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Opko Health Inc (OPK)
NASDAQ:OPK

Opko Health (OPK) AI Stock Analysis

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OPK

Opko Health

(NASDAQ:OPK)

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Neutral 50 (OpenAI - 4o)
Rating:50Neutral
Price Target:
$1.50
▲(17.19% Upside)
Opko Health's overall stock score reflects significant financial challenges, with declining revenues and profitability issues being the most impactful factors. The strategic initiatives and partnerships highlighted in the earnings call provide some optimism, but technical and valuation metrics remain weak.
Positive Factors
Strategic Partnerships
The collaboration with Regeneron and potential milestone payments exceeding $1 billion enhance Opko's R&D capabilities and long-term growth prospects.
4Kscore Test Expansion
The FDA label expansion and increased test volume indicate strong demand and potential for sustained revenue growth in diagnostics.
Asset Sale for Focused Growth
The sale of non-core assets allows Opko to streamline operations and focus on profitable growth areas, enhancing long-term financial health.
Negative Factors
Declining Diagnostics Revenue
The decline in diagnostics revenue reflects challenges in maintaining market share and could impact future profitability if not addressed.
Negative Profitability
Sustained negative profitability margins indicate operational inefficiencies and financial strain, posing risks to long-term viability.
Cash Flow Challenges
Persistent cash flow issues limit Opko's ability to invest in growth opportunities and may affect its financial flexibility over time.

Opko Health (OPK) vs. SPDR S&P 500 ETF (SPY)

Opko Health Business Overview & Revenue Model

Company DescriptionOPKO Health, Inc., a healthcare company, engages in the diagnostics and pharmaceuticals businesses in the United States, Ireland, Chile, Spain, Israel, Mexico, and internationally. The company's Diagnostics segment operates BioReference Laboratories that offers laboratory testing services for the detection, diagnosis, evaluation, monitoring, and treatment of diseases, including esoteric testing, molecular diagnostics, anatomical pathology, genetics, women's health, and correctional healthcare to physician offices, clinics, hospitals, employers and governmental units; and a novel diagnostic instrument system to provide blood test results in the point-of-care setting, as well as 4Kscore prostate cancer testing services. Its Pharmaceutical segment offers Rayaldee to treat secondary hyperparathyroidism in adults with stage 3 or 4 chronic kidney disease, and vitamin D insufficiency; OPK88004, an orally administered selective androgen receptor modulator; OPK88003, a once-weekly administered peptide for the treatment of type 2 diabetes and associated obesity that is in Phase IIb trials; and hGH-CTP, a once-weekly human growth hormone injection that completed Phase III clinical trial in partnership with Pfizer, Inc. This segment develops and commercializes longer-acting proprietary versions of already approved therapeutic proteins. The company also offers specialty APIs; develops, manufactures, markets, and sells pharmaceutical, nutraceutical, veterinary, and ophthalmic products; commercializes food supplements and over the counter products; manufactures and sells products primarily in the generics market; and imports, markets, distributes, and sells pharmaceutical products in a range of indications, including cardiovascular products, vaccines, antibiotics, gastro-intestinal products, hormones, and others. In addition, it operates pharmaceutical platforms in Ireland, Chile, Spain, and Mexico. The company was founded in 1991 and is headquartered in Miami, Florida.
How the Company Makes MoneyOpko Health generates revenue through multiple streams, primarily from the sale of pharmaceuticals and diagnostic tests. The company markets its proprietary drugs and therapies, including treatments for endocrinology and urology. Additionally, Opko's 4Kscore Test contributes significantly to its revenue, being a leading diagnostic tool for prostate cancer detection. The company also engages in partnerships and collaborations with other healthcare organizations, which can result in shared revenue from co-developed products or licensing agreements. Furthermore, Opko has a focus on research and development, which may lead to new product offerings and additional revenue streams in the future.

Opko Health Earnings Call Summary

Earnings Call Date:Oct 29, 2025
(Q3-2025)
|
% Change Since: |
Next Earnings Date:Feb 19, 2026
Earnings Call Sentiment Positive
The earnings call reflects strong strategic moves such as the sale of non-core assets and significant partnerships, contributing to financial improvements and shareholder value. However, there are challenges in diagnostics revenue decline and slower-than-expected market conversion affecting Pfizer profit share.
Q3-2025 Updates
Positive Updates
Sale of BioReference Health's Oncology Division
Completed the sale of BioReference Health's oncology division, providing $192.5 million at closing and $32.5 million in performance-based earn-out, streamlining lab business for profitable growth.
Significant Partnerships for Therapeutics
Announced a research collaboration and license agreement with Regeneron, with milestone payments potentially totaling over $1 billion, and continued partnership with Merck on EBV vaccine development.
Stock Repurchase Program
Repurchased $25.1 million worth of stock in 2025, with $126 million remaining under the program, demonstrating commitment to increasing shareholder value.
4Kscore Test Growth
4Kscore test volume increased more than 20% in the third quarter compared to the previous year, with FDA label expansion opening new markets.
Improved Financial Performance
Consolidated operating income improved to $48.1 million from $14.2 million in 2024, driven by improved results at BioReference.
Negative Updates
Decline in Diagnostics Revenue
Q3 2025 diagnostics revenue was $95.2 million, down from $121.3 million in Q3 2024, primarily due to the sale of oncology assets.
Foreign Currency Headwinds
Lower sales in Chile and foreign currency pressures affected pharmaceutical revenues.
Challenges with Pfizer Profit Share
Slow market conversion to weekly regimen affecting Pfizer profit share, with a forecasted increase of only 10% to 15% for 2026.
Company Guidance
During the OPKO Health Third Quarter 2025 Financial Results Conference Call, the company provided guidance on several key metrics and strategic initiatives. OPKO Health completed the sale of BioReference Health's oncology division, yielding $192.5 million at closing and a potential $32.5 million in performance-based earn-out, which will be used in part for a stock repurchase program with $126 million remaining for repurchases. The company reported a 20% increase in the 4Kscore test volume, with expected revenue growth due to a recent FDA label expansion. The pharmaceutical segment is advancing with four candidates in clinical trials and several in pre-IND stages, supported by partnerships providing nondilutive funding. A significant collaboration was announced with Regeneron to leverage ModeX's MSTAR platform for developing multispecific antibodies, with potential milestone payments exceeding $1 billion. Financially, OPKO ended the third quarter with $428 million in cash and cash equivalents and repurchased nearly 25 million shares for approximately $33.5 million this year. The company projected a Q4 2025 revenue range of $135-$140 million and outlined a 2026 outlook anticipating low single-digit revenue growth in diagnostics and mid-single-digit growth in pharmaceuticals, with a focus on profitability and strategic capital allocation to enhance shareholder value.

