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Penumbra (PEN)
NYSE:PEN
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Penumbra (PEN) AI Stock Analysis

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PEN

Penumbra

(NYSE:PEN)

Rating:75Outperform
Price Target:
$280.00
▲(11.39% Upside)
Penumbra's strong financial performance and positive earnings call sentiment are the most significant factors contributing to its overall score. The company's robust revenue growth and improved profitability are key strengths. However, the high P/E ratio and challenges in international markets slightly offset these positives. Technical indicators suggest neutral momentum, neither significantly aiding nor hindering the stock's outlook.
Positive Factors
Financial Performance
PEN's 2Q25 revenue and EPS beat consensus and management raised their 2025 revenue guidance.
Product Innovation
Penumbra continues to focus on innovation, believing that its technology will be the competitive moat as the VTE field grows more competitive.
Salesforce Expansion
Penumbra has invested in a separate salesforce focused on peripheral embolization, hiring over 50 embolization reps and over 40 vascular specialists, to support its recent product, Ruby XL.
Negative Factors
Guidance Deceleration
Guidance increase raised questions about a second-half implied deceleration in U.S. throm.
Market Limitations
Investors are reminded that stroke growth is somewhat capped by the size of the end-market, meaning Thunderbolt will not have the benefit of a large TAM of patients already in the funnel.
Thrombectomy Growth
Thrombectomy growth slowed to 13% CC in 2Q25 from 21% CC in 1Q25.

Penumbra (PEN) vs. SPDR S&P 500 ETF (SPY)

Penumbra Business Overview & Revenue Model

Company DescriptionPenumbra, Inc. designs, develops, manufactures, and markets medical devices in the United States and internationally. The company offers aspiration based thrombectomy systems and accessory devices, including revascularization device for mechanical thrombectomy, such as Penumbra System under the Penumbra RED, JET, ACE, 3D Revascularization Device, and Penumbra ENGINE brands, as well as components and accessories; neurovascular embolization coiling systems to treat patients with various sizes of aneurysms and other neurovascular lesions under the Penumbra Coil 400, POD400, PAC400, and Penumbra SMART Coil brand names; and neurovascular access systems designed to provide intracranial access for use in a range of neurovascular therapies under the Neuron, Neuron MAX, Select, BENCHMARK, BMX96, DDC, and PX SLIM brands. It also provides neurosurgical aspiration tools for the removal of tissue and fluids under the Artemis Neuro Evacuation Device brand; aspiration-based thrombectomy systems for vascular applications under the Indigo System brand; and detachable embolic coil systems for peripheral embolization under the Ruby Coil and Ruby LP brand names. In addition, the company offers microcatheter for the delivery of detachable coils and occlusion devices under the LANTERN brand; and detachable, microcatheter-deliverable occlusion devices designed primarily to occlude peripheral vessels under the POD (Penumbra Occlusion Device) brand, as well as immersive computer-based technologies and immersive therapeutics to promote health, motor function, and cognition under the Real Immersive System brand; and a complementary device for use with Ruby Coil and POD for vessel occlusion under the Packing Coil and Packing Coil LP brands. The company sells its products through direct sales organizations and distributors. Penumbra, Inc. was incorporated in 2004 and is headquartered in Alameda, California.
How the Company Makes MoneyPenumbra generates revenue through the sale of its medical devices, which are primarily used in hospitals and healthcare facilities for interventional procedures. The company's key revenue streams include the direct sales of its proprietary products, such as thrombectomy devices and other catheter-based interventions. Additionally, Penumbra engages in partnerships with hospitals and healthcare systems to provide comprehensive training and support for its products, further driving sales. The company also benefits from recurring revenue through the sale of disposables and accessories associated with its devices, which are necessary for their operation. Furthermore, ongoing investments in research and development enable Penumbra to expand its product offerings and enter new markets, contributing to its overall earnings.

