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Molecular Partners (MOLN)
NASDAQ:MOLN

Molecular Partners (MOLN) AI Stock Analysis

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MOLN

Molecular Partners

(NASDAQ:MOLN)

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Neutral 42 (OpenAI - 5.2)
Rating:42Neutral
Price Target:
$4.00
▼(-4.99% Downside)
The score is primarily weighed down by weak financial performance (near-zero TTM revenue, ongoing losses, and significant negative free cash flow) despite low leverage. Technicals are slightly negative in the near term with muted momentum, and valuation provides limited support because the company is loss-making and no dividend yield data is available.
Positive Factors
Proprietary DARPin platform
Molecular Partners’ proprietary DARPin platform is a structural competitive advantage: it enables multispecific, half-life engineered and radiolabeled constructs across oncology modalities. That platform-driven versatility supports durable program diversification and partner interest beyond single-drug risk.
Strategic partnerships and external expertise
Active collaborations (e.g., Orano Med) and engagement from consortia and KOLs materially de-risk development and commercialization pathways. Partnerships bring funding, radiopharma expertise, and distribution scale, improving the long-term chance that clinical assets reach patients and generate milestone/royalty revenues.
Multi-year cash runway
Management reports cash to fund operations into 2028, which provides a multi-year runway to advance multiple early-stage trials and nominate new candidates. A sustained runway reduces near-term financing pressure, allowing more controlled execution of pivotal data-generation and partnering strategies.
Negative Factors
Near-zero revenue and deep net losses
The company currently lacks recurring product revenue and records material net losses, meaning ongoing operations depend on milestone payments, external funding or equity raises. This structural absence of commercial cash flows increases dilution and operational risk until a partnered product reaches market.
Sustained negative cash flow
Consistent negative operating and free cash flow shows the business is consuming cash to fund trials rather than generating it. Unless clinical successes trigger milestones or partnerships, the structural cash burn limits internal capital for parallel programs and raises the likelihood of future financing at dilutive terms.
Eroding balance sheet equity and assets
Material declines in equity and total assets over recent periods reflect cumulative losses and balance-sheet consumption. This erosion reduces the company’s buffer against setbacks, weakens financial flexibility for large trials or commercial launches, and signals diminished shareholder value until positive cash flows emerge.

Molecular Partners (MOLN) vs. SPDR S&P 500 ETF (SPY)

Molecular Partners Business Overview & Revenue Model

Company DescriptionMolecular Partners AG operates as a clinical-stage biopharmaceutical company, focuses on the discovery, development, and commercialization of therapeutic proteins. Its products candidates include Abicipar, a DARPin therapeutic candidate, which is in Phase III clinical trials for the treatment of neovascular wet age-related macular degeneration, as well as for diabetic macular edema; and MP0420, a multi-specific DARPin therapeutic candidate for the SARS-CoV-2 virus. The company develops MP0310, which is in Phase Ia clinical trials for immuno-oncology; MP0317, a tumor-localized immune agonist that activates immune cells in the tumor, which is in Phase I clinical trials; and MP0274 that is in Phase I clinical trials for HER2-positive cancers. It also develops MP0423 for treating COVID-19; MP0533, a CD3 T cell candidate for acute myeloid leukemia; and MP0250 for vascular endothelial growth factor, hepatocyte growth factor, and human serum albumin to increase half-life. Molecular Partners AG has agreements and collaboration with Novartis AG to develop, manufacture, and commercialize DARPin-conjugated radioligand therapies; Amgen SA; Allergan, Inc.; and discovery alliance with AbbVie Inc. in ophthalmology, as well as other third-party collaborators. The company was incorporated in 2004 and is headquartered in Schlieren, Switzerland.
How the Company Makes MoneyMolecular Partners generates revenue through a combination of strategic partnerships, research and development collaborations, and potential product sales. The company often enters into licensing agreements with larger pharmaceutical companies, providing them access to its DARPin technology in exchange for upfront payments, milestone payments tied to clinical and commercial achievements, and royalties on future sales. Additionally, the company may receive funding from grants or public investments aimed at supporting innovative biotech research. Key partnerships with major industry players can significantly enhance its financial resources and facilitate the development and commercialization of its products.

