Integra Lifesciences Holdings Corp. (IART)
NASDAQ:IART
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Integra Lifesciences (IART) AI Stock Analysis

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IART

Integra Lifesciences

(NASDAQ:IART)

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Neutral 45 (OpenAI - 4o)
Rating:45Neutral
Price Target:
$11.00
▼(-6.38% Downside)
Integra Lifesciences faces significant financial and operational challenges, reflected in its low financial performance and valuation scores. The technical analysis indicates bearish momentum, further weighing down the stock's outlook. While the earnings call highlighted some strategic advancements, the overall sentiment remains cautious due to ongoing disruptions and lowered guidance.
Positive Factors
Strong Operational Efficiency
Exceeding EPS guidance through operational efficiency and cost management indicates robust internal processes, supporting long-term profitability.
International Revenue Growth
Strong international growth, especially in China, suggests successful global expansion strategies, enhancing market position and revenue diversification.
Improved Manufacturing Yields
Significant improvements in manufacturing efficiency can lead to cost savings and better inventory management, strengthening supply chain resilience.
Negative Factors
Supply Chain Disruptions
Ongoing supply chain issues can hinder product availability and sales, affecting revenue consistency and customer satisfaction over the medium term.
Negative Profit Margins
Sustained negative profit margins indicate operational inefficiencies and financial strain, challenging the company's ability to generate sustainable profits.
Lowered Revenue Guidance
Reduced revenue guidance reflects challenges in meeting market expectations, potentially impacting investor confidence and strategic planning.

Integra Lifesciences (IART) vs. SPDR S&P 500 ETF (SPY)

Integra Lifesciences Business Overview & Revenue Model

Company DescriptionIntegra LifeSciences Holdings Corporation develops, manufactures, and markets surgical implants and medical instruments for use in neurosurgery, extremity reconstruction, and general surgery. It operates in two segments, Codman Specialty Surgical and Tissue Technologies. The company offers neurosurgery and neuro critical care products, including tissue ablation equipment, dural repair products, cerebral spinal fluid management devices, intracranial monitoring equipment, and cranial stabilization equipment; and surgical headlamps and instrumentation, as well as asset management software and support, and after-market services. It also sells approximately 40,000 instrument patterns, and surgical and lighting products to hospitals and surgery centers, as well as dental, podiatry, and veterinary offices. In addition, the company provides regenerative technology products for the treatment of acute and chronic wounds; and surgical tissue repair products for hernia repair, peripheral nerve repair and protection, and tendon repair. Further, it offers skin and wound repair, plastics and surgical reconstruction products, bone grafts, and nerve and tendon repair products. The company offers its products directly through various sales forces and other distribution channels to the hospitals, integrated health networks, group purchasing organizations, clinicians, surgery centers, and health care providers in the United States, Europe, Asia Pacific, and internationally. Integra LifeSciences Holdings Corporation was incorporated in 1989 and is headquartered in Princeton, New Jersey.
How the Company Makes MoneyIntegra Lifesciences generates revenue through a combination of its diverse product offerings, including advanced wound care products, neurosurgery instruments, and orthopedic implants. The company earns income by selling these products directly to hospitals, surgical centers, and healthcare providers. Key revenue streams include sales of regenerative tissue products, which are used in surgical procedures to promote healing and tissue regeneration, as well as sales from neurosurgical instruments and devices. Additionally, Integra benefits from strategic partnerships with other healthcare organizations and distributors that expand its market reach. The company's focus on innovation and its pipeline of new products also contribute significantly to its earnings potential, allowing it to address unmet medical needs and tap into new markets.

