Replimune Group Inc (REPL)
NASDAQ:REPL
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Replimune Group
(NASDAQ:REPL)
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Rating:47Neutral
Price Target:
$7.00
▼(-3.05% Downside)
Action:ReiteratedDate:02/19/26
The score is primarily held down by weak financial performance (no revenue, widening losses, and high cash burn with declining equity), with only modest offset from neutral technical indicators. Valuation is also constrained by a negative P/E and no dividend yield support.
Positive Factors
Late-stage programs with imminent regulatory milestone
A scheduled PDUFA and multiple Phase 3/late-stage programs represent a structural transition opportunity from development to commercialization. Approval would create a sustainable revenue source, validate the platform, and materially change funding and strategic priorities over the next several months.
Negative Factors
No revenue and widening net losses
With zero product revenue and accelerating net losses, the company remains fully dependent on external capital. Continued widening losses reduce financial flexibility and increase the risk that future funding needs or execution setbacks will force dilutive financing or program slowdowns within the next several quarters.
Read all positive and negative factors
Positive Factors
Negative Factors
Late-stage programs with imminent regulatory milestone
A scheduled PDUFA and multiple Phase 3/late-stage programs represent a structural transition opportunity from development to commercialization. Approval would create a sustainable revenue source, validate the platform, and materially change funding and strategic priorities over the next several months.
Read all positive factors
Replimune Group (REPL) vs. SPDR S&P 500 ETF (SPY)
Market Cap
$596.17M
Dividend YieldN/A
Average Volume (3M)1.49M
Price to Earnings (P/E)―
Beta (1Y)0.86
Revenue GrowthN/A
EPS Growth-15.77%
CountryUS
Employees479
SectorHealthcare
Sector Strength45
IndustryBiotechnology
Share Statistics
EPS (TTM)-0.77
Shares Outstanding82,572,620
10 Day Avg. Volume1,535,963
30 Day Avg. Volume1,486,981
Financial Highlights & Ratios
PEG Ratio0.61
Price to Book (P/B)1.89
Price to Sales (P/S)0.00
P/FCF Ratio-3.95
Enterprise Value/Market Cap0.93
Enterprise Value/RevenueN/A
Enterprise Value/Gross Profit-651.04
Enterprise Value/Ebitda-1.77
Forecast
1Y Price Target
$12.50Price Target Upside73.13% Upside
Rating ConsensusModerate Buy
Number of Analyst Covering3
EPS Forecast (FY)-3.08
Revenue Forecast (FY)$1.95M
Replimune Group Business Overview & Revenue Model
Company Description
Replimune Group, Inc., a biotechnology company, develops oncolytic immuno-gene therapies to treat cancer. It uses its proprietary Immunotherapy platform to design and develop product candidates that are intended to activate the immune system again...
How the Company Makes Money
Replimune does not appear to generate meaningful recurring revenue from commercial product sales because its core product candidates are in clinical development rather than marketed products. The company primarily funds operations through financin...
Replimune Group Key Performance Indicators (KPIs)
Any
Revenue by Geography
Breaks down revenue across different regions, revealing where the company is strongest and where it may face risk or growth potential due to local economic conditions or market share shifts.
Breaks down revenue across different regions, revealing where the company is strongest and where it may face risk or growth potential due to local economic conditions or market share shifts.
Data provided by:
The Fly
The FlyReplimune Group Earnings Call Summary
Earnings Call Date:May 22, 2025
(Q4-2025)
| % Change Since: |
Next Earnings Date:May 14, 2026
Earnings Call Sentiment Positive
The earnings call provided a positive outlook, highlighting significant regulatory achievements, strong commercial readiness, and financial stability. However, the increase in net loss and operational expenses presents challenges. The overall sentiment is optimistic about RP1's potential launch and market adoption.Positive Updates
Breakthrough Therapy Designation and Priority Review for RP1
RP1 has been recognized as a breakthrough therapy with priority review, with a PDUFA date set for July 22, 2025. The company has completed late-cycle meetings and manufacturing inspections with the FDA, indicating substantial regulatory progress.
Negative Updates
Increased Net Loss
The company's net loss increased to $74.1 million for the fiscal fourth quarter and $247.3 million for the fiscal year ended March 31, 2025, compared to $55.1 million and $215.8 million, respectively, for the prior year.
Read all updates
Q4-2025 Updates
Positive
Negative
Breakthrough Therapy Designation and Priority Review for RP1
RP1 has been recognized as a breakthrough therapy with priority review, with a PDUFA date set for July 22, 2025. The company has completed late-cycle meetings and manufacturing inspections with the FDA, indicating substantial regulatory progress.
