Market ReactionLarimar shares are down about 30%, related to commentary regarding the tolerability profile of nomlabofusp and the resultant protocol change.
Regulatory ChallengesShares are trading down ~14% in sympathy to negative regulatory news from UniQure and Biohaven, with the FDA questioning the validity of external natural history comparisons for demonstration of efficacy in rare neurological disorders.
Safety ConcernsAnaphylaxis remains a key debate concerning the safety of nomlabofusp.