EyePoint Pharmaceuticals (EYPT) AI Stock Analysis

• Market Cap: $825.75M
• Dividend Yield: N/A
• Average Volume (3M): 1.32M
• Price to Earnings (P/E): ―
• Beta (1Y): 2.07
• Revenue Growth: 2.99%
• EPS Growth: -49.11%
• Country: US
• Employees: 165
• Sector: Healthcare
• Sector Strength: 45
• Industry: Biotechnology
• EPS (TTM): -0.85
• Shares Outstanding: 68,927,420
• 10 Day Avg. Volume: 1,687,443
• 30 Day Avg. Volume: 1,324,642
• PEG Ratio: -0.12
• Price to Book (P/B): 1.25
• Price to Sales (P/S): 9.69
• P/FCF Ratio: -3.22
• Enterprise Value/Market Cap: 0.51
• Enterprise Value/Revenue: 8.17
• Enterprise Value/Gross Profit: 8.59
• Enterprise Value/Ebitda: -2.40
• 1Y Price Target: $33.00
• Price Target Upside: 172.50% Upside
• Rating Consensus: Strong Buy
• Number of Analyst Covering: 7

• Rating: 47 Neutral
• Price Target: $12.00 ▼(-0.91% Downside)

EyePoint Pharmaceuticals' overall stock score is primarily influenced by its financial performance challenges, including negative profitability and cash flow issues. The technical analysis suggests mixed signals with short-term bearish momentum but potential for a reversal. The earnings call provides optimism with significant clinical progress and a strong cash position, but valuation remains a concern due to ongoing losses and lack of dividends.

Positive Factors

Strong Financial Position

A robust cash position ensures operational stability and supports strategic initiatives, allowing the company to focus on long-term growth and innovation without immediate financial constraints.

Phase III Trial Progress

Successful trial enrollment and progress towards regulatory approval for DURAVYU positions EyePoint as a leader in wet-AMD treatment, potentially transforming its market presence and driving future revenue.

Manufacturing Facility Completion

The new facility enhances production capabilities, supporting commercial scale-up and ensuring quality control, which is vital for meeting future demand and sustaining competitive advantage.

Negative Factors

Decreased Revenue

A significant drop in revenue indicates potential challenges in market penetration or product demand, which could affect the company's ability to fund future growth and innovation.

Increased Operating Expenses

Rising operating costs, primarily from clinical trials, may pressure margins and cash flow, necessitating efficient cost management to maintain financial health and support long-term objectives.

Net Loss Increase

An increasing net loss reflects ongoing profitability challenges, which can hinder reinvestment in R&D and strategic initiatives, potentially impacting future growth and market competitiveness.

EyePoint Pharmaceuticals Business Overview & Revenue Model

Company Description

EyePoint Pharmaceuticals, Inc. is a biotechnology company focused on developing and commercializing innovative therapies for eye diseases. The company specializes in sustained-release drug delivery systems to treat chronic ocular conditions, particularly in the areas of retinal diseases, glaucoma, and ocular inflammation. EyePoint's core products include Yutiq, an implant for the treatment of non-infectious uveitis, and Dextenza, a dissolvable insert for the treatment of post-surgical pain and inflammation.

How the Company Makes Money

EyePoint Pharmaceuticals generates revenue primarily through the sale of its FDA-approved products Yutiq and Dextenza. The company benefits from a direct sales force that markets these products to healthcare providers, contributing to its revenue streams. Additionally, EyePoint may engage in partnerships or collaborations with other pharmaceutical companies to expand its product offerings and reach new markets, which can also enhance its earnings potential. Furthermore, the company may explore licensing agreements for its proprietary drug delivery technologies, providing another avenue for revenue generation.

EyePoint Pharmaceuticals Financial Statement Overview

Summary

EyePoint Pharmaceuticals shows revenue growth but struggles with profitability and cash flow management. The balance sheet is strong with low leverage, yet persistent negative returns and cash flow challenges pose risks. Strategic focus on improving operational efficiency and cost management is crucial.

