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Pacira (PCRX)
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Pacira Pharmaceuticals (PCRX) AI Stock Analysis

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PCRX

Pacira Pharmaceuticals

(NASDAQ:PCRX)

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Neutral 69 (OpenAI - 4o)
Rating:69Neutral
Price Target:
$26.00
▲(18.99% Upside)
Pacira Pharmaceuticals' overall stock score is driven by its stable financial performance and positive earnings call highlights, including strong revenue growth and strategic initiatives. However, the stock's high valuation and technical indicators suggest caution, as it appears overvalued and shows signs of weak momentum.
Positive Factors
Revenue Growth
Consistent revenue growth, particularly from core products like EXPAREL, indicates strong market demand and positions Pacira for continued expansion.
Pipeline Expansion
Expanding the product pipeline with innovative formulations like AMT-143 enhances long-term growth prospects and strengthens competitive positioning.
Cash Flow and Shareholder Returns
Strong cash flow and strategic share repurchases reflect financial health and commitment to shareholder value, supporting sustainable growth.
Negative Factors
Zilretta Sales
Sluggish sales of Zilretta indicate challenges in market penetration and could impact overall revenue growth if not addressed.
GPO Discount Impact
Higher-than-expected discounting pressures from GPO agreements may compress margins, affecting profitability and pricing strategy.
Elective Procedure Market
Sluggish growth in elective procedures could limit demand for Pacira's products, impacting revenue potential in a key market segment.

Pacira Pharmaceuticals (PCRX) vs. SPDR S&P 500 ETF (SPY)

Pacira Pharmaceuticals Business Overview & Revenue Model

Company DescriptionPacira Pharmaceuticals, Inc. is a biopharmaceutical company focused on the development and commercialization of innovative non-opioid pain management solutions. The company operates primarily in the pharmaceutical sector, with a strong emphasis on improving patient outcomes in surgical and non-surgical settings. Pacira's core product, EXPAREL, is a liposomal formulation of bupivacaine designed to provide prolonged local analgesia and reduce the need for opioids post-surgery. The company is dedicated to enhancing the way pain is managed and is committed to advancing its pipeline of products aimed at improving recovery and patient experiences in various surgical procedures.
How the Company Makes MoneyPacira Pharmaceuticals generates revenue primarily through the sales of its flagship product, EXPAREL, which is marketed to hospitals, surgical centers, and healthcare providers. The company also earns revenue from collaborations and partnerships with other pharmaceutical firms, which may include licensing agreements or co-development arrangements for its pipeline products. Additionally, Pacira may benefit from government reimbursements and healthcare insurance payments for its products, which are crucial for driving sales and expanding market access. The company has strategically focused on building relationships with healthcare professionals and institutions to promote the adoption of non-opioid pain management solutions, contributing to its overall revenue growth.

Pacira Pharmaceuticals Earnings Call Summary

Earnings Call Date:Nov 06, 2025
(Q3-2025)
|
% Change Since: |
Next Earnings Date:Feb 19, 2026
Earnings Call Sentiment Positive
The earnings call highlighted strong revenue growth, improved manufacturing efficiencies, and significant pipeline expansion. However, some challenges were noted with Zilretta's slower-than-expected sales growth and discount impacts from new GPO agreements affecting pricing. Elective procedure market growth was also described as sluggish.
Q3-2025 Updates
Positive Updates
Revenue Growth
Year-over-year revenues increased by 6%, driven by strong performance from EXPAREL and iovera. EXPAREL demand increased with year-over-year volumes up approximately 9%, marking the highest quarterly growth in over 3 years.
Manufacturing and Gross Margin
Improved manufacturing efficiencies and gross margins supported an increase in full-year guidance. Non-GAAP gross margins improved to 82% in the third quarter from 78% last year.
Pipeline Expansion
Clinical pipeline expanded with the in-licensing of AMT-143, a novel long-acting formulation of bupivacaine. The company also reported progress in its Phase II study of PCRX-201 for osteoarthritis of the knee.
Market Access and Coverage
The company is ahead of plan to surpass the full-year goal of 100 million covered lives across commercial and government payers. Approximately 60 million commercial lives now have access to EXPAREL via separate reimbursement.
Cash Flow and Shareholder Returns
Significant operating cash flow and a strong balance sheet enable investments in new growth initiatives. The company executed an additional $50 million in share repurchases during the quarter.
Negative Updates
Zilretta Sales
Zilretta sales were slower than anticipated, with only a slight increase to $29.0 million from $28.4 million in 2024.
GPO Discount Impact
Discounting from the third GPO agreement resulted in a higher-than-expected single-digit year-over-year impact on net selling prices.
Elective Procedure Market
Elective procedures were sluggish in the first half of the year, and while there were modest improvements in the third quarter, the growth was not monumental.
Company Guidance
During the Pacira BioSciences third quarter 2025 earnings call, the company provided several key performance metrics and guidance. Year-over-year revenues increased by 6%, driven by a 9% rise in EXPAREL demand, marking the highest quarterly growth in over three years. The company reported EXPAREL sales of $139.9 million, Zilretta sales of $29.0 million, and iovera sales of $6.5 million for the third quarter. Non-GAAP gross margins improved to 82%, compared to 78% the previous year, with the guidance for full-year revenues narrowed to $725 million to $735 million. The company also highlighted its strategic initiatives, such as the in-licensing of AMT-143, a novel long-acting formulation of bupivacaine, and emphasized its robust patent protection with the listing of the 21st EXPAREL patent in the FDA's Orange Book. With significant cash flows, a strong balance sheet, and strategic share repurchases totaling $50 million, Pacira BioSciences is well-positioned to advance its 5x30 growth strategy, aiming for a five-year double-digit compound annual growth rate (CAGR) for revenue.

