Meiragtx Holdings (MGTX) AI Stock Analysis

• Market Cap: $585.97M
• Dividend Yield: N/A
• Average Volume (3M): 462.09K
• Price to Earnings (P/E): ―
• Beta (1Y): 1.40
• Revenue Growth: 96.83%
• EPS Growth: -61.92%
• Country: US
• Employees: 375
• Sector: Healthcare
• Sector Strength: 45
• Industry: Biotechnology
• EPS (TTM): -0.62
• Shares Outstanding: 80,490,890
• 10 Day Avg. Volume: 351,599
• 30 Day Avg. Volume: 462,092
• PEG Ratio: -0.07
• Price to Book (P/B): 6.27
• Price to Sales (P/S): 12.78
• P/FCF Ratio: -3.89
• Enterprise Value/Market Cap: 1.26
• Enterprise Value/Revenue: 26.97
• Enterprise Value/Gross Profit: 65.76
• Enterprise Value/Ebitda: -5.15
• 1Y Price Target: $21.50
• Price Target Upside: 195.33% Upside
• Rating Consensus: Strong Buy
• Number of Analyst Covering: 6
• EPS Forecast (FY): -1.08
• Revenue Forecast (FY): $134.51M

• Rating: 47 Neutral
• Price Target: $7.50 ▲(3.02% Upside)

The score is held down primarily by weak financial performance (declining revenue, heavy losses, high leverage/negative equity, and negative cash flows) and bearish technical signals. Offsetting these risks, recent corporate events—especially the Eli Lilly collaboration and the share repurchase/lock-up—provide meaningful strategic and financing support.

Positive Factors

Strategic Collaboration

The collaboration with Eli Lilly provides a $75 million upfront payment and potential milestone payments, enhancing MeiraGTx's revenue streams and solidifying its leadership in genetic medicine.

Revenue Growth

A substantial revenue growth rate indicates strong market demand for MeiraGTx's gene therapy products, supporting long-term business expansion and sustainability.

Market Position

Success in the AAV-AIPL1 program for vision restoration highlights MeiraGTx's innovative edge and strengthens its competitive position in the gene therapy market.

Negative Factors

Financial Instability

The negative equity and high leverage indicate financial instability, which can hinder MeiraGTx's ability to invest in R&D and limit operational flexibility.

Profitability Challenges

Persistent negative profit margins reflect ongoing struggles to achieve profitability, necessitating significant improvements in cost management and revenue generation.

Cash Flow Difficulties

Negative cash flows highlight challenges in generating sufficient cash to support operations, increasing reliance on external financing and impacting long-term viability.

Meiragtx Holdings Business Overview & Revenue Model

Company Description

MeiraGTx Holdings plc, a clinical stage gene therapy company, focusing on developing treatments for patients with serious diseases. The company develops various therapies for ocular diseases, including inherited blindness, as well as Xerostomia following radiation treatment for head and neck cancers; degenerative diseases; neurodegenerative diseases, such as amyotrophic lateral sclerosis; and Parkinson's diseases. Its programs in clinical development include Phase 1/2 clinical stage programs in Achromatopsia, X-Linked Retinitis Pigmentosa, RPE65-deficiency, and radiation-induced Xerostomia, as well as Parkinson's program. The company also focuses on initiating a clinical program in xerostomia related to Sjogren's syndrome and have preclinical programs in neurodegenerative diseases. It has a research collaboration agreement with Janssen Pharmaceuticals, Inc. to develop regulatable gene therapy treatment using the company's proprietary riboswitch technology. MeiraGTx Holdings plc was incorporated in 2015 and is based in New York, New York.

How the Company Makes Money

Meiragtx Holdings generates revenue primarily through the development and commercialization of its gene therapy products. The company earns money by conducting clinical trials and subsequently bringing successful therapies to market, which can lead to significant sales revenue from healthcare providers and patients. Additionally, MGTX may enter into strategic partnerships and collaborations with larger pharmaceutical companies for co-development and marketing of its therapies, receiving milestone payments and royalties based on sales performance. Grants and funding from research institutions or government bodies can also contribute to its revenue, especially in the early stages of product development.

Meiragtx Holdings Financial Statement Overview

Summary

Meiragtx Holdings is facing significant financial challenges, including declining revenues, negative profit margins, high leverage, and cash flow difficulties. The income statement, balance sheet, and cash flow scores are all low, reflecting the need for substantial improvement in revenue generation, cost management, and financial stability.

Income Statement

Meiragtx Holdings has faced significant challenges in its income statement, with declining revenue and negative profit margins. The TTM data shows a revenue decline of 27.69%, and the net profit margin is deeply negative at -415.39%. The company is struggling to achieve profitability, as indicated by negative EBIT and EBITDA margins. These factors contribute to a low score, reflecting the need for substantial improvement in revenue generation and cost management.

Balance Sheet

The balance sheet reveals a concerning financial position with a negative stockholders' equity and a high debt-to-equity ratio of 27.19 in the TTM period. This indicates significant leverage and financial instability. The return on equity is also negative, highlighting the company's inability to generate returns for shareholders. The equity ratio is not calculable due to negative equity, further emphasizing financial distress.

