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Sionna Therapeutics, Inc. (SION)
NASDAQ:SION
US Market

Sionna Therapeutics, Inc. (SION) AI Stock Analysis

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SION

Sionna Therapeutics, Inc.

(NASDAQ:SION)

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Neutral 47 (OpenAI - 5.2)
Rating:47Neutral
Price Target:
$39.00
▼(-9.74% Downside)
The score is primarily constrained by weak financial performance—no revenue, widening losses, rising cash burn, and deeply negative equity—implying elevated financing risk. Technicals are mixed but currently soft (below key short-term averages with weak momentum), while valuation is also pressured by ongoing unprofitability and lack of dividend support.

Sionna Therapeutics, Inc. (SION) vs. SPDR S&P 500 ETF (SPY)

Sionna Therapeutics, Inc. Business Overview & Revenue Model

Company DescriptionSionna Therapeutics, Inc. is a biopharmaceutical company. The Company provides treatment paradigm for cystic fibrosis patients by developing medicines that normalize the function of the cystic fibrosis transmembrane conductance regulator.
How the Company Makes Money

Sionna Therapeutics, Inc. Financial Statement Overview

Summary
Income Statement
Balance Sheet
Cash Flow
BreakdownTTMDec 2024Dec 2023Dec 2022
Income Statement
Total Revenue0.000.000.000.00
Gross Profit-247.00K-668.00K0.000.00
EBITDA-75.29M-69.89M-49.75M-41.25M
Net Income-70.68M-61.69M-47.26M-40.24M
Balance Sheet
Total Assets339.27M185.75M51.95M87.37M
Cash, Cash Equivalents and Short-Term Investments248.33M147.54M38.52M82.61M
Total Debt8.97M9.75M10.48M0.00
Total Liabilities17.60M349.46M166.83M157.29M
Stockholders Equity321.67M-163.71M-114.88M-69.92M
Cash Flow
Free Cash Flow-61.65M-52.81M-44.81M-37.94M
Operating Cash Flow-61.45M-52.79M-43.70M-36.07M
Investing Cash Flow-126.11M-126.91M27.35M-29.26M
Financing Cash Flow202.64M178.97M31.00K110.86M

Sionna Therapeutics, Inc. Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
70
Outperform
$2.01B53.3015.02%1128.17%
56
Neutral
$1.29B-9.00-29.01%-27.61%-69.49%
53
Neutral
$1.25B-6.66-56.52%-100.34%52.85%
51
Neutral
$7.86B-0.30-43.30%2.27%22.53%-2.21%
50
Neutral
$1.30B-12.86-51.65%53.28%21.77%
48
Neutral
$829.19M-1.70-49.06%-78.55%7.74%
47
Neutral
$1.66B-27.03-28.07%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
SION
Sionna Therapeutics, Inc.
43.21
20.97
94.29%
STOK
Stoke Therapeutics
35.17
26.17
290.78%
VIR
Vir Biotechnology
6.16
-5.94
-49.09%
IMTX
Immatics
9.84
3.41
53.03%
TNGX
Tango Therapeutics
11.79
8.87
303.77%
AMLX
Amylyx Pharmaceuticals Inc
11.99
8.49
242.57%
Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Jan 04, 2026