| Breakdown | TTM | Dec 2024 | Dec 2023 | Dec 2022 | Dec 2021 | Dec 2020 |
|---|---|---|---|---|---|---|
Income Statement | ||||||
| Total Revenue | 63.83B | 63.63B | 59.55B | 100.33B | 81.29B | 41.65B |
| Gross Profit | 42.99B | 41.85B | 30.34B | 62.09B | 46.88B | 29.88B |
| EBITDA | 22.77B | 18.13B | 9.56B | 41.03B | 30.79B | 13.17B |
| Net Income | 10.75B | 8.02B | 2.13B | 31.36B | 22.15B | 9.16B |
Balance Sheet | ||||||
| Total Assets | 206.09B | 213.40B | 226.50B | 197.21B | 181.48B | 154.23B |
| Cash, Cash Equivalents and Short-Term Investments | 13.25B | 20.48B | 12.69B | 22.73B | 31.07B | 12.22B |
| Total Debt | 61.80B | 63.65B | 70.84B | 34.86B | 37.00B | 38.27B |
| Total Liabilities | 117.08B | 124.90B | 137.21B | 101.29B | 104.01B | 90.76B |
| Stockholders Equity | 88.69B | 88.20B | 89.01B | 95.66B | 77.20B | 63.24B |
Cash Flow | ||||||
| Free Cash Flow | 12.44B | 9.84B | 4.79B | 26.03B | 29.87B | 11.61B |
| Operating Cash Flow | 15.19B | 12.74B | 8.70B | 29.27B | 32.58B | 14.40B |
| Investing Cash Flow | 3.54B | 2.65B | -32.28B | -15.78B | -22.55B | -4.27B |
| Financing Cash Flow | -18.17B | -17.14B | 26.07B | -14.83B | -9.82B | -9.65B |
Name | Overall Rating | Market Cap | P/E Ratio | ROE | Dividend Yield | Revenue Growth | EPS Growth |
|---|---|---|---|---|---|---|---|
| ― | $138.10B | 13.03 | 12.16% | 7.04% | 14.72% | ― | |
| ― | $449.57B | 18.04 | 33.62% | 2.72% | 5.08% | 71.07% | |
| ― | $217.38B | 13.42 | 35.44% | 3.74% | 2.00% | 20.01% | |
| ― | $237.12B | 17.75 | 32.93% | 3.28% | 11.53% | -15.21% | |
| ― | $157.25B | 23.90 | 99.14% | 3.22% | 13.10% | 110.67% | |
| ― | $397.72B | 108.29 | 112.90% | 2.91% | 6.05% | -29.75% | |
| ― | $7.86B | -0.30 | -43.30% | 2.27% | 22.53% | -2.21% |
Pfizer Inc. is conducting a clinical study titled ‘Open-Label Induction and Maintenance Study of Oral CP-690,550 (Tofacitinib) in Children with Moderately to Severely Active Ulcerative Colitis.’ The study aims to evaluate the efficacy, safety, and pharmacokinetics of tofacitinib in pediatric patients with moderate to severe ulcerative colitis (UC). This research is significant as it could provide a new treatment option for children who have not responded to existing therapies.
Pfizer Inc. is conducting a Phase 3 clinical study titled ‘Phase 3, Multicenter, Open-label Study to Assess the Long-term Safety and Tolerability of Rimegepant for the Acute Treatment of Migraine (With or Without Aura) in Children and Adolescents ≥ 6 to < 18 Years of Age.' The study aims to evaluate the long-term safety of rimegepant, a drug intended for the acute treatment of migraines in young patients. This research is significant as it could lead to new treatment options for pediatric migraine sufferers.
Pfizer Inc. is conducting a clinical study titled ‘A Phase 2b/3, Randomized, Double-Blind Study to Investigate the Efficacy, Safety, and Tolerability of Ponsegromab (PF-06946860) Compared With Placebo Both With Background First-Line Chemotherapy in Adult Participants With Cachexia and Metastatic Pancreatic Ductal Adenocarcinoma.’ The study aims to evaluate the effectiveness and safety of ponsegromab, a drug intended to treat cachexia and metastatic pancreatic cancer, conditions that often lead to significant weight loss and fatigue in patients.
Pfizer Inc. is conducting a Phase 2B clinical study titled ‘A Phase 2B Randomized, Double-Blind, 12-Week Placebo-Controlled Study with a 12-Week Double-Blind Extension Period to Evaluate the Efficacy, Safety and Tolerability of Ritlecitinib (PF-06651600) in Adult Participants with Chronic Spontaneous Urticaria.’ The study aims to assess the safety and effectiveness of ritlecitinib for treating chronic spontaneous urticaria (CSU), a condition characterized by itchy hives and swellings not well-managed by antihistamines.
Pfizer Inc. is conducting a Phase 3 study titled ‘A PHASE 3, RANDOMIZED, DOUBLE BLIND, PLACEBO CONTROLLED STUDY OF PF-06821497 (MEVROMETOSTAT) WITH ENZALUTAMIDE IN METASTATIC CASTRATION RESISTANT PROSTATE CANCER (MEVPRO-2)’. The study aims to determine if the investigational drug PF-06821497, when combined with enzalutamide, is more effective than enzalutamide alone in treating men with metastatic castration-resistant prostate cancer (mCRPC) who have not previously been treated with ARSi or abiraterone.
Pfizer Inc. is conducting a Phase 3 clinical trial titled ‘A PHASE 3, RANDOMIZED, OPEN-LABEL STUDY OF PF-06821497 (MEVROMETOSTAT) IN COMBINATION WITH ENZALUTAMIDE COMPARED WITH ENZALUTAMIDE OR DOCETAXEL IN PARTICIPANTS WITH METASTATIC CASTRATION RESISTANT PROSTATE CANCER PREVIOUSLY TREATED WITH ABIRATERONE ACETATE (MEVPRO-1)’. The study aims to evaluate the safety and efficacy of PF-06821497 combined with enzalutamide in treating metastatic castration-resistant prostate cancer (mCRPC) after prior treatment with abiraterone acetate. The primary objective is to assess radiographic progression-free survival (rPFS).
Pfizer Inc. is conducting a Phase 3 clinical study titled ‘An Interventional Efficacy and Safety, Phase 3, Randomized, Double-Blind, 3-Arm Study to Investigate Ibuzatrelvir in Adults with Symptomatic COVID-19 Who Are Severely Immunocompromised.’ The study aims to evaluate the efficacy and safety of the drug ibuzatrelvir, alone and in combination with remdesivir, compared to remdesivir alone, in treating symptomatic COVID-19 in severely immunocompromised adults. This study is significant as it targets a vulnerable population that is at higher risk of severe outcomes from COVID-19.
Pfizer Inc. is conducting a Phase 3 clinical study titled ‘An Interventional Efficacy and Safety, Phase 3, Double-Blind, 2-Arm Study to Investigate Orally Administered Ibuzatrelvir Compared with Placebo in Non-Hospitalized Symptomatic Adult and Adolescent Participants with COVID-19 Who Are at High Risk of Progressing to Severe Illness.’ The study aims to evaluate the efficacy and safety of ibuzatrelvir in preventing severe COVID-19 in non-hospitalized patients at high risk of severe disease progression.
Pfizer Inc. is conducting a Phase 3 clinical study titled ‘AN INTERVENTIONAL EFFICACY AND SAFETY, PHASE 3, DOUBLE-BLIND, PARALLEL GROUP STUDY TO INVESTIGATE INTERMITTENT PREVENTION OF MENSTRUAL MIGRAINE WITH RIMEGEPANT COMPARED WITH PLACEBO IN WOMEN PARTICIPANTS 18 TO 45 YEARS OF AGE.’ The study aims to evaluate the efficacy and safety of rimegepant for the intermittent prevention of menstrual migraines in women aged 18 to 45. This research is significant as it targets a specific population suffering from menstrual migraines, potentially offering a new preventive treatment option.
Pfizer Inc. is conducting a Phase 3 clinical study titled ‘A Randomized, 2-Arm, Phase 3 Study of Elranatamab (PF-06863135) Versus Lenalidomide in Patients with Newly Diagnosed Multiple Myeloma After Undergoing Autologous Stem-Cell Transplantation.’ The study aims to evaluate the efficacy of elranatamab monotherapy compared to lenalidomide monotherapy in patients with newly diagnosed multiple myeloma post-transplant. This research is significant as it explores potential advancements in treatment options for multiple myeloma, a challenging blood cancer.
Study Overview: Pfizer Inc. is conducting a Phase 3, multicenter, randomized, double-blind, placebo-controlled study titled ‘Randomized Study in Children and Adolescents With Migraine: Acute Treatment.’ The study aims to evaluate the efficacy and safety of Rimegepant for treating moderate to severe migraines in children and adolescents aged 6 to 18. This research is significant as it targets a younger demographic often underserved in migraine treatment options.
Pfizer Inc. is conducting a Phase 3 study titled A Phase 3 Study to Investigate the Safety, Tolerability, and Immunogenicity of Revaccinating Pregnant Participants During Subsequent Pregnancies and Persistence of Immunity of a Single Dose of a Bivalent Respiratory Syncytial Virus (RSV) Vaccine. The study aims to evaluate the safety and effectiveness of a second dose of the RSVpreF vaccine in pregnant women and to assess how long immunity lasts from a single dose given in a previous pregnancy.
Study Overview: Pfizer Inc. is conducting a Phase 3 clinical trial titled ‘BEATRIX: A Study to Learn About a Group B Streptococcus Vaccine in Healthy Pregnant Women and Their Babies.’ The study aims to evaluate the safety, tolerability, and immunogenicity of a multivalent Group B Streptococcus vaccine in healthy pregnant women and their infants. This research is significant as it targets the prevention of Group B Streptococcus infections, which can pose serious health risks to newborns.
Pfizer Inc. is conducting a Phase 3 clinical study titled ‘MagnetisMM-32’ to evaluate the efficacy of elranatamab in patients with relapsed or refractory multiple myeloma (MM) who have previously undergone anti-CD38 therapy. The study aims to compare elranatamab monotherapy against several combination therapies to determine its safety and effectiveness.
Pfizer Inc. is conducting a clinical study titled ‘A Phase 1A/B Open-Label Master Study of PF-07799544 as a Single-Agent and in Combination with Other Targeted Agents in Participants with Advanced Solid Tumors.’ The study aims to evaluate the safety and effects of PF-07799544, administered alone and in combination with other drugs, in individuals with advanced solid tumors. This study is significant as it targets patients with limited treatment options, potentially offering new hope in cancer therapy.
Study Overview: Pfizer Inc. is conducting a Phase 1 clinical study titled A Phase 1, Open-label, Fixed Sequence Study to Evaluate The Effect of Steady-State Dosing of PF-08049820 on the Single Dose Pharmacokinetics of Oral Contraceptives, Midazolam, and Dabigatran in Healthy Adult Female Participants. The study aims to understand how PF-08049820 affects the movement of other medications through the body, which is crucial for planning future studies.
