Caribou Biosciences (CRBU)
NASDAQ:CRBU
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Caribou Biosciences
(NASDAQ:CRBU)
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Rating:47Neutral
Price Target:
$2.00
▼(-9.09% Downside)
Action:ReiteratedDate:04/01/26
The score is held down primarily by weak financial performance (near-zero 2025 revenue, heavy losses, and sustained cash burn with equity erosion). Technicals are only modestly supportive with mixed trend and subdued momentum. A meaningful offset is the positive RMAT designation for CB-011, but it does not fully counterbalance current financial and funding risk.
Positive Factors
RMAT designation (CB-011)
RMAT status provides an enduring regulatory advantage: it can enable expedited review, increased FDA engagement, and priority development pathways. Over 2–6 months this materially lowers regulatory uncertainty for CB-011 and improves the probability of streamlined approval timelines.
Negative Factors
Persistent cash burn
Sustained large negative operating and free cash flow indicates the company repeatedly consumes capital to fund trials. Over months this elevates refinancing risk, forces dilution or restructuring of collaborations, and constrains investment in broader pipeline development absent new funding.
Read all positive and negative factors
Positive Factors
Negative Factors
RMAT designation (CB-011)
RMAT status provides an enduring regulatory advantage: it can enable expedited review, increased FDA engagement, and priority development pathways. Over 2–6 months this materially lowers regulatory uncertainty for CB-011 and improves the probability of streamlined approval timelines.
Read all positive factors
Caribou Biosciences (CRBU) vs. SPDR S&P 500 ETF (SPY)
Market Cap
$212.60M
Dividend YieldN/A
Average Volume (3M)1.20M
Price to Earnings (P/E)―
Beta (1Y)2.14
Revenue Growth-19.00%
EPS Growth-2.72%
CountryUS
Employees147
SectorHealthcare
Sector Strength45
IndustryBiotechnology
Share Statistics
EPS (TTM)-0.28
Shares Outstanding96,637,200
10 Day Avg. Volume1,354,975
30 Day Avg. Volume1,199,069
Financial Highlights & Ratios
PEG Ratio0.28
Price to Book (P/B)1.22
Price to Sales (P/S)13.31
P/FCF Ratio-1.32
Enterprise Value/Market Cap1.07
Enterprise Value/Revenue20.38
Enterprise Value/Gross Profit23.10
Enterprise Value/Ebitda-1.74
Forecast
1Y Price Target
$8.75Price Target Upside297.73% Upside
Rating ConsensusStrong Buy
Number of Analyst Covering8
EPS Forecast (FY)-1.34
Revenue Forecast (FY)$21.44M
Caribou Biosciences Business Overview & Revenue Model
Company Description
Caribou Biosciences, Inc., a clinical-stage biopharmaceutical company, engages in the development of genome-edited allogeneic cell therapies for the treatment of hematologic malignancies and solid tumors in the United States and internationally. I...
How the Company Makes Money
Caribou Biosciences primarily generates revenue through collaboration and licensing arrangements tied to its genome-editing technologies and development programs. These agreements typically include upfront payments, research funding or cost reimbu...
Caribou Biosciences Financial Statement Overview
Summary
Income Statement
18
Very Negative
Balance Sheet
42
Neutral
Cash Flow
20
Very Negative
| Breakdown | Dec 2025 | Dec 2024 | Dec 2023 | Dec 2022 | Dec 2021 |
|---|---|---|---|---|---|
Income Statement | |||||
| Total Revenue | 11.16M | 9.99M | 34.48M | 13.85M | 9.60M |
| Gross Profit | 7.51M | 6.07M | 30.95M | 10.21M | 8.61M |
| EBITDA | -132.55M | -162.69M | -112.53M | -95.71M | -65.61M |
| Net Income | -148.13M | -149.10M | -102.07M | -99.42M | -66.92M |
Balance Sheet | |||||
| Total Assets | 175.37M | 313.31M | 432.21M | 373.76M | 442.36M |
| Cash, Cash Equivalents and Short-Term Investments | 139.34M | 209.54M | 328.83M | 247.66M | 375.83M |
| Total Debt | 27.23M | 26.49M | 27.11M | 27.75M | 259.00K |
| Total Liabilities | 53.19M | 60.36M | 63.81M | 72.89M | 54.53M |
| Stockholders Equity | 122.17M | 252.95M | 368.40M | 300.87M | 387.82M |
Cash Flow | |||||
| Free Cash Flow | -112.35M | -144.71M | -104.90M | -97.42M | -35.64M |
| Operating Cash Flow | -110.99M | -138.20M | -93.29M | -90.97M | -32.52M |
| Investing Cash Flow | 102.24M | 86.61M | -68.18M | -93.25M | -176.40M |
| Financing Cash Flow | 4.82M | 16.72M | 154.30M | 2.13M | 433.43M |
Caribou Biosciences Technical Analysis
Positive
2.20
Price Trends
1.85
Positive
1.76
Positive
1.91
Positive
Market Momentum
0.07
Negative
61.67
Neutral
87.05
Negative
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For CRBU, the sentiment is Positive. The current price of 2.2 is above the 20-day moving average (MA) of 1.94, above the 50-day MA of 1.85, and above the 200-day MA of 1.91, indicating a bullish trend. The MACD of 0.07 indicates Negative momentum. The RSI at 61.67 is Neutral, neither overbought nor oversold. The STOCH value of 87.05 is Negative, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Positive sentiment for CRBU.
Caribou Biosciences Risk Analysis
Caribou Biosciences disclosed 83 risk factors in its most recent earnings report. Caribou Biosciences reported the most risks in the "Tech & Innovation" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks
Caribou Biosciences Peers Comparison
UnderperformOutperform
Sector (51)
Name | Overall Rating | Market Cap | P/E Ratio | ROE | Dividend Yield | Revenue Growth | EPS Growth |
|---|---|---|---|---|---|---|---|
51 Neutral | $7.86B | -0.30 | -43.30% | 2.27% | 22.53% | -2.21% | |
50 Neutral | $303.59M | -4.62 | -69.63% | ― | 158.54% | 66.90% | |
50 Neutral | $378.50M | -1.34 | -121.73% | ― | ― | -17.21% | |
50 Neutral | $216.71M | -3.95 | -977.67% | ― | ― | 17.36% | |
47 Neutral | $212.60M | -1.42 | -74.28% | ― | -19.00% | -2.72% | |
47 Neutral | $113.97M | -0.95 | -2983.24% | ― | -37.13% | 40.47% | |
47 Neutral | $762.02M | -0.19 | 72.70% | ― | ― | -1072.48% |
* Healthcare Sector Average
CRBU
Caribou Biosciences
2.20
1.40
175.00%
SGMO
Sangamo Therapeutics
0.26
-0.47
-64.40%
CLLS
Cellectis SA
4.42
3.04
220.29%
CABA
Cabaletta Bio
3.44
2.27
194.02%
ELTX
Elicio Therapeutics
13.55
8.75
182.29%
VOR
Vor Biopharma
16.59
2.86
20.83%
Caribou Biosciences Corporate Events
Business Operations and StrategyProduct-Related AnnouncementsRegulatory Filings and Compliance
Caribou Biosciences Gains RMAT Status for CB-011 Therapy
Positive
Mar 31, 2026
On March 31, 2026, Caribou Biosciences announced that the U.S. Food and Drug Administration granted Regenerative Medicine Advanced Therapy designation to CB-011, its allogeneic anti-BCMA CAR-T cell therapy for relapsed or refractory multiple myelo...
Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
Disclaimer
This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.