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Penumbra (PEN)
NYSE:PEN
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Penumbra (PEN) AI Stock Analysis

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PEN

Penumbra

(NYSE:PEN)

Rating:75Outperform
Price Target:
$286.00
▲(12.51%Upside)
Penumbra's overall stock score of 75 reflects its strong financial performance and positive earnings call insights, highlighting robust revenue growth and successful market execution. However, the high valuation and mixed technical indicators temper the outlook, suggesting caution for potential investors.
Positive Factors
Earnings
PEN's 2Q25 revenue and EPS beat consensus and management raised their 2025 revenue guidance.
Market Development
Penumbra has seen more strength on the pulmonary embolism side, indicating a strong market development in VTE with a positive outlook.
Product Launch
Thunderbolt is expected to be a material growth driver as it looks to take market share from competitors.
Negative Factors
Market Limitation
Investors are reminded that stroke growth is somewhat capped by the size of the end-market, meaning Thunderbolt will not have the benefit of a large TAM of patients already in the funnel.
Product Growth
Thrombectomy growth slowed to 13% CC in 2Q25 from 21% CC in 1Q25.

Penumbra (PEN) vs. SPDR S&P 500 ETF (SPY)

Penumbra Business Overview & Revenue Model

Company DescriptionPenumbra, Inc. is a global healthcare company that designs, develops, manufactures, and markets innovative medical devices for the treatment of various medical conditions. The company operates primarily in the neuro and peripheral vascular sectors, providing minimally invasive solutions that address challenging medical conditions such as stroke and vascular diseases. Penumbra's core products include aspiration systems, thrombectomy devices, and embolization products, which are used by healthcare professionals to improve patient outcomes worldwide.
How the Company Makes MoneyPenumbra generates revenue primarily through the sale of its medical devices to hospitals and healthcare providers. The company’s revenue model is based on direct sales and distribution partnerships, where it sells its products to end-users or through third-party distributors. Key revenue streams include the sales of neuro and peripheral vascular devices, each contributing significantly to the company’s overall earnings. Additionally, Penumbra collaborates with various healthcare institutions and invests in research and development to innovate and expand its product offerings, thus driving growth and maintaining a competitive edge in the medical device industry.

Penumbra Earnings Call Summary

Earnings Call Date:Jul 29, 2025
(Q2-2025)
|
% Change Since: 11.91%|
Next Earnings Date:Oct 29, 2025
Earnings Call Sentiment Positive
Penumbra's earnings call reflected strong revenue growth and successful execution in the thrombectomy business, particularly in the U.S., with positive clinical trial developments. However, challenges in international markets, particularly in China, and operating margin variability due to strategic investments posed some concerns.
Q2-2025 Updates
Positive Updates
Strong Revenue Growth
Penumbra reported total revenue of $339.5 million for Q2 2025, representing a 13.4% year-over-year growth on a reported basis and 12.7% on a constant currency basis.
U.S. Thrombectomy Business Success
The U.S. thrombectomy business increased by 22.6% year-over-year to $188.5 million, with the U.S. VTE franchise growing by 42% year-over-year.
Gross Margin Improvement
The gross margin for Q2 2025 was 66%, up from 54.4% in Q2 2024, excluding a one-time inventory write-off.
Positive Clinical Trial Enrollment
Enrollment in the STORM-PE trial was completed ahead of schedule, with results expected to be presented at a major medical conference in the fall.
Increased Full-Year Revenue Guidance
Total revenue guidance for 2025 was increased to a range of $1.355 billion to $1.370 billion, representing 13% to 15% year-over-year growth.
Negative Updates
Challenges in China
International revenue decreased by 3.2% reported and 5.8% in constant currency, primarily due to a decrease in China revenue.
Operating Margin Variability
Operating margins were impacted by investments in the commercial team, with non-GAAP operating expenses at $183.2 million or 54% of revenue.
Softness in Neurovascular Market
The neurovascular stroke market experienced slower growth, although Penumbra continued to gain market share.
Company Guidance
During Penumbra's second quarter 2025 earnings call, the company provided updated guidance due to its strong performance, raising its total revenue forecast to a range of $1.355 billion to $1.370 billion, reflecting a year-over-year growth of 13% to 15%. The U.S. thrombectomy business is expected to grow by 20% to 21% compared to 2024. Penumbra reported total revenue of $339.5 million for the second quarter, a 13.4% increase on a reported basis and 12.7% on a constant currency basis from the previous year. U.S. thrombectomy revenue grew 22.6% year-over-year to $188.5 million, driven by a 42% increase in the U.S. VTE franchise. The company's gross margin was 66%, with expectations to exceed 70% by the end of 2026. Operating income reached $40.8 million or 12% of revenue, a significant improvement from a loss of $1.6 million in the same period last year. Adjusted EBITDA was $61.4 million, representing 18.1% of total revenue, up from $13 million or 4.3% in the second quarter of the previous year.