Pfizer Inc. is conducting a study titled Palbociclib Treatment Patterns and Outcomes in HR+/HER2- MBC: Flatiron Database Analysis to explore the real-world use and effects of Palbociclib in patients with hormone receptor-positive, HER2-negative metastatic breast cancer (MBC). The study aims to understand the clinical impact of Palbociclib when combined with hormonal therapies and its influence on subsequent chemotherapy use.
Pfizer Inc. and BioNTech SE are conducting a clinical study titled ‘A Phase 1/2 Randomized, Observer-Blind Study to Evaluate the Safety, Tolerability, and Immunogenicity of a Modified RNA Vaccine Against Varicella Zoster Virus in Healthy Individuals.’ The study aims to assess the safety and immune response of a new modified RNA vaccine for shingles in adults aged 50 to 85, highlighting its potential to enhance current vaccination options.
Pfizer Inc. is conducting a Phase 3 clinical study titled ‘MAGNETISMM-6’ to evaluate the efficacy and safety of Elranatamab in combination with other drugs for patients with newly diagnosed multiple myeloma who are not eligible for transplant. The study aims to determine if Elranatamab, combined with Daratumumab and Lenalidomide, or with Lenalidomide alone, provides superior clinical benefits compared to the existing combination of Daratumumab, Lenalidomide, and Dexamethasone.
Pfizer and Bristol-Myers Squibb are conducting a Phase 1B study titled ‘A Study to Learn About the Effects of the Combination of Elranatamab (PF-06863135) and Iberdomide in Patients With Relapsed or Refractory Multiple Myeloma (MagnetisMM-30).’ The study aims to assess the safety and tolerability of combining elranatamab and iberdomide in treating relapsed or refractory multiple myeloma, a challenging cancer type that affects plasma cells.
Pfizer Inc. is currently conducting a Phase I clinical study titled A Phase I Dose Escalation and Expanded Cohort Study Of PF-06821497 (Mevrometostat) in the Treatment of Adult Patients with Relapsed/Refractory Small Cell Lung Cancer (SCLC), Castration Resistant Prostate Cancer (CRPC) and Follicular Lymphoma (FL). The study aims to evaluate the safety and efficacy of Mevrometostat in treating these challenging cancer types, highlighting its potential significance in oncology therapeutics.
Pfizer Inc. is conducting a clinical study titled ‘A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study of Mevrometostat (PF-06821497) With Enzalutamide in Metastatic Castration-Sensitive Prostate Cancer (MEVPRO-3).’ The study aims to determine if the combination of the investigational drug Mevrometostat and Enzalutamide is more effective than Enzalutamide alone in treating patients with metastatic castration-sensitive prostate cancer (mCSPC) who are androgen receptor pathway inhibitor (ARPI) naïve.
Pfizer Inc. is conducting a Phase 3 clinical study titled ‘A Phase 3, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy and Safety of Rimegepant in Migraine Prevention in Children and Adolescents ≥ 6 to <18 Years of Age.' The study aims to assess the effectiveness and safety of rimegepant as a preventative treatment for migraines in pediatric subjects, a significant step in addressing this debilitating condition in younger populations.
Pfizer Inc. is conducting a Phase 3 clinical study titled An Open-Label, 3-Arm, Multicenter, Randomized Phase 3 Study to Evaluate the Efficacy and Safety of Elranatamab (PF-06863135) Monotherapy and Elranatamab + Daratumumab Versus Daratumumab + Pomalidomide + Dexamethasone in Participants with Relapsed/Refractory Multiple Myeloma Who Have Received at Least 1 Prior Line of Therapy Including Lenalidomide and a Proteasome Inhibitor. The study aims to assess the efficacy and safety of the BCMA-CD3 bispecific antibody elranatamab, alone and in combination with daratumumab, compared to a standard combination therapy for multiple myeloma patients who have undergone previous treatments.
Pfizer Inc. has initiated a new clinical study titled ‘Elranatamab Post Trial Access Study for Participants With Multiple Myeloma (MM).’ The study aims to provide continued access to elranatamab for participants with multiple myeloma who have shown clinical benefits in previous Pfizer-sponsored trials. This study is significant as it supports ongoing treatment for patients benefiting from elranatamab, a promising therapy in the fight against multiple myeloma.
Pfizer Inc. is currently conducting a clinical study titled AN INTERVENTIONAL, EFFICACY, AND SAFETY, PHASE 3 RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY WITH AN OPEN-LABEL EXTENSION TO INVESTIGATE RIMEGEPANT IN MIGRAINE PREVENTION IN ADOLESCENTS 12 TO LESS THAN 18 YEARS OF AGE WITH CHRONIC MIGRAINE. The study aims to evaluate the effectiveness and safety of rimegepant, a dissolvable tablet, in preventing migraines in adolescents who experience frequent migraine attacks. This research is significant as it targets a younger demographic often affected by chronic migraines.
Pfizer Inc. is conducting a clinical trial titled ‘AN OPEN-LABEL PHASE 1 STUDY TO EVALUATE PF-08046037 AS MONOTHERAPY AND PART OF COMBINATION THERAPY IN PARTICIPANTS WITH ADVANCED MALIGNANCIES.’ The study aims to assess the safety and efficacy of PF-08046037, alone or combined with sasanlimab, in treating advanced or metastatic malignancies, including non-small cell lung cancer, head and neck squamous cell carcinoma, melanoma, and pancreatic ductal adenocarcinoma. This research is significant as it explores potential new treatments for these challenging conditions.
Study Overview: Pfizer Inc. is launching a clinical study titled Zavicefta Combination for Intravenous Infusion Special Investigation in Japan. The study aims to evaluate the safety and effectiveness of Zavicefta in patients with sepsis or renal impairment. This research is significant as it seeks to understand how Zavicefta performs in real-world clinical settings, potentially offering new treatment insights for serious infections and kidney function loss.
Pfizer Inc. is conducting a Phase 2B clinical study titled ‘A PHASE 2B, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, DOSE-RANGING STUDY TO EVALUATE THE EFFICACY AND SAFETY OF PF-08049820 IN ADULT PARTICIPANTS WITH MODERATE TO SEVERE ATOPIC DERMATITIS.’ The study aims to determine the safety and effectiveness of PF-08049820, a potential treatment for atopic dermatitis, a condition characterized by severe itching and rashes.
Pfizer Inc. is conducting a Phase 3 clinical study titled A PHASE 3, MULTICENTER, DOUBLE-BLIND, RANDOMIZED, PLACEBO-CONTROLLED STUDY TO EVALUATE THE EFFICACY AND SAFETY OF PF-06823859 IN PARTICIPANTS WITH ACTIVE IDIOPATHIC INFLAMMATORY MYOPATHIES (INCLUDING PARTICIPANTS WITH ACTIVE DERMATOMYOSITIS OR POLYMYOSITIS). The study aims to evaluate the efficacy and safety of PF-06823859, also known as dazukibart, in treating idiopathic inflammatory myopathies, specifically dermatomyositis (DM) and polymyositis (PM). These conditions cause muscle inflammation leading to weakness and, in DM, a characteristic skin rash.
Pfizer Inc. is conducting a clinical study titled AN OPEN-LABEL, RANDOMIZED, CONTROLLED PHASE 3 STUDY OF SIGVOTATUG VEDOTIN IN COMBINATION WITH PEMBROLIZUMAB COMPARED WITH PEMBROLIZUMAB MONOTHERAPY AS FIRST-LINE TREATMENT IN PARTICIPANTS WITH PD-L1 HIGH (≥50% OF TUMOR CELLS EXPRESSING PD-L1), LOCALLY ADVANCED, UNRESECTABLE, OR METASTATIC NON-SMALL CELL LUNG CANCER (BE6A LUNG-02). This study aims to evaluate the efficacy of a combination therapy of Sigvotatug Vedotin and pembrolizumab versus pembrolizumab alone in treating non-small cell lung cancer (NSCLC) with high PD-L1 levels. The study’s significance lies in potentially improving treatment outcomes for patients with advanced NSCLC.
Study Overview: Pfizer Inc. is conducting a Phase 3 clinical trial titled A RANDOMIZED, PHASE 3, OPEN-LABEL STUDY TO EVALUATE PF-08046054/SGN-PDLlV VERSUS DOCETAXEL IN ADULT PARTICIPANTS WITH PREVIOUSLY-TREATED PROGRAMMED CELL DEATH LIGAND 1 (PD-Ll) POSITIVE NON-SMALL-CELL LUNG CANCER (NSCLC). The study aims to determine the effectiveness of PF-08046054 compared to the standard chemotherapy drug, docetaxel, in treating adults with PD-L1 positive NSCLC that has progressed after previous treatments. This research is significant as it explores new treatment options for a challenging cancer type.
Pfizer Inc. is conducting a Phase 1 clinical study titled A Phase 1 Open-label Study to Investigate PF-08046876 in Adult Participants With Advanced Solid Tumors. The study aims to evaluate the safety and effects of PF-08046876, an investigational anticancer therapy known as an antibody drug conjugate (ADC), in patients with advanced cancers such as bladder, lung, and pancreatic cancer. The significance of this study lies in its potential to offer a new treatment option for individuals with these challenging conditions.
Pfizer Inc. is conducting a Phase 1 clinical study titled ‘A Phase 1 Open-Label Study of PF-07934040 as a Single Agent and in Combination With Other Targeted Agents in Participants With Advanced Solid Tumors Harboring Mutations in the KRAS Gene.’ The study aims to evaluate the safety and efficacy of PF-07934040, a panKRAS inhibitor, both alone and in combination with other anti-cancer therapies, in patients with advanced solid tumors that have a KRAS gene mutation. This study is significant as it targets difficult-to-treat cancers such as non-small cell lung cancer, colorectal cancer, and pancreatic ductal adenocarcinoma.
Pfizer Inc. is conducting a clinical study titled A Phase 1b/2, Open-Label, Multicohort Study of Disitamab Vedotin in Adults With HER2 Expressing Advanced Breast Cancer. The study aims to assess the safety and effects of disitamab vedotin, a potential treatment for advanced breast cancer that is difficult to treat and has spread in the body. This research is significant as it targets patients with HER2-expressing tumors who have already undergone previous treatments.
Pfizer Inc. and Genmab are conducting a Phase 4 clinical study titled A Prospective Low-Interventional Phase 4 Single Arm Study of Ocular Assessments in Patients Treated With Tivdak® in Recurrent or Metastatic Cervical Cancer. The study aims to evaluate the ocular side effects of Tivdak, a drug used in treating recurrent or metastatic cervical cancer, highlighting its significance in understanding potential adverse effects on patients’ eyes.
Pfizer Inc. is conducting a Korea Post Marketing Surveillance (PMS) Study of Vizimpro, officially titled ‘A Prospective, Single-arm, Open-label, Non-interventional, Multi-centre, Post Marketing Surveillance (PMS) Study of Vizimpro®.’ The study aims to evaluate the effectiveness and safety of Vizimpro, a drug approved for the treatment of EGFR NSCLC 1L in Korea, under general clinical practice conditions. This is significant as it ensures the drug’s continued safety and efficacy post-approval.