Income Statement

EyePoint Pharmaceuticals shows a mixed performance. Revenue grew from 2024 to TTM (Trailing-Twelve-Months) by 29.5%, indicating a positive growth trajectory. However, profitability remains a concern with significant negative net profit margins of -261.8% in TTM, alongside negative EBIT and EBITDA margins. This suggests challenges in controlling costs and generating profits despite increasing revenues.

Balance Sheet

The company maintains a strong equity position, with a debt-to-equity ratio of only 0.08 in the TTM (Trailing-Twelve-Months). The equity ratio stands at 82.3%, indicating a solid balance sheet with low leverage. However, the return on equity is negative, reflecting ongoing profitability challenges that may affect future financial stability.

Cash Flow

EyePoint Pharmaceuticals faces significant cash flow issues. The free cash flow is negative, and the operating cash flow to net income ratio is unfavorable, indicating that the company is using more cash in operations than it generates. The free cash flow to net income ratio is also negative, highlighting a need for improved cash management and operational efficiency.

Breakdown	TTM	Dec 2024	Dec 2023	Dec 2022	Dec 2021	Dec 2020
Income Statement
Total Revenue	51.90M	43.27M	46.02M	41.40M	36.94M	34.44M
Gross Profit	49.38M	39.56M	41.39M	33.08M	28.76M	28.61M
EBITDA	-176.92M	-129.23M	-69.00M	-96.62M	-50.15M	-35.49M
Net Income	-175.38M	-130.87M	-70.80M	-102.25M	-58.42M	-45.39M
Balance Sheet
Total Assets	301.15M	418.46M	355.18M	180.36M	263.37M	91.72M
Cash, Cash Equivalents and Short-Term Investments	255.73M	370.91M	331.05M	144.56M	211.56M	44.91M
Total Debt	21.82M	21.86M	4.91M	46.35M	39.20M	40.99M
Total Liabilities	55.14M	81.96M	88.86M	83.99M	78.99M	73.18M
Stockholders Equity	246.01M	336.50M	266.32M	96.37M	184.38M	18.54M
Cash Flow
Free Cash Flow	-194.04M	-130.28M	-1.61M	-67.16M	-50.25M	-14.80M
Operating Cash Flow	-190.59M	-126.23M	1.88M	-65.00M	-50.10M	-14.44M
Investing Cash Flow	8.10M	-219.35M	-3.31M	-17.27M	-33.12M	-362.00K
Financing Cash Flow	162.87M	164.02M	187.07M	-690.00K	216.90M	37.49M

EyePoint Pharmaceuticals Technical Analysis

• Technical Analysis Sentiment: Positive
• Last Price: 12.11
• 50DMA: Negative
• 100DMA: Positive
• 200DMA: Positive
• MACD: Positive
• RSI: Neutral
• STOCH: Neutral

Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For EYPT, the sentiment is Positive. The current price of 12.11 is below the 20-day moving average (MA) of 12.75, below the 50-day MA of 12.77, and above the 200-day MA of 8.91, indicating a neutral trend. The MACD of -0.36 indicates Positive momentum. The RSI at 45.26 is Neutral, neither overbought nor oversold. The STOCH value of 29.97 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Positive sentiment for EYPT.

EyePoint Pharmaceuticals Peers Comparison

Name	Overall Rating	Market Cap	P/E Ratio	ROE	Dividend Yield	Revenue Growth	EPS Growth
STOK	―	$1.77B	38.20	18.17%	―	1218.82%	―
PHAR	―	$931.40M	―	-3.40%	―	22.68%	42.45%
Sector *	―	$7.86B	-0.30	-43.30%	2.27%	22.53%	-2.21%
MGTX	―	$701.50M	―	-379.53%	―	366.84%	-35.87%
URGN	―	$877.63M	-6.28	―	―	10.85%	-1.41%
EYPT	―	$825.75M	-4.52	-73.95%	―	2.99%	-49.11%
TNGX	―	$833.90M	―	-76.09%	―	-42.84%	-17.32%

EyePoint Pharmaceuticals Corporate Events

EyePoint Pharma’s DEXYCU Study: A Potential Game-Changer in Pediatric Cataract Treatment

EyePoint Pharmaceuticals is conducting a Phase 3/4 clinical study titled ‘A Phase 3/4, Prospective, Randomized, Active Treatment-Controlled, Parallel-Design, Multicenter Study to Evaluate the Safety of DEXYCU for the Treatment of Inflammation Following Ocular Surgery for Childhood Cataract.’ The study aims to assess the safety of DEXYCU, a dexamethasone intraocular suspension, in treating inflammation after ocular surgery in children with cataracts, a significant concern in pediatric ophthalmology.

