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Lyell Immunopharma (LYEL)
NASDAQ:LYEL
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Lyell Immunopharma (LYEL) AI Stock Analysis

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LYEL

Lyell Immunopharma

(NASDAQ:LYEL)

Rating:54Neutral
Price Target:
$11.00
▲(0.36% Upside)
Lyell Immunopharma's overall stock score reflects a challenging financial situation with no revenue and ongoing losses, balanced by positive corporate events and moderate technical indicators. The recent funding and promising clinical trial data are significant positives, but the company's valuation remains low due to negative earnings.
Positive Factors
Clinical data
LYL314 has shown promising early complete responses lasting at least 6 months, equating to ~51% of all treated patients maintaining durable complete responses for six months.
Regulatory progress
RMAT designation for LYL314 is a positive sign in turbulent times at the FDA.
Negative Factors
Clinical development risks
Increasing competition among CAR-T products for B cell lymphomas as well as personnel changes at the FDA may increase the risk of clinical development.
Financial performance
Lyell reported a net loss of $0.69 per share, which was worse than the analyst's estimate of a net loss of $0.18 per share.
Market competition
The CD19-targeted CAR-T space is considered crowded and may not support another entrant with the current under $3 billion aggregated annual sales across competitors.

Lyell Immunopharma (LYEL) vs. SPDR S&P 500 ETF (SPY)

Lyell Immunopharma Business Overview & Revenue Model

Company DescriptionLyell Immunopharma, Inc., a T cell reprogramming company, engages in developing T cell therapies for patients with solid tumors. The company develops therapies using technology platforms, such as Gen-R, an ex vivo genetic reprogramming technology to overcome T cell exhaustion; and Epi-R, an ex vivo epigenetic reprogramming technology to generate population of T cells with durable stemness. Its pipeline includes LYL797, a T cell product candidate for the treatment of non-small cell lung cancer and triple negative breast cancers; LYL845, that targets multiple solid tumors; and NY-ESO-1 for synovial sarcoma and other solid tumor indications. The company entered into research and development collaboration and license agreement with GlaxoSmithKline for NY-ESO-1 program. Lyell Immunopharma, Inc. was incorporated in 2018 and is headquartered in South San Francisco, California.
How the Company Makes MoneyLyell Immunopharma generates revenue primarily through strategic collaborations and partnerships with pharmaceutical and biotechnology companies. These partnerships often involve licensing agreements, milestone payments, and royalties associated with the development and commercialization of T-cell therapies. Additionally, Lyell may receive funding from grants and research collaborations aimed at advancing their scientific innovations. The company also invests in developing proprietary technologies and seeks to monetize these innovations through clinical success, leading to potential product sales and additional partnerships.

Lyell Immunopharma Financial Statement Overview

Summary
Lyell Immunopharma is facing substantial financial challenges, primarily due to its inability to generate revenue and persistent operational losses. The balance sheet is relatively stronger, with a manageable level of debt and a good equity base. However, the company's cash flow situation is strained, with heavy reliance on financing for liquidity. Overall, the financial position reflects high operational risk and the need for strategic shifts to improve revenue and profitability.
Income Statement
30
Negative
Lyell Immunopharma has faced significant challenges in revenue generation, with revenue dropping to zero in the latest year. The company has consistently reported negative net income, resulting in negative net profit margins. The absence of revenue and persistent losses indicate financial difficulties in scaling operations or commercializing products.
Balance Sheet
60
Neutral
The balance sheet shows a strong equity position with a low debt-to-equity ratio, reflecting financial prudence. However, the decline in stockholders' equity over the years may indicate operational challenges. The equity ratio remains healthy, suggesting solid capital management despite operational losses.
Cash Flow
40
Negative
Lyell Immunopharma's cash flow statement highlights significant operating cash outflows due to ongoing losses. While free cash flow remains negative, the company has maintained a consistent level of cash reserves. The ability to generate positive cash flow from financing activities has been crucial in sustaining operations.
BreakdownTTMDec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income Statement
Total Revenue60.00K61.00K130.00K84.68M10.65M7.76M
Gross Profit60.00K61.00K130.00K68.22M-3.88M281.00K
EBITDA-199.95M-200.64M-226.76M-166.65M-199.94M-207.64M
Net Income-331.40M-342.99M-234.63M-4.75M-285.50M-198.53M
Balance Sheet
Total Assets385.45M490.86M750.03M937.56M1.13B908.28M
Cash, Cash Equivalents and Short-Term Investments276.79M370.53M546.22M640.15M614.79M612.62M
Total Debt46.60M58.97M63.17M67.70M67.82M54.57M
Total Liabilities86.53M108.03M95.08M104.31M197.62M189.84M
Stockholders Equity298.92M382.82M654.95M833.25M929.79M718.44M
Cash Flow
Free Cash Flow-172.00M-162.86M-166.38M-193.83M-191.75M-212.35M
Operating Cash Flow-171.48M-162.39M-163.69M-169.56M-126.25M-160.87M
Investing Cash Flow137.54M122.42M184.05M-11.54M-121.57M-273.52M
Financing Cash Flow621.00K1.33M1.74M10.63M401.24M476.79M