Penumbra Financial Statement Overview

Summary
Penumbra exhibits strong financial performance with robust revenue growth, effective cost management, and a solid balance sheet. Profitability metrics are healthy, though there is room for improvement in operating margins. Cash flow generation is robust, supporting operational and strategic needs.
Income Statement
85
Very Positive
Penumbra's income statement demonstrates strong growth and profitability trends. The TTM revenue of $1.24 billion represents a substantial increase from prior years, indicating robust revenue growth. The gross profit margin stands at an impressive 63.5%, and the net profit margin at 3.4%, highlighting efficient cost management and profitability. However, the EBIT margin of 9.2% and EBITDA margin of 5.1% indicate room for improvement in operating efficiency.
Balance Sheet
78
Positive
The balance sheet shows a solid financial structure with a debt-to-equity ratio of 0.18, reflecting conservative leverage and financial stability. The equity ratio is strong at 76.1%, indicating a high proportion of equity financing and reduced financial risk. The return on equity (ROE) is modest at 3.5%, suggesting potential for enhanced profitability.
Cash Flow
82
Very Positive
Penumbra's cash flow statement is characterized by strong operational cash flow with a high operating cash flow to net income ratio of 4.24, indicating robust cash generation from operations. The free cash flow to net income ratio is 3.56, reflecting healthy cash surplus. The free cash flow growth rate of 2.06% is positive, though slightly modest, indicating stable cash generation.
BreakdownTTMDec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income Statement
Total Revenue1.28B1.19B1.06B847.13M747.59M560.41M
Gross Profit850.92M755.00M682.64M535.21M475.38M338.18M
EBITDA183.35M49.53M112.00M6.08M7.84M-22.34M
Net Income147.70M14.01M90.95M-2.00M2.62M-19.26M
Balance Sheet
Total Assets1.67B1.53B1.56B1.37B1.24B822.98M
Cash, Cash Equivalents and Short-Term Investments421.77M340.13M289.19M188.03M254.88M264.83M
Total Debt220.53M223.39M234.34M235.77M173.55M77.28M
Total Liabilities380.86M382.25M377.36M372.03M290.32M185.19M
Stockholders Equity1.29B1.15B1.18B998.86M953.93M641.50M
Cash Flow
Free Cash Flow161.62M147.30M82.12M-74.96M-11.68M-58.00M
Operating Cash Flow201.49M168.48M97.33M-55.66M9.50M-33.24M
Investing Cash Flow8.68M77.62M-16.08M54.79M-21.73M-104.15M
Financing Cash Flow-76.96M-87.01M16.20M11.62M836.00K134.92M

Penumbra Technical Analysis

Technical Analysis Sentiment
Positive
Last Price254.21
Price Trends
50DMA
251.47
Positive
100DMA
265.26
Negative
200DMA
256.57
Negative
Market Momentum
MACD
-4.94
Negative
RSI
61.08
Neutral
STOCH
42.79
Neutral
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For PEN, the sentiment is Positive. The current price of 254.21 is above the 20-day moving average (MA) of 238.14, above the 50-day MA of 251.47, and below the 200-day MA of 256.57, indicating a neutral trend. The MACD of -4.94 indicates Negative momentum. The RSI at 61.08 is Neutral, neither overbought nor oversold. The STOCH value of 42.79 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Positive sentiment for PEN.

Penumbra Risk Analysis

Penumbra disclosed 58 risk factors in its most recent earnings report. Penumbra reported the most risks in the "Finance & Corporate" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 2 New Risks
1.
We cannot guarantee we will make any additional repurchases of our common stock under our share repurchase program or otherwise. Q4, 2024
2.
We are exposed to the risk of nonpayment by our customers, which could adversely affect our financial condition or results of operations. Q4, 2024

Penumbra Peers Comparison

Overall Rating
UnderperformOutperform
Sector (52)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
80
Outperform
$13.69B33.467.86%2.42%5.16%56.79%
80
Outperform
$20.51B53.6837.92%23.49%71.25%
75
Outperform
$8.91B213.0512.03%12.92%918.46%
74
Outperform
$14.92B37.0411.41%0.56%0.43%
69
Neutral
$7.32B39.984.63%32.26%112.87%
58
Neutral
$6.89B-27.51%-2.46%-637.11%
52
Neutral
$7.47B0.53-62.70%2.38%14.92%0.82%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
PEN
Penumbra
254.21
82.96
48.44%
ALGN
Align Tech
203.57
-24.76
-10.84%
BIO
Bio-Rad Laboratories
250.08
-91.17
-26.72%
PODD
Insulet
298.27
101.02
51.21%
SNN
Smith & Nephew Snats
30.93
0.93
3.10%
GMED
Globus Medical
53.45
-16.65
-23.75%

Penumbra Corporate Events

Executive/Board ChangesShareholder MeetingsBusiness Operations and StrategyRegulatory Filings and Compliance
Penumbra Amends Incorporation Certificate After Stockholder Vote
Neutral
May 30, 2025

On May 28, 2025, Penumbra, Inc. filed an Amended and Restated Certificate of Incorporation with the State of Delaware, following stockholder approval at its Annual Meeting. During the meeting, stockholders voted on several proposals, including the election of Class I directors, ratification of PricewaterhouseCoopers LLP as the independent auditor, and approval of executive compensation. Additionally, amendments to the company’s charter were approved to phase in board declassification and eliminate supermajority voting requirements, reflecting significant governance changes aimed at enhancing corporate flexibility and shareholder influence.

The most recent analyst rating on (PEN) stock is a Buy with a $232.00 price target. To see the full list of analyst forecasts on Penumbra stock, see the PEN Stock Forecast page.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Jul 31, 2025