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BioNTech SE
(NASDAQ:BNTX)
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Rating:51Neutral
Price Target:
$98.00
▼(-4.78% Downside)
Action:Reiterated
Date:06/05/26
The score is primarily supported by a very strong, low-leverage balance sheet and improving (but still volatile) recent cash generation. Offsetting this, technical indicators point to a sustained downtrend and weak momentum, while valuation is constrained by ongoing losses (negative P/E) and no provided dividend yield.
Positive Factors
Low leverage and substantial equity
A very low debt-to-equity ratio and strong equity base give BioNTech durable financial flexibility to fund multi-year R&D programs, support manufacturing scale-up and absorb post-peak revenue shocks without immediate refinancing risk, enabling sustained investment in oncology.
Negative Factors
Large, persistent operating and net losses
Despite very high gross margins, operating costs have overwhelmed profitability for multiple years. Persistent losses erode retained earnings over time, can force reprioritization of pipeline projects, and raise the risk that the company must cut spend or seek external funding if product commercialization lags.
Read all positive and negative factors
Positive Factors
Negative Factors
Low leverage and substantial equity
A very low debt-to-equity ratio and strong equity base give BioNTech durable financial flexibility to fund multi-year R&D programs, support manufacturing scale-up and absorb post-peak revenue shocks without immediate refinancing risk, enabling sustained investment in oncology.
Read all positive factors
BioNTech SE Key Performance Indicators (KPIs)
BioNTech SE (BNTX) vs. SPDR S&P 500 ETF (SPY)
Market Cap
$23.31B
Dividend YieldN/A
Average Volume (3M)928.14K
Price to Earnings (P/E)―
Beta (1Y)1.21
Revenue Growth10.01%
EPS Growth-71.78%
CountryUS
Employees7,807
SectorHealthcare
Sector Strength45
IndustryBiotechnology
Share Statistics
EPS (TTM)-5.09
Shares Outstanding252,884,260
10 Day Avg. Volume789,368
30 Day Avg. Volume928,137
Financial Highlights & Ratios
PEG Ratio-0.29
Price to Book (P/B)1.02
Price to Sales (P/S)7.10
P/FCF Ratio72.58
Enterprise Value/Market Cap<0.01
Enterprise Value/Revenue<0.01
Enterprise Value/Gross Profit<0.01
Enterprise Value/Ebitda>-0.01
Forecast
1Y Price Target
$125.85Price Target Upside22.28% Upside
Rating ConsensusStrong Buy
Number of Analyst Covering13
EPS Forecast (FY)-4.51
Revenue Forecast (FY)$2.17B
BioNTech SE Business Overview & Revenue Model
Company Description
BioNTech SE, a biotechnology firm, specializes in the creation and marketing of immune-based treatments for malignancies and various infectious diseases. A significant part of its oncology pipeline includes the FixVac cancer vaccine program, which...
How the Company Makes Money
BioNTech makes money primarily by commercializing products and by partnering its technology and drug candidates with larger pharmaceutical companies. Its largest historical revenue and profit driver has been its COVID-19 vaccine collaboration with...
BioNTech SE Earnings Call Summary
Earnings Call Date:Mar 10, 2026
(Q4-2025)
| % Change Since: |
Next Earnings Date:Aug 04, 2026
Earnings Call Sentiment Positive
Overall the call presented a constructive picture: BioNTech outperformed its raised 2025 guidance, preserved a very strong cash position (EUR 17.2 billion), advanced a broad late-stage oncology pipeline with multiple planned readouts in 2026–2030, and executed strategic deals to derisk programs. Offsetting this, management guided materially lower revenues for 2026 (EUR 2.0–2.3bn vs EUR 2.9bn in 2025), highlighted near-term increases in R&D and SG&A to support oncology launches, reported an adjusted net loss (EUR 117m) and disclosed a trial discontinuation in one indication. The founders' planned transition to a new company introduces execution uncertainty but is framed as an orderly process through end-2026. On balance, the positive operational progress, portfolio de-risking and very strong liquidity outweigh the near-term revenue headwinds and costs.Positive Updates
COVID Vaccine Leadership and Market Share
Launched a variant-adapted COVID vaccine with Pfizer; product distributed in over 180 countries and holds more than 50% market share in major markets. Management describes COMIRNATY as a cash-generative franchise with favorable economics under the Pfizer collaboration.
