Sangamo Biosciences (SGMO) AI Stock Analysis

• Market Cap: $162.92M
• Dividend Yield: N/A
• Average Volume (3M): 6.13M
• Price to Earnings (P/E): ―
• Beta (1Y): 1.31
• Revenue Growth: 565.52%
• EPS Growth: 79.44%
• Country: US
• Employees: 183
• Sector: Healthcare
• Sector Strength: 41
• Industry: Biotechnology
• EPS (TTM): -0.08
• Shares Outstanding: 301,709,470
• 10 Day Avg. Volume: 6,938,033
• 30 Day Avg. Volume: 6,132,180
• PEG Ratio: N/A
• Price to Book (P/B): N/A
• Price to Sales (P/S): N/A
• P/FCF Ratio: N/A
• Enterprise Value/Market Cap: 0.76
• Enterprise Value/Revenue: 1.52
• Enterprise Value/Gross Profit: 1.56
• Enterprise Value/Ebitda: -2.18
• 1Y Price Target: $3.90
• Price Target Upside: 572.41% Upside
• Rating Consensus: Moderate Buy
• Number of Analyst Covering: 6

• Rating: 46 Neutral
• Price Target: $0.50 ▼(-13.79% Downside)

Sangamo Biosciences faces significant financial challenges, with declining revenue and persistent negative cash flows being the most impactful factors. While there are promising developments in the clinical pipeline and positive corporate events, the financial instability and reliance on future funding and partnerships pose substantial risks. The technical analysis and valuation offer limited support, resulting in a cautious overall stock score.

Positive Factors

Clinical Trials

The registrational Phase 1/2 STAAR trial in Fabry disease has delivered positive top-line results across renal, cardiac, and quality-of-life endpoints.

Partnerships

The proprietary STAC-BBB capsid has now attracted three blue-chip pharma partnerships, generating $88 million in upfront payments with more than $4.6 billion in potential milestones.

Regulatory Pathway

SGMO announced alignment with FDA on a regulatory pathway to accelerated filing for their AAV-based GTx '920 for Fabry disease.

Negative Factors

Financial Performance

SGMO reported a net loss of ~$20M.

Risks

Risks include clinical development risk tied to isa-vec, commercialization risk, and reimbursement risk among others.

Sangamo Biosciences Business Overview & Revenue Model

Company Description

Sangamo Therapeutics, Inc., a clinical-stage biotechnology company, focuses on translating science into genomic medicines that transform patients' lives using platform technologies in gene therapy, cell therapy, genome editing, and genome regulation. The company offers zinc finger protein (ZFP), a technology platform for making zinc finger nucleases, which are proteins used in modifying DNA sequences by adding or knocking out specific genes; and ZFP transcription factors proteins used in increasing or decreasing gene expression. It develops SB-525, which is in Phase III AFFINE clinical trial for the treatment of hemophilia A; ST-920, a gene therapy, which is in Phase I/II STAAR clinical trials for the treatment of Fabry disease; and SAR445136, a cell therapy, which is in Phase I/II PRECIZN-1 clinical trials for the treatment of sickle cell disease. The company also develops TX200, chimeric antigen receptor for the treatment of HLA-A2 mismatched kidney transplant rejection; KITE-037, a cell therapy for the treatment of cancer; ST-501 for the treatment of tauopathies; and ST-502 for the treatment of synucleinopathies, including Parkinson's disease and neuromuscular disease. It has collaborative and strategic partnerships with Biogen MA, Inc.; Kite Pharma, Inc.; Pfizer Inc.; Sanofi S.A.; Novartis Institutes for BioMedical Research, Inc.; Shire International GmbH; Dow AgroSciences LLC; Sigma-Aldrich Corporation; Genentech, Inc.; Open Monoclonal Technology, Inc.; F. Hoffmann-La Roche Ltd and Hoffmann-La Roche Inc.; and California Institute for Regenerative Medicine. The company was formerly known as Sangamo BioSciences, Inc. and changed its name to Sangamo Therapeutics, Inc. in January 2017. Sangamo Therapeutics, Inc. was incorporated in 1995 and is headquartered in Brisbane, California.

How the Company Makes Money

Sangamo generates revenue through a combination of collaborations, licensing agreements, and funding from governmental grants and private investments. Key revenue streams include milestone payments and royalties from partnerships with major pharmaceutical companies, such as Pfizer and Biogen, in which Sangamo provides its gene editing technology for the development of novel therapies. Additionally, the company may receive upfront payments in collaboration agreements, as well as potential future earnings tied to the successful commercialization of partnered products. Sangamo also engages in research grants and funding opportunities to support its R&D efforts, further contributing to its overall revenue.

Sangamo Biosciences Financial Statement Overview

Summary

Sangamo Biosciences is facing significant financial challenges across all verticals. The company exhibits declining revenue and profitability, a weakening balance sheet with increased leverage, and persistent negative cash flows. These factors collectively indicate financial instability and increased operational risks, which require strategic interventions to stabilize the company's financial health.

Income Statement

Sangamo Biosciences has shown significant volatility in its revenue and profitability metrics. There has been a substantial decline in total revenue from $176.23M in 2023 to $57.8M in 2024, representing a negative revenue growth trend. Gross profit margins have been inconsistent, and the company consistently reports negative EBIT and net income margins, indicating ongoing operational and profitability challenges.

