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Collegium Pharmaceutical (COLL)
NASDAQ:COLL
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Collegium Pharmaceutical (COLL) AI Stock Analysis

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COLL

Collegium Pharmaceutical

(NASDAQ:COLL)

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Neutral 70 (OpenAI - 4o)
Rating:70Neutral
Price Target:
$52.00
▲(12.48% Upside)
Collegium Pharmaceutical's strong financial performance and positive earnings call are significant strengths, driving the overall score. However, technical indicators suggest the stock is currently overbought, and valuation concerns due to a high P/E ratio and lack of dividend yield weigh on the score.
Positive Factors
Revenue Growth
The substantial revenue growth indicates strong market demand and effective product positioning, which supports long-term business expansion.
Cash Flow Generation
Robust cash flow growth enhances financial flexibility, allowing the company to invest in strategic initiatives and manage debt effectively.
Product Portfolio Expansion
The success of Jornay PM highlights the company's ability to innovate and capture market share, supporting sustained revenue streams.
Negative Factors
High Debt Levels
High leverage can limit financial flexibility and increase vulnerability to economic downturns, impacting long-term stability.
Declining Net Profit Margin
A declining net profit margin suggests rising costs or inefficiencies, which could pressure future profitability if not addressed.
Gross to Net Variability
Variability in gross to net improvements can lead to unpredictable revenue recognition, complicating financial planning and forecasting.

Collegium Pharmaceutical (COLL) vs. SPDR S&P 500 ETF (SPY)

Collegium Pharmaceutical Business Overview & Revenue Model

Company DescriptionCollegium Pharmaceutical, Inc. is a specialty pharmaceutical company focused on developing and commercializing innovative products for the treatment of pain and other central nervous system conditions. The company primarily operates in the pharmaceutical sector, with a core focus on abuse-deterrent formulations of medications to address the opioid crisis and improve patient safety. Collegium's flagship product is Xtampza ER, an extended-release oxycodone formulation designed to provide effective pain management while minimizing the potential for misuse.
How the Company Makes MoneyCollegium Pharmaceutical generates revenue primarily through the sale of its prescription drugs, particularly Xtampza ER. The company employs a revenue model based on direct sales to healthcare providers and pharmacies, as well as through partnerships with other pharmaceutical companies for the distribution of its products. Additionally, Collegium may receive royalty payments from licensing agreements or collaborations, enhancing its revenue streams. The ongoing demand for pain management solutions, particularly those that are abuse-deterrent, positions the company to capitalize on market needs, thereby contributing to its overall earnings.

Collegium Pharmaceutical Earnings Call Summary

Earnings Call Date:Nov 06, 2025
(Q3-2025)
|
% Change Since: |
Next Earnings Date:Feb 19, 2026
Earnings Call Sentiment Positive
Collegium Pharmaceuticals reported a strong quarter with record revenues and growth across key product lines, particularly Jornay PM and the pain portfolio. The company has shown effective strategic capital deployment and increased financial guidance for 2025, indicating confidence in continued growth. However, there are some concerns regarding gross to net variability and the delayed impact of sales force expansion.
Q3-2025 Updates
Positive Updates
Record Quarterly Net Revenue
Collegium Pharmaceuticals achieved record quarterly net revenue of $209.4 million, which is a 31% year-over-year increase.
Strong Growth in Jornay PM
Jornay PM generated a record $41.8 million in net revenue with a prescription growth of 20% year-over-year.
Pain Portfolio Revenue Growth
Net revenue from the pain portfolio grew to a record $167.6 million, up 11% year-over-year.
Adjusted EBITDA Growth
Adjusted EBITDA grew 27% year-over-year to $133 million.
Increased Financial Guidance for 2025
Collegium raised its 2025 financial guidance, expecting total revenue growth of approximately 24% year-over-year.
Strategic Capital Deployment
The company repaid $16.1 million of debt and ended the third quarter with $285.9 million in cash, cash equivalents, and marketable securities.
Expansion of Sales Force
The company expanded its ADHD sales force to approximately 180 representatives, targeting an increased number of prescribers.
Negative Updates
Gross to Net Variability
Gross to net improvements varied, with Jornay’s gross to net improving from 70% in Q1 to 62% in Q3, affecting net revenue dynamics.
No Significant Immediate Impact from Sales Force Expansion
The impact of the expanded sales force is expected to be more significant in 2026, with only early signals of impact in Q3 2025.
Rebate Settlements Affecting Nucynta Revenues
Nucynta revenues were influenced by rebate settlements, with a $2.8 million benefit attributed to prior period activities.
Company Guidance
In the third quarter of 2025, Collegium Pharmaceuticals reported significant financial growth, characterized by a 31% year-over-year increase in net revenue, reaching a record $209.4 million. The company's lead growth driver, Jornay PM, achieved a net revenue of $41.8 million, marking a 20% rise in prescriptions, while their pain portfolio amassed $167.6 million, reflecting an 11% increase. Additionally, the company generated $78.4 million in cash from operations and repaid $16.1 million of debt, ending the quarter with $285.9 million in cash. Due to sustained financial strength, Collegium raised its 2025 guidance, projecting a 24% year-over-year revenue growth and adjusted EBITDA between $460 million and $470 million. The strategic focus remains on expanding Jornay PM's market presence, maximizing pain portfolio durability, and pursuing business development opportunities to enhance shareholder value.

