Challenges In Lung Receptor OccupancyLung receptor occupancy could not be established, likely due to low receptor expression and limitations with imaging lung vs. brain.
Market Reaction To Trial ResultsContineum shares are trading down modestly (~14%) after hours, following an announcement that the Phase II VISTA trial of PIPE-307, an M1 muscarinic receptor antagonist licensed by Johnson & Johnson, as an adjunctive treatment in relapsing-remitting multiple sclerosis did not meet its prespecified primary or secondary efficacy endpoints.
PIPE-307 Trial ResultsCTNM disclosed that the ph2 VISTA trial of PIPE-307 (M1R antagonist) in RRMS did not meet either its prespecified primary or secondary endpoints.