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Arcus Biosciences Inc (RCUS)
NYSE:RCUS
US Market

Arcus Biosciences (RCUS) AI Stock Analysis

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Arcus Biosciences

(NYSE:RCUS)

Rating:48Neutral
Price Target:
$8.00
▼(-6.87%Downside)
Arcus Biosciences faces significant financial and technical challenges, with negative profitability and bearish momentum weighing heavily on the stock score. Although strategic collaborations and promising clinical data offer potential for future growth, current valuations and operational inefficiencies suggest caution. The strong cash position and clinical advancements provide some optimism but are overshadowed by ongoing financial struggles.
Positive Factors
Clinical Development
Arcus is set to begin their first Phase 3 registration trial with the combination therapy compared to monotherapy, indicating progress in clinical development.
Clinical Efficacy
Arcus's combination data at ASCO exceeded expectations, suggesting a stronger future performance for the stock.
Financial Stability
Arcus ended the quarter with $1 billion in cash, cash equivalents, and marketable securities, which they expect will fund operations through three pivotal readouts.
Negative Factors
Commercial Uncertainty
Despite positive updates, investors remain cautious due to uncertainties over the commercial picture and seek more clarity before re-engaging.
Competitive Challenges
Difficulties competing with established players like Merck and Bristol and the considerable cost of running necessary studies pose challenges.
Market Reception
The response to the new data was relatively tepid, as it was presented alongside more established and novel studies that garnered more attention.

Arcus Biosciences (RCUS) vs. SPDR S&P 500 ETF (SPY)

Arcus Biosciences Business Overview & Revenue Model

Company DescriptionArcus Biosciences (RCUS) is a biopharmaceutical company focused on creating innovative cancer immunotherapies. Headquartered in Hayward, California, the company specializes in the development and commercialization of novel combination therapies aimed at treating cancer more effectively. Arcus leverages its robust drug discovery and development capabilities to advance a pipeline of proprietary and partnered therapeutic candidates targeting a range of cancer types.
How the Company Makes MoneyArcus Biosciences generates revenue primarily through strategic collaborations, licensing agreements, and partnerships with larger pharmaceutical companies. These collaborations often involve upfront payments, milestone payments based on the achievement of specific development or regulatory goals, and royalties on sales of commercialized products. The company invests heavily in research and development to advance its pipeline of drug candidates, with the aim of securing approvals that can lead to significant revenue streams from product sales and expanded licensing opportunities. Additionally, Arcus's ability to enter into lucrative partnerships with major industry players is a critical factor contributing to its financial performance.

Arcus Biosciences Key Performance Indicators (KPIs)

Any
Any
Revenue by Segment
Revenue by Segment
Breaks down revenue by different business units or product lines, highlighting which areas are driving growth and which may need strategic adjustments.
Chart InsightsArcus Biosciences' revenue from License and Development Services shows volatility, with a notable spike in Q1 2024. However, the latest earnings call highlights a decline in quarterly revenue, attributed to collaboration dynamics with Gilead. Despite this, Arcus maintains a strong cash position and is strategically focused on advancing its casdatifan program, targeting a significant market opportunity in RCC. The company's collaborations, particularly with AstraZeneca, and rapid trial enrollments underscore its potential for future growth, though pipeline reprioritization poses some risk.
Data provided by:Main Street Data