Integra Lifesciences Earnings Call Summary

Earnings Call Date:Oct 30, 2025
(Q3-2025)
|
% Change Since: |
Next Earnings Date:Feb 25, 2026
Earnings Call Sentiment Neutral
The earnings call highlighted strong operational efficiency and strategic advancements like the early relaunch of key products. However, these positives were counterbalanced by supply chain disruptions, challenges in the ENT and Private Label segments, and a lowered full-year guidance, reflecting a mixed performance.
Q3-2025 Updates
Positive Updates
Strong Organic Revenue Growth
Despite challenges, the company achieved organic revenue growth of approximately 5% year-over-year, with total revenues for the quarter being $402 million.
Adjusted EPS Exceeds Guidance
Adjusted EPS for the quarter was $0.54, exceeding the top end of the guidance range, reflecting strong operational efficiency and cost management.
Significant Improvement in Integra Skin Production
Integra Skin manufacturing yields improved by more than 50%, and inventory levels increased by 2.5x since January.
Successful Relaunch of PriMatrix and Durepair
PriMatrix and Durepair were reintroduced ahead of schedule due to a dual sourcing strategy, improving supply chain resilience.
Strong International Growth
International revenue grew 14.6% driven by strong demand and renewed availability of products, with China showing a 24% year-over-year increase.
Negative Updates
Revenue Below Expectations
Revenue growth was below guidance due to two supply interruptions in the CSS business and insufficient safety stock levels.
Challenges in ENT and Private Label Business
ENT business was flat due to reimbursement pressure and timing of capital equipment purchases, while Private Label sales declined 12.6%.
MediHoney Under Pressure
MediHoney sales were impacted due to ongoing remediation under the Compliance Master Plan.
Lowered Full Year Guidance
Full year 2025 revenue and adjusted EPS guidance were revised to $1.62 billion to $1.64 billion and $2.19 to $2.24, respectively.
Gross Margin Decline
Gross margin for the quarter was 62.9%, down 10 basis points year-over-year due to increased remediation costs and tariffs.
Company Guidance
During the Integra LifeSciences Third Quarter 2025 Earnings Conference Call, the company provided updated guidance for the fiscal year. The full-year 2025 revenue is projected to be between $1.62 billion and $1.64 billion, with an adjusted EPS range of $2.19 to $2.24. The third quarter revenue was $402 million, representing an organic growth of 5% year-over-year, although it fell below the guidance range due to supply interruptions in the CSS business. Despite this, the adjusted EPS for the quarter exceeded expectations at $0.54. The company is focused on executing its Compliance Master Plan, improving operational efficiency, and maintaining disciplined cost management. They anticipate modest revenue growth in 2026, supported by strategic initiatives and cost-saving measures expected to yield $25 million to $30 million in savings.

Integra Lifesciences Financial Statement Overview

Summary
Integra Lifesciences is facing significant financial challenges, particularly in profitability and cash flow generation. The negative net profit margin and deteriorating profitability metrics highlight operational inefficiencies. While there are improvements in leverage, the company needs to enhance its revenue and profit margins for sustainable growth.
Income Statement
45
Neutral
Integra Lifesciences shows a concerning trend in its income statement. The TTM data reveals a negative net profit margin of -30.15%, indicating significant losses. The EBIT and EBITDA margins are also negative, reflecting operational challenges. Despite a slight revenue growth of 1.31% in the TTM, the company's profitability metrics have deteriorated compared to previous years, highlighting a need for strategic adjustments.
Balance Sheet
55
Neutral
The balance sheet presents a mixed picture. The debt-to-equity ratio has improved to 0.21 in the TTM, suggesting better leverage management compared to previous years. However, the return on equity is negative at -38.51%, indicating that the company is not generating sufficient returns on shareholders' equity. The equity ratio stands at a moderate level, reflecting a balanced asset structure.
Cash Flow
50
Neutral
Cash flow analysis shows challenges in maintaining positive free cash flow growth, with a significant decline of -281.61% in the TTM. The operating cash flow to net income ratio is 0.25, indicating limited cash flow generation relative to net income. However, the free cash flow to net income ratio is relatively strong at 0.78, suggesting some ability to convert earnings into cash.
BreakdownTTMDec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income Statement
Total Revenue1.64B1.61B1.54B1.56B1.54B1.37B
Gross Profit895.93M882.06M888.39M970.31M944.64M851.03M
EBITDA-354.54M193.29M255.96M384.60M366.33M267.93M
Net Income-495.33M-6.94M67.74M180.55M169.07M133.89M
Balance Sheet
Total Assets3.65B4.04B3.78B3.89B3.78B3.62B
Cash, Cash Equivalents and Short-Term Investments267.88M273.57M309.10M456.66M513.45M470.17M
Total Debt213.51M1.98B1.68B1.63B1.67B1.66B
Total Liabilities2.61B2.49B2.19B2.09B2.10B2.10B
Stockholders Equity1.04B1.55B1.59B1.80B1.68B1.51B
Cash Flow
Free Cash Flow69.90M24.96M73.09M217.38M264.35M139.94M
Operating Cash Flow89.31M129.38M139.96M264.47M312.43M203.83M
Investing Cash Flow-77.41M-390.81M-94.18M-58.58M-161.44M-68.07M
Financing Cash Flow-3.16M237.86M-229.93M-251.95M-98.23M121.63M

Integra Lifesciences Technical Analysis

Technical Analysis Sentiment
Negative
Last Price11.75
Price Trends
50DMA
14.04
Negative
100DMA
13.68
Negative
200DMA
15.94
Negative
Market Momentum
MACD
-0.74
Positive
RSI
37.12
Neutral
STOCH
58.60
Neutral
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For IART, the sentiment is Negative. The current price of 11.75 is below the 20-day moving average (MA) of 13.38, below the 50-day MA of 14.04, and below the 200-day MA of 15.94, indicating a bearish trend. The MACD of -0.74 indicates Positive momentum. The RSI at 37.12 is Neutral, neither overbought nor oversold. The STOCH value of 58.60 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Negative sentiment for IART.

