Nomlabofusp’s Manageable Risk, Strong Efficacy Signals, and Significant FA Market Upside Underpin Buy Rating on LRMRAhead of topline data in 2Q26 and a planned June 2026 BLA submission seeking accelerated approval, we surveyed up to 24 US-based neurologists and cardiologists who collecv ely manage 267 Friedreich's Ataxia paen ts annually. We aimed to be er understand the potenal for LRMR’s nomlabofusp, a frataxin protein replacement therapy, to address unmet needs in FA, as well as physicians’ percepons of the therapy’s anaphylaxis rate. Key takeaways from physician responses on efficacy expectaons, anaphylaxis tolerability, and compev e posioning f ollow. Anaphylaxis risk considered manageable, not disqualifying. When asked about perceived manageability of anaphylaxis (based on data to date), physicians were split between anaphylaxis being highly manageable (46% rated 7-to-10) and moderately manageable (50% rated 4-to-6), which is encouraging, in our opinion (Figure 6).