noise
Addressed recent market confusion and noise from competitive commentary, particularly concerning lung transplantation in the U.S.
Company Guidance
During the TransMedics second quarter 2025 earnings call, the company provided a robust set of financial and operational metrics that underscored their strong performance and future growth strategies. The company reported total revenue of $157.4 million for the quarter, representing approximately 38% growth year-over-year and about 10% sequential growth from the first quarter of 2025. Gross margin remained steady at 61.4%, similar to the previous quarter, while operating profit increased to $36.6 million, up from $27.4 million in the prior quarter. The company also highlighted a significant addition of approximately $90 million to its balance sheet, ending the quarter with over $400 million in cash. TransMedics raised its full-year 2025 revenue guidance to between $585 million and $605 million, reflecting approximately 35% growth over 2024 at the midpoint. The company also discussed its strategic initiatives, including achieving 10,000 U.S. NOP transplants by 2028, exploring international expansion, and advancing clinical programs for its next-gen OCS Heart and Lung platforms. Despite expected minor seasonal fluctuations in the third quarter, TransMedics remains focused on sustaining its upward momentum and expanding its market presence.

TransMedics Group Financial Statement Overview

Summary
TransMedics Group shows strong financial performance with impressive revenue growth and operational profitability, especially in the TTM period. The balance sheet is stable with manageable leverage, although liabilities have increased. Cash flow management has improved significantly, reflecting efficient capital use. The company is well-positioned for potential growth but should monitor its leverage levels.
Income Statement
85
Very Positive
TransMedics Group has demonstrated a strong revenue growth trajectory with a significant increase in total revenue from $93.46M in 2022 to $531.29M in the TTM (Trailing-Twelve-Months) period. Gross profit margin improved to 59.8% in TTM, indicating efficient cost management. Net profit margin stands at 13.5% in TTM, reflecting enhanced profitability. However, the company faced a negative EBIT margin in past years, indicating volatility, which is mitigated in the latest TTM results.
Balance Sheet
78
Positive
The balance sheet reflects a moderate debt-to-equity ratio of 1.44 in TTM, suggesting a balanced approach to leverage. The return on equity (ROE) improved significantly to 22.5% in TTM, driven by profitability gains. The equity ratio is 35.7%, showcasing a solid equity base. The company has maintained sufficient cash reserves, yet the total liabilities have increased, posing potential risks.
Cash Flow
80
Positive
TransMedics Group has shown a positive shift in operating cash flow to $115.27M in TTM from a negative position in previous years. Free cash flow turned positive, marking a substantial improvement in cash flow management. The operating cash flow to net income ratio is 1.61, indicating strong cash conversion efficiency. Although capital expenditures are significant, the overall cash flow profile is robust.
BreakdownTTMDec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income Statement
Total Revenue531.29M441.54M241.62M93.46M30.26M25.64M
Gross Profit317.68M262.08M154.09M65.27M21.16M16.64M
EBITDA111.94M69.95M-7.70M-28.96M-38.49M-23.15M
Net Income71.66M35.46M-25.03M-36.23M-44.22M-28.75M
Balance Sheet
Total Assets890.52M804.08M706.05M277.15M134.89M152.03M
Cash, Cash Equivalents and Short-Term Investments400.57M336.65M394.81M201.18M92.45M125.64M
Total Debt518.82M518.29M515.95M67.56M8.60M34.66M
Total Liabilities572.42M575.47M568.85M89.77M67.04M48.13M
Stockholders Equity318.10M228.60M137.20M187.38M67.85M103.89M
Cash Flow
Free Cash Flow17.35M-80.94M-192.09M-57.72M-32.38M-30.72M
Operating Cash Flow115.27M48.80M-13.03M-45.82M-28.86M-30.27M
Investing Cash Flow-97.48M-129.30M-193.95M54.51M29.27M-41.60M
Financing Cash Flow19.16M22.87M400.42M167.93M1.39M75.55M

TransMedics Group Technical Analysis

Technical Analysis Sentiment
Positive
Last Price130.52
Price Trends
50DMA
116.19
Positive
100DMA
120.17
Positive
200DMA
101.19
Positive
Market Momentum
MACD
2.45
Negative
RSI
68.89
Neutral
STOCH
84.19
Negative
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For TMDX, the sentiment is Positive. The current price of 130.52 is above the 20-day moving average (MA) of 116.34, above the 50-day MA of 116.19, and above the 200-day MA of 101.19, indicating a bullish trend. The MACD of 2.45 indicates Negative momentum. The RSI at 68.89 is Neutral, neither overbought nor oversold. The STOCH value of 84.19 is Negative, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Positive sentiment for TMDX.

TransMedics Group Risk Analysis

TransMedics Group disclosed 71 risk factors in its most recent earnings report. TransMedics Group reported the most risks in the "Production" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks

TransMedics Group Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
$4.45B67.4928.21%48.09%2410.18%
$2.29B45.308.07%22.05%785.52%
$2.55B29.395.18%7.81%-26.32%
$3.00B-13.94-17.87%8.57%-1154.64%
$2.38B-14.61-376.89%26.27%15.58%
$7.86B-0.30-43.30%2.27%22.53%-2.21%
$4.28B-45.67-12.98%26.70%48.19%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
TMDX
TransMedics Group
130.52
4.28
3.39%
ATEC
Alphatec Holdings
16.11
10.84
205.69%
ITGR
Integer Holdings
70.20
-57.73
-45.13%
GKOS
Glaukos
74.67
-59.41
-44.31%
LIVN
LivaNova
54.89
1.73
3.25%
INSP
Inspire Medical Systems
77.52
-117.16
-60.18%

TransMedics Group Corporate Events

Business Operations and StrategyM&A Transactions
TransMedics Group Acquires Aircraft for Organ Transport
Positive
Oct 6, 2025

On October 3, 2025, TransMedics, Inc., a subsidiary of TransMedics Group, acquired a fixed-wing aircraft from Teaghlach Aviation, LLC for approximately $14.5 million. This acquisition is part of a series of transactions to build a fleet of 22 aircraft, aimed at enhancing the company’s capabilities in transporting donor organs for its National OCS Program.

The most recent analyst rating on (TMDX) stock is a Buy with a $150.00 price target. To see the full list of analyst forecasts on TransMedics Group stock, see the TMDX Stock Forecast page.

TransMedics Group Q2 2025 Earnings Call Highlights
Aug 1, 2025

TransMedics Group’s recent earnings call for Q2 2025 exuded a predominantly positive sentiment, underscored by impressive financial performance and strategic advancements. The company reported record revenue growth and a robust cash position, signaling strong operational health. Despite facing challenges in the lung perfusion market and anticipating some seasonal impacts in the upcoming quarter, the overall outlook remains optimistic, with strengths and positive developments outweighing the hurdles.

TransMedics Reports Strong Q2 2025 Financial Results
Jul 31, 2025

TransMedics Group, Inc., headquartered in Andover, Massachusetts, is a leading medical technology company specializing in portable extracorporeal warm perfusion and assessment of donor organs for transplantation, aiming to improve organ quality and increase donor organ utilization for end-stage heart, lung, and liver failure treatments.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Oct 25, 2025