Cash Flow

Cash flow analysis shows negative operating and free cash flows, with a slight improvement in free cash flow to net income ratio at 1.04 in the TTM period. However, the operating cash flow to net income ratio is negative, indicating cash flow challenges. The company needs to enhance its cash generation capabilities to support operations and reduce reliance on external financing.

Breakdown	TTM	Dec 2024	Dec 2023	Dec 2022	Dec 2021	Dec 2020
Income Statement
Total Revenue	27.42M	33.28M	14.02M	15.92M	37.70M	15.56M
Gross Profit	11.24M	9.49M	14.02M	15.92M	37.70M	15.56M
EBITDA	-143.50M	-121.69M	-57.05M	-116.07M	-71.40M	-53.68M
Net Income	-168.69M	-147.79M	-84.03M	-129.62M	-79.56M	-57.99M
Balance Sheet
Total Assets	189.47M	269.75M	326.74M	318.24M	320.16M	363.70M
Cash, Cash Equivalents and Short-Term Investments	14.84M	103.66M	129.57M	115.52M	137.70M	209.52M
Total Debt	88.06M	84.80M	89.26M	92.25M	23.73M	22.25M
Total Liabilities	230.03M	201.92M	188.57M	200.50M	134.76M	125.14M
Stockholders Equity	-40.56M	67.83M	138.18M	117.74M	185.40M	238.56M
Cash Flow
Free Cash Flow	-121.04M	-109.45M	-125.54M	-118.06M	-65.75M	-100.99M
Operating Cash Flow	-116.27M	-104.50M	-105.36M	-73.10M	-10.53M	-63.97M
Investing Cash Flow	-4.24M	23.48M	34.03M	-44.96M	-61.72M	-37.02M
Financing Cash Flow	11.19M	54.53M	84.02M	95.20M	1.71M	82.73M

Meiragtx Holdings Technical Analysis

• Technical Analysis Sentiment: Negative
• Last Price: 7.28
• 50DMA: Negative
• 100DMA: Negative
• 200DMA: Negative
• MACD: Positive
• RSI: Neutral
• STOCH: Neutral

Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For MGTX, the sentiment is Negative. The current price of 7.28 is below the 20-day moving average (MA) of 8.08, below the 50-day MA of 8.21, and below the 200-day MA of 7.39, indicating a bearish trend. The MACD of -0.20 indicates Positive momentum. The RSI at 37.60 is Neutral, neither overbought nor oversold. The STOCH value of 22.12 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Negative sentiment for MGTX.

Meiragtx Holdings Peers Comparison

Name	Overall Rating	Market Cap	P/E Ratio	ROE	Dividend Yield	Revenue Growth	EPS Growth
TSHA	61 Neutral	$1.41B	-14.50	-64.93%	―	-36.36%	-945.72%
TERN	61 Neutral	$4.02B	-36.60	-29.12%	―	―	12.45%
ERAS	52 Neutral	$1.65B	-12.89	-32.00%	―	―	45.66%
Sector *	51 Neutral	$7.86B	-0.30	-43.30%	2.27%	22.53%	-2.21%
MGTX	47 Neutral	$585.97M	―	-611.42%	―	96.83%	-61.92%
FDMT	47 Neutral	$417.09M	-1.85	-45.38%	―	―	―

Meiragtx Holdings Corporate Events

MeiraGTx Announces Share Repurchase and Investor Lock-Up

On December 31, 2025, MeiraGTx Holdings plc agreed to repurchase 2.3 million of its ordinary shares from Perceptive Life Sciences Master Fund, an affiliate of Perceptive Advisors, at $7.91 per share, matching the Nasdaq volume-weighted average price that day, for a total of approximately $18.2 million; Perceptive Master Fund sold the shares as part of year-end portfolio tax optimization. As part of the agreement, Perceptive Master Fund and its affiliates, which collectively own more than 10% of MeiraGTx’s outstanding shares and whose affiliate Perceptive Credit Holdings III also holds a $75 million company note, consented to the repurchase and accepted a 12‑month lock-up on further share sales, a move that reinforces a stable shareholder base and underscores the tight financial and governance links between MeiraGTx and its key biotech-focused investor, whose executive Ellen Hukkelhoven also serves on the company’s board.

The most recent analyst rating on (MGTX) stock is a Buy with a $20.00 price target. To see the full list of analyst forecasts on Meiragtx Holdings stock, see the MGTX Stock Forecast page.

MeiraGTx and Eli Lilly Collaborate on Genetic Medicines

On November 7, 2025, MeiraGTx entered into a strategic collaboration with Eli Lilly to develop and commercialize genetic medicines in ophthalmology. The agreement grants Lilly exclusive rights to MeiraGTx’s AAV-AIPL1 program, which has shown unprecedented success in restoring vision in children with Leber congenital amaurosis 4. MeiraGTx will receive a $75 million upfront payment and is eligible for over $400 million in milestone payments, along with tiered royalties. This collaboration highlights MeiraGTx’s leadership in genetic medicine and Lilly’s interest in expanding its ophthalmology portfolio, potentially bringing transformative treatments to patients worldwide.

The most recent analyst rating on (MGTX) stock is a Hold with a $9.50 price target. To see the full list of analyst forecasts on Meiragtx Holdings stock, see the MGTX Stock Forecast page.