Pacira Pharmaceuticals Financial Statement Overview

Summary
Pacira Pharmaceuticals exhibits stable financial health with consistent revenue growth and improved operational efficiency. The company has effectively managed its debt, enhancing its financial stability. Cash flow generation remains strong, supporting future growth opportunities. However, profitability margins could be improved to enhance shareholder value.
Income Statement
68
Positive
Pacira Pharmaceuticals shows a modest revenue growth rate of 1.55% TTM, with a stable gross profit margin of 58.9%. However, the net profit margin is relatively low at 4.13%, indicating limited profitability. The EBIT and EBITDA margins have improved over the previous year, suggesting better operational efficiency.
Balance Sheet
72
Positive
The company has significantly reduced its debt-to-equity ratio to 0.013 TTM, indicating strong financial stability. The return on equity is modest at 3.87%, reflecting moderate profitability. The equity ratio is healthy, showing a solid capital structure.
Cash Flow
75
Positive
Pacira Pharmaceuticals has achieved a free cash flow growth rate of 6.1% TTM, demonstrating strong cash generation capabilities. The operating cash flow to net income ratio is robust at 1.32, indicating efficient cash conversion. The free cash flow to net income ratio is also strong at 0.88.
BreakdownTTMDec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income Statement
Total Revenue716.79M700.97M674.98M666.82M541.53M429.65M
Gross Profit567.46M530.54M490.31M467.53M401.28M312.32M
EBITDA147.82M29.12M154.59M140.38M113.95M63.51M
Net Income21.44M-99.56M41.95M15.91M41.98M145.52M
Balance Sheet
Total Assets1.30B1.55B1.57B1.68B2.08B1.27B
Cash, Cash Equivalents and Short-Term Investments246.33M484.62M278.58M288.65M656.41M521.66M
Total Debt425.31M638.85M586.04M763.39M1.13B541.13M
Total Liabilities570.36M775.17M704.26M906.19M1.34B654.83M
Stockholders Equity727.21M778.35M870.13M775.01M730.41M619.69M
Cash Flow
Free Cash Flow124.20M178.75M139.49M115.20M79.85M39.23M
Operating Cash Flow141.44M189.39M154.65M145.27M125.72M77.03M
Investing Cash Flow79.78M-83.28M77.54M-225.19M-20.79M-277.61M
Financing Cash Flow-319.93M17.36M-183.03M-401.53M380.69M222.30M

Pacira Pharmaceuticals Technical Analysis

Technical Analysis Sentiment
Positive
Last Price21.85
Price Trends
50DMA
23.44
Positive
100DMA
23.94
Negative
200DMA
24.40
Negative
Market Momentum
MACD
0.15
Negative
RSI
55.47
Neutral
STOCH
40.98
Neutral
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For PCRX, the sentiment is Positive. The current price of 21.85 is below the 20-day moving average (MA) of 22.97, below the 50-day MA of 23.44, and below the 200-day MA of 24.40, indicating a neutral trend. The MACD of 0.15 indicates Negative momentum. The RSI at 55.47 is Neutral, neither overbought nor oversold. The STOCH value of 40.98 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Positive sentiment for PCRX.

Pacira Pharmaceuticals Risk Analysis

Pacira Pharmaceuticals disclosed 69 risk factors in its most recent earnings report. Pacira Pharmaceuticals reported the most risks in the "Finance & Corporate" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks

Pacira Pharmaceuticals Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
76
Outperform
$1.26B12.1314.84%-0.03%-27.66%
70
Neutral
$1.46B28.7722.96%26.34%-32.79%
69
Neutral
$981.78M2.90%3.14%
64
Neutral
$1.90B51.747.83%48.87%
57
Neutral
$2.09B-0.32%79.88%99.60%
55
Neutral
$2.65B-1.86%4.54%-130.59%
51
Neutral
$7.86B-0.30-43.30%2.27%22.53%-2.21%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
PCRX
Pacira Pharmaceuticals
23.81
6.90
40.80%
AVDL
Avadel Pharmaceuticals
21.40
10.34
93.49%
SUPN
Supernus Pharmaceuticals
46.26
9.69
26.50%
ANIP
ANI Pharmaceuticals
84.36
27.13
47.41%
AMPH
Amphastar Pharmaceuticals
27.36
-17.83
-39.46%
COLL
Collegium Pharmaceutical
46.23
15.73
51.57%

