Clinical DifferentiationUse of Flu/Cy lymphodepletion achieving consistent complete B-cell depletion supports stronger proof-of-concept signals and may enhance investigator and patient willingness to enroll.
Regulatory PathwayElimination of the patient-by-patient stagger enables simultaneous enrollment and dose escalation within cohorts, which is expected to accelerate trial timelines and improve data collection speed.
Trial GovernanceConsolidation under a single independent data and safety monitoring board permits pooled data review and harmonized dosing decisions, improving development efficiency across parallel studies.