Lyell Immunopharma Technical Analysis

Technical Analysis Sentiment
Positive
Last Price10.96
Price Trends
50DMA
10.37
Positive
100DMA
9.72
Positive
200DMA
11.95
Negative
Market Momentum
MACD
0.09
Positive
RSI
55.92
Neutral
STOCH
72.65
Neutral
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For LYEL, the sentiment is Positive. The current price of 10.96 is below the 20-day moving average (MA) of 10.97, above the 50-day MA of 10.37, and below the 200-day MA of 11.95, indicating a neutral trend. The MACD of 0.09 indicates Positive momentum. The RSI at 55.92 is Neutral, neither overbought nor oversold. The STOCH value of 72.65 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Positive sentiment for LYEL.

Lyell Immunopharma Risk Analysis

Lyell Immunopharma disclosed 81 risk factors in its most recent earnings report. Lyell Immunopharma reported the most risks in the "Tech & Innovation" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks

Lyell Immunopharma Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
54
Neutral
$210.55M-76.59%11.11%-46.50%
54
Neutral
$356.62M123.38%15.73%38.73%
52
Neutral
$304.97M-38.87%
51
Neutral
$7.83B-0.18-40.10%2.29%21.46%-2.03%
49
Neutral
$117.19M-25.25%12.13%-8.23%
44
Neutral
$128.02M-52.11%-31.23%14.92%
39
Underperform
$156.25M-26.94%26.33%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
LYEL
Lyell Immunopharma
11.28
-17.92
-61.37%
FATE
Fate Therapeutics
1.12
-2.42
-68.36%
ADCT
ADC Therapeutics
3.22
0.35
12.20%
NKTX
Nkarta
2.24
-3.26
-59.27%
SEER
Seer
2.06
0.35
20.47%
FDMT
4D Molecular Therapeutics
6.46
-8.79
-57.64%

Lyell Immunopharma Corporate Events

Private Placements and FinancingBusiness Operations and Strategy
Lyell Immunopharma Secures $100 Million in Private Placement
Positive
Jul 25, 2025

On July 24, 2025, Lyell Immunopharma entered into a Securities Purchase Agreement to raise up to $100 million through a private placement with institutional and accredited investors. The initial closing, expected around July 25, 2025, will generate approximately $50 million, with the potential for an additional $50 million upon achieving specific clinical or corporate milestones within a year. The proceeds will fund pivotal-stage clinical trials of LYL314 and support general corporate purposes, with expectations to sustain operations into mid-2027. This financial move positions Lyell to advance its clinical trials and potentially submit a Biologics License Application in 2027 for LYL314 in treating large B-cell lymphoma.

Product-Related AnnouncementsBusiness Operations and Strategy
Lyell Immunopharma Announces Promising CAR T-Cell Trial Data
Positive
Jun 17, 2025

On June 17, 2025, Lyell Immunopharma announced new clinical data from its ongoing Phase 1/2 trial of LYL314, a CAR T-cell therapy for large B-cell lymphoma (LBCL). The trial showed promising results with high overall response rates and manageable safety profiles in both third- or later-line (3L+) and second-line (2L) settings. The company plans to initiate a randomized pivotal trial by early 2026 and has the manufacturing capacity to support clinical development and early commercial launch if approved.

Executive/Board ChangesStock Split
Lyell Immunopharma Expands Board, Appoints New Director
Neutral
Jun 9, 2025

On June 9, 2025, Lyell Immunopharma‘s Board of Directors expanded from seven to eight members, appointing Mark Bachleda, Pharm.D., M.B.A., as a Class I director. Dr. Bachleda will serve until the 2028 annual stockholders meeting, receiving compensation and equity grants as per the company’s policy, adjusted for a recent reverse stock split.

Shareholder MeetingsStock Split
Lyell Immunopharma Announces 1-for-20 Reverse Stock Split
Neutral
May 28, 2025

On May 27, 2025, Lyell Immunopharma announced a reverse stock split at a 1-for-20 ratio, authorized by its stockholders during the annual meeting on May 15, 2025. Effective May 30, 2025, this move will consolidate every 20 shares into one, adjusting stock options and equity plans proportionately, with trading on a split-adjusted basis starting June 2, 2025, on Nasdaq. This action aims to streamline the company’s stock structure without altering shareholders’ proportional ownership.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Aug 26, 2025