Opko Health Financial Statement Overview

Summary
Opko Health is facing substantial financial difficulties with declining revenues, negative profitability, and cash flow challenges. Despite some stability in leverage, negative returns and cash flow inefficiencies pose significant risks.
Income Statement
45
Neutral
Opko Health's income statement reveals a challenging financial environment. The company has experienced declining revenue over the past few years, with a TTM revenue growth rate of -3.31%. Profitability metrics are concerning, with a negative net profit margin of -26.68% and an EBIT margin of -5.29% in the TTM period. The gross profit margin has decreased to 32.65% from 43.61% in the previous year. These figures indicate significant pressure on the company's profitability and operational efficiency.
Balance Sheet
55
Neutral
The balance sheet of Opko Health shows moderate leverage with a debt-to-equity ratio of 0.31 in the TTM period, which is an improvement from previous years. However, the return on equity remains negative at -13.18%, indicating that the company is not generating positive returns for its shareholders. The equity ratio stands at a reasonable level, suggesting a stable capital structure despite the ongoing losses.
Cash Flow
40
Negative
Opko Health's cash flow statement highlights significant challenges. The company has negative operating cash flow and free cash flow in the TTM period, with a free cash flow growth rate of -18.22%. The operating cash flow to net income ratio is -1.40, reflecting inefficiencies in converting income into cash. Although the free cash flow to net income ratio is positive at 1.08, it is primarily due to the negative net income, indicating cash flow issues.
BreakdownTTMDec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income Statement
Total Revenue642.07M713.14M863.50M1.00B1.77B1.44B
Gross Profit247.95M311.03M318.13M288.22M581.52M541.00M
EBITDA45.12M135.28M-65.52M-270.81M83.57M155.98M
Net Income-140.80M-53.22M-188.86M-328.40M-30.14M30.59M
Balance Sheet
Total Assets2.00B2.20B2.01B2.17B2.40B2.47B
Cash, Cash Equivalents and Short-Term Investments415.20M431.94M95.88M153.19M134.71M72.21M
Total Debt395.42M504.44M326.56M305.55M254.75M294.57M
Total Liabilities690.02M834.76M622.48M605.61M714.59M801.51M
Stockholders Equity1.31B1.37B1.39B1.56B1.69B1.67B
Cash Flow
Free Cash Flow-212.06M-208.50M-44.47M-119.77M6.18M5.79M
Operating Cash Flow-197.03M-183.49M-28.20M-95.19M38.34M39.48M
Investing Cash Flow348.33M352.21M-18.20M91.04M35.95M-18.33M
Financing Cash Flow-140.19M184.17M-11.30M22.97M-10.35M-35.08M

Opko Health Technical Analysis

Technical Analysis Sentiment
Negative
Last Price1.28
Price Trends
50DMA
1.33
Negative
100DMA
1.39
Negative
200DMA
1.38
Negative
Market Momentum
MACD
>-0.01
Negative
RSI
45.01
Neutral
STOCH
61.73
Neutral
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For OPK, the sentiment is Negative. The current price of 1.28 is below the 20-day moving average (MA) of 1.31, below the 50-day MA of 1.33, and below the 200-day MA of 1.38, indicating a bearish trend. The MACD of >-0.01 indicates Negative momentum. The RSI at 45.01 is Neutral, neither overbought nor oversold. The STOCH value of 61.73 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Negative sentiment for OPK.

Opko Health Risk Analysis

Opko Health disclosed 56 risk factors in its most recent earnings report. Opko Health reported the most risks in the "Legal & Regulatory" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks

Opko Health Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
77
Outperform
$1.05B17.2524.11%14.46%
62
Neutral
$1.19B-90.54-2.69%10.15%-295.52%
55
Neutral
$1.71B-12.99%10.10%-44.29%
53
Neutral
$864.62M-20.44-3.80%13.60%74.64%
51
Neutral
$7.86B-0.30-43.30%2.27%22.53%-2.21%
50
Neutral
$998.01M-5.19-13.32%-9.75%-31.28%
41
Neutral
$569.54M-1.39-72.52%0.21%-233.51%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
OPK
Opko Health
1.28
-0.19
-12.93%
MYGN
Myriad Genetics
6.04
-6.48
-51.76%
NEO
NeoGenomics
12.83
-1.15
-8.23%
CDNA
CareDx
20.57
-1.49
-6.75%
FLGT
Fulgent Genetics
28.65
11.15
63.71%
CSTL
Castle Biosciences
40.75
15.66
62.42%
Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Dec 09, 2025