Penumbra Earnings Call Summary

Earnings Call Date:Jul 29, 2025
(Q2-2025)
|
% Change Since: 10.66%|
Next Earnings Date:Oct 29, 2025
Earnings Call Sentiment Positive
The earnings call reflected a positive sentiment with strong revenue growth driven by the U.S. thrombectomy business and strategic investments in new products like RUBY XL. However, challenges remain in the international segment due to China and a slower-growing stroke market.
Q2-2025 Updates
Positive Updates
Strong Revenue Growth
Penumbra reported total revenue of $339.5 million for the second quarter of 2025, representing a year-over-year growth of 13.4% on a reported basis and 12.7% on a constant currency basis.
U.S. Thrombectomy Business Performance
Second quarter U.S. thrombectomy revenue increased 22.6% year-over-year to $188.5 million, led by 42% year-over-year growth in the U.S. VTE franchise.
International Thrombectomy Growth
International thrombectomy business increased by 16.2%, excluding the impact of China, the growth was 14.4% year-over-year.
Improved Gross Margin
Gross margin for the second quarter of 2025 was 66%, compared to 54.4% in the second quarter of 2024, which included a one-time $33.4 million Immersive Healthcare inventory write-off.
STORM-PE Study Completion
Completed enrollment in STORM-PE, a prospective multicenter randomized controlled trial, ahead of schedule, with results expected to be presented in the fall.
Negative Updates
International Revenue Decline
International regions decreased 3.2% reported and 5.8% in constant currency, primarily due to a decrease in China revenue.
Gross Margin Sequential Decrease
Gross margin slightly decreased sequentially due to investment in the launch of the XL product and higher international mix.
Challenges in Neurovascular Business
The stroke market experienced slower growth, although Penumbra reported growth ahead of the underlying market.
Company Guidance
During Penumbra's Second Quarter 2025 Conference Call, the company updated its guidance for the year, reflecting strong financial performance and strategic initiatives. Total revenue for Q2 2025 was reported at $339.5 million, marking a 13.4% increase year-over-year on a reported basis and 12.7% on a constant currency basis. The U.S. thrombectomy business was a key driver, with revenue growing by 22.6% year-over-year, largely due to a 42% increase in the U.S. Venous Thromboembolism (VTE) franchise. Despite a 3.2% decline in international sales, excluding China, international thrombectomy revenue grew by 14.4%. Gross margin for the quarter was 66%, with an outlook to exceed 70% by the end of 2026. Operating expenses were at $183.2 million, or 54% of revenue, and adjusted EBITDA reached $61.4 million, representing 18.1% of total revenue. The company raised its full-year 2025 revenue guidance to between $1.355 billion and $1.370 billion, indicating 13% to 15% growth, while maintaining gross and operating margin targets.

Penumbra Financial Statement Overview

Summary
Penumbra exhibits strong financial performance with robust revenue growth, effective cost management, and a solid balance sheet. Profitability metrics are healthy, though there is room for improvement in operating margins. Cash flow generation is robust, supporting operational and strategic needs.
Income Statement
85
Very Positive
Penumbra's income statement demonstrates strong growth and profitability trends. The TTM revenue of $1.24 billion represents a substantial increase from prior years, indicating robust revenue growth. The gross profit margin stands at an impressive 63.5%, and the net profit margin at 3.4%, highlighting efficient cost management and profitability. However, the EBIT margin of 9.2% and EBITDA margin of 5.1% indicate room for improvement in operating efficiency.
Balance Sheet
78
Positive
The balance sheet shows a solid financial structure with a debt-to-equity ratio of 0.18, reflecting conservative leverage and financial stability. The equity ratio is strong at 76.1%, indicating a high proportion of equity financing and reduced financial risk. The return on equity (ROE) is modest at 3.5%, suggesting potential for enhanced profitability.
Cash Flow
82
Very Positive
Penumbra's cash flow statement is characterized by strong operational cash flow with a high operating cash flow to net income ratio of 4.24, indicating robust cash generation from operations. The free cash flow to net income ratio is 3.56, reflecting healthy cash surplus. The free cash flow growth rate of 2.06% is positive, though slightly modest, indicating stable cash generation.
BreakdownTTMDec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income Statement
Total Revenue1.28B1.19B1.06B847.13M747.59M560.41M
Gross Profit850.92M755.00M682.64M535.21M475.38M338.18M
EBITDA183.35M49.53M112.00M6.08M7.84M-22.34M
Net Income147.70M14.01M90.95M-2.00M2.62M-19.26M
Balance Sheet
Total Assets1.67B1.53B1.56B1.37B1.24B822.98M
Cash, Cash Equivalents and Short-Term Investments421.77M340.13M289.19M188.03M254.88M264.83M
Total Debt220.53M223.39M234.34M235.77M173.55M77.28M
Total Liabilities380.86M382.25M377.36M372.03M290.32M185.19M
Stockholders Equity1.29B1.15B1.18B998.86M953.93M641.50M
Cash Flow
Free Cash Flow161.62M147.30M82.12M-74.96M-11.68M-58.00M
Operating Cash Flow201.49M168.48M97.33M-55.66M9.50M-33.24M
Investing Cash Flow8.68M77.62M-16.08M54.79M-21.73M-104.15M
Financing Cash Flow-76.96M-87.01M16.20M11.62M836.00K134.92M

