tiprankstipranks
Trending News
More News >
Compugen Ltd (CGEN)
NASDAQ:CGEN

Compugen (CGEN) AI Stock Analysis

Compare
1,036 Followers

Top Page

CGEN

Compugen

(NASDAQ:CGEN)

Select Model
Select Model
Select Model
Neutral 52 (OpenAI - 4o)
Rating:52Neutral
Price Target:
$1.50
▼(-18.48% Downside)
Compugen's overall stock score is primarily influenced by its financial performance and technical analysis. The company's strategic partnerships and potential future milestones provide some optimism, but current financial challenges and valuation concerns weigh heavily on the score.

Compugen (CGEN) vs. SPDR S&P 500 ETF (SPY)

Compugen Business Overview & Revenue Model

Company DescriptionCompugen Ltd. (CGEN) is a biotechnology company focused on discovering and developing therapeutic and diagnostic products for cancer and autoimmune diseases. The company operates primarily in the biopharmaceutical sector, leveraging its proprietary computational discovery platform to identify novel drug candidates and biomarkers. Compugen's core products include monoclonal antibodies and immune checkpoint inhibitors, aimed at enhancing the efficacy of existing therapies and providing new treatment options for patients.
How the Company Makes MoneyCompugen generates revenue primarily through collaborations, licensing agreements, and research grants. The company partners with major pharmaceutical companies to co-develop its drug candidates, receiving upfront payments, milestone payments, and royalties on future sales. These partnerships are a key revenue stream, as they provide funding for research and development while sharing the financial risks associated with bringing new therapies to market. Additionally, Compugen may receive funding through government grants aimed at supporting innovative medical research, further contributing to its earnings.

Compugen Earnings Call Summary

Earnings Call Date:Nov 10, 2025
(Q3-2025)
|
% Change Since: |
Next Earnings Date:Feb 19, 2026
Earnings Call Sentiment Neutral
While Compugen's strategic focus on Fc reduced anti-TIGIT programs and partnerships with AstraZeneca show promise, the company faces financial challenges including a significant revenue decline and net loss. Additionally, extended timelines for clinical trials could impact progress. However, there is potential for substantial milestones and royalties from partnerships, and promising clinical data for ovarian cancer treatments.
Q3-2025 Updates
Positive Updates
Strong Position in Fc Reduced Anti-TIGIT Programs
Compugen emphasizes its strategic focus on Fc reduced anti-TIGIT programs, which are believed to have advantages over Fc active anti-TIGIT antibodies. The company highlights the potential improved immune activation and safety profile of COM902, an Fc reduced anti-TIGIT monoclonal antibody, with Phase III data from Arcus Gilead expected in 2026 as a potential catalyst.
Substantial Potential for AstraZeneca Partnership
The partnership with AstraZeneca for RILVA, an Fc reduced anti-PD-one TIGIT bispecific, is projected to have a potential commercial opportunity with a non-risk adjusted peak year revenue target of more than $5 billion. Compugen is eligible for regulatory and commercial milestones and mid-single digit tiered royalties.
Promising COM701 Data for Ovarian Cancer
Phase I trials of COM701 demonstrated clinical benefits for heavily pretreated platinum-resistant ovarian cancer patients, particularly those without liver metastasis. The ongoing MYA ovarian platform trial is addressing an unmet need for maintenance therapy in platinum-sensitive ovarian cancer.
Negative Updates
Significant Revenue Decline
Revenues for the third quarter of 2025 were approximately $1.9 million, compared to $17.1 million for the same period in 2024, reflecting a substantial decrease due to the recognition of upfront and milestone payments from a previous license agreement with Gilead.
Extended Timelines for Clinical Trials
The MYA ovarian platform trial's interim analysis has been extended from 2026 to Q1 2027, due to factors such as site openings and enrollment rates, potentially delaying the program's progress.
Net Loss Compared to Previous Year
Compugen reported a net loss of approximately $6.98 million for the third quarter of 2025, compared to a net profit of approximately $1.28 million in the same period of 2024, indicating financial challenges.
Company Guidance
During Compugen's third quarter 2025 results conference call, the company provided guidance on various key metrics and strategic initiatives. Compugen emphasized its commitment to advancing its differentiated Fc reduced anti-TIGIT programs, highlighting the potential advantages over Fc active anti-TIGIT antibodies in terms of safety and efficacy. The company anticipates readouts from its TIGIT programs in 2026, with the potential for significant commercial opportunities, particularly with their partner AstraZeneca's rilfrogostomy, which has an estimated peak year revenue target of over $5 billion. Additionally, Compugen discussed its financial outlook, with a cash runway expected to fund operations into 2027. The company reported a cash balance of approximately $86 million as of September 30, 2025, and noted revenues of $1.9 million for 2025 compared to $17.1 million in 2024. R&D expenses for 2025 were approximately $5.8 million, while G&A expenses were about $2.2 million. The net loss for the year was approximately $6.98 million, with a loss per share of $0.07. Compugen remains focused on advancing its pipeline, including ongoing trials and partnerships with AstraZeneca and Gilead, which provide potential for over $1 billion in milestone payments and royalties.

