Treatment ChallengesThe benefit of obinutuzumab pretreatment remained limited, indicating challenges in enhancing treatment efficacy.
Treatment EffectivenessThe presence of anti-drug antibodies coincided with reduced serum MP0533 exposure levels and the loss of T cell activation in 53% of patients, limiting the treatment's effectiveness.
Tumor TargetingIn spite of DLL3's 'very low' cell surface density, MP0712 has achieved ~60% injected dose on the tumor.