Negative Updates
Projected 2026 Revenue Decline
2026 revenue guidance of EUR 2.0–2.3 billion implies a decline versus 2025 (EUR 2.9 billion) of approximately 20.7% to 31.0%, driven primarily by expected lower COVID-19 vaccine revenues in the U.S. and Europe and the seasonal normalization of demand.
Read all updates
Q4-2025 Updates
Positive
Negative
COVID Vaccine Leadership and Market Share
Launched a variant-adapted COVID vaccine with Pfizer; product distributed in over 180 countries and holds more than 50% market share in major markets. Management describes COMIRNATY as a cash-generative franchise with favorable economics under the Pfizer collaboration.
Read all positive updates
Company Guidance
The company provided adjusted (non‑IFRS) 2026 guidance calling for total revenues of EUR 2.0–2.3 billion, with the same amount and quarterly timing from the BMS collaboration (including a EUR 613 million recognition in the third quarter) but lower COMIRNATY/COVID‑19 vaccine revenues versus 2025; it expects similar pandemic‑preparedness and services revenues but no one‑time Pfizer opt‑out proceeds. Adjusted operating spend is guided to R&D EUR 2.2–2.5 billion and SG&A EUR 700–800 million as BioNTech increases late‑stage oncology investment while reducing non‑priority R&D; 2025 results were EUR 2.9 billion revenue, ~EUR 2.1 billion R&D, an adjusted non‑IFRS net loss of EUR 117 million, and EUR 17.2 billion cash, cash equivalents and securities. Management emphasized guidance and reporting will be on an adjusted basis (excluding legal, impairments, restructuring, bargain purchase and divestiture items), noted COVID revenue seasonality (last four months drive the year) and reiterated operational priorities tied to multiple late‑stage readouts and portfolio de‑risking.BioNTech SE Financial Statement Overview
Summary
Income Statement
33
Negative
Balance Sheet
86
Very Positive
Cash Flow
62
Positive
| Breakdown | TTM | Dec 2025 | Dec 2024 | Dec 2023 | Dec 2022 | Dec 2021 |
|---|---|---|---|---|---|---|
Income Statement | ||||||
| Total Revenue | 2.80B | 2.76B | 2.75B | 3.82B | 17.31B | 18.98B |
| Gross Profit | 2.05B | 2.14B | 2.21B | 3.22B | 14.32B | 16.07B |
| EBITDA | -704.66M | -628.00M | -367.10M | 1.38B | 13.10B | 15.00B |
| Net Income | -1.26B | -1.09B | -665.30M | 930.30M | 9.43B | 10.29B |
Balance Sheet | ||||||
| Total Assets | 21.10B | 21.98B | 22.53B | 23.01B | 23.28B | 15.83B |
| Cash, Cash Equivalents and Short-Term Investments | 14.65B | 14.83B | 16.78B | 16.55B | 14.06B | 2.07B |
| Total Debt | 303.12M | 267.29M | 254.20M | 219.10M | 212.20M | 301.50M |
| Total Liabilities | 2.38B | 2.76B | 3.12B | 2.76B | 3.22B | 3.94B |
| Stockholders Equity | 18.72B | 19.22B | 19.41B | 20.25B | 20.06B | 11.89B |
Cash Flow | ||||||
| Free Cash Flow | 1.26B | 269.81M | -244.60M | 4.67B | 13.21B | 735.70M |
| Operating Cash Flow | 857.99M | 438.00M | 207.70M | 5.37B | 13.58B | 889.70M |
| Investing Cash Flow | -955.08M | -2.37B | -2.08B | -6.95B | -35.30M | -566.10M |
| Financing Cash Flow | -16.12M | -50.81M | -45.90M | -778.60M | -1.42B | 94.20M |
BioNTech SE Technical Analysis
Positive
102.92
Price Trends
91.31
Positive
93.90
Negative
98.73
Negative
Market Momentum
0.03
Positive
51.18
Neutral
56.93
Neutral
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For BNTX, the sentiment is Positive. The current price of 102.92 is above the 20-day moving average (MA) of 92.35, above the 50-day MA of 91.31, and above the 200-day MA of 98.73, indicating a neutral trend. The MACD of 0.03 indicates Positive momentum. The RSI at 51.18 is Neutral, neither overbought nor oversold. The STOCH value of 56.93 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Positive sentiment for BNTX.
