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Zymeworks Inc (ZYME)
NASDAQ:ZYME
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Zymeworks (ZYME) AI Stock Analysis

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ZYME

Zymeworks

(NASDAQ:ZYME)

Rating:59Neutral
Price Target:
$15.00
▲(19.43%Upside)
Zymeworks' overall stock score reflects a mixed outlook. The company's strong technical momentum and positive earnings call sentiment are undermined by financial performance issues and poor valuation metrics. Key strengths include revenue growth and strategic partnerships, while challenges such as persistent losses and high R&D costs weigh on the score.
Positive Factors
Clinical Development
The FDA has cleared the IND application for ZW251, allowing the company to initiate Phase 1 clinical studies, marking a significant step forward in its development.
Regulatory Approvals
Zanidatamab receives marketing authorization in the E.U. for 2L + HER2+ BTC, highlighting its superior performance with a 51.6% objective response rate compared to the standard 5-15%.
Negative Factors
Financial Stability
The company faces a cash burn of $200 million annually with approximately 2 years of cash left, which could impact financial stability.
Market Sentiment
Investors have questioned data timeline pushes from 2H 2024 to 2Q 2025 and 2H 2025, raising concerns about the trial's progress.

Zymeworks (ZYME) vs. SPDR S&P 500 ETF (SPY)

Zymeworks Business Overview & Revenue Model

Company DescriptionZymeworks Inc., a clinical-stage biopharmaceutical company, discovers, develops, and commercializes biotherapeutics for the treatment of cancer. The company's lead product candidates include zanidatamab, a novel bispecific antibody that is in Phase 1 and Phase 2 clinical trials for the treatment of biliary tract, gastroesophageal adenocarcinomas, breast, and colorectal cancer; and ZW49, a biparatopic anti-human epidermal growth factor receptor 2 (HER2) antibody-drug conjugate that is in Phase 1 clinical trial for the treatment of advanced or metastatic HER2-expressing tumors. The company has strategic partnerships with Merck Sharp & Dohme Research Ltd.; Eli Lilly and Company; Bristol-Myers Squibb company; GlaxoSmithKline Intellectual Property Development Ltd.; Daiichi Sankyo Co., Ltd.; Janssen Biotech, Inc.; BeiGene, Ltd.; and Exelixis, Inc. It also has licensing and research collaboration with LEO Pharma A/S to research, develop, and commercialize bispecific antibodies; and Iconic Therapeutics, Inc. Zymeworks Inc. was incorporated in 2003 and is headquartered in Vancouver, Canada.
How the Company Makes MoneyZymeworks generates revenue primarily through collaborative partnerships, licensing agreements, and milestone payments with other pharmaceutical and biotechnology companies. These partnerships often involve the co-development of therapeutic products, wherein Zymeworks provides its proprietary platforms and expertise in exchange for upfront payments, research funding, and potential milestone and royalty payments based on the successful development and commercialization of the resulting products. Additionally, the company may earn revenue from the direct commercialization of its own therapeutic candidates once they receive regulatory approval and are brought to market. Key partnerships with companies such as Merck and Eli Lilly have significantly contributed to its revenue streams.

Zymeworks Earnings Call Summary

Earnings Call Date:May 08, 2025
(Q1-2025)
|
% Change Since: 10.95%|
Next Earnings Date:Aug 07, 2025
Earnings Call Sentiment Positive
The earnings call reflects a generally positive sentiment with significant revenue growth, strategic partnerships, and a strong cash position outweighing the increased operating expenses.
Q1-2025 Updates
Positive Updates
Significant Revenue Growth
Zymeworks reported a revenue increase to $27.1 million for Q1 2025, up from $10 million in the same period in 2024, largely driven by milestone revenues from partnerships with GSK and Daiichi Sankyo.
Positive Opinion from EMA
The EMA's Committee for Medicinal Products for Human Use adopted a positive opinion for the approval of zanidatamab for advanced HER2+ biliary tract cancer, which could increase royalty revenues for Zymeworks.
Strong Pipeline and Partnerships
Zymeworks presented six posters at the AACR Annual Meeting, showcasing its progress in antibody drug conjugates and T-cell engagers. Notable partnerships with Jazz and JNJ highlight ongoing and future developments.
Reduction in Net Loss
Net loss decreased to $22.6 million for Q1 2025 from $31.7 million in Q1 2024, attributed to increased revenue.
Robust Cash Position
Zymeworks had $321.6 million in cash resources as of March 31, 2025, expected to fund operations into the second half of 2027.
Negative Updates
Increased Operating Expenses
Operating expenses rose to $52.7 million for Q1 2025, a 10% increase from $47.3 million in Q1 2024, driven by higher research and development expenses.
Increased R&D and Administrative Costs
Research and development expenses increased to $35.7 million for Q1 2025, and general and administrative expenses rose to $17 million, primarily due to stock-based compensation.
Company Guidance
During the first quarter of 2025, Zymeworks reported a net loss of $22.6 million, a decrease from $31.7 million in the same period of 2024, due to an increase in revenue to $27.1 million from $10 million, partly driven by milestone revenues from GSK and Daiichi Sankyo. Operating expenses rose by 10% to $52.7 million, mainly from increased R&D expenses, while cash resources slightly decreased to $321.6 million. The company anticipates its cash, combined with expected regulatory milestones, to fund operations into the second half of 2027. Key developments included six poster presentations at AACR, highlighting progress in their antibody drug conjugate and T-cell engager pipeline, and anticipated presentations at upcoming medical conferences. The potential approval of zanidatamab by the EMA could lead to increased royalty revenue, while collaborations like the one with JNJ could yield substantial future financial benefits.

