Amylyx Pharmaceuticals, Inc. (AMLX)
NASDAQ:AMLX
Want to see AMLX full AI Analyst Report?
Top Page
Amylyx Pharmaceuticals Inc
(NASDAQ:AMLX)
Select Model
Select Model
Rating:51Neutral
Price Target:
$13.00
▼(-29.19% Downside)
Action:Reiterated
Date:05/09/26
The score is held back primarily by deteriorated financial performance (revenue collapse, large losses, and ongoing cash burn) and weak technical momentum. These are partially offset by a strong balance sheet with low leverage and a more positive clinical/regulatory execution narrative from the earnings call, with the key inflection being the Phase III LUCIDITY readout in Q3 2026.
Positive Factors
Balance sheet strength
A very low debt load and sizable equity provide structural financial cushion, reducing insolvency risk and preserving flexibility to fund clinical programs. This improves the company’s ability to progress trials and commercial preparations over the next 2–6 months without immediate financing dependency.
Negative Factors
Revenue collapse & loss profile
A structural loss of commercial revenue and sustained large net losses signal that past revenue streams have evaporated, leaving the company dependent on clinical outcomes. Continued negative profitability erodes shareholder equity and reduces operating flexibility absent successful product approval or new revenue sources.
Read all positive and negative factors
Positive Factors
Negative Factors
Balance sheet strength
A very low debt load and sizable equity provide structural financial cushion, reducing insolvency risk and preserving flexibility to fund clinical programs. This improves the company’s ability to progress trials and commercial preparations over the next 2–6 months without immediate financing dependency.
Read all positive factors
Amylyx Pharmaceuticals Inc (AMLX) vs. SPDR S&P 500 ETF (SPY)
Market Cap
$1.60B
Dividend YieldN/A
Average Volume (3M)1.02M
Price to Earnings (P/E)―
Beta (1Y)1.49
Revenue GrowthN/A
EPS Growth51.42%
CountryUS
Employees123
SectorHealthcare
Sector Strength45
IndustryBiotechnology
Share Statistics
EPS (TTM)-1.48
Shares Outstanding111,186,320
10 Day Avg. Volume935,987
30 Day Avg. Volume1,022,724
Financial Highlights & Ratios
PEG Ratio0.12
Price to Book (P/B)3.74
Price to Sales (P/S)0.00
P/FCF Ratio-9.25
Enterprise Value/Market Cap0.61
Enterprise Value/RevenueN/A
Enterprise Value/Gross Profit-47.98
Enterprise Value/Ebitda-6.45
Forecast
1Y Price Target
$24.57Price Target Upside33.83% Upside
Rating ConsensusStrong Buy
Number of Analyst Covering8
EPS Forecast (FY)-1.41
Revenue Forecast (FY)N/A
Amylyx Pharmaceuticals Inc Business Overview & Revenue Model
Company Description
Amylyx Pharmaceuticals, Inc., a clinical-stage biopharmaceutical company, engages in developing various therapeutics for amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases. The company's product pipeline includes AMX0035, a d...
How the Company Makes Money
null...
Amylyx Pharmaceuticals Inc Earnings Call Summary
Earnings Call Date:May 07, 2026
(Q1-2026)
| % Change Since: |
Next Earnings Date:Aug 06, 2026
Earnings Call Sentiment Positive
The call emphasized strong operational execution: pivotal Phase III LUCIDITY enrollment completed and on track for a Q3 2026 top-line readout, active NDA preparation, clear commercial planning (including an EAP for up to 250 patients), and multiple pipeline programs advancing (AMX0318 IND-enabling work, AMX0035 longer-term data, AMX0114 cohort progress). Financially, while the company has a cash position of $279.8M with runway into 2028, cash declined ~11.7% year-over-year and operating expenses increased (total operating expenses +16% YoY; R&D +24.9% YoY), driven by development and milestone payments—risks remain tied to the upcoming LUCIDITY result and the need to convert clinical success into regulatory approval and commercial uptake.Positive Updates
Pivotal Phase III LUCIDITY Enrollment Complete and On Track
Randomized and dosed the last participant in late March; clear line of sight to complete the 16-week trial with top-line readout expected in Q3 2026. Study is powered at 90% and was designed to replicate prior positive trials (prior trials showed ~55% and 64% reductions in hypoglycemic events).
Negative Updates
Decrease in Cash Position Year-over-Year
Cash and marketable securities declined from $317.0M (prior comparable period) to $279.8M, a decrease of approximately $37.2M or ~11.7%, increasing reliance on execution of planned milestones to preserve runway.
Read all updates
Q1-2026 Updates
Positive
Negative
Pivotal Phase III LUCIDITY Enrollment Complete and On Track
Randomized and dosed the last participant in late March; clear line of sight to complete the 16-week trial with top-line readout expected in Q3 2026. Study is powered at 90% and was designed to replicate prior positive trials (prior trials showed ~55% and 64% reductions in hypoglycemic events).
