Competitive ChallengesCompeting with established players like Gilead, Bristol, and Novartis is likely to be challenging, especially given their sizeable infrastructure investments.
Market SaturationThe CD19-targeted CAR-T space is crowded, and the opportunity for another entrant like Lyell is limited.
Strategy UncertaintyThe decision to discontinue next-gen, early-stage, solid tumor CAR-T LYL119 adds to the uncertainty surrounding Lyell's strategy.