Zymeworks Financial Statement Overview

Summary
Zymeworks is struggling financially with inconsistent revenue growth and persistent losses impacting profitability. The balance sheet shows a strong equity position but limited debt utilization. Cash flows are under pressure, reflecting the need for operational improvements to achieve sustainability.
Income Statement
30
Negative
Zymeworks has experienced significant volatility in its revenue and profitability. The TTM (Trailing-Twelve-Months) shows a gross profit margin of 90.5%, but the net profit margin is negative at -121.7%, indicating substantial net losses. Revenue growth has been inconsistent, with a notable decline from 2022 to 2023, although there was recovery in 2024. EBIT and EBITDA margins remain negative, reflecting ongoing operational challenges.
Balance Sheet
40
Negative
The balance sheet reveals a stable equity base with an equity ratio of 76.4% in TTM, which indicates strong capitalization. However, the debt-to-equity ratio is low at 0.057, suggesting limited leverage use. Return on equity is negative due to net losses, pointing to inefficiencies in generating shareholder value.
Cash Flow
35
Negative
Cash flow analysis shows negative free cash flow in TTM, indicating cash burn. The operating cash flow to net income ratio is 0.65, suggesting cash flow challenges but better than net income. Free cash flow remains negative, affecting the company's ability to fund operations without external financing.
BreakdownDec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income Statement
Total Revenue76.30M76.01M412.48M26.68M38.95M
Gross Profit65.11M-66.98M203.78M-172.86M-131.94M
EBITDA-105.42M-120.70M147.24M-206.09M-177.17M
Net Income-122.69M-118.67M124.34M-211.84M-180.55M
Balance Sheet
Total Assets463.09M580.88M648.73M389.13M538.38M
Cash, Cash Equivalents and Short-Term Investments225.78M374.33M492.23M252.61M426.35M
Total Debt18.48B26.72M28.11M32.33M8.64M
Total Liabilities124.32M116.07M155.77M140.04M128.45M
Stockholders Equity338.77B464.81M492.96M249.09M409.92M
Cash Flow
Free Cash Flow-113.11M-122.38M130.98M-205.74M-157.67M
Operating Cash Flow-110.04M-118.30M144.11M-192.45M-151.40M
Investing Cash Flow38.76M-207.25M-53.85M144.60M-43.44M
Financing Cash Flow-20.45M81.85M108.58M8.01M308.98M

Zymeworks Technical Analysis

Technical Analysis Sentiment
Neutral
Last Price12.56
Price Trends
50DMA
12.77
Positive
100DMA
12.32
Positive
200DMA
13.24
Negative
Market Momentum
MACD
0.22
Positive
RSI
44.69
Neutral
STOCH
17.17
Positive
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For ZYME, the sentiment is Neutral. The current price of 12.56 is below the 20-day moving average (MA) of 13.56, below the 50-day MA of 12.77, and below the 200-day MA of 13.24, indicating a neutral trend. The MACD of 0.22 indicates Positive momentum. The RSI at 44.69 is Neutral, neither overbought nor oversold. The STOCH value of 17.17 is Positive, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Neutral sentiment for ZYME.

Zymeworks Risk Analysis

Zymeworks disclosed 73 risk factors in its most recent earnings report. Zymeworks reported the most risks in the "Tech & Innovation" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks

Zymeworks Peers Comparison

Overall Rating
UnderperformOutperform
Sector (52)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
59
Neutral
$949.12M-29.80%85.05%15.96%
55
Neutral
$966.73M-63.17%-40.51%-35.07%
54
Neutral
$860.82M-50.67%41.86%10.48%
52
Neutral
$7.47B0.53-62.70%2.38%14.92%0.82%
43
Neutral
$940.88M-48.45%7.15%
42
Neutral
$291.78M-62.58%4.28%
33
Underperform
$1.00B-71.44%19.94%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
ZYME
Zymeworks
12.56
2.36
23.14%
RCUS
Arcus Biosciences
9.13
-5.92
-39.34%
REPL
Replimune Group
7.03
-3.07
-30.40%
ORIC
Oric Pharmaceuticals
9.97
0.26
2.68%
NRIX
Nurix Therapeutics
11.26
-9.52
-45.81%
SANA
Sana Biotechnology
4.06
-0.98
-19.44%

Zymeworks Corporate Events

Private Placements and FinancingRegulatory Filings and Compliance
Zymeworks Amends Warrant Agreement with EcoR1 Capital
Neutral
Jun 27, 2025

On June 26, 2025, Zymeworks Inc. amended its Pre-Funded Warrants agreement with EcoR1 Capital Fund, removing a limitation that restricted the exercise of warrants if it led to ownership exceeding 19.99% of the company’s shares. This amendment facilitated the full exercise of 5,086,521 Pre-Funded Warrants by EcoR1, resulting in the issuance of 5,086,480 shares of common stock, increasing the total outstanding shares to 74,844,505 as of June 27, 2025. The transaction was exempt from registration under the Securities Act of 1933.

The most recent analyst rating on (ZYME) stock is a Buy with a $25.00 price target. To see the full list of analyst forecasts on Zymeworks stock, see the ZYME Stock Forecast page.

Business Operations and StrategyRegulatory Filings and Compliance
Zymeworks Updates Communication Channels for Stakeholders
Neutral
May 8, 2025

Zymeworks announces that it communicates material information through various channels, including filings with the Securities and Exchange Commission, press releases, and social media platforms. The company encourages stakeholders to review these sources for important updates, as they may contain significant information about the company’s operations and product candidates.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Jul 18, 2025