MAIA-ovarian Trial Initiation and Active Enrollment
COM701 randomized MAIA-ovarian adaptive platform trial launched and all sites open and enrolling across the U.S., Israel and France; interim analysis for median PFS expected by Q1 2027, supporting a potential registration path and combination backbone in relapsed platinum-sensitive ovarian cancer.
Clinical Activity and Differentiated Biology for COM701
Pooled ESMO data showed COM701 monotherapy and combinations were well tolerated with consistent durable responses in heavily pretreated platinum-resistant ovarian cancer; unique PVRIG biology may drive activity across PD-L1 positive and negative patients and inform broader development.
Strong Partner Progress on Rilvegostomig (Rilve)
AstraZeneca presented multiple abstracts at AACR including promising preclinical and DESTINY-Gastric03 Phase II combinability and antitumor activity; AZ estimates non-risk-adjusted peak annual revenue potential > $5 billion for Rilve — Compugen eligible for up to $195M in future regulatory/commercial milestones plus mid-single-digit tiered royalties.
GS-0321 (formerly COM503) Advancement with Gilead
GS-0321 Phase I dose-escalation trial progressing as planned; Compugen has received $90M to date from Gilead and is eligible for up to $758M in additional milestone payments plus up to double-digit royalties.
AI-Powered Discovery Platform Momentum (Unigen)
Unigen computational target discovery platform credited with identifying targets for COM701, COM902 and GS-0321, underpinning continued investment in early-stage immuno-oncology discovery and future innovative programs.
Solid Cash Position and Multi-Year Runway
Cash, cash equivalents, short-term deposits and marketable securities totaled approximately $134.9M as of March 31, 2026; company expects cash runway into 2029 (assuming no further inflows), supported by a December 2025 transaction with AstraZeneca that provided $65M of nondilutive capital.