Pfizer Inc. is conducting a Phase 1 clinical study titled ‘A PHASE 1, OPEN-LABEL, TWO-PERIOD, CROSS-OVER STUDY TO EVALUATE DOSE PROPORTIONALITY OF ATIRMOCICLIB (PF-07220060) PHARMACOKINETICS WHEN ADMINISTERED UNDER FED CONDITIONS TO HEALTHY PARTICIPANTS.’ The study aims to assess how the pharmacokinetics of atirmociclib, a drug under investigation, varies with different doses in healthy individuals. This research is significant as it could provide insights into the optimal dosing strategy for future therapeutic applications.
Study Overview: Pfizer Inc. is conducting a clinical study titled ‘A 16-Week, Multicenter, Interventional, Phase 3, Randomized, Double-Blind, Placebo-Controlled, Parallel Group Study to Investigate Efficacy and Safety of Abrocitinib in Children 6 to Less Than 12 Years of Age with Moderate-to-Severe Atopic Dermatitis.’ The study aims to evaluate the effectiveness and safety of abrocitinib in treating moderate-to-severe eczema in children, a condition that significantly impacts quality of life.
Pfizer Inc. has initiated a new clinical study titled ‘A Phase 3, Multicenter, Long-Term, Open Label Study Evaluating the Safety and Efficacy of Abrocitinib, With or Without Topical Medications Administered to Pediatric Participants Aged 2 Years and Older With Moderate-to-Severe Atopic Dermatitis.’ The study aims to assess the long-term safety and efficacy of abrocitinib, an oral suspension drug, in children with moderate-to-severe eczema. This research is significant as it could provide a new treatment option for pediatric patients suffering from this chronic skin condition.
Pfizer Inc. is conducting an observational cohort study titled ‘Treating Atopic Dermatitis With Abrocitinib and Its Impact in Real Life.’ The study aims to evaluate the effectiveness and safety of Abrocitinib in adult patients with moderate to severe atopic dermatitis, a chronic skin condition characterized by inflammation and irritation. This research is significant as it seeks to provide real-world insights into the drug’s performance outside of controlled clinical environments.
Pfizer Inc. is conducting a study titled ‘A Multicenter, Non-interventional Prospective Active Surveillance Study Among Participants Receiving Somatrogon Under Routine Clinical Care in India’ to assess the safety of Somatrogon, a long-acting growth hormone, in treating pediatric growth hormone deficiency (p GHD) in India. The study aims to monitor side effects in children with p GHD, a condition characterized by insufficient growth hormone production leading to short stature.
Pfizer Inc. is conducting a Phase 1 clinical study titled ‘A PHASE 1, RANDOMIZED, DOUBLE BLIND, SPONSOR-OPEN, PLACEBO-CONTROLLED, SINGLE DOSE ESCALATION STUDY TO EVALUATE THE SAFETY, TOLERABILITY, AND PHARMACOKINETICS OF SUBCUTANEOUS ADMINISTRATION OF PF-07999415 IN HEALTHY ADULT PARTICIPANTS.’ The study aims to assess the safety and effects of PF-07999415 in healthy adults aged 18 to 65. This research is significant as it could pave the way for new therapeutic options.
Pfizer Inc. is conducting a Phase 1B clinical trial titled ‘A Clinical Trial of Four Medicines (Elranatamab Plus Carfilzomib and Dexamethasone or Maplirpacept) in People With Relapsed Refractory Multiple Myeloma.’ The study aims to evaluate the safety and tolerability of elranatamab combined with other drugs in treating relapsed refractory multiple myeloma, a significant concern in oncology.
Pfizer Inc. is conducting a Phase 2A clinical study titled A PHASE 2A MULTICENTER, OBSERVER-BLINDED, RANDOMIZED 2 ARM STUDY TO INVESTIGATE PHARMACOKINETICS, SAFETY, TOLERABILITY AND EFFICACY OF INTRAVENOUS AZTREONAM-AVIBACTAM ± METRONIDAZOLE COMPARED TO BEST AVAILABLE THERAPY (BAT) IN PEDIATRIC PARTICIPANTS 9 MONTHS TO LESS THAN 18 YEARS OF AGE WITH SERIOUS GRAM-NEGATIVE BACTERIAL INFECTIONS INCLUDING COMPLICATED INTRA-ABDOMINAL INFECTION. The study aims to evaluate the pharmacokinetics, safety, and efficacy of Aztreonam-Avibactam (ATM-AVI) in pediatric patients with serious gram-negative bacterial infections.
Pfizer Inc. is conducting a Phase 1 clinical study titled A Phase 1, Open-Label, Dose Escalation and Dose Expansion Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Anti-Tumor Activity of PF-07799933 (ARRY-440) as a Single Agent and in Combination Therapy in Participants 16 Years and Older with Advanced Solid Tumors with BRAF Alterations. The study aims to assess the safety and effects of PF-07799933, both alone and in combination with other treatments, in patients with advanced solid tumors that have BRAF alterations, where existing treatments have failed.
Pfizer Inc. is conducting a clinical study titled ‘Low Interventional Cohort Study of Myocarditis/Pericarditis Associated With COMIRNATY in Persons Less Than 21 Years of Age.’ The study aims to evaluate the safety and effects of the COMIRNATY vaccine in preventing COVID-19 in individuals under 21, focusing on potential myocarditis/pericarditis associations. This research is significant as it seeks to ensure the vaccine’s safety and efficacy in younger populations.
Study Overview: Pfizer Inc. is conducting a Phase 3 study titled A PHASE 3, EXTERNAL AND SYNTHETIC PLACEBO-CONTROLLED RANDOMIZED STUDY WITH DOSE-UP FOR NON-RESPONDERS TO INVESTIGATE SAFETY AND EFFICACY OF RITLECITINIB 50 MG AND 100 MG ONCE DAILY IN ADULT AND ADOLESCENT PARTICIPANTS 12 YEARS OF AGE AND OLDER WITH ALOPECIA AREATA. The study aims to evaluate the safety and efficacy of two doses of ritlecitinib in treating alopecia areata, a condition causing hair loss. This study is significant as it explores a higher dose of an already approved treatment to potentially enhance therapeutic outcomes.
Pfizer Inc. is conducting a Phase 3 study titled A PHASE 3 RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY TO INVESTIGATE THE EFFICACY AND SAFETY OF RITLECITINIB IN PEDIATRIC PARTICIPANTS 6 TO LESS THAN 12 YEARS OF AGE WITH SEVERE ALOPECIA AREATA. The study aims to evaluate the safety and effectiveness of ritlecitinib, a potential treatment for severe alopecia areata, a condition causing significant hair loss.
Study Overview: Pfizer Inc. is conducting a Phase 1 clinical study titled A PHASE 1, OPEN-LABEL, FIXED SEQUENCE, 2-PERIOD STUDY IN HEALTHY PARTICIPANTS TO INVESTIGATE THE EFFECT OF CARBAMAZEPINE ON PF-07248144 PHARMACOKINETICS. The study aims to understand how carbamazepine affects the body’s processing of PF-07248144, focusing on safety, tolerability, and pharmacokinetics when PF-07248144 is taken alone and with carbamazepine.
Study Overview: The clinical study titled A Phase 2 Open-label Extension Study for Subjects With Prostate Cancer Who Previously Participated in an Enzalutamide Clinical Study aims to gather long-term safety data for prostate cancer patients who have benefited from enzalutamide treatment in prior studies. This study, sponsored by Astellas Pharma with collaboration from Pfizer, is significant as it seeks to ensure ongoing safety and efficacy for patients continuing this treatment.
Pfizer Inc. is conducting a long-term clinical study titled ‘A Long-Term Study to Learn About The Study Medicine Called Ritlecitinib in Children With Severe Alopecia Areata.’ This study aims to assess the safety and efficacy of ritlecitinib, a potential treatment for severe alopecia areata, a condition causing significant hair loss. Participants are children who have completed previous Pfizer studies and exhibit at least 50% scalp hair loss due to the condition. This study is significant as it could potentially lead to a new treatment option for this challenging condition.
Pfizer Inc. is conducting a Phase 1 clinical study titled A PHASE 1, OPEN-LABEL, DOSE ESCALATION AND DOSE EXPANSION STUDY TO EVALUATE THE SAFETY, TOLERABILITY, PHARMACOKINETICS, AND ANTITUMOR ACTIVITY OF PF-08052667 AS A SINGLE AGENT AND IN COMBINATION THERAPY IN PARTICIPANTS 18 YEARS OF AGE AND OLDER WITH BLADDER CANCER. The study aims to assess the safety and effectiveness of PF-08052667, alone and in combination with Bacillus Calmette Guerin (BCG) and sasanlimab, for treating non-muscle invasive bladder cancer that is likely to recur or progress.
Pfizer Inc. is currently conducting a post-marketing surveillance study titled ‘Korean Post-marketing Surveillance for Xeljanz XR.’ The study aims to evaluate the safety and effectiveness of Xeljanz XR, an extended-release tablet containing Tofacitinib citrate, under routine clinical practice in Korea. This surveillance is significant as it forms part of the risk management plan for the drug, targeting patients with conditions such as Rheumatoid Arthritis, Psoriatic Arthritis, and Ankylosing Spondylitis.
Study Overview: Pfizer Inc. is conducting a study titled ‘Evaluation of the Clinical Benefit of ToFAcitinib Treatment in Patients With Moderate to Severe Ulcerative Colitis Under Real-life Conditions of Use: TOFAst Study.’ The study aims to assess the effectiveness of tofacitinib in treating moderate to severe ulcerative colitis in a real-world setting in France, highlighting its significance in improving patient outcomes.
Pfizer Inc. is conducting a clinical study titled ‘A Phase 2, Randomized, Double-Blind, Placebo-Controlled Study to Investigate the Efficacy and Safety of PF-07275315 and PF-07264660 in Adult Participants with Moderate-Severe Atopic Dermatitis.’ The study aims to evaluate the safety and effectiveness of two investigational drugs, PF-07275315 and PF-07264660, in treating moderate to severe atopic dermatitis, a chronic skin condition characterized by itchy, red rashes.
Pfizer Inc. is conducting a Phase 3 clinical study titled ‘AN INTERVENTIONAL, OPEN-LABEL, RANDOMIZED, MULTICENTER PHASE 3 STUDY OF PF-07220060 PLUS LETROZOLE COMPARED TO CDK4/6 INHIBITOR PLUS LETROZOLE IN PARTICIPANTS OVER 18 YEARS OF AGE WITH HORMONE RECEPTOR (HR)-POSITIVE, HER2-NEGATIVE ADVANCED/METASTATIC BREAST CANCER WHO HAVE NOT RECEIVED ANY PRIOR SYSTEMIC ANTICANCER TREATMENT FOR ADVANCED/METASTATIC DISEASE (FOURLIGHT-3)’. The study aims to evaluate the safety and efficacy of PF-07220060 with letrozole versus standard treatments in patients with HR-positive, HER2-negative advanced or metastatic breast cancer who have not received prior systemic treatment.
Pfizer Inc. is conducting a Phase 1 clinical study titled ‘A PHASE 1, RANDOMIZED, MULTI-CENTER, DOUBLE-BLIND, SPONSOR OPEN, PLACEBO-CONTROLLED, SINGLE DOSE-ESCALATION AND MULTIPLE DOSE STUDY TO EVALUATE THE SAFETY, TOLERABILITY, AND PHARMACOKINETICS OF PF-07985631 IN HEALTHY ADULT PARTICIPANTS.’ The study aims to assess the safety and effects of PF-07985631, a potential treatment for IgA nephropathy, a kidney disease. This study is significant as it could lead to new treatment options for this condition.