Penumbra Technical Analysis

Technical Analysis Sentiment
Positive
Last Price251.37
Price Trends
50DMA
246.12
Positive
100DMA
261.37
Negative
200DMA
259.70
Negative
Market Momentum
MACD
3.01
Negative
RSI
60.13
Neutral
STOCH
77.43
Neutral
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For PEN, the sentiment is Positive. The current price of 251.37 is above the 20-day moving average (MA) of 244.39, above the 50-day MA of 246.12, and below the 200-day MA of 259.70, indicating a neutral trend. The MACD of 3.01 indicates Negative momentum. The RSI at 60.13 is Neutral, neither overbought nor oversold. The STOCH value of 77.43 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Positive sentiment for PEN.

Penumbra Risk Analysis

Penumbra disclosed 58 risk factors in its most recent earnings report. Penumbra reported the most risks in the "Finance & Corporate" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks

Penumbra Peers Comparison

Overall Rating
UnderperformOutperform
Sector (46)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
78
Outperform
$16.05B32.629.20%2.00%6.28%61.96%
76
Outperform
$23.05B101.3419.18%25.99%-40.46%
75
Outperform
$9.87B67.8012.03%12.92%918.46%
72
Outperform
$7.80B24.564.59%-0.33%
70
Outperform
$8.26B23.448.62%17.43%775.48%
63
Neutral
$10.42B24.2211.41%0.56%0.43%
46
Neutral
C$209.14M-0.30-24.12%3.18%19.38%-2.35%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
PEN
Penumbra
251.37
41.25
19.63%
ALGN
Align Tech
140.67
-93.30
-39.88%
BIO
Bio-Rad Laboratories
285.03
-29.91
-9.50%
PODD
Insulet
327.85
142.81
77.18%
SNN
Smith & Nephew Snats
36.97
6.85
22.74%
GMED
Globus Medical
60.50
-11.55
-16.03%

Penumbra Corporate Events

Executive/Board ChangesShareholder MeetingsBusiness Operations and StrategyRegulatory Filings and Compliance
Penumbra Amends Incorporation Certificate After Stockholder Vote
Neutral
May 30, 2025

On May 28, 2025, Penumbra, Inc. filed an Amended and Restated Certificate of Incorporation with the State of Delaware, following stockholder approval at its Annual Meeting. During the meeting, stockholders voted on several proposals, including the election of Class I directors, ratification of PricewaterhouseCoopers LLP as the independent auditor, and approval of executive compensation. Additionally, amendments to the company’s charter were approved to phase in board declassification and eliminate supermajority voting requirements, reflecting significant governance changes aimed at enhancing corporate flexibility and shareholder influence.

The most recent analyst rating on (PEN) stock is a Buy with a $232.00 price target. To see the full list of analyst forecasts on Penumbra stock, see the PEN Stock Forecast page.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Aug 13, 2025