Record Revenue and Improved Margins
Fiscal 2025 total revenue of $726,000,000 and fourth-quarter consolidated non-GAAP gross margin improved to 80% (vs. 79% a year ago). Company reported highest gross margins in its history and is targeting a five-percentage-point margin improvement vs. 2024 (76% non-GAAP) by 2030.
EXPAREL Q4 Sales and Volume Growth
Fourth-quarter EXPAREL sales of $155.8M vs. $147.7M in Q4 2024 (~+5.5% revenue), with volume growth of approximately +7% year-over-year in Q4 driven by broader payer coverage and commercial initiatives.
Expanded Payer Coverage and Market Access
Ended 2025 with 102,000,000 lives covered for EXPAREL outside the surgical bundle (management noted this climbed to ~110,000,000 in early 2026), highlighting major commercial payer wins (Aetna, Cigna, TRICARE, Humana) and Medicare ASP+6% outpatient reimbursement.
Strategic Partnerships and Ex-U.S. Expansion
Signed major partnerships: LG Chem to commercialize EXPAREL in select Asia Pacific countries (South Korea, Thailand) with regulatory filings anticipated in 2026 and revenue expected to begin in 2027; J&J MedTech partnership now fully trained and expanding ZILRETTA reach in the U.S.
Strengthened IP and Litigation Outcome
Secured a volume-limited settlement with Fresenius providing EXPAREL runway visibility through 2039 and expanded IP estate to 21 patents across two families (up from a single patent at first Paragraph IV filing).
Progress on Pipeline with Near-Term Milestones
Advancing a data-rich phase: Phase II ASCEND Part A (PCRX-201) 52-week data expected end of year (49 patients enrolled); Part B to enroll ~90 patients starting midyear; interim analyses and top-line readouts for ZILRETTA shoulder OA and ioverao spasticity planned in 2026.
Cash Position and Shareholder Returns
Exited Q4 with $238,000,000 in cash and investments. Executed share repurchases (management referenced $150,000,000 of repurchases year-to-date, including $50,000,000 in Q4), retired ~2,000,000 shares and reduced outstanding shares to ~41,000,000; $150,000,000 remaining on buyback authorization.
Operational Manufacturing Improvements
Better-than-expected yields from new 200-liter EXPAREL facilities lowered per-unit costs and improved margins; management is adjusting production to hit inventory targets and expects steady margin increases via continuous improvement initiatives.