Molecular Partners Earnings Call Summary

Earnings Call Date:Mar 06, 2025
(Q4-2024)
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% Change Since: |
Next Earnings Date:Mar 12, 2026
Earnings Call Sentiment Positive
The earnings call highlighted significant progress in Molecular Partners' programs, particularly in the radio DARPin franchise and the improved efficacy of the 533-DARPIn program. The expansion of the Orano Med collaboration and strong financial position further bolster the company's outlook. However, the discontinuation of the Novartis collaboration and initial challenges with the T Cell Engager program were noted as setbacks. Overall, the highlights significantly outweigh the lowlights.
Q4-2024 Updates
Positive Updates
Successful Year of Execution
Molecular Partners successfully executed their plans in 2024, advancing programs toward clinical readouts and expanding their collaboration with Orano Med.
Lead DARPin Program Progress
The radio DARPin franchise showed significant progress with the lead compound DLL3 targeting 712 passing all IND-enabling studies and ready to enter clinical trials.
Strategic Collaboration with Orano Med
Molecular Partners expanded their collaboration with Orano Med to secure isotope supply for 10 products, enhancing their radio DARPin franchise.
Strong Financial Position
Ending the year with CHF149 million in cash, the company is well-capitalized with a runway into 2027, ensuring continued investment in their pipeline.
Improved Efficacy in T Cell Engager Program
The 533-DARPIn program for AML showed promising results with three complete responses out of eight patients after adjustments in dosing regimen.
Negative Updates
Discontinuation of Novartis Collaboration
The collaboration with Novartis was discontinued after three years due to lack of strategic interest in the research targets.
Challenges with Initial T Cell Engager Results
The 533-DARPIn program initially faced underwhelming results due to target-mediated drug disposition problems, requiring adjustments in dosing.
Company Guidance
During the Molecular Partners Fourth Quarter and Full Year 2024 Results Call, several key metrics and strategic developments were highlighted. The company reported operating expenses of CHF 66 million for the year, which was within their guidance range of CHF 65 million to CHF 70 million. They ended the year with a cash balance of CHF 149 million, having raised CHF 20 million in a financing round in October, and reported a cash burn of approximately CHF 54 million for the year. This funding positions them well financially, with a runway extending into 2027. Revenue for 2024 was CHF 5 million, primarily from their collaboration with Novartis, which has now concluded. The company is advancing its radio DARPin program, with their lead candidate MP0712 set to begin clinical trials and dosimetry studies in 2025. The expansion of their collaboration with Orano Med was also a significant milestone, securing access to 10 product slots for the promising isotope Lead-212. Additionally, Molecular Partners is continuing to refine its T cell engager platform, with plans to densify dosing schedules and further investigate premedication strategies in upcoming trials.