Pacira Pharmaceuticals Corporate Events

Pacira BioSciences Reports Strong Q3 Growth Amid Challenges
Nov 8, 2025

Pacira BioSciences’ recent earnings call conveyed a generally positive sentiment, highlighting robust revenue growth and improved manufacturing efficiencies. The company also shared exciting developments in its clinical pipeline. However, the call was not without its challenges, as slower-than-expected sales growth for Zilretta and pricing impacts from new GPO agreements were noted. Additionally, the growth in the elective procedure market was described as sluggish.

Pacira BioSciences Reports Strong Q3 2025 Results
Nov 7, 2025

Pacira BioSciences, Inc., a leader in non-opioid pain management therapies, reported its financial results for the third quarter of 2025, showcasing a steady performance in its innovative healthcare solutions sector. The company, known for its flagship products like EXPAREL, ZILRETTA, and iovera°, continues to focus on transforming patient care through advanced pain management solutions.

Pacira’s Pediatric Analgesia Study: A Potential Game-Changer for Postoperative Pain Management
Oct 27, 2025

Pacira Pharmaceuticals is conducting a study titled ‘A Multicenter, Open-label, Randomized, Bupivacaine-Controlled Study to Evaluate the Pharmacokinetics and Safety of EXPAREL for Postoperative Analgesia in Subjects Aged 0 to Less Than 6 Years Undergoing Cardiac Surgery.’ The study aims to assess the pharmacokinetics and safety of EXPAREL, a local infiltration analgesic, compared to bupivacaine in young pediatric patients post-cardiac surgery. This research is significant as it explores pain management solutions for a vulnerable age group.

Pacira’s Innovative Study on Knee OA Pain Management: What Investors Need to Know
Oct 27, 2025

Study Overview: Pacira Pharmaceuticals is conducting a study titled ‘Innovations in Genicular Outcomes Registry’ to gather prospective data on pain management for chronic knee osteoarthritis (OA) and pain optimization for knee arthroplasty due to OA. This research is significant as it aims to improve treatment outcomes for patients suffering from knee OA, a common and debilitating condition.

Pacira’s Phase 2 Study: A New Approach to Hip Osteoarthritis Treatment
Oct 27, 2025

Pacira Pharmaceuticals is conducting a Phase 2 clinical study titled ‘A Phase 2, Randomized, Open-Label, Two-Arm Study to Evaluate a Procedure for Intra-Articular Injection of ZILRETTA Versus Triamcinolone Acetonide, Immediate Release (TCA-IR) in Subjects With Osteoarthritis of the Hip.’ The study aims to assess the effectiveness of an injection procedure using two different needle sizes in patients with hip osteoarthritis, highlighting its potential significance in improving treatment outcomes.

Pacira’s New Osteoarthritis Treatment: A Promising Clinical Study Update
Oct 27, 2025

Pacira Pharmaceuticals is conducting a Phase 2 clinical study titled ‘A Phase 2, Two-Part, Randomized, Double-Blind, Active-Controlled Study to Assess the Safety and Tolerability of Enekinragene Inzadenovec (PCRX-201) in Subjects With Painful Osteoarthritis of the Knee.’ The study aims to evaluate the safety and tolerability of PCRX-201, a potential treatment for knee osteoarthritis, in patients aged 45 to 80. This research is significant as it explores a new therapeutic option for managing osteoarthritis pain.

Pacira’s ZILRETTA Study: A Potential Game-Changer for Osteoarthritis Pain Management
Oct 27, 2025

Pacira Pharmaceuticals, Inc. is currently recruiting for a Phase 3 clinical study titled ‘A Study to Evaluate the Efficacy and Safety of ZILRETTA in Subjects With Glenohumeral Osteoarthritis.’ The primary objective is to assess the efficacy of ZILRETTA on pain relief following an intra-articular injection compared to a normal saline placebo. Secondary objectives include comparing ZILRETTA’s efficacy to triamcinolone acetonide injectable suspension (TCA-IR) and evaluating its safety.

Pacira’s Promising Study on Iovera° System for Spasticity: A Potential Game-Changer
Oct 27, 2025

Study Overview: Pacira Pharmaceuticals is conducting a multicenter, randomized, double-blind, sham-controlled study titled ‘A Multicenter, Randomized, Double-Blind, Sham-Controlled Study Assessing the Efficacy and Safety of Iovera®° System in Subjects With Upper Extremity Spasticity.’ The study aims to evaluate the efficacy and safety of the iovera° system in treating upper extremity spasticity, a condition often associated with cerebral or spinal issues. This study is significant as it could offer a new treatment option for patients suffering from this debilitating condition.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Nov 13, 2025