BioNTech SE Risk Analysis
BioNTech SE disclosed 1 risk factors in its most recent earnings report. BioNTech SE reported the most risks in the "Legal & Regulatory" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks
BioNTech SE Peers Comparison
UnderperformOutperform
Sector (51)
Name | Overall Rating | Market Cap | P/E Ratio | ROE | Dividend Yield | Revenue Growth | EPS Growth |
|---|---|---|---|---|---|---|---|
82 Outperform | $22.47B | 18.08 | 19.24% | ― | 5.87% | 8.18% | |
81 Outperform | $23.10B | 15.84 | 29.31% | ― | 21.48% | 1853.63% | |
68 Neutral | $24.49B | -75.67 | -6.85% | ― | -89.16% | -84.69% | |
63 Neutral | $16.82B | 21.20 | 14.55% | ― | 21.02% | -24.83% | |
60 Neutral | $23.60B | ― | -36.73% | ― | -29.97% | 6.60% | |
51 Neutral | $7.86B | -0.30 | -43.30% | 2.27% | 22.53% | -2.21% | |
51 Neutral | $23.31B | -16.14 | -6.67% | ― | 10.01% | -71.78% |
* Healthcare Sector Average
BNTX
BioNTech SE
92.33
-19.11
-17.15%
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BioNTech SE Corporate Events
BioNTech Launches $1 Billion ADS Share Buyback Program on Nasdaq
Jun 8, 2026
On June 8, 2026, BioNTech disclosed operational details of a previously authorized share repurchase program of up to $1.0 billion in American Depositary Shares, approved by its Supervisory and Management Boards on May 7, 2026. The buyback, aimed a...
BioNTech and Bristol Myers Squibb Report Strong Interim Phase 2 Lung Cancer Data for Bispecific Pumitamig
Jun 1, 2026
On May 30, 2026, BioNTech and Bristol Myers Squibb reported interim Phase 2 results from the global Phase 2/3 ROSETTA Lung-02 trial of pumitamig, an investigational PD-L1xVEGF-A bispecific immunomodulator, combined with chemotherapy in previously ...
BioNTech Highlights Late-Stage Oncology Pipeline and New Data Ahead of 2026 ASCO Meeting
May 22, 2026
On May 22, 2026, BioNTech announced it will present new clinical data and trial updates from its late-stage oncology pipeline at the 2026 ASCO Annual Meeting in Chicago, running from May 29 to June 2. The centerpiece will be oral presentations on ...
BioNTech Shareholders Back All Proposals and Strengthen Supervisory Board at 2026 AGM
May 15, 2026
On May 15, 2026, BioNTech SE held its 2026 Annual General Meeting as a virtual assembly, with 92% of share capital represented and all management proposals approved by a majority of shareholders. The strong turnout and unanimous backing signal bro...
BioNTech Launches $1 Billion ADS Buyback to Support Long-Term Growth Strategy
May 7, 2026
On May 7, 2026, BioNTech SE announced it had authorized a new share repurchase program for up to $1.0 billion of its American Depositary Shares, with purchases allowed through May 6, 2027 and funded from existing cash resources. The buyback is int...
BioNTech Posts Wider Q1 Loss as It Doubles Down on Oncology and Plans $1 Billion Buyback
May 5, 2026
On May 5, 2026, BioNTech reported first-quarter 2026 revenues of €118.1 million, down from €182.8 million a year earlier, reflecting lower COVID-19 vaccine sales and resulting in a net loss of €531.9 million. The company reaffirm...
BioNTech Posts Wider Q1 2026 Operating Loss as R&D Spend Weighs on Results
May 5, 2026
On May 5, 2026, BioNTech SE filed a Form 6-K with U.S. regulators reporting unaudited financial results for the quarter ended March 31, 2026 and providing a development update. The company posted first-quarter 2026 revenues of €118.1 million...
BioNTech Reports Strong Phase 2 Data for HER2-Targeted ADC in Recurrent Endometrial Cancer
Apr 13, 2026
On April 11, 2026, BioNTech SE reported positive primary analysis results from a Phase 2 cohort of its HER2-targeted antibody-drug conjugate trastuzumab pamirtecan in patients with advanced, HER2-expressing recurrent endometrial cancer who had pro...
Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
Disclaimer
This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.