Molecular Partners Financial Statement Overview

Summary
Molecular Partners faces significant financial challenges, with declining revenue, negative profitability margins, and consistent net losses. While the balance sheet shows strong equity financing and low leverage, the company's cash flow and profitability issues raise concerns about its ability to sustain operations without external funding.
Income Statement
18
Very Negative
The company has experienced a decline in revenue over the past year, with a negative revenue growth rate of approximately -29.37% from 2023 to 2024. Gross profit margin is high at 100% in 2024 due to low total revenue, but net profit margin is negative due to substantial net losses, indicating challenges in controlling operational costs. EBIT and EBITDA margins are also negative, reflecting ongoing operational inefficiencies.
Balance Sheet
62
Positive
The balance sheet shows a relatively low debt-to-equity ratio of 0.02 in 2024, suggesting low leverage and financial risk. However, the equity ratio is high at 89.34%, indicating strong equity financing. Return on equity is negative due to net losses, which is a concern for profitability. Overall, the company has a solid equity base but struggles with profitability.
Cash Flow
24
Negative
The company reports negative free cash flow, which has slightly increased from the previous year's negative free cash flow. The operating cash flow to net income ratio is close to 1, indicating that cash flow performance aligns with net income losses. However, negative free cash flow is a concern for long-term sustainability.
BreakdownTTMDec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income Statement
Total Revenue0.004.97M7.04M189.56M9.33M9.34M
Gross Profit-40.40M-42.53M-40.81M138.81M-46.39M-46.73M
EBITDA-58.02M-51.65M-59.52M119.00M-60.66M-59.58M
Net Income-60.24M-54.04M-61.98M117.85M-63.78M-62.76M
Balance Sheet
Total Assets112.15M158.53M198.35M262.26M172.67M187.55M
Cash, Cash Equivalents and Short-Term Investments104.52M149.44M186.89M249.14M132.81M173.72M
Total Debt1.53M2.44M3.65M4.85M6.04M7.22M
Total Liabilities16.62M16.89M21.92M27.09M65.38M80.33M
Stockholders Equity95.53M141.64M176.43M235.17M107.29M107.22M
Cash Flow
Free Cash Flow-54.01M-59.97M-59.81M117.15M-92.26M-30.67M
Operating Cash Flow-53.30M-59.25M-59.01M118.57M-90.95M-28.98M
Investing Cash Flow56.10M40.49M44.64M-101.12M-22.24M-21.75M
Financing Cash Flow14.45M14.43M-1.17M-1.57M50.58M113.20M

Molecular Partners Technical Analysis

Technical Analysis Sentiment
Positive
Last Price4.21
Price Trends
50DMA
4.25
Negative
100DMA
3.99
Positive
200DMA
3.89
Positive
Market Momentum
MACD
-0.02
Positive
RSI
48.82
Neutral
STOCH
19.71
Positive
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For MOLN, the sentiment is Positive. The current price of 4.21 is below the 20-day moving average (MA) of 4.28, below the 50-day MA of 4.25, and above the 200-day MA of 3.89, indicating a neutral trend. The MACD of -0.02 indicates Positive momentum. The RSI at 48.82 is Neutral, neither overbought nor oversold. The STOCH value of 19.71 is Positive, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Positive sentiment for MOLN.

Molecular Partners Risk Analysis

Molecular Partners disclosed 100 risk factors in its most recent earnings report. Molecular Partners reported the most risks in the "Finance & Corporate" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks

Molecular Partners Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
53
Neutral
$299.31M-4.64-57.84%-84.46%33.32%
52
Neutral
$185.20M-6.62-52.95%-88.47%-1658.33%
51
Neutral
$7.86B-0.30-43.30%2.27%22.53%-2.21%
48
Neutral
$147.03M-1.49-26.69%25.84%
44
Neutral
$225.81M-1.39-59.98%-10.57%1.98%
43
Neutral
$112.99M-3.74-745.66%
42
Neutral
$168.11M-2.21-49.86%-100.00%11.02%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
MOLN
Molecular Partners
4.21
-1.60
-27.54%
CGEN
Compugen
1.98
-0.14
-6.60%
ONCY
Oncolytics Biotech
1.05
0.21
25.30%
NKTX
Nkarta
2.07
-0.42
-16.87%
CCCC
C4 Therapeutics
2.33
-1.53
-39.64%
STTK
Shattuck Labs
4.73
3.64
333.94%

Molecular Partners Corporate Events

Molecular Partners Launches New Clinical Trials and Maps 2026 Milestones Ahead of J.P. Morgan Healthcare Conference
Jan 12, 2026

