Competitive PressureBeam Therapeutics will be presenting data at ASH, showing >60% HbF induction in patients, which exceeds the levels reported in Editas's RUBY trial and may exert competitive pressure on reni-cel.
Strategic ShiftEditas Medicine announced a strategic transition to focus entirely on development of in vivo therapies after failing to find a partner for its clinical-stage ex vivo-edited sickle cell/beta thalassemia therapy reni-cel.
Workforce ReductionEditas will discontinue development of reni-cel and execute a ~65% workforce reduction, including departure of Editas's CMO.