Arcus Biosciences Earnings Call Summary

Earnings Call Date:May 06, 2025
(Q1-2025)
|
% Change Since: 5.79%|
Next Earnings Date:Jul 31, 2025
Earnings Call Sentiment Neutral
Arcus Biosciences demonstrated strong financial management and strategic advancements in their casdatifan program, with promising data and collaborations. However, there are concerns about pipeline reprioritization, particularly in the TIGIT program, and a decline in quarterly revenue.
Q1-2025 Updates
Positive Updates
Cash Position and Capital Allocation
Arcus Biosciences has a strong balance sheet with $1 billion in cash and investments, bolstered by a $150 million equity financing. This financial position is expected to fund operations through initial pivotal readouts for key programs, including PEAK-1.
Casdatifan Development Progress
Significant progress in the casdatifan program, with promising initial data from the cas plus cabo cohort of ARC-20 accepted for an oral presentation at ASCO. The program includes eight cohorts evaluating different dosing regimens, combinations, and settings for clear cell RCC.
Strategic Collaborations
Arcus is collaborating with AstraZeneca to develop casdatifan in combination with their anti-PD-1 anti-CTLA-4 bispecific antibody, volrustomig, offering the first TKI-free HIF-2 alpha combination option for first-line RCC.
Enrollment and Study Progress
The PRISM-1 trial in pancreatic cancer is enrolling rapidly and expected to be fully enrolled by the end of 2025, ahead of initial expectations. There is also strong enrollment interest in the PEAK-1 trial.
Negative Updates
Pipeline Reprioritization and Program Halt
The adenosine modulator program, specifically the A2 receptor antagonist etruma, is not moving forward at this time despite a good meeting with the FDA.
TIGIT Program Concerns
Questions raised about under-investment in the TIGIT program compared to AstraZeneca, with only two major Phase 3 studies ongoing for TIGIT-based therapies.
Revenue Decline
Reported GAAP revenue for Q1 2025 was $28 million, down from $36 million in Q4 2024, primarily driven by the collaboration with Gilead.
Company Guidance
During the Arcus Biosciences First Quarter 2025 Earnings and Financial Results Call, the company provided several key metrics and guidance on its financial and clinical trajectory. Arcus reported $1 billion in cash and investments, with expectations to maintain this strong financial position through its initial pivotal readouts for three major programs, including the PEAK-1 trial for casdatifan. The company anticipates recognizing GAAP revenue between $75 million to $90 million for the full year 2025, primarily driven by its collaboration with Gilead. In terms of clinical development, Arcus highlighted the rapid enrollment of the PRISM-1 trial, expected to be fully enrolled by the end of 2025, and the STAR-221 trial's timeline to read out in 2026. The company emphasized its focus on casdatifan, targeting a $5 billion market opportunity in RCC, with the completion of its Phase 3 PEAK-1 study and ongoing collaborations with AstraZeneca to advance TKI-free regimens.

Arcus Biosciences Financial Statement Overview

Summary
Arcus Biosciences shows strong gross profit margins but struggles with profitability due to consistent negative net income and EBIT. The balance sheet is moderately leveraged with sufficient cash reserves, but the cash flow statement highlights ongoing challenges in cash generation.
Income Statement
42
Neutral
Arcus Biosciences has experienced fluctuating revenue with a decline from 2021 to TTM (Trailing-Twelve-Months). Gross profit margins are strong, but the company has consistently reported negative net income, EBIT, and EBITDA, indicating ongoing operational challenges. The net profit margin is negative due to substantial losses, which is a concern for profitability.
Balance Sheet
55
Neutral
The balance sheet shows a moderate debt-to-equity ratio, supported by a healthy level of cash and short-term investments relative to debt. However, the decline in stockholders' equity over recent periods indicates potential erosion in shareholder value. The equity ratio is reasonable, but the company relies on external financing, suggesting moderate financial stability.
Cash Flow
38
Negative
The cash flow statement reveals negative free cash flow in TTM, indicating challenges in generating cash from operations. The operating cash flow to net income ratio is unfavorable due to negative net income. Despite some stability in operating cash flows, the company needs to improve its cash generation to sustain operations without relying heavily on external financing.
BreakdownTTMDec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income Statement
Total Revenue141.00M258.00M117.00M112.00M382.88M77.52M
Gross Profit136.00M248.00M-223.00M98.00M375.82M-81.48M
EBITDA-390.00M-268.00M-283.00M-250.00M61.96M-118.47M
Net Income-391.00M-283.00M-307.00M-267.00M53.00M-116.68M
Balance Sheet
Total Assets1.16B1.15B1.09B1.34B1.59B772.29M
Cash, Cash Equivalents and Short-Term Investments997.00M978.00M759.00M1.14B681.30M735.09M
Total Debt60.00M60.00M11.00M120.00M116.89M15.24M
Total Liabilities625.00M665.00M633.00M688.00M750.45M269.99M
Stockholders Equity531.00M485.00M462.00M657.00M841.45M502.30M
Cash Flow
Free Cash Flow-303.00M-176.00M-330.00M426.00M-282.25M108.11M
Operating Cash Flow-300.00M-170.00M-306.00M438.00M-256.17M111.17M
Investing Cash Flow117.00M-84.00M194.00M-413.00M-3.87M-434.37M
Financing Cash Flow190.00M277.00M33.00M33.00M237.34M438.68M