Pfizer Inc. is conducting a Phase 2 clinical study titled ‘A Prospective, Randomized, Open-Label Phase 2 Study to Evaluate the Superiority of Inotuzumab Ozogamicin Monotherapy Versus ALLR3 for Induction Treatment of Childhood High Risk First Relapse B-Cell Precursor Acute Lymphoblastic Leukaemia.’ The study aims to assess the effectiveness and safety of Inotuzumab Ozogamicin (InO) compared to the ALLR3 regimen in children aged 1 to under 18 years with high-risk first relapse acute lymphoblastic leukemia (ALL). This research is significant as it explores potentially superior treatment options for pediatric patients facing this challenging condition.
Pfizer Inc. has announced a new clinical study titled ‘Describing Prescription Patterns in an Ulcerative Colitis Population and Generating an Updated Ulcerative Colitis Treatment Paradigm.’ The study aims to analyze treatment patterns and develop an updated treatment flow for patients with ulcerative colitis, a chronic inflammatory bowel disease. This research is significant as it seeks to optimize treatment strategies and improve patient outcomes.
Pfizer Inc. is conducting a prospective, multi-center observational study titled ‘Real World Efficiency of Abrocitinib Treatment at Patients With Moderate to Severe Atopic Dermatitis Who Had Inadequate Response to Previous Biologic Therapies.’ The study aims to evaluate the effectiveness of abrocitinib in patients with moderate-to-severe atopic dermatitis who have not responded adequately to up to two previous biologic therapies. This research is significant as it seeks to provide real-world insights into the drug’s performance, potentially offering a new treatment avenue for patients with limited options.
Pfizer Inc. is conducting a Phase 1 clinical study titled ‘A PHASE 1 OPEN-LABEL STUDY OF PF-07985045 AS A SINGLE-AGENT AND IN COMBINATION WITH OTHER ANTI-CANCER AGENTS IN PARTICIPANTS WITH ADVANCED SOLID TUMORS.’ The study aims to assess the safety and effectiveness of the investigational drug PF-07985045, both alone and in combination with other anti-cancer therapies, for patients with advanced solid tumors that have a KRAS gene mutation. This research is significant as it seeks to find optimal dosing and expand treatment options for cancers such as non-small cell lung cancer, colorectal cancer, and pancreatic ductal adenocarcinoma.
Pfizer Inc. is conducting a Phase 1 clinical study titled A PHASE 1, RANDOMIZED STUDY WITH DOUBLE-BLIND AND SPONSOR-OPEN, PLACEBO-CONTROLLED SINGLE- AND MULTIPLE-DOSE ESCALATION TO EVALUATE THE SAFETY, TOLERABILITY, PHARMACOKINETICS, AND PHARMACODYNAMICS OF PF-08049820 IN HEALTHY ADULT PARTICIPANTS. The study aims to assess the safety and tolerability of PF-08049820, a potential treatment for moderate to severe atopic dermatitis, in healthy adults. This study is significant as it explores a new treatment avenue for eczema, a condition causing severe itching and rashes.
Pfizer Inc. is conducting a study titled ‘Post Marketing Surveillance (PMS) Study for Cibinqo Tablet (Abrocitinib) in Patients With Moderate to Severe Atopic Dermatitis (AD) in Korea.’ The study aims to evaluate the safety and effectiveness of Cibinqo, a treatment for atopic dermatitis, a chronic skin condition characterized by itchy, red rashes. This research is significant as it seeks to provide real-world data on the drug’s performance post-market approval.
Pfizer Inc and BioNTech SE have initiated a clinical study titled ‘A Master Phase 1/2/3 Protocol to Investigate the Safety, Tolerability, and Immunogenicity of Variant-Adapted BNT162b2 RNA-Based Vaccine Candidate(s) in Healthy Children.’ The study aims to evaluate the safety and immune response of a variant-adapted COVID-19 RNA vaccine in children. This trial is significant as it could lead to improved vaccine formulations for younger populations.
Study Overview: Pfizer Inc. is conducting a study titled ‘Korean Post-marketing Surveillance for Prevenar 20’ to assess the safety of Prevenar 20, a Pneumococcal 20-valent conjugate vaccine, in the Korean market. The study aims to monitor the vaccine’s safety among participants aged 6 weeks and older, providing critical insights into its post-market performance.
Pfizer Inc. is conducting a Phase 2 open-label extension study titled ‘A Phase 2, Open-Label Extension Study to Investigate the Safety and Efficacy of PF-07868489 Administered to Adult Participants with Pulmonary Arterial Hypertension’. The study aims to assess the long-term safety, tolerability, and effects of PF-07868489, a potential treatment for pulmonary arterial hypertension (PAH), a condition characterized by high blood pressure in the arteries of the lungs.
Pfizer Inc. is currently conducting a study titled ‘The Real-world Treatment Patterns and Clinical Outcomes in Moderate-to-severe Atopic Dermatitis (AD) Patients Receiving Abrocitinib.’ The study aims to observe real-world treatment patterns and clinical outcomes over a 12-month period for patients with moderate-to-severe atopic dermatitis using Abrocitinib. The significance of this study lies in its potential to provide valuable insights into patient demographics and baseline characteristics in a real-world setting.
Pfizer Inc. is currently conducting an observational study titled ‘CIBINQO™ Pregnancy Registry: An Observational Study of the Safety of Abrocitinib Exposure in Pregnant Women and Their Offspring.’ The study aims to assess the safety of the drug Abrocitinib (CIBINQO) in pregnant women and their children. This research is significant as it seeks to ensure the well-being of both mothers and infants when exposed to the medication during pregnancy.
Study Overview: Pfizer Inc. is conducting a study titled ‘Prospective Observational Post Marketing Surveillance Study to Observe Safety and Effectiveness of Zavicefta IV’. The primary aim is to assess the safety and effectiveness of Zavicefta, a medication used for treating complex infections, after its release in the Korean market. This study is significant as it fulfills the regulatory requirements set by Korea’s Ministry of Food and Drug Safety, focusing on infections like complicated intra-abdominal infections, urinary tract infections, and hospital-acquired pneumonia.
Study Overview: Pfizer Inc. is conducting a Korea Post Marketing Surveillance (PMS) Study of Talzenna® to assess its effectiveness and safety in treating gBRCA advanced breast cancer. This prospective, single-arm, open-label, non-interventional, multi-centre study aims to identify any issues associated with Talzenna in real-world clinical practice in Korea.
Pfizer Inc. is conducting a clinical study titled ‘A Phase 1, Randomized, Double-Blind, Sponsor-Open, Placebo-Controlled, Dose Escalation Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Multiple-Dose Topical Administration of PF-07905428 in Healthy Participants and Participants With Acne Vulgaris.’ The study aims to assess the safety and effectiveness of PF-07905428, a topical treatment for acne vulgaris, in individuals aged 18 to 40.
Pfizer Inc. is currently conducting the MUltiple Myeloma Italian ObServational sTudy (MUST) to understand the treatment practices for patients with Triple Class Refractory Multiple Myeloma (TCR-MM) in Italy. The study aims to describe the standard of care provided to these patients and assess treatment costs across approximately 25 centers specializing in blood diseases. This research is significant as it seeks to improve the understanding of current clinical practices for a challenging condition where the cancer does not respond to the three main classes of medicines.
Pfizer Inc. is conducting a clinical study titled An Interventional Phase 1b, Randomized, Double-Blind, Sponsor-Open, Placebo-Controlled Study to Investigate the Safety, Tolerability, and Pharmacodynamic Effect of PF-07258669 Compared to Placebo in Older Participants Including Those at Risk of Malnutrition. The study aims to assess the safety and effects of PF-07258669, a drug developed to treat unintended weight loss in older adults, a condition often linked to decreased appetite and poor nutrition.
Pfizer Inc. has announced a new clinical study titled CORRELATE-UK: COnsistency of Response With RimegEpant Oral Lyophilisate in Acute Treatment of migrainE in the United Kingdom. The study aims to evaluate the consistency of response to Rimegepant, a drug used for the acute treatment of migraines, in a non-interventional, prospective setting. This study is significant as it seeks to provide insights into the effectiveness of Rimegepant for migraine sufferers in the UK.
Study Overview: Pfizer Inc. is spearheading a study titled ‘HYMPAVZI S.C. INJECTION 150 mg Pen SPECIAL INVESTIGATION,’ aimed at evaluating the safety of the drug Hympavzi in Japanese patients with congenital hemophilia who do not have inhibitors. This study is significant as it seeks to ensure the safe application of Hympavzi in real-world settings, potentially improving treatment outcomes for hemophilia patients.
Pfizer Inc. has launched a Phase 1 clinical study titled ‘AN INTERVENTIONAL, PHASE 1, OPEN-LABEL, TWO-COHORT, TWO-PERIOD, FIXED SEQUENCE STUDY TO ESTIMATE THE EFFECT OF MULTIPLE DOSES OF ITRACONAZOLE AND PROBENECID ON THE PHARMACOKINETICS OF SINGLE DOSE PF-07220060 ADMINISTERED UNDER THE FED CONDITION TO HEALTHY PARTICIPANTS.’ The study aims to understand how the body processes the drug PF-07220060 when taken with itraconazole and probenecid, which are inhibitors affecting drug metabolism. This research is significant for optimizing dosing strategies and ensuring drug safety and efficacy.
Pfizer Inc. is spearheading a new observational study titled ‘Temporal Changes in Clinical Characteristics and Functions, and Their Relationship With Outcomes of Atrial Fibrillation.’ The study aims to explore the evolving clinical features and functions associated with atrial fibrillation (AF), a common heart arrhythmia, and their impact on patient outcomes. By leveraging data linkage from a single center patient data and a national claims database in Korea, the study seeks to provide valuable insights into AF management.
Pfizer Inc., in collaboration with Astellas Pharma Global Development, Inc., is conducting a clinical study titled ‘A Multicenter, Phase 4, Open-label, Single-arm, Safety Study of Enfortumab Vedotin in Adult Indian Participants With Previously Treated Locally Advanced or Metastatic Urothelial Cancer.’ The study aims to confirm the safety of enfortumab vedotin in Indian adults with advanced urothelial cancer, a type of cancer affecting the bladder lining.
Pfizer Inc. is conducting a Phase 1 clinical study titled A PHASE 1, RANDOMIZED, DOUBLE-BLIND, THIRD-PARTY-UNBLINDED STUDY TO EVALUATE THE SAFETY AND TOLERABILITY OF A VACCINE AGAINST E COLI IN HEALTHY ADULTS. The study aims to assess the safety and tolerability of an investigational vaccine against Escherichia coli (E coli) in healthy adults, which is significant for preventing infections caused by this common bacterium.
