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Spyre Therapeutics (SYRE)
NASDAQ:SYRE
US Market

Spyre Therapeutics (SYRE) AI Stock Analysis

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Spyre Therapeutics

(NASDAQ:SYRE)

Rating:43Neutral
Price Target:
Spyre Therapeutics is facing significant financial challenges with consistent revenue and profitability issues. Its strong equity position is overshadowed by operational cash flow problems and persistent losses. Technically, the stock is under bearish pressure, and the valuation is complicated by a negative P/E ratio and lack of dividends. These factors combined result in a low overall stock score, reflecting the high-risk nature of investing in this biotechnology company.
Positive Factors
Clinical Development
SYRE continues to execute well against their strategy of developing combinations for inflammatory bowel disease, with supportive Ph 1 TL1A data, initiation of Ph 2, and an expanded approach in rheumatology.
Safety Profile
No serious adverse events were reported in the study, indicating a favorable safety profile for SYRE's products.
Negative Factors
Market Sentiment
Short interest in Spyre Therapeutics is relatively high at 23.6% of the float, which could indicate skepticism about the company’s prospects among some investors.
Pipeline Expansion Concerns
Today's stock reaction likely reflects some doubt on expanding pipeline focus and clinical development plans.

Spyre Therapeutics (SYRE) vs. SPDR S&P 500 ETF (SPY)

Spyre Therapeutics Business Overview & Revenue Model

Company DescriptionSpyre Therapeutics, Inc., a preclinical stage biotechnology company, focuses on developing therapeutics for patients living with inflammatory bowel disease (IBD). It develops SPY001, a human monoclonal immunoglobulin G1 antibody designed to bind selectively to the a4ß7 integrin being developed for the treatment of IBD (ulcerative colitis and Crohn's disease). The company is also developing SPY002, a human monoclonal antibody (mAb)candidates designed to bind to tumor necrosis factor-like ligand 1A; and SPY120, a combination of SPY001 (anti-a4ß7) and SPY002 (anti-TL1A) antibodies, which are in preclinical studies. In addition, its other early-stage programs include SPY003, an anti-IL-23 mAb; SPY004, a novel mechanism of action (MOA) mAb; SPY130, a combination of anti-a4ß7 and anti-IL-23 mAbs; and SPY230, a combination of anti-TL1A and anti-IL-23 mAbs. The company was formerly known as Aeglea BioTherapeutics, Inc. and changed its name to Spyre Therapeutics, Inc. in November 2023. Spyre Therapeutics, Inc. was incorporated in 2013 and is based in Waltham, Massachusetts.
How the Company Makes MoneySpyre Therapeutics generates revenue primarily through the development and commercialization of its proprietary therapeutic products. The company earns money by selling its approved drugs to healthcare providers, hospitals, and directly to patients through pharmacies. Additionally, Spyre may engage in strategic partnerships and collaborations with larger pharmaceutical companies for co-development, licensing, or distribution of its products, which can provide upfront payments, milestone payments, and royalties. The company's revenue model is also supported by research grants and funding for its clinical trials and development programs.

Spyre Therapeutics Financial Statement Overview

Summary
Spyre Therapeutics operates in the biotechnology industry with a high-risk financial profile characterized by consistent revenue challenges and profitability issues. The balance sheet reflects a strong equity position with no debt, but the lack of operational cash flow and persistent losses are concerning. The company needs significant revenue growth and profitability improvements to enhance its financial health.
Income Statement
25
Negative
Spyre Therapeutics has consistently struggled to generate revenue over the years, with recent data showing zero total revenue. The company has recorded negative EBIT and net income, leading to negative profit margins. Despite a slight improvement in EBIT, the overall lack of revenue and profitability presents significant challenges.
Balance Sheet
65
Positive
The balance sheet shows a strong equity position with no total debt reported in the latest period, resulting in a robust equity ratio. The company maintains a solid cash position, though the absence of revenue raises concerns about long-term sustainability. The return on equity remains negative due to ongoing net losses.
Cash Flow
40
Negative
Operating cash flow has been consistently negative, indicating challenges in generating cash from core operations. Despite positive financing activities that have bolstered cash reserves, the company struggles with negative free cash flow, which reflects ongoing operational inefficiencies.
BreakdownTTMDec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income Statement
Total Revenue0.000.00886.00K2.33M18.74M0.00
Gross Profit0.000.00-78.00K365.00K16.74M-1.62M
EBITDA-214.36M-207.97M-127.82M-83.21M-63.66M-79.27M
Net Income-208.93M-208.02M-338.79M-83.81M-65.80M-80.89M
Balance Sheet
Total Assets569.78M608.48M341.86M71.14M109.93M161.62M
Cash, Cash Equivalents and Short-Term Investments564.82M603.09M339.28M55.71M93.13M146.27M
Total Debt0.000.0084.56M4.63M5.06M5.45M
Total Liabilities87.17M90.68M157.84M20.84M25.98M21.79M
Stockholders Equity482.61M517.80M184.02M50.30M83.94M139.83M
Cash Flow
Free Cash Flow-169.86M-157.41M-99.91M-80.18M-54.29M-80.06M
Operating Cash Flow-169.86M-157.41M-99.91M-80.14M-53.72M-75.78M
Investing Cash Flow-248.38M-353.29M-108.39M57.01M-22.62M-7.60M
Financing Cash Flow238.87M410.91M361.08M42.68M1.39M154.51M