Read all positive updates
Company Guidance
Management reiterated that avexitide’s pivotal Phase III LUCIDITY trial (90 mg once daily, 16‑week study; FDA‑agreed primary endpoint = composite of Level 2 [<54 mg/dL] and Level 3 hypoglycemic events) is fully enrolled, remains on track for a top‑line readout in Q3 2026, and that NDA preparations are underway with potential FDA approval and a commercial launch targeted in 2027; they also launched a U.S. expanded access program for up to 250 adults, estimate ~160,000 U.S. PBH patients after sleeve or Roux‑en‑Y surgery, and are building commercial and medical teams. Financials/guidance included $279.8M in cash and marketable securities (vs. $317M a year earlier) supporting a cash runway into 2028, Q1 operating expenses of $43.8M (up 16% year‑over‑year) with R&D $27.6M (vs. $22.1M) and SG&A $16.2M (vs. $15.7M), $6.1M non‑cash stock‑based comp (vs. $6.8M), and a $4M milestone paid to Gubra; other pipeline timelines noted: AMX0318 IND‑enabling work targeting a 2027 IND, AMX0035 week‑96 data planned for an upcoming meeting, and AMX0114 Cohort 2 fully enrolled with Cohort 1 biomarker data to be presented at ENCALS in June (LUCIDITY was powered ~90% and prior avexitide studies showed ~55% [PREVENT] and ~64% (90 mg) reductions, p=0.0031).Amylyx Pharmaceuticals Inc Financial Statement Overview
Summary
Income Statement
18
Very Negative
Balance Sheet
62
Positive
Cash Flow
24
Negative
| Breakdown | TTM | Dec 2025 | Dec 2024 | Dec 2023 | Dec 2022 | Dec 2021 |
|---|---|---|---|---|---|---|
Income Statement | ||||||
| Total Revenue | 0.00 | 0.00 | 87.37M | 380.79M | 22.23M | 0.00 |
| Gross Profit | -20.20M | -525.00K | 45.22M | 355.35M | 19.24M | 0.00 |
| EBITDA | -150.30M | -144.16M | -290.98M | 39.89M | -200.85M | -82.64M |
| Net Income | -150.11M | -144.74M | -301.74M | 49.27M | -198.38M | -87.93M |
Balance Sheet | ||||||
| Total Assets | 293.60M | 332.64M | 193.63M | 517.45M | 391.45M | 105.61M |
| Cash, Cash Equivalents and Short-Term Investments | 279.77M | 316.98M | 176.50M | 371.36M | 346.94M | 96.12M |
| Total Debt | 5.63M | 5.96M | 1.98M | 4.24M | 6.28M | 0.00 |
| Total Liabilities | 20.44M | 27.39M | 28.87M | 84.02M | 50.85M | 256.78M |
| Stockholders Equity | 273.16M | 305.26M | 164.76M | 433.43M | 340.61M | -151.17M |
Cash Flow | ||||||
| Free Cash Flow | -120.53M | -123.48M | -167.80M | 10.68M | -182.40M | -75.15M |
| Operating Cash Flow | -120.40M | -123.34M | -167.65M | 11.92M | -179.87M | -74.80M |
| Investing Cash Flow | 93.96M | 14.04M | 75.65M | 92.05M | -238.99M | -46.41M |
| Financing Cash Flow | 194.58M | 257.03M | 348.00K | 3.54M | 431.79M | 158.51M |
Amylyx Pharmaceuticals Inc Technical Analysis
Neutral
18.36
Price Trends
15.24
Negative
14.75
Negative
13.68
Positive
Market Momentum
-0.50
Negative
47.07
Neutral
89.17
Negative
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For AMLX, the sentiment is Neutral. The current price of 18.36 is above the 20-day moving average (MA) of 14.45, above the 50-day MA of 15.24, and above the 200-day MA of 13.68, indicating a neutral trend. The MACD of -0.50 indicates Negative momentum. The RSI at 47.07 is Neutral, neither overbought nor oversold. The STOCH value of 89.17 is Negative, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Neutral sentiment for AMLX.
Amylyx Pharmaceuticals Inc Risk Analysis
Amylyx Pharmaceuticals Inc disclosed 89 risk factors in its most recent earnings report. Amylyx Pharmaceuticals Inc reported the most risks in the "Tech & Innovation" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks
Amylyx Pharmaceuticals Inc Peers Comparison
UnderperformOutperform
Sector (51)
Name | Overall Rating | Market Cap | P/E Ratio | ROE | Dividend Yield | Revenue Growth | EPS Growth |
|---|---|---|---|---|---|---|---|
77 Outperform | $1.83B | 12.54 | 17.19% | ― | 20.71% | -5.53% | |
61 Neutral | $2.26B | -4.71 | 123.57% | ― | 75.92% | -569.22% | |
61 Neutral | $5.08B | -394.55 | -1.78% | ― | -79.52% | -43.40% | |
52 Neutral | $2.09B | -9.98 | -67.40% | ― | ― | -5.22% | |
51 Neutral | $7.86B | -0.30 | -43.30% | 2.27% | 22.53% | -2.21% | |
51 Neutral | $1.60B | -10.57 | -55.68% | ― | ― | 51.42% | |
45 Neutral | $1.66B | ― | -866.46% | ― | ― | 39.46% |
* Healthcare Sector Average
AMLX
Amylyx Pharmaceuticals Inc
14.35
9.25
181.37%
BCRX
BioCryst
8.91
-1.82
-16.96%
DNTH
Dianthus Therapeutics
93.01
75.48
430.58%
HRMY
Harmony Biosciences Holdings
31.59
-3.97
-11.16%
PHVS
Pharvaris
30.16
13.67
82.90%
BHVN
Biohaven Ltd.
11.01
-4.67
-29.78%
Amylyx Pharmaceuticals Inc Corporate Events
Business Operations and StrategyProduct-Related Announcements
Amylyx Highlights Pipeline Progress in Updated Corporate Presentation
Positive
Mar 24, 2026
On March 24, 2026, Amylyx Pharmaceuticals updated its corporate presentation to reflect several clinical development milestones across its rare disease pipeline. The company reported completion of enrollment in the Phase 3 LUCIDITY trial of avexit...
Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
Disclaimer
This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.