Pfizer Inc. is conducting a Phase 1 study titled ‘A Phase 1 Multiple-Dose, Open-Label Pharmacokinetic Study of Etrasimod in Healthy Lactating Women.’ The study aims to understand how the drug etrasimod is absorbed into the blood and breast milk of healthy breastfeeding women. This research is significant as it seeks to ensure the safety of breastfeeding while using this medication.
Study Overview: Pfizer Inc. is conducting a study titled ‘Korean Post Marketing Surveillance for Litfulo Capsule’ to explore the safety and effects of Litfulo in treating Severe Alopecia Areata. This observational study aims to gather real-world data on the medication’s performance, which is crucial for understanding its potential impact on patients suffering from this condition.
Pfizer Inc. has initiated a study titled ‘Post-Approval Safety Monitoring Program to Assess the Safety and Efficacy Profile of TUKYSA in Usual Practice’ to evaluate the clinical usefulness of TUKYSA in Korea. The study aims to gather, review, and verify safety and efficacy data for HER2-positive locally advanced unresectable and metastatic breast cancer treatments in real-world settings, as part of Korea’s re-examination system for pharmaceuticals.
Study Overview: Pfizer Inc. is conducting a study titled ‘Special Investigation for CIBINQO (Long Term)’ to evaluate the safety and effectiveness of CIBINQO for treating atopic dermatitis under Japanese medical practice. This study aims to provide valuable insights into the long-term use of CIBINQO, potentially offering a new therapeutic option for patients with this chronic skin condition.
Pfizer Inc. is currently conducting a Phase 1 clinical study titled ‘A PHASE 1, FIRST IN HUMAN, RANDOMIZED, DOUBLE-BLIND, SPONSOR-OPEN, PLACEBO-CONTROLLED, SINGLE- AND MULTIPLE DOSE ESCALATION, PARALLEL GROUP STUDY TO EVALUATE THE SAFETY, TOLERABILITY, PHARMACOKINETICS AND PHARMACODYNAMICS OF PF-07832837 IN HEALTHY PARTICIPANTS AND PARTICIPANTS WITH MODERATE TO SEVERE ATOPIC DERMATITIS.’ The study aims to assess the safety, tolerability, and pharmacokinetics of PF-07832837 in both healthy individuals and those with moderate to severe atopic dermatitis, while also evaluating its pharmacodynamics in affected participants.
Pfizer Inc. is conducting a Phase 3 study titled A Phase 3 Randomized Withdrawal and Dose-Up Titration, Multicenter Extension Study Investigating the Safety, Efficacy, and Tolerability of Ritlecitinib in Adult and Adolescent Participants with Nonsegmental Vitiligo. This study aims to assess the safety and effectiveness of ritlecitinib in treating non-segmental vitiligo, a chronic skin condition characterized by loss of pigmentation. The study is significant as it explores whether continued treatment with ritlecitinib can maintain or improve repigmentation achieved in a previous study.
Pfizer Inc. is conducting a study titled ‘A Retrospective Study to Evaluate the Real-World Effectiveness of Lorlatinib Among ROS1-Positive NSCLC Patients.’ The study aims to assess the effectiveness of lorlatinib, a treatment for non-small cell lung cancer (NSCLC) that has spread and is difficult to control. This research is significant as it could provide insights into the safety and efficacy of lorlatinib for patients with ROS1-positive NSCLC who have undergone previous treatments.
Pfizer Inc. is conducting a Phase 1 study titled ‘A Phase 1, Open-label, Fixed Sequence, 2-period Study in Healthy Adult Male Participants to Assess the Mass Balance, Absolute Bioavailability, Fraction Absorbed, and Pharmacokinetics of [14C]PF-07104091.’ The study aims to understand how the body processes the investigational drug PF-07104091, focusing on its absorption, distribution, metabolism, and excretion in healthy adult males.
Pfizer Inc. is conducting a Phase 1/2A clinical study titled A PHASE 1/2A DOSE ESCALATION AND EXPANSION STUDY TO EVALUATE SAFETY, TOLERABILITY, PHARMACOKINETIC, PHARMACODYNAMIC, AND ANTI-TUMOR ACTIVITY OF PF-07248144 IN PARTICIPANTS WITH ADVANCED OR METASTATIC SOLID TUMORS. The study aims to assess the safety and efficacy of PF-07248144 in treating advanced or metastatic solid tumors, including breast, prostate, and lung cancers. This study is significant as it explores new treatment avenues for these challenging conditions.
The FLOTILLA Study, officially titled ‘ENCORAFENIB/BINIMETINIB MASTER PROTOCOL: AN OPEN-LABEL CONTINUATION STUDY FOR PARTICIPANTS CONTINUING FROM ENCORAFENIB/BINIMETINIB CLINICAL STUDIES,’ aims to provide continued access to the study medicines encorafenib and binimetinib for participants from prior clinical trials. The study’s key objective is to ensure ongoing treatment for those benefiting from these drugs, focusing on solid tumors, thereby maintaining the therapeutic benefits observed in earlier trials.
Pfizer Inc. is conducting a Phase 3 study titled ‘A Phase 3, Non-Investigational Product, Multi Country Cohort Study to Describe the Long-Term Safety and Effectiveness of a Prior Single-Dose Treatment with Investigative Giroctocogene Fitelparvovec or Fidanacogene Elaparvovec in Participants with Hemophilia A or Hemophilia B, Respectively.’ The study aims to assess the long-term safety and efficacy of these treatments in patients who have previously participated in Pfizer-sponsored trials. This research is significant as it could provide critical insights into the lasting impacts of these gene therapies on hemophilia patients.
Pfizer Inc. is currently conducting a Phase 2 clinical study titled ‘AN INTERVENTIONAL PHASE 2, OPEN-LABEL, MULTI-CENTER STUDY TO EVALUATE SAFETY AND EFFICACY OF PF-06835375 IN ADULT PARTICIPANTS WITH MODERATE TO SEVERE PRIMARY IMMUNE THROMBOCYTOPENIA.’ The study aims to assess the safety and efficacy of PF-06835375 in adults with primary immune thrombocytopenia (ITP), a condition characterized by low platelet counts. This research is significant as it targets both persistent and chronic ITP, potentially offering new treatment options for these patients.
Pfizer Inc. is currently conducting a clinical study titled ‘A Phase 2, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of an Oral Branched-Chain Ketoacid Dehydrogenase Kinase Inhibitor, PF-07328948, in Adults with Heart Failure (BRANCH-HF)’. The study aims to assess the safety and effectiveness of PF-07328948 as a potential treatment for heart failure, a condition affecting millions worldwide. This study is significant as it could lead to new treatment options for heart failure patients.
Pfizer Inc. is conducting a Phase 1 study titled A Phase 1, Single-Arm Study to Evaluate the Safety and Tolerability of a 20-valent Pneumococcal Conjugate Vaccine in Healthy Chinese Adults, Children, and Infants. The primary objective is to assess the safety of the 20vPnC vaccine across various age groups in China, which is crucial for preventing pneumococcal disease.
Pfizer Inc. is conducting a Phase 3 study titled ‘A PHASE 3, MULTI-CENTER, OPEN-LABEL EXTENSION STUDY TO INVESTIGATE THE LONG-TERM SAFETY, TOLERABILITY, AND EFFICACY OF DAZUKIBART IN PARTICIPANTS WITH IDIOPATHIC INFLAMMATORY MYOPATHIES.’ The study aims to understand how dazukibart, an anti-interferon beta therapy, works in individuals with idiopathic inflammatory myopathies, specifically dermatomyositis and polymyositis, which cause muscle weakness and impact quality of life.
Study Overview: Pfizer Inc. is conducting a Phase 3 clinical study titled An Interventional, Open-Label, Randomized, Multicenter, Phase 3 Study of PF-07248144 Plus Fulvestrant Compared to Investigator’s Choice of Therapy in Adult Participants With Hormone Receptor-Positive, HER2-Negative Advanced/Metastatic Breast Cancer Whose Disease Progressed After Prior CDK4/6 Inhibitor-based Therapy. The study aims to assess the safety and effectiveness of PF-07248144 combined with fulvestrant in treating HR-positive, HER2-negative advanced or metastatic breast cancer that has progressed following previous treatment.
Pfizer Inc. is conducting an observational study titled ‘Observational Study of Tofacitinib in Ulcerative Colitis in Sweden (ODEN)’ to evaluate the effectiveness and treatment adherence of tofacitinib in patients with ulcerative colitis in Sweden. The study aims to gather real-world evidence on how patients adhere to and respond to this treatment in clinical practice, using data from the National Swedish registry (SWIBREG) and the Swedish Prescribed Drug Register.
Study Overview: Pfizer Inc. is conducting a Phase 1 study titled A PHASE 1, OPEN-LABEL, RANDOMIZED, SINGLE DOSE, CROSSOVER, PIVOTAL BIOEQUIVALENCE STUDY TO COMPARE ATIRMOCICLIB (PF-07220060) HIGHER DRUG LOAD IR MST TABLETS AND ATIRMOCICLIB IR MST TABLETS ADMINISTERED UNDER FED CONDITIONS IN HEALTHY ADULT PARTICIPANTS. The study aims to assess the bioequivalence of two tablet formulations of Atirmociclib, focusing on how the different formulations affect the drug’s absorption, processing, and elimination in the body.
Pfizer Inc. is conducting a clinical trial titled An Open-Label Study in Pediatric (<18 Years of Age), Severe Hemophilia A Participants (Coagulation Factor Activity <1%) With or Without Inhibitors or Moderately Severe to Severe Hemophilia B Participants (Coagulation Factor Activity =2%) With or Without Inhibitors Comparing 12 Months of Historical Standard Treatment to Marstacimab Prophylaxis. The study aims to evaluate the safety and effectiveness of marstacimab, a potential treatment for hemophilia in pediatric patients. This research is significant as it could offer a new prophylactic option for managing bleeding episodes in children with hemophilia.
Pfizer Inc. is conducting a clinical study titled ‘A Phase 1B Open-Label Non-Randomized Study to Assess the Safety, Pharmacokinetics, and Pharmacodynamics of Marstacimab Treatment Following the Discontinuation of Emicizumab Therapy in Adolescent and Adult Participants with Severe Hemophilia A Without Inhibitors.’ The study aims to evaluate the safety and effectiveness of marstacimab, a new treatment for severe hemophilia A, in patients transitioning from emicizumab. This research is significant as it could provide new insights into treatment options for hemophilia A patients.
Study Overview: Pfizer Inc. is conducting a multinational, prospective observational study titled PRESTO – Characterization and Clinical Outcomes of Alopecia Areata (AA) Patients Treated With Ritlecitinib in a Real-world Cohort. The study aims to evaluate the characteristics and clinical outcomes of patients with alopecia areata (AA) treated with ritlecitinib, a drug recently approved for severe AA. This research is significant as it seeks to provide real-world evidence on the effectiveness of ritlecitinib, complementing previous clinical trial data.
Pfizer Inc. and Astellas Pharma Inc. are conducting a study titled ‘Real-world Clinical Outcomes With Androgen Receptor Pathway Inhibitors (ARPIs) in Metastatic Castration-sensitive Prostate Cancer (mCSPC) in the Flatiron Health Electronic Health Records (EHR) Database.’ The study aims to understand the duration of treatment with apalutamide and enzalutamide in men with mCSPC, a common cancer in men that has spread and is controlled by lowering testosterone levels.
