Strong Revenue Growth (Q4 and Full Year 2025)
Q4 2025 total revenue of $160.8M (reported ~ $161M) representing ~32% year-over-year growth and ~12% sequential growth versus Q3 2025; Full year 2025 revenue $605.5M, up ~37% year-over-year.
Improved Profitability and Operating Leverage
Full year 2025 operating profit of ~$108.6M (~18% of revenue) with operating margin expansion from 8.5% in 2024 to 18% in 2025; Q4 2025 operating profit ~$21.3M (~13.2% of Q4 revenue).
Strong Cash Position
Ended 2025 with ~$488.4M in cash and cash equivalents, up $22M from September 30, 2025, supporting continued investment and optionality.
Large Increase in OCS Clinical Volume and Market Impact
Total U.S. OCS transplants in 2025 totaled 5,139, up from 3,735 in 2024; OCS represented ~26% of U.S. liver/heart/lung transplants in 2025 (versus ~20% in 2024); company asserts U.S. transplant volumes for these organs grew 25% since 2022 including OCS (would have declined ~1% without OCS).
Organ-Level Adoption — Liver and Heart Momentum
OCS Liver: 4,197 cases in 2025 representing ~36% of overall U.S. liver volume (up from 26% in 2024); OCS Heart: 854 cases (~18% of heart volume, modestly up from 17%).
Product and Service Revenue Strength
Q4 product revenue ~$100M (up ~34% YoY, +15% sequential) and service revenue ~$60M (up ~29% YoY, +8% sequential); full year product revenue $372M and service revenue $233M.
Logistics and Operational Expansion
Transplant logistics service revenue Q4 ~$28.6M, up ~32% YoY and ~5% sequentially; owned and operated 22 aircraft by year-end and maintained ~80% coverage of NOP missions requiring air transport (vs 75% in 2024).
International Progress and Guidance
International revenue showing early growth (Q4 international ~$4.8M, +24% YoY, +33% sequential; full year $16.7M, +9.3% YoY); 2026 revenue guidance of $727M–$757M (+20%–25% vs 2025) with long-term gross margin target around ~60%.
Pipeline and Platform Investments
Ongoing clinical programs (ENHANCE Heart Part A/B, DENOVO Lung), OCS Kidney development and OCS Gen 3.0 platform development underway; company expects these to be major near-, mid- and long-term growth catalysts.