Spyre Therapeutics Technical Analysis

Technical Analysis Sentiment
Neutral
Last Price15.50
Price Trends
50DMA
15.29
Positive
100DMA
16.57
Negative
200DMA
22.11
Negative
Market Momentum
MACD
-0.08
Positive
RSI
48.30
Neutral
STOCH
40.49
Neutral
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For SYRE, the sentiment is Neutral. The current price of 15.5 is below the 20-day moving average (MA) of 16.21, above the 50-day MA of 15.29, and below the 200-day MA of 22.11, indicating a neutral trend. The MACD of -0.08 indicates Positive momentum. The RSI at 48.30 is Neutral, neither overbought nor oversold. The STOCH value of 40.49 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Neutral sentiment for SYRE.

Spyre Therapeutics Risk Analysis

Spyre Therapeutics disclosed 70 risk factors in its most recent earnings report. Spyre Therapeutics reported the most risks in the "Tech & Innovation" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks

Spyre Therapeutics Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
56
Neutral
$892.72M-64.16%-30.25%-5.92%
51
Neutral
$7.55B0.30-61.90%2.27%17.11%1.58%
VIVIR
50
Neutral
$706.40M-44.59%-73.79%-5.24%
49
Neutral
$871.84M-29.80%85.05%15.96%
48
Neutral
$885.20M-63.17%-40.51%-35.07%
43
Neutral
$934.88M2.31-50.47%-100.00%94.68%
42
Neutral
$940.01M-51.85%0.71%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
SYRE
Spyre Therapeutics
15.50
-9.99
-39.19%
ZYME
Zymeworks
12.89
4.01
45.16%
RCUS
Arcus Biosciences
8.59
-5.53
-39.16%
VIR
Vir Biotechnology
5.43
-3.10
-36.34%
NRIX
Nurix Therapeutics
12.44
-7.03
-36.11%
PHVS
Pharvaris
17.82
1.17
7.03%

Spyre Therapeutics Corporate Events

Financial DisclosuresRegulatory Filings and Compliance
Spyre Therapeutics Faces Internal Control Challenges
Negative
Nov 18, 2024

In a rapidly changing financial landscape, our company has identified a significant weakness in our internal control over financial reporting, particularly affecting earnings per share calculations. This issue could lead to material misstatements, impacting our financial condition and stock price. Management is committed to improving controls and believes that remediation efforts will enhance existing systems, but failure to rectify these issues promptly could undermine investor confidence and affect our Nasdaq listing.

Product-Related AnnouncementsBusiness Operations and Strategy
Spyre Therapeutics Reports Promising Trial Results for SPY001
Positive
Nov 12, 2024

Spyre Therapeutics announced the promising interim results from its Phase 1 trial of SPY001, a novel monoclonal antibody targeting α4β7 for the treatment of inflammatory bowel disease. The trial revealed that SPY001, with a half-life exceeding 90 days, was well-tolerated and showed potential for long-term maintenance dosing, either every three or six months. Spyre plans to begin a Phase 2 trial in mid-2025, aiming to enhance the efficacy of current treatments with this innovative therapy and other combinations.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Apr 22, 2025