Clinical Trial DelaysOther atebimetinib clinical trial combination arms are now expected to initiate in 2026 instead of the previously planned 2025.
Efficacy ComparisonAtebimetinib's efficacy is similar or slightly worse versus Dara, raising the question if physicians will prefer it in 1L to preserve options for 2L.
Safety ConcernsThe safety profile deteriorated slightly with higher percentages of neutropenia, anemia, and fatigue.