Read all positive updates
Company Guidance
During the Replimune Fiscal Year Fourth Quarter 2025 Financial Results and Corporate Update Conference Call, significant progress was highlighted across regulatory, clinical, and commercial fronts as the company approaches the potential approval and launch of RP1. The product has been recognized as a breakthrough therapy with a priority review and a PDUFA date set for July 22, 2025. The Ignite 3 confirmatory study is underway, with over 100 planned global sites, focusing on overall survival as the primary endpoint. Replimune estimates that approximately 13,000 patients progress on or after PD-1 treatment annually in the U.S., with 80% of these patients potentially eligible for RP1. The company ended the fiscal year with $483.8 million in cash and cash equivalents and anticipates a cash runway into the fourth quarter of 2026. Research and development expenses totaled $189.4 million for the fiscal year, with a net loss of $247.3 million. The company has completed its commercial infrastructure build-out, comprising approximately 60 people, and plans to provide critical services through the Replimune Connect Plus patient support hub.Replimune Group Financial Statement Overview
Summary
Income Statement
12
Very Negative
Balance Sheet
54
Neutral
Cash Flow
18
Very Negative
| Breakdown | TTM | Mar 2025 | Mar 2024 | Mar 2023 | Mar 2022 | Mar 2021 |
|---|---|---|---|---|---|---|
Income Statement | ||||||
| Total Revenue | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| Gross Profit | -848.00K | 0.00 | 0.00 | 0.00 | -4.58M | -4.14M |
| EBITDA | -311.38M | -253.92M | -227.77M | -171.72M | -114.41M | -76.48M |
| Net Income | -314.85M | -247.30M | -215.79M | -174.28M | -118.04M | -80.87M |
Balance Sheet | ||||||
| Total Assets | 333.59M | 551.33M | 487.72M | 646.59M | 461.19M | 543.10M |
| Cash, Cash Equivalents and Short-Term Investments | 269.14M | 483.80M | 420.67M | 583.39M | 395.65M | 476.30M |
| Total Debt | 78.86M | 76.17M | 75.87M | 60.76M | 32.84M | 33.28M |
| Total Liabilities | 123.05M | 135.49M | 113.21M | 91.30M | 49.96M | 44.37M |
| Stockholders Equity | 210.54M | 415.84M | 374.51M | 555.29M | 411.23M | 498.73M |
Cash Flow | ||||||
| Free Cash Flow | -283.27M | -198.94M | -191.13M | -130.32M | -84.52M | -63.78M |
| Operating Cash Flow | -277.91M | -192.25M | -185.47M | -128.05M | -82.18M | -61.39M |
| Investing Cash Flow | 216.64M | -23.80M | 97.20M | -142.50M | -1.81M | -188.78M |
| Financing Cash Flow | 10.48M | 252.40M | 16.28M | 311.30M | 6.60M | 372.46M |
Replimune Group Technical Analysis
Negative
7.22
Price Trends
7.53
Negative
8.43
Negative
7.64
Negative
Market Momentum
-0.16
Negative
46.50
Neutral
80.44
Negative
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For REPL, the sentiment is Negative. The current price of 7.22 is below the 20-day moving average (MA) of 7.37, below the 50-day MA of 7.53, and below the 200-day MA of 7.64, indicating a bearish trend. The MACD of -0.16 indicates Negative momentum. The RSI at 46.50 is Neutral, neither overbought nor oversold. The STOCH value of 80.44 is Negative, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Negative sentiment for REPL.
Replimune Group Risk Analysis
Replimune Group disclosed 60 risk factors in its most recent earnings report. Replimune Group reported the most risks in the "Finance & Corporate" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks
Replimune Group Peers Comparison
UnderperformOutperform
Sector (51)
Name | Overall Rating | Market Cap | P/E Ratio | ROE | Dividend Yield | Revenue Growth | EPS Growth |
|---|---|---|---|---|---|---|---|
57 Neutral | $1.21B | -5.55 | -38.79% | ― | ― | 4.29% | |
56 Neutral | $2.54B | -7.25 | -65.77% | ― | -8.75% | -8.79% | |
51 Neutral | $7.86B | -0.30 | -43.30% | 2.27% | 22.53% | -2.21% | |
47 Neutral | $596.17M | -3.16 | -102.69% | ― | ― | -15.77% | |
47 Neutral | $1.52B | -5.54 | -57.51% | ― | 48.32% | -1.91% | |
46 Neutral | $261.33M | -13.95 | -38.76% | ― | ― | -5.71% | |
46 Neutral | $739.22M | -4.22 | -141.99% | ― | ― | 31.16% |
* Healthcare Sector Average
REPL
Replimune Group
7.22
-2.53
-25.95%
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Replimune Group Corporate Events
Business Operations and StrategyFinancial DisclosuresPrivate Placements and Financing
Replimune amends Hercules loan, strengthens funding runway
Positive
Feb 3, 2026
On January 29, 2026, Replimune Group amended its loan and security agreement with Hercules Capital, extending a key revenue milestone to September 30, 2027, adjusting tranche sizes, and pushing the start of debt amortization from October 1, 2026 t...
Business Operations and StrategyProduct-Related Announcements
Replimune Highlights RP1, RP2 Progress Ahead of JPM Conference
Positive
Jan 12, 2026
On January 12, 2026, Replimune released an updated corporate presentation highlighting recent strategic developments and clinical data for its RP1 and RP2 oncolytic immunotherapy programs ahead of its appearance at the J.P. Morgan Healthcare Confe...
Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
Disclaimer
This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.