Arcus Biosciences Technical Analysis

Technical Analysis Sentiment
Negative
Last Price8.59
Price Trends
50DMA
8.80
Negative
100DMA
9.10
Negative
200DMA
12.41
Negative
Market Momentum
MACD
-0.18
Positive
RSI
47.18
Neutral
STOCH
45.27
Neutral
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For RCUS, the sentiment is Negative. The current price of 8.59 is below the 20-day moving average (MA) of 8.96, below the 50-day MA of 8.80, and below the 200-day MA of 12.41, indicating a bearish trend. The MACD of -0.18 indicates Positive momentum. The RSI at 47.18 is Neutral, neither overbought nor oversold. The STOCH value of 45.27 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Negative sentiment for RCUS.

Arcus Biosciences Risk Analysis

Arcus Biosciences disclosed 60 risk factors in its most recent earnings report. Arcus Biosciences reported the most risks in the "Tech & Innovation" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks

Arcus Biosciences Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
59
Neutral
$1.02B-57.92%-13.37%2.57%
56
Neutral
$892.72M-64.16%-30.25%-5.92%
54
Neutral
$746.32M222.83%29.88%35.11%
51
Neutral
$7.55B0.30-61.90%2.27%17.11%1.58%
VIVIR
50
Neutral
$706.40M-44.59%-73.79%-5.24%
50
Neutral
$670.01M-17.80%56.10%
48
Neutral
$885.20M-63.17%-40.51%-35.07%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
RCUS
Arcus Biosciences
8.59
-5.53
-39.16%
NTLA
Intellia Therapeutics
10.73
-12.03
-52.86%
XERS
Xeris Pharmaceuticals
4.73
2.62
124.17%
VIR
Vir Biotechnology
5.43
-3.10
-36.34%
NRIX
Nurix Therapeutics
12.44
-7.03
-36.11%
DAWN
Day One Biopharmaceuticals
6.73
-6.98
-50.91%

Arcus Biosciences Corporate Events

Executive/Board ChangesShareholder Meetings
Arcus Biosciences Holds Annual Stockholders Meeting
Neutral
Jun 12, 2025

On June 10, 2025, Arcus Biosciences held its annual meeting of stockholders, where key proposals were voted on, including the election of Class I directors and the ratification of Ernst & Young LLP as the independent auditor for the fiscal year ending December 31, 2025. Additionally, the Board of Directors revised the Non-Employee Director Compensation Program, reflecting the company’s ongoing efforts to align its governance and compensation practices with industry standards.

The most recent analyst rating on (RCUS) stock is a Buy with a $25.00 price target. To see the full list of analyst forecasts on Arcus Biosciences stock, see the RCUS Stock Forecast page.

Product-Related Announcements
Arcus Biosciences Presents Promising Phase 1/1b Trial Data
Positive
Jun 2, 2025

On June 1, 2025, Arcus Biosciences presented updated data from its Phase 1/1b clinical trial ARC-20, involving the combination of casdatifan and cabozantinib for patients with clear cell renal cell carcinoma. The interim analysis, with a data cutoff date of March 14, 2025, showed a confirmed objective response rate of 46% and an acceptable safety profile, indicating potential efficacy and safety for this treatment combination.

The most recent analyst rating on (RCUS) stock is a Buy with a $25.00 price target. To see the full list of analyst forecasts on Arcus Biosciences stock, see the RCUS Stock Forecast page.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Jun 28, 2025