Balance Sheet

The balance sheet reflects a strained financial position with a declining equity base, from $82.89M in 2023 to $22.77M in 2024. The debt-to-equity ratio has worsened due to reduced equity, suggesting increased leverage. The equity ratio declined significantly, indicating reduced shareholder equity relative to total assets, potentially increasing financial risk.

Cash Flow

The cash flow statements highlight persistent negative free cash flow, with a slight improvement from -$246M in 2023 to -$67.4M in 2024. Operating cash flow has remained negative, raising concerns about the company's ability to generate cash from operations. The free cash flow to net income ratio remains unfavorable, reflecting poor cash conversion.

Breakdown	TTM	Dec 2024	Dec 2023	Dec 2022	Dec 2021	Dec 2020
Income Statement
Total Revenue	81.71M	57.80M	176.23M	111.30M	110.70M	118.19M
Gross Profit	79.58M	57.80M	154.04M	99.19M	101.26M	-62.45M
EBITDA	-56.86M	-89.09M	-240.71M	-189.17M	-173.90M	-123.87M
Net Income	-63.31M	-97.94M	-257.83M	-192.28M	-178.30M	-121.12M
Balance Sheet
Total Assets	97.56M	101.64M	165.32M	562.51M	721.92M	938.55M
Cash, Cash Equivalents and Short-Term Investments	38.34M	41.92M	81.00M	277.63M	376.55M	641.42M
Total Debt	23.46M	30.57M	38.10M	43.11M	48.08M	42.09M
Total Liabilities	77.96M	78.86M	82.43M	267.55M	346.58M	441.18M
Stockholders Equity	19.60M	22.77M	82.89M	294.96M	375.34M	497.37M
Cash Flow
Free Cash Flow	-36.19M	-67.41M	-246.00M	-243.80M	-256.53M	155.16M
Operating Cash Flow	-35.90M	-67.14M	-224.84M	-223.63M	-233.25M	169.88M
Investing Cash Flow	1.53M	37.52M	153.53M	59.28M	248.20M	-271.63M
Financing Cash Flow	43.54M	28.38M	14.59M	84.66M	32.86M	153.10M

Sangamo Biosciences Technical Analysis

• Technical Analysis Sentiment: Neutral
• Last Price: 0.58
• 50DMA: Positive
• 100DMA: Negative
• 200DMA: Negative
• MACD: Negative
• RSI: Neutral
• STOCH: Neutral

Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For SGMO, the sentiment is Neutral. The current price of 0.58 is above the 20-day moving average (MA) of 0.53, above the 50-day MA of 0.52, and below the 200-day MA of 1.08, indicating a neutral trend. The MACD of <0.01 indicates Negative momentum. The RSI at 58.52 is Neutral, neither overbought nor oversold. The STOCH value of 79.15 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Neutral sentiment for SGMO.

Sangamo Biosciences Peers Comparison

Name	Overall Rating	Market Cap	P/E Ratio	ROE	Dividend Yield	Revenue Growth	EPS Growth
FDMT	52 Neutral	$331.59M	―	-38.87%	―	―	―
Sector *	51 Neutral	$7.46B	-0.16	-46.00%	2.25%	22.76%	-2.28%
SGMO	46 Neutral	$162.92M	―	-298.41%	―	565.52%	79.44%
IKT	46 Neutral	$127.12M	―	-97.49%	―	-100.00%	51.51%
TERN	45 Neutral	$592.45M	―	-35.02%	―	―	20.37%
ANNX	38 Underperform	$261.12M	―	-66.75%	―	―	19.76%
ELTX	30 Underperform	$162.40M	―	-9999.00%	―	―	-4.60%

Sangamo Biosciences Corporate Events

Sangamo Announces Positive Results for Fabry Disease Therapy

On June 24, 2025, Sangamo Therapeutics, Inc. announced positive topline results from its Phase 1/2 STAAR study of isaralgagene civaparvovec, a gene therapy for Fabry disease. The study showed significant improvements in kidney function and quality of life measures, with a favorable safety profile. These results support the potential of isaralgagene civaparvovec as a one-time treatment for Fabry disease, paving the way for a Biologics Licensing Application under the Accelerated Approval pathway by early 2026.

The most recent analyst rating on (SGMO) stock is a Buy with a $1.50 price target. To see the full list of analyst forecasts on Sangamo Biosciences stock, see the SGMO Stock Forecast page.

Sangamo Biosciences Approves Amendments to Equity Plan

On June 12, 2025, Sangamo Therapeutics, Inc. held its annual meeting where stockholders approved significant amendments to the 2018 Equity Incentive Plan. This included increasing the number of shares available for issuance and the number of shares for incentive stock options. The meeting also saw the election of directors, approval of executive compensation, and ratification of Ernst & Young LLP as the company’s independent auditor. These decisions reflect Sangamo’s strategic focus on expanding its equity incentives to attract and retain talent, which could enhance its competitive position in the biotech industry.

The most recent analyst rating on (SGMO) stock is a Buy with a $3.00 price target. To see the full list of analyst forecasts on Sangamo Biosciences stock, see the SGMO Stock Forecast page.