Pfizer Inc. is conducting a Phase 1 study titled ‘A Study to Learn About How a New Pneumococcal Vaccine Works in Adults.’ The primary goal is to assess the safety and tolerability of a new multivalent pneumococcal conjugate vaccine in adults. This study is significant as it could lead to advancements in preventing infections caused by Streptococcus pneumoniae.
Pfizer Inc. is conducting a post-marketing surveillance study titled ‘Korean Post-marketing Surveillance for Xeljanz® 5 mg Film-coated Tablets and Xeljanz® 1 mg/mL Oral Solution in Patients With Active pJIA and jPsA.’ The study aims to evaluate the safety and effectiveness of Xeljanz in treating Juvenile Idiopathic Arthritis (JIA) in routine clinical practice in Korea. This is significant as it addresses the persistent joint pain, swelling, and stiffness experienced by JIA patients.
Pfizer Inc. and BioNTech SE have announced an update on their ongoing Phase 3 clinical study titled A Phase 3 Protocol to Investigate the Safety, Tolerability, and Immunogenicity of BNT162b2 RNA-Based Variant-Adapted Vaccine Candidate(s) Against SARS-CoV-2 in Adults, Including Those at Higher Risk of Severe COVID-19. The study aims to evaluate the safety and immune response of an updated COVID-19 vaccine targeting a circulating variant of SARS-CoV-2, specifically for adults at higher risk of severe disease.
Study Overview: Pfizer Inc. has initiated a study titled Impact of Nirmatrelvir and Ritonavir (PAXLOVID®) on Mortality, Progression to Severe Disease, and Activities of Daily Living (ADL) Worsening in Long-term Care Hospitals (LTCHs) in Korea. The study aims to evaluate the effectiveness of Paxlovid in reducing severe illness, mortality, and daily activity decline in adults aged 60 and older residing in Korean long-term care hospitals who have contracted COVID-19.
Pfizer Inc. is conducting a study titled ‘Post Marketing Surveillance to Observe Safety and Effectiveness of PAXLOVID in Patients With Positive Results of Viral Testing, and Who Are at High Risk for Progression to Severe COVID-19.’ The study aims to evaluate the real-world safety and effectiveness of PAXLOVID in patients at high risk of severe COVID-19, particularly in Korea. This is significant as it provides insights into the drug’s performance outside controlled clinical environments.
Pfizer Inc. is conducting a study titled ‘Real World Evaluation of COVID-19 Burden and Nirmatrelvir/Ritonavir in Taiwan Using National Health Insurance Research Database.’ The study aims to understand the effects of living with COVID-19 and evaluate the effectiveness of the drug combination nirmatrelvir-ritonavir in treating COVID-19. This research is significant as it provides insights into the disease’s impact and treatment efficacy in real-world settings.
Pfizer Inc. has launched a clinical study titled ‘EPIC-Peds’ to evaluate the safety, pharmacokinetics, and efficacy of the antiviral drugs nirmatrelvir and ritonavir in pediatric patients with COVID-19 who are not hospitalized but are at risk of severe disease. This study is significant as it aims to provide a treatment option for children under 18 years, potentially reducing the risk of severe COVID-19 outcomes in this vulnerable group.
Pfizer Inc. is conducting a clinical study titled ‘An Open-Label, Single-Arm Study to Evaluate the Efficacy, Pharmacokinetics, and Safety of Etrasimod in Adolescent Subjects With Moderately to Severely Active Ulcerative Colitis.’ The study aims to assess the safety and effectiveness of etrasimod, a drug intended to treat ulcerative colitis in adolescents aged 12 to under 18 years. This research is significant as it targets a younger demographic with limited treatment options.
Pfizer Inc. is conducting a study titled ‘A Prospective, Single-arm, Multicenter, Observational Safety Surveillance Study of VyndaMx® (Tafamidis Capsule 61 mg) in Patients With Transthyretin Amyloid Cardiomyopathy (ATTR-CM) in India.’ The study aims to evaluate the safety of Tafamidis in treating ATTR-CM, a heart condition caused by amyloid protein buildup. This study is significant as it seeks to ensure the safety of Tafamidis, a drug intended to improve heart function in affected patients.
Pfizer Inc. is conducting a Korean Regulatory Post Marketing Surveillance study for Somavert, officially titled ‘Korean Post-marketing Surveillance for Somavert.’ The study aims to assess the safety and effectiveness of Somavert, a drug used to treat acromegaly, during its post-marketing phase as required by the Korean Ministry of Food and Drug Safety (MFDS). This study is significant as it ensures the continued monitoring of the drug’s performance in real-world settings.
Study Overview: Pfizer Inc. is conducting a clinical study titled Clinical Benefit of Tafamidis 61mg for Transthyretin Amyloid Cardiomyopathy (ATTR-CM) Patients in Korean Population in the Real-world Setting, Multicenter, Non-interventional Study. The study aims to evaluate the safety and effectiveness of Tafamidis 61mg in treating patients diagnosed with ATTR-CM, a serious heart condition. This study is significant as it seeks to provide real-world insights into the treatment’s impact on the Korean population.
Pfizer Inc. has initiated a Phase 3 clinical study titled ‘An Interventional Efficacy and Safety, Phase 3, Double-Blind, 3-Arm, Study to Investigate Pain Response with Intranasal Zavegepant Compared with Placebo in the Acute Treatment of Multiple Migraine Attacks in Adult Participants.’ The study aims to demonstrate that Zavegepant, administered intranasally, provides freedom from pain two hours after treatment across multiple migraine attacks. This research is significant as it targets adult participants suffering from frequent migraines, potentially offering a new treatment avenue.
Pfizer Inc. is conducting a clinical study titled ‘A Prospective, Single-arm, Open-label, Non-interventional, Multi-centre, Post Marketing Surveillance (PMS) Study of Mylotarg®.’ The study aims to evaluate the safety and effects of Mylotarg in treating acute myeloid leukemia (AML), a condition affecting white blood cells. The study is significant as it seeks to provide insights into the safety profile of Mylotarg, potentially influencing its use in AML treatment.
Pfizer Inc. is conducting a clinical study titled ‘A Phase 1 / 2, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Single Escalating Doses of PF-07868489 in Healthy Adult Participants and, Additionally, Clinical Activity of Repeat Doses in Participants with Pulmonary Arterial Hypertension.’ The study aims to assess the safety and effects of PF-07868489 in healthy adults and those with pulmonary arterial hypertension (PAH), a condition that affects blood flow in the lungs.
Pfizer Inc. is currently conducting a Phase 1 clinical study titled ‘A PHASE 1, MULTICENTER, OPEN-LABEL, SINGLE-DOSE STUDY TO EVALUATE THE SAFETY, TOLERABILITY AND PHARMACOKINETICS OF ZAVEGEPANT IN CHILDREN 6 TO LESS THAN 12 YEARS OF AGE WITH HISTORY OF MIGRAINE.’ The study aims to assess the safety and bodily processing of Zavegepant, a nasal spray medication, in children aged 6 to less than 12 years who have a history of migraines. This research is significant as it explores treatment options for a younger demographic suffering from migraines.
Pfizer Inc. is conducting a Phase 1 clinical study titled A Phase 1, Randomized, Double-Blind, Sponsor-Open, Placebo-Controlled Study to Assess Safety, Tolerability, and Pharmacokinetics of Single and Multiple Ascending Oral Doses of PF-07899895 Administered as Immediate and Modified Release Formulations in Healthy Adult Participants. The study aims to evaluate the safety, tolerability, and how the body processes the drug PF-07899895 in healthy adults. This research is significant as it lays the groundwork for potential future treatments.
Pfizer Inc. is conducting a Phase 4 study titled ‘A Phase 4 Study Using a Test-Negative Design to Evaluate the Effectiveness of a 20-valent Pneumococcal Conjugate Vaccine Against Vaccine-type Radiologically-confirmed Community-acquired Pneumonia in Adults >/= 65 Years of Age.’ The study aims to assess the effectiveness of the 20-valent pneumococcal conjugate vaccine (20vPnC) in preventing pneumonia caused by specific strains of Streptococcus pneumoniae in adults aged 65 and older. This research is significant as it seeks to provide real-world evidence of the vaccine’s efficacy in preventing serious pneumonia cases.
Pfizer Inc. is currently conducting a clinical study titled ‘XALKORI ROS1+NSCLC DRUG USE INVESTIGATION’ to evaluate the safety and efficacy of Xalkori (crizotinib) in patients with non-small cell lung cancer (NSCLC). The study aims to gather data on unexpected adverse drug reactions, the incidence of these reactions, and factors influencing the drug’s safety and efficacy.
Pfizer Inc. and BioNTech SE are conducting a clinical study titled ‘A Phase 1/2 Randomized, Double-Blinded Study to Evaluate the Safety, Tolerability, and Immunogenicity of Modified RNA Vaccine Candidates Against Influenza and COVID-19 in Healthy Individuals.’ The study aims to understand the effects of flu and COVID-19 vaccines when administered alone or in combination. This research is significant as it could lead to more efficient vaccination strategies against these prevalent diseases.
Pfizer Inc. has launched a study titled ‘Effectiveness of Etrasimod on Disease Activity and Patient-reported Outcomes in Ulcerative Colitis – EFFECT-UC’. This observational study aims to evaluate the effectiveness of etrasimod, a drug for treating moderate to severe ulcerative colitis. The study is significant as it seeks to provide real-world insights into the drug’s impact on disease activity and patient-reported outcomes.
Pfizer Inc. is conducting a clinical study titled A Phase 2, Randomized, Double-Blind, Placebo-Controlled, Parallel-group, Dose-Ranging Study to Investigate the Efficacy and Safety of PF-07275315 in Adult Participants With Inadequately Controlled Moderate-to-Severe Asthma. The study aims to evaluate the safety and efficacy of PF-07275315, a potential treatment for moderate-to-severe asthma, a condition that significantly impacts quality of life.
Pfizer Inc. is conducting a Post Marketing Surveillance (PMS) study titled ‘A Prospective, Single-arm, Open-label, Non-interventional, Multi-centre, Post Marketing Surveillance (PMS) Study of Cresemba to Evaluate Safety and Effectiveness in Patients With Invasive Aspergillosis or Invasive Mucormycosis in Korea.’ The study aims to assess the safety and effectiveness of Cresemba, a drug used to treat invasive Aspergillosis and Mucormycosis, during the post-marketing phase as required by the Ministry of Food and Drug Safety (MFDS) in Korea.
Pfizer Inc. has announced a new clinical study titled ‘Real-world Database Study to Observe Safety and Effectiveness of Ibrance,’ focusing on patients with advanced or metastatic breast cancer. The study aims to evaluate the safety and effectiveness of Palbociclib, marketed as Ibrance, by analyzing real-world data. This research is significant as it seeks to provide insights into the treatment’s safety profile and its impact on patients in everyday clinical settings.