Collegium Pharmaceutical Financial Statement Overview

Summary
Collegium Pharmaceutical shows strong revenue growth and operational efficiency with healthy margins and cash flow metrics. However, high debt levels and a declining net profit margin present potential risks. The company should focus on managing its leverage and improving profitability to enhance financial stability.
Income Statement
75
Positive
Collegium Pharmaceutical has shown a consistent revenue growth trend, with a TTM revenue growth rate of 7.08%. The gross profit margin is strong at 56.69%, indicating efficient cost management. However, the net profit margin has decreased to 5.13% from 10.96% in the previous year, suggesting increased expenses or other financial pressures. The EBIT and EBITDA margins are healthy, reflecting good operational efficiency.
Balance Sheet
60
Neutral
The company has a high debt-to-equity ratio of 3.57, indicating significant leverage, which could pose financial risks. The return on equity has decreased to 15.60% from 30.23% in the previous year, suggesting reduced profitability for shareholders. The equity ratio is not explicitly provided, but the high leverage suggests a lower proportion of equity in the capital structure.
Cash Flow
80
Positive
Collegium Pharmaceutical has demonstrated strong cash flow performance with a 43.36% growth in free cash flow. The operating cash flow to net income ratio is 0.44, indicating a solid conversion of income to cash. The free cash flow to net income ratio is nearly 1, showing efficient cash generation relative to net income.
BreakdownTTMDec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income Statement
Total Revenue757.07M631.45M566.77M463.93M276.87M310.02M
Gross Profit433.17M377.34M326.17M209.49M150.62M179.84M
EBITDA392.72M341.70M308.33M173.31M86.56M118.01M
Net Income58.44M69.19M48.16M-25.00M71.52M26.75M
Balance Sheet
Total Assets1.61B1.66B1.14B1.17B692.08M643.84M
Cash, Cash Equivalents and Short-Term Investments305.71M162.76M310.55M173.69M186.43M174.12M
Total Debt936.27M859.30M674.28M709.17M258.75M266.58M
Total Liabilities1.33B1.43B947.88M979.29M489.15M457.81M
Stockholders Equity274.81M228.84M195.43M194.84M202.93M186.03M
Cash Flow
Free Cash Flow289.30M203.33M274.29M122.61M101.61M-279.83M
Operating Cash Flow290.92M204.98M274.75M124.23M103.56M93.94M
Investing Cash Flow-55.23M-287.76M-70.81M-573.69M-1.94M-373.77M
Financing Cash Flow-129.70M-60.60M-140.18M436.72M-89.30M286.47M

Collegium Pharmaceutical Technical Analysis

Technical Analysis Sentiment
Positive
Last Price46.23
Price Trends
50DMA
37.68
Positive
100DMA
36.39
Positive
200DMA
32.68
Positive
Market Momentum
MACD
2.55
Negative
RSI
72.35
Negative
STOCH
61.49
Neutral
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For COLL, the sentiment is Positive. The current price of 46.23 is above the 20-day moving average (MA) of 42.60, above the 50-day MA of 37.68, and above the 200-day MA of 32.68, indicating a bullish trend. The MACD of 2.55 indicates Negative momentum. The RSI at 72.35 is Negative, neither overbought nor oversold. The STOCH value of 61.49 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Positive sentiment for COLL.

Collegium Pharmaceutical Risk Analysis

Collegium Pharmaceutical disclosed 41 risk factors in its most recent earnings report. Collegium Pharmaceutical reported the most risks in the "Legal & Regulatory" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks

Collegium Pharmaceutical Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
76
Outperform
$1.26B12.1314.84%-0.03%-27.66%
70
Neutral
$1.46B28.7722.96%26.34%-32.79%
69
Neutral
$981.78M2.90%3.14%
64
Neutral
$1.90B51.747.83%48.87%
57
Neutral
$2.09B-0.32%79.88%99.60%
55
Neutral
$2.65B-1.86%4.54%-130.59%
51
Neutral
$7.86B-0.30-43.30%2.27%22.53%-2.21%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
COLL
Collegium Pharmaceutical
46.68
15.35
48.99%
AVDL
Avadel Pharmaceuticals
21.49
9.90
85.42%
PCRX
Pacira Pharmaceuticals
23.57
5.76
32.34%
SUPN
Supernus Pharmaceuticals
45.59
8.28
22.19%
ANIP
ANI Pharmaceuticals
84.85
26.98
46.62%
AMPH
Amphastar Pharmaceuticals
27.70
-18.18
-39.63%

Collegium Pharmaceutical Corporate Events

Collegium Pharmaceuticals Reports Record Growth and Optimistic Outlook
Nov 8, 2025

Collegium Pharmaceuticals’ recent earnings call painted a picture of robust growth and strategic confidence. The company reported record revenues and growth across its key product lines, notably Jornay PM and its pain portfolio. This positive sentiment was bolstered by effective strategic capital deployment and an increase in financial guidance for 2025, signaling confidence in sustained growth. However, there were some concerns regarding gross to net variability and the delayed impact of sales force expansion.

Collegium Pharmaceutical Reports Record Q3 2025 Results
Nov 7, 2025

Collegium Pharmaceutical Inc., a biopharmaceutical company, focuses on developing and commercializing innovative medications for pain management and neuropsychiatry, with a notable product, Jornay PM, for ADHD treatment.

Business Operations and StrategyFinancial Disclosures
Collegium Pharmaceutical Reports Strong Q3 2025 Financial Results
Positive
Nov 6, 2025

Collegium Pharmaceutical reported strong financial results for the third quarter of 2025, with record net revenue of $209.4 million, a 31% increase year-over-year. The company raised its full-year 2025 guidance, expecting net revenue between $775 to $785 million and adjusted EBITDA between $460 to $470 million. The growth was driven by a 20% increase in Jornay PM prescriptions and a robust performance in its pain portfolio. The company continues to focus on strategic business development and disciplined capital deployment to support patient care and drive shareholder value.

The most recent analyst rating on (COLL) stock is a Buy with a $46.00 price target. To see the full list of analyst forecasts on Collegium Pharmaceutical stock, see the COLL Stock Forecast page.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Nov 13, 2025