Integra Lifesciences Risk Analysis

Integra Lifesciences disclosed 34 risk factors in its most recent earnings report. Integra Lifesciences reported the most risks in the "Legal & Regulatory" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks

Integra Lifesciences Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
76
Outperform
$1.79B26.8418.31%29.47%23.24%
66
Neutral
$1.41B12.916.60%1.90%4.69%-51.57%
66
Neutral
$608.31M65.454.97%1.58%
61
Neutral
$1.09B-1.90%18.72%85.77%
52
Neutral
$592.01M-4.92-24.60%4.31%3.26%
51
Neutral
$7.86B-0.30-43.30%2.27%22.53%-2.21%
45
Neutral
$915.23M-38.71%4.99%-7151.40%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
IART
Integra Lifesciences
11.75
-10.74
-47.75%
CNMD
Conmed
42.04
-27.76
-39.77%
OFIX
Orthofix
14.95
-3.34
-18.26%
UFPT
Ufp Technologies
231.58
-47.36
-16.98%
AXGN
AxoGen
23.55
10.75
83.98%
BVS
Bioventus
7.35
-3.90
-34.67%

Integra Lifesciences Corporate Events

Integra LifeSciences Earnings Call: Mixed Sentiment and Strategic Advancements
Nov 1, 2025

The recent earnings call for Integra LifeSciences presented a mixed sentiment, reflecting both operational successes and ongoing challenges. The company showcased strong operational efficiency and strategic advancements, such as the early relaunch of key products. However, these positives were tempered by supply chain disruptions, challenges in the ENT and Private Label segments, and a lowered full-year guidance, indicating a mixed performance overall.

Integra LifeSciences Reports Strong Q3 2025 Results
Oct 31, 2025

Integra LifeSciences Holdings Corporation, a global leader in medical technology, specializes in neurosurgery, tissue reconstruction, and surgical instrumentation, offering innovative solutions to healthcare professionals worldwide.

Integra LifeSciences’ Innovative Approach to Ulcer Treatment: A Study Update
Oct 27, 2025

Integra LifeSciences (IART) is conducting a multicenter, prospective, randomized, controlled platform trial titled ‘Multicenter, Prospective, Randomized, Controlled Platform Trial Assessing Clinical Utility of Cellular, Acellular and Matrix-like Products (CAMPs) and Standard of Care vs SOC Alone in Hard-to-Heal Diabetic Foot and Venous Leg Ulcers.’ The study aims to evaluate the effectiveness of multiple CAMPs and standard care compared to standard care alone in healing diabetic foot and venous leg ulcers.

Integra LifeSciences Advances with MIRROR Registry Study on Hematoma Evacuation
Oct 27, 2025

Integra LifeSciences is currently recruiting participants for its clinical study titled ‘The MIRROR Registry: Minimally Invasive IntRaceRebral HemORrhage Evacuation.’ The study aims to evaluate the effectiveness of the Aurora® Surgiscope in providing surgical access and visualization for the minimally invasive removal of hematoma in the brain. This research is significant as it explores various methods of hematoma removal based on surgeon preference and examines the impact of patient selection and timing of surgery.

Integra LifeSciences’ Pediatric Study: A Real-World Evaluation of the AERA® Device
Oct 27, 2025

Integra LifeSciences (IART) is conducting a study titled ‘A Real World, Observational Pediatric Registry of the Acclarent AERA® Eustachian Tube Balloon Dilation System.’ The study aims to gather real-world evidence on the clinical performance of the AERA® device in pediatric patients with Eustachian Tube Dysfunction. This research is significant as it seeks to confirm the device’s effectiveness in a real-world setting, potentially influencing treatment protocols for this condition.

Integra LifeSciences’ New Study on Burn Treatment: What Investors Need to Know
Oct 27, 2025

Study Overview: Integra LifeSciences is conducting an observational cohort analysis titled ‘An Observational Cohort Analysis of Tissue Quality of Integra Dermal Matrix (Integra®)-Treated Burns and NovoSorb® Biodegradable Temporizing Matrix (BTM)-Treated Burns 12-36 Months Post Final Skin Graft Application.’ The study aims to evaluate the tissue quality of burns treated with Integra and BTM, providing insights into their long-term effectiveness and patient outcomes.

Integra LifeSciences’ Bactiseal Catheter Safety Study: Key Insights for Investors
Oct 27, 2025

Integra LifeSciences is conducting a study titled ‘A Multi-center, Retrospective Registry Study on the Safety of Bactiseal Catheter’ to evaluate the safety of the Bactiseal catheter in patients with hydrocephalus. The study aims to monitor adverse events within two years post-implantation, providing crucial safety data for this medical device.

Integra LifeSciences’ CODMAN CERTAS Valve Study: Market Implications and Progress
Oct 27, 2025

Study Overview: Integra LifeSciences is conducting a post-market clinical follow-up study titled Post-Market Clinical Follow-up of Patients With CODMAN CERTAS Plus Programmable Valve. The study aims to assess the long-term performance and safety of the CODMAN CERTAS Plus Programmable Valve in patients with various conditions such as hydrocephalus and brain tumors. This study is significant as it provides valuable data on the device’s real-world effectiveness.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Nov 04, 2025