Compugen Financial Statement Overview

Summary
Income Statement
50
Neutral
Balance Sheet
55
Neutral
Cash Flow
60
Neutral
Breakdown
Income Statement
Total Revenue
Gross Profit
EBITDA
Net Income
Balance Sheet
Total Assets
Cash, Cash Equivalents and Short-Term Investments
Total Debt
Total Liabilities
Stockholders Equity
Cash Flow
Free Cash Flow
Operating Cash Flow
Investing Cash Flow
Financing Cash Flow

Compugen Technical Analysis

Technical Analysis Sentiment
Negative
Last Price1.84
Price Trends
50DMA
1.63
Negative
100DMA
1.57
Negative
200DMA
1.55
Negative
Market Momentum
MACD
-0.02
Negative
RSI
47.19
Neutral
STOCH
32.48
Neutral
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For CGEN, the sentiment is Negative. The current price of 1.84 is above the 20-day moving average (MA) of 1.54, above the 50-day MA of 1.63, and above the 200-day MA of 1.55, indicating a bearish trend. The MACD of -0.02 indicates Negative momentum. The RSI at 47.19 is Neutral, neither overbought nor oversold. The STOCH value of 32.48 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Negative sentiment for CGEN.

Compugen Peers Comparison

Overall Rating
UnderperformOutperform
Sector (―)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
56
Neutral
$201.58M-1.27-59.98%-10.57%1.98%
54
Neutral
$207.56M-3.28-57.84%-84.46%33.32%
52
Neutral
$144.04M-5.15-52.95%-88.47%-1658.33%
48
Neutral
$197.49M-5.87-158.88%-16.26%
39
Underperform
$128.56M-26.69%25.84%
30
Underperform
$143.24M-2.3817.36%
* Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
CGEN
Compugen
1.54
-0.03
-1.91%
NKTX
Nkarta
1.81
-0.60
-24.90%
CCCC
C4 Therapeutics
2.12
-1.67
-44.06%
STTK
Shattuck Labs
3.35
2.11
170.16%
ELTX
Elicio Therapeutics
8.07
2.92
56.70%
NVCT
Nuvectis Pharma
7.75
2.53
48.47%

Compugen Corporate Events

Compugen Reports Q3 2025 Results and Advances Clinical Trials
Nov 10, 2025

On November 10, 2025, Compugen Ltd. reported its third quarter 2025 financial results and provided a corporate update. The company highlighted the presentation of COM701 Phase 1 data at ESMO 2025, which informed the design of the ongoing MAIA-ovarian platform trial. Compugen is enrolling patients in the U.S., Israel, and France for this trial, with interim analysis expected in Q1 2027. The company also presented the Phase 1 trial design for GS-0321 at SITC 2025. Partner AstraZeneca shared promising results from Phase 2 trials of rilvegostomig in NSCLC and bladder cancer. Financially, Compugen reported a solid cash position expected to fund operations into Q3 2027, despite a net loss of $6.98 million for the quarter.

Compugen Presents Promising COM701 Analysis at ESMO 2025
Oct 14, 2025

On October 13, 2025, Compugen Ltd. announced the presentation of a pooled analysis of COM701 in three Phase 1 trials for patients with platinum-resistant ovarian cancer at the ESMO 2025 conference. The analysis, which included 60 evaluable patients, demonstrated that COM701 was well tolerated and showed durable responses, particularly in patients without liver metastases. This supports the rationale for its use as maintenance therapy in earlier treatment settings. Compugen is currently conducting the MAIA-ovarian trial to assess COM701 as a maintenance treatment in relapsed platinum-sensitive ovarian cancer, with interim analysis results expected by the end of 2026. The company is expanding trial sites to include locations in the U.S., Israel, and France, and anticipates its cash reserves will support operations into 2027.

Compugen’s Shareholders Approve All Proposals at 2025 Annual Meeting
Sep 17, 2025

On September 16, 2025, Compugen Ltd. conducted its 2025 Annual General Meeting of Shareholders, where all proposals were approved by the necessary majority vote. This approval signifies continued shareholder support and could potentially strengthen Compugen’s strategic initiatives and market position in the biotechnology sector.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Nov 10, 2025