Pfizer Inc. is currently conducting a study titled ‘Real-World Characteristics and Treatment Patterns of Patients With Transthyretin Amyloid Cardiomyopathy (ATTR-CM): A Multi-Country, Non-Interventional, Disease Registry.’ The study aims to observe the natural progression and treatment patterns of patients diagnosed with ATTR-CM, providing valuable insights into the disease’s real-world characteristics. This registry is significant as it helps in understanding the disease better, potentially guiding future therapeutic strategies.
Pfizer Inc. has initiated a clinical study titled ‘A Phase 1, Randomized, Crossover Design Study to Assess Palatability of Osivelotor (PF-07940367) Pediatric Formulations With Dosing Vehicle (Part 1) and Randomized, Single-Dose, Parallel Design Study to Estimate Relative Bioavailability of Osivelotor Pediatric Formulation With Dosing Vehicle and With Water Compared to Clinical Tablet Formulation, and Effect of Food and/or Acid-Reducing Agent On Bioavailability In Healthy Adult Participants (Part 2)’. The study aims to evaluate how different preparations of the drug Osivelotor taste and enter the bloodstream when consumed with food, liquids, or an antacid in healthy adults. This research is significant for improving treatment options for sickle cell disease.
Pfizer Inc. is currently conducting a clinical study titled ‘LOREA: Analysis of the Effectiveness and Safety of Lorlatinib in Untreated ALK-Positive NSCLC Patients in a French Real-World Context.’ The study aims to evaluate the effectiveness and safety of Lorlatinib, a treatment for ALK-positive non-small-cell lung carcinoma (NSCLC), in a real-world setting in France. This research is significant as it seeks to provide insights into the drug’s performance outside of controlled clinical environments.
Pfizer Inc. is conducting a post-marketing surveillance study titled A Prospective, Single-arm, Open-label, Non-interventional, Multi-centre, Post Marketing Surveillance (PMS) Study of Lorviqua (Registered) in Korea. The study aims to monitor the real-world use of Lorviqua, focusing on its safety and adverse events in patients with Metastatic ALK+ Non-Small Cell Lung Cancer.
Study Overview: Pfizer Inc. is conducting a clinical study titled ‘A Treatment Protocol for Participants Continuing From Pfizer-sponsored Palbociclib Clinical Studies.’ The study aims to provide ongoing access to study medicines and assess their safety for participants who have previously benefited from Pfizer-sponsored Palbociclib studies. The significance lies in ensuring continued treatment for patients with breast cancer and head and neck cancer, while monitoring safety outcomes.
Pfizer Inc. is conducting an open-label extension study titled AN OPEN-LABEL EXTENSION STUDY TO EVALUATE THE LONG-TERM SAFETY, TOLERABILITY, AND EFFICACY OF MARSTACIMAB PROPHYLAXIS IN SEVERE (COAGULATION FACTOR ACTIVITY <1%) HEMOPHILIA A PARTICIPANTS WITH OR WITHOUT INHIBITORS OR MODERATELY SEVERE TO SEVERE HEMOPHILIA B PARTICIPANTS (COAGULATION FACTOR ACTIVITY ≤2%) WITH OR WITHOUT INHIBITORS. The study aims to evaluate the long-term safety, tolerability, and efficacy of marstacimab prophylaxis in participants with severe hemophilia A or B, with or without inhibitors. This research is significant as it addresses a critical need for effective long-term treatment options for hemophilia patients.
Pfizer Inc. is conducting a study titled A Multi-Center, Prospective, Non-Interventional Study of Real-World Effectiveness of Etrasimod in Patients With Ulcerative Colitis (ENDEAVOUR-UC). The study aims to evaluate the real-world effectiveness of etrasimod in treating adult patients with moderate to severe ulcerative colitis. This observational study is significant as it seeks to understand the impact of etrasimod when used as a standard care treatment option.
Pfizer Inc. has completed a study titled ‘Evaluation of Satisfaction With Rimegepant and Triptans Utilizing Migraine Buddy Retrospective Data.’ The study aimed to assess user satisfaction with the migraine treatments Nurtec (rimegepant) and triptans, using real-world data from the Migraine Buddy app. This research is significant as it provides insights into patient satisfaction in a real-life setting, which can guide treatment decisions.
Pfizer Inc. is conducting a Phase 3 clinical study titled AN OPEN-LABEL, RANDOMIZED, CONTROLLED PHASE 3 STUDY OF SIGVOTATUG VEDOTIN IN COMBINATION WITH PEMBROLIZUMAB COMPARED WITH PEMBROLIZUMAB MONOTHERAPY AS FIRST-LINE TREATMENT IN PARTICIPANTS WITH PD-L1 HIGH (≥50% OF TUMOR CELLS EXPRESSING PD-L1), LOCALLY ADVANCED, UNRESECTABLE, OR METASTATIC NON-SMALL CELL LUNG CANCER (BE6A LUNG-02). The study aims to evaluate the effectiveness of a combination treatment of Sigvotatug Vedotin and pembrolizumab versus pembrolizumab alone in patients with advanced non-small cell lung cancer (NSCLC) with high PD-L1 levels.
Pfizer Inc. is conducting a clinical study titled ‘A Phase 1/2A Dose Escalation and Expansion Study to Evaluate Safety, Tolerability, Pharmacokinetic, Pharmacodynamic, and Anti-Tumor Activity of PF-07248144 in Participants with Advanced or Metastatic Solid Tumors.’ The study aims to assess the safety and effectiveness of PF-07248144, a KAT6 inhibitor, both as a standalone treatment and in combination with other drugs, in treating advanced or metastatic solid tumors.
Pfizer Inc. is conducting a study titled ‘Real-world Clinical Outcomes of Tucatinib, Trastuzumab, and Capecitabine Following Trastuzumab Deruxtecan for the Treatment of HER2-positive Metastatic Breast Cancer.’ The study aims to evaluate real-world outcomes such as time to next treatment and overall survival for patients with HER2-positive metastatic breast cancer in the U.S. This research is significant as it provides insights into the effectiveness of the tucatinib-trastuzumab-capecitabine combination following T-DXd therapy.
Pfizer Inc. is conducting a study titled An Open-Label Phase 1 Study to Evaluate PF-08046032 as Monotherapy and Part of Combination Therapy in Participants With Advanced Malignancies. The study aims to assess the effects of PF-08046032, alone and in combination with sasanlimab, on adults with advanced cancers, including certain lymphomas and solid tumors. This research is significant as it explores new treatment avenues for patients whose diseases have progressed despite standard treatments.
Pfizer Inc. is conducting a Phase 1 clinical study titled A PHASE 1, RANDOMIZED STUDY WITH DOUBLE-BLIND AND SPONSOR-OPEN, PLACEBO-CONTROLLED SINGLE- AND MULTIPLE-DOSE ESCALATION TO EVALUATE THE SAFETY, TOLERABILITY, PHARMACOKINETICS, AND PHARMACODYNAMICS OF PF-08049820 IN HEALTHY ADULT PARTICIPANTS. The study aims to assess the safety and how the body processes PF-08049820, a drug developed for treating moderate to severe atopic dermatitis, in healthy adults. This research is significant as it could lead to new treatment options for eczema, a condition causing severe itching and rashes.
Study Overview: Pfizer Inc. is conducting a Phase 1 open-label study titled A Phase 1 Open-Label Study of PF-07934040 as a Single Agent and in Combination With Other Targeted Agents in Participants With Advanced Solid Tumors Harboring Mutations in the KRAS Gene. The study aims to evaluate the safety and efficacy of PF-07934040, alone and in combination with other treatments, for advanced solid tumors with KRAS mutations. This research is significant as it targets cancers that are difficult to treat and often resistant to existing therapies.
Pfizer Inc. has initiated a study titled ‘Post-Approval Safety Monitoring Program to Assess the Safety and Efficacy Profile of TUKYSA in Usual Practice’ to evaluate the safety and effectiveness of Tukysa once it is available in the Korean market. The study aims to re-confirm the clinical usefulness of Tukysa by collecting and reviewing safety and efficacy information in general practice, which is crucial for re-examination under Korean pharmaceutical regulations.
Study Overview: Pfizer Inc. is conducting a study titled PREVENAR 20 SUSPENSION LIQUID FOR INJECTION SPECIAL INVESTIGATION to assess the safety of the 20-valent Pneumococcal Conjugate Vaccine (PREVENAR 20) in infants aged between two to six months. The study aims to observe the vaccine’s safety under real-world clinical conditions in Japan, focusing on infants receiving the vaccine for the first time.
Pfizer Inc. is conducting a clinical study titled ‘A Phase 1b/2, Open-Label, Multicohort Study of Disitamab Vedotin in Adults With HER2 Expressing Advanced Breast Cancer.’ The study aims to evaluate the safety and efficacy of disitamab vedotin, a potential treatment for advanced breast cancer that is difficult to treat and has spread in the body. This research is significant as it targets patients with HER2-expressing tumors who have undergone previous treatments.
Pfizer Inc. is currently conducting a study titled ‘Treating Atopic Dermatitis With Abrocitinib and Its Impact in Real Life: An Observational Cohort Study To Describe the Effectiveness of Abrocitinib in Patients With Moderate-to-Severe Atopic Dermatitis.’ The study aims to evaluate the safety and effectiveness of Abrocitinib, a treatment for moderate to severe atopic dermatitis, in a real-world setting. This research is significant as it seeks to provide insights into the drug’s performance outside of controlled clinical trials.
Pfizer Inc. is conducting an open-label Phase 1 study titled ‘AN OPEN-LABEL PHASE 1 STUDY TO INVESTIGATE PF-08046031 IN ADULTS WITH ADVANCED MELANOMA AND OTHER SOLID TUMORS.’ The study aims to evaluate the safety and side effects of PF-08046031, a drug intended for patients with advanced melanoma and other solid tumors lacking approved treatments. The study is significant as it explores potential new treatment avenues for challenging cancer types.
Pfizer Inc. is currently conducting a study titled ‘The Real-world Treatment Patterns and Clinical Outcomes in Moderate-to-severe Atopic Dermatitis (AD) Patients Receiving Abrocitinib,’ aiming to evaluate the real-world treatment patterns and clinical outcomes for patients with moderate-to-severe atopic dermatitis over a 12-month period. This study is significant as it seeks to provide insights into the effectiveness and demographic characteristics of patients treated with Abrocitinib, a drug designed to manage symptoms of atopic dermatitis.
Study Overview: Pfizer Inc. is conducting a Phase 3 clinical study titled A 104-Week Study of Ritlecitinib Oral Capsules in Adults With Nonsegmental Vitiligo (Active and Stable) Tranquillo 2. The study aims to evaluate the efficacy, safety, and tolerability of ritlecitinib, a potential oral treatment for nonsegmental vitiligo, a condition causing skin depigmentation. This study is significant as there are currently no approved oral medications for this condition.
Pfizer Inc. is conducting a post-marketing surveillance study titled Post Marketing Surveillance (PMS) Study for Cibinqo Tablet (Abrocitinib) in Patients With Moderate to Severe Atopic Dermatitis (AD) in Korea. The study aims to assess the safety and effectiveness of Cibinqo, a tablet form of Abrocitinib, in treating moderate to severe atopic dermatitis. This condition is characterized by a persistent itchy red rash, and the study seeks to provide insights into the real-world application of the treatment.