On January 11, 2026, Molecular Partners reported broad clinical and pipeline progress ahead of its presentation at the 44th J.P. Morgan Healthcare Conference, underscoring its push to establish leadership in targeted radiotherapeutics and novel immune-oncology modalities. The company has initiated a Phase 1/2a U.S. trial of its lead Radio-DARPin MP0712 for small cell lung cancer and other neuroendocrine tumors, with first patient dosing expected in the first quarter of 2026 and initial data due later in the year, supported by encouraging compassionate-use imaging data to be shown at the Theranostics World Congress 2026. Its second radiotherapy program, MP0726 for mesothelin-positive cancers including ovarian cancer, continues to advance alongside four additional radio-oncology projects, guided by a new scientific advisory board of nuclear medicine experts. Beyond radiotherapy, a Phase 2 investigator-initiated trial of tumor-localized CD40 agonist MP0317 in cholangiocarcinoma has begun treating patients in early 2026, and the Phase 1/2a study of tetra-specific T cell engager MP0533 in relapsed/refractory AML is ongoing with densified dosing showing tolerability and early antitumor signals as of data presented in December 2025. Molecular Partners also plans to nominate its first Switch-DARPin candidate, a logic-gated T cell engager for solid tumors, in the first half of 2026. Financially, the company reported unaudited cash and cash equivalents of CHF 93.1 million as of December 31, 2025, which management believes will fund operations into 2028, providing a multi-year runway to execute its 2026 clinical and strategic milestones, with full 2025 results scheduled for March 12, 2026.

The most recent analyst rating on (MOLN) stock is a Buy with a $8.00 price target. To see the full list of analyst forecasts on Molecular Partners stock, see the MOLN Stock Forecast page.

Molecular Partners Presents Promising MP0533 Trial Data at ASH Meeting
Dec 8, 2025

On December 7, 2025, Molecular Partners presented updated data from their ongoing Phase 1/2a trial of MP0533, a multispecific T-cell engager, at the ASH Annual Meeting. The trial, which involves patients with relapsed/refractory acute myeloid leukemia (AML), demonstrated promising clinical benefits with an acceptable safety profile across various dosing regimens. The data indicated that MP0533 could significantly improve treatment options for AML patients, particularly those with low disease burden, and supports further investigation in a Phase 2 setting.

The most recent analyst rating on (MOLN) stock is a Buy with a $8.00 price target. To see the full list of analyst forecasts on Molecular Partners stock, see the MOLN Stock Forecast page.

Molecular Partners Unveils Promising MP0712 Data at TRP Summit
Nov 12, 2025

On November 12, 2025, Molecular Partners presented new data on its lead Radio-DARPin, MP0712, targeting DLL3 at the TRP Summit Europe. The data included initial human images showing specific uptake in primary tumors and metastatic lesions, supporting the mechanism of action. The company is preparing for a Phase 1 trial in the US by the end of 2025, with initial data expected in 2026. This development marks a significant milestone in the clinical advancement of MP0712, potentially impacting the treatment of small cell lung cancer and other neuroendocrine cancers.

The most recent analyst rating on (MOLN) stock is a Hold with a $4.50 price target. To see the full list of analyst forecasts on Molecular Partners stock, see the MOLN Stock Forecast page.

Molecular Partners Advances Clinical Pipeline with New IND Filing and Financial Update
Oct 30, 2025

On October 30, 2025, Molecular Partners announced its Q3 2025 financial results and clinical progress, highlighting the filing of an IND application for MP0712, a Radio-DARPin targeting DLL3, with a Phase 1 trial expected to start by the end of 2025. The company also shared updates on other programs, including MP0533 for AML and MP0317 for cholangiocarcinoma, alongside a strong financial position with a cash runway until 2028. These developments reflect Molecular Partners’ strategic advancements in oncology, potentially enhancing its industry standing and offering significant implications for stakeholders.

The most recent analyst rating on (MOLN) stock is a Hold with a $3.50 price target. To see the full list of analyst forecasts on Molecular Partners stock, see the MOLN Stock Forecast page.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Jan 13, 2026