EyePoint Pharmaceuticals Raises $141M in Public Offering

On October 14, 2025, EyePoint Pharmaceuticals announced an underwritten public offering of 11,000,000 shares of its common stock and pre-funded warrants for 1,500,000 shares, raising approximately $141 million. The offering, which closed on October 16, 2025, aims to fund the clinical development of DURAVYU™ and support pipeline initiatives. This move is expected to bolster EyePoint’s financial position and advance its strategic objectives in the biopharmaceutical industry.

The most recent analyst rating on (EYPT) stock is a Hold with a $11.50 price target. To see the full list of analyst forecasts on EyePoint Pharmaceuticals stock, see the EYPT Stock Forecast page.

EyePoint Pharmaceuticals Launches Phase 3 DURAVYU Program

On October 14, 2025, EyePoint Pharmaceuticals announced the initiation of its pivotal Phase 3 program for DURAVYU, targeting diabetic macular edema (DME), with first patient dosing expected in Q1 2026. The program follows a non-inferiority approval pathway and includes two trials, COMO and CAPRI, each enrolling approximately 240 patients. New preclinical data highlights DURAVYU’s potential as a multi-mechanism treatment, inhibiting both VEGF-mediated vascular permeability and IL-6 mediated inflammation, which are key contributors to DME and wet AMD. This advancement positions DURAVYU as a promising option for addressing the multifactorial nature of DME and reducing treatment burdens for patients.

The most recent analyst rating on (EYPT) stock is a Buy with a $28.00 price target. To see the full list of analyst forecasts on EyePoint Pharmaceuticals stock, see the EYPT Stock Forecast page.

EyePoint Pharmaceuticals Completes Promising Study on EYP-1901 for Diabetic Retinopathy

EyePoint Pharmaceuticals has recently completed a Phase 2 clinical study titled A Phase 2, Multicenter, Prospective, Double-masked, Parallel Study of EYP-1901, a Tyrosine Kinase Inhibitor (TKI), Compared to Sham for the Improvement of Moderately Severe to Severe Nonproliferative Diabetic Retinopathy (NPDR). The study aimed to evaluate the efficacy and safety of EYP-1901, a novel intravitreal drug, in improving the condition of patients with NPDR. This study is significant as it explores a potential new treatment option for diabetic retinopathy, a leading cause of blindness.

EyePoint Pharma’s Earnings Call: Clinical Wins Amid Financial Challenges

EyePoint Pharma’s recent earnings call painted a picture of strong operational execution and clinical progress, despite financial challenges. The company showcased rapid enrollment in pivotal trials and robust financial positioning, although it faced a decline in revenue and increased losses due to higher operating costs. This balance of positive clinical achievements and financial hurdles was a key theme throughout the call.

EyePoint Pharma Advances DURAVYU Trials Amid Financial Challenges

EyePoint Pharmaceuticals, Inc. is a clinical-stage biopharmaceutical company focused on developing and commercializing innovative treatments for serious retinal diseases, with its lead product candidate DURAVYU™ aimed at improving patient outcomes in conditions such as wet age-related macular degeneration (AMD) and diabetic macular edema (DME).

EyePoint Completes Enrollment for Phase 3 Trials

On July 29, 2025, EyePoint Pharmaceuticals announced the completion of enrollment for its Phase 3 pivotal trials, LUGANO and LUCIA, evaluating DURAVYU for wet AMD. The trials enrolled over 800 patients, marking one of the fastest enrollments for such programs. Interim safety data confirmed DURAVYU’s favorable safety profile, with no serious adverse events related to the drug. The trials are designed to support regulatory approval and aim to reduce treatment burden with a 6-month redosing schedule, potentially shifting the treatment paradigm for wet AMD.

The most recent analyst rating on (EYPT) stock is a Buy with a $30.00 price target. To see the full list of analyst forecasts on EyePoint Pharmaceuticals stock, see the EYPT Stock Forecast page.