Pfizer Inc. and BioNTech SE have recently completed a clinical study titled ‘A Phase 1/2, Randomized, Observer-Blinded Study to Evaluate the Safety, Tolerability, and Immunogenicity of Combined Vaccine Candidates Against Influenza and COVID-19 in Healthy Individuals.’ The study aimed to assess the safety and immune response of combined influenza and COVID-19 vaccines in healthy adults, highlighting its potential significance in streamlining vaccination processes.
Pfizer Inc. is conducting an observational study titled ‘CIBINQO™ Pregnancy Registry: An Observational Study of the Safety of Abrocitinib Exposure in Pregnant Women and Their Offspring.’ The study aims to assess the safety of the drug Abrocitinib, marketed as CIBINQO, in pregnant women and their children. This research is significant as it seeks to provide insights into the safety profile of Abrocitinib during pregnancy, which is crucial for patient safety and regulatory compliance.
Pfizer Inc. is conducting an open-label Phase 1 clinical trial titled AN OPEN-LABEL PHASE 1 STUDY TO EVALUATE PF-08046037 AS MONOTHERAPY AND PART OF COMBINATION THERAPY IN PARTICIPANTS WITH ADVANCED MALIGNANCIES. The study aims to assess the safety and effects of PF-08046037, alone or combined with sasanlimab, in patients with advanced or metastatic malignancies, including non-small cell lung cancer, head and neck squamous cell carcinoma, melanoma, and pancreatic ductal adenocarcinoma. This study is significant as it explores potential new treatments for these challenging cancer types.
Pfizer Inc. is currently conducting a clinical study titled ‘Open-Label Induction and Maintenance Study of Oral CP-690,550 (Tofacitinib) in Children with Moderately to Severely Active Ulcerative Colitis.’ The study aims to evaluate the efficacy, safety, and pharmacokinetics of tofacitinib in pediatric patients with moderate to severe ulcerative colitis (UC), especially those who have not responded well to other treatments. The primary goal is to assess remission rates using the central read Mayo score after 44 weeks in the maintenance phase.
Pfizer Inc. has initiated a clinical study titled A Phase 1, Randomized, Double-Blind, Sponsor-Open, Placebo-Controlled, Dose Escalation Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Multiple-Dose Topical Administration of PF-07905428 in Healthy Participants and Participants With Acne Vulgaris. The study aims to assess the safety and efficacy of PF-07905428, a topical treatment for moderate to severe acne vulgaris in individuals aged 18 to 40. This research is significant as it could potentially offer a new treatment option for acne sufferers.
Pfizer Inc. has initiated a Phase 1 clinical study titled A PHASE 1 OPEN-LABEL STUDY OF PF-07985045 AS A SINGLE-AGENT AND IN COMBINATION WITH OTHER ANTI-CANCER AGENTS IN PARTICIPANTS WITH ADVANCED SOLID TUMORS. The study aims to evaluate the safety and efficacy of PF-07985045, a KRAS inhibitor, both alone and in combination with other anti-cancer therapies in patients with advanced solid tumors exhibiting KRAS gene mutations. This study is significant as it targets challenging cancer types such as non-small cell lung cancer, colorectal cancer, and pancreatic ductal adenocarcinoma.
Pfizer Inc. is conducting a Phase 3 study titled ‘A Phase 3, Multi-Center, Open-Label Extension Study to Investigate the Long-Term Safety, Tolerability, and Efficacy of Dazukibart in Participants with Idiopathic Inflammatory Myopathies.’ The study aims to assess the long-term effects of dazukibart, an anti-interferon beta therapy, on patients with idiopathic inflammatory myopathies such as dermatomyositis and polymyositis. These conditions cause muscle weakness and can severely impact quality of life.
Pfizer Inc. is initiating a Phase 3, long-term study titled A Long-term Study of the Medicine Called Abrocitinib in Children Aged 2 Years and Older With Moderate to Severe Eczema. The study aims to evaluate the safety and efficacy of the drug Abrocitinib, administered as a liquid oral suspension, in children with moderate-to-severe atopic dermatitis. This research is significant as it seeks to provide a long-term treatment option for pediatric eczema, a condition that affects many children globally.
Pfizer Inc. is conducting a clinical study titled AN OPEN-LABEL, 3-ARM, MULTICENTER, RANDOMIZED PHASE 3 STUDY TO EVALUATE THE EFFICACY AND SAFETY OF ELRANATAMAB (PF-06863135) MONOTHERAPY AND ELRANATAMAB + DARATUMUMAB VERSUS DARATUMUMAB + POMALIDOMIDE + DEXAMETHASONE IN PARTICIPANTS WITH RELAPSED/REFRACTORY MULTIPLE MYELOMA WHO HAVE RECEIVED AT LEAST 1 PRIOR LINE OF THERAPY INCLUDING LENALIDOMIDE AND A PROTEASOME INHIBITOR. The study aims to assess the efficacy and safety of the BCMA-CD3 bispecific antibody elranatamab, alone and in combination with daratumumab, compared to a standard combination therapy in patients with multiple myeloma who have undergone previous treatments.
Pfizer Inc. recently updated its clinical study titled A Phase 2a, Open-label, Single and Multiple Dose Study to Evaluate the Pharmacokinetics, Safety, Tolerability and Treatment Effect of GBT440 in Pediatric Participants With Sickle Cell Disease. The study aimed to assess the pharmacokinetics, safety, and efficacy of voxelotor in children with sickle cell disease, focusing on different age groups and dosing regimens.
Study Overview: Pfizer and AbbVie are conducting a clinical study titled ‘A PHASE 2A, 2-PART, OPEN-LABEL, NON-RANDOMIZED, MULTICENTER, SINGLE AND MULTIPLE DOSE TRIAL TO EVALUATE PHARMACOKINETICS, SAFETY AND TOLERABILITY OF AZTREONAM AND AVIBACTAM ± METRONIDAZOLE IN NEONATES AND INFANTS FROM BIRTH TO LESS THAN 9 MONTHS OF AGE WITH SUSPECTED OR CONFIRMED INFECTIONS DUE TO GRAM-NEGATIVE PATHOGENS REQUIRING INTRAVENOUS ANTIBIOTIC TREATMENT.’ The study aims to assess the safety and effects of the combination antibiotic aztreonam-avibactam (ATM-AVI) in treating gram-negative bacterial infections in newborns and infants.
Pfizer Inc. is conducting a study titled ‘Prospective Observational Post Marketing Surveillance Study to Observe Safety and Effectiveness of Zavicefta IV.’ The study aims to assess the safety and effectiveness of Zavicefta, a medication used to treat complex infections in the abdomen, urinary tract, and pneumonia, particularly in a hospital setting. This study is significant as it complies with the Ministry of Food and Drug Safety (MFDS) of Korea’s regulations for new drugs.
Pfizer Inc. is currently conducting an observational study titled ‘Observational Study of Tofacitinib in Ulcerative Colitis in Sweden (ODEN).’ The study aims to evaluate the effectiveness and treatment adherence of the drug tofacitinib in patients with ulcerative colitis within Swedish clinical practice. This research is significant as it leverages data from the National Swedish registry (SWIBREG) to provide insights into real-world clinical outcomes.
Pfizer Inc. is conducting a Phase 1 clinical trial titled ‘A PHASE 1, FIRST IN HUMAN, RANDOMIZED, DOUBLE-BLIND, SPONSOR-OPEN, PLACEBO-CONTROLLED, SINGLE- AND MULTIPLE DOSE ESCALATION, PARALLEL GROUP STUDY TO EVALUATE THE SAFETY, TOLERABILITY, PHARMACOKINETICS AND PHARMACODYNAMICS OF PF-07832837 IN HEALTHY PARTICIPANTS AND PARTICIPANTS WITH MODERATE TO SEVERE ATOPIC DERMATITIS.’ The study aims to assess the safety, tolerability, and pharmacokinetics of PF-07832837 in both healthy adults and patients with moderate to severe atopic dermatitis, with an additional focus on pharmacodynamics in affected patients.
Pfizer Inc. is currently conducting a study titled ‘Special Investigation for CIBINQO (Long Term)’ aimed at evaluating the safety and effectiveness of the drug CIBINQO for treating atopic dermatitis under Japanese medical practice. This study is significant as it seeks to provide insights into the long-term use of CIBINQO, potentially offering a new therapeutic option for individuals suffering from this chronic skin condition.
Pfizer Inc. is conducting a Phase 3 clinical study titled An Interventional, Efficacy, and Safety, Phase 3 Randomized, Double-Blind, Placebo-Controlled Study with an Open-Label Extension to Investigate Rimegepant in Migraine Prevention in Adolescents 12 to Less Than 18 Years of Age with Chronic Migraine. The study aims to evaluate the efficacy and safety of rimegepant, a dissolvable tablet, in adolescents experiencing frequent migraines. This research is significant as it targets a younger demographic suffering from chronic migraines, potentially offering a new preventive treatment option.
Study Overview: Pfizer Inc. has initiated a Korea Post Marketing Surveillance (PMS) Study of Talzenna®, officially titled A Prospective, Single-arm, Open-label, Non-interventional, Multi-centre, Post Marketing Surveillance (PMS) Study of Talzenna(Registered). The study aims to assess the effectiveness and safety of Talzenna in treating gBRCA advanced breast cancer in Korea, following its regulatory approval. This surveillance is crucial to identify any potential issues or questions arising from its use in general clinical practice.
Pfizer Inc. is conducting a Phase 3 clinical study titled ‘An Interventional, Open-Label, Randomized, Multicenter, Phase 3 Study of PF-07248144 Plus Fulvestrant Compared to Investigator’s Choice of Therapy in Adult Participants With Hormone Receptor-Positive, HER2-Negative Advanced/Metastatic Breast Cancer Whose Disease Progressed After Prior CDK4/6 Inhibitor-based Therapy.’ The study aims to assess the safety and efficacy of PF-07248144 combined with fulvestrant in treating HR-positive, HER2-negative advanced or metastatic breast cancer that has progressed after previous treatment.
Pfizer Inc. is conducting a Phase 2 clinical study titled A Prospective, Randomized, Open-Label Phase 2 Study to Evaluate the Superiority of Inotuzumab Ozogamicin Monotherapy Versus ALLR3 for Induction Treatment of Childhood High Risk First Relapse B-Cell Precursor Acute Lymphoblastic Leukemia. The study aims to assess the effectiveness of Inotuzumab Ozogamicin (InO) compared to the ALLR3 regimen in children aged 1 to under 18 years with high-risk first relapse acute lymphoblastic leukemia (ALL). This research is significant as it explores potential improvements in treatment for a vulnerable pediatric population.
Pfizer Inc. is conducting a clinical study titled ‘MagnetisMM-4: Umbrella Study of Elranatamab (PF-06863135) in Combination With Anti-Cancer Treatments in Multiple Myeloma.’ The study aims to determine the Recommended Phase 2 Dose and assess the clinical benefits of elranatamab, a BCMA-CD3 bispecific antibody, when combined with other anti-cancer therapies for patients with multiple myeloma. This research is significant as it explores new therapeutic combinations for a challenging cancer type.
Pfizer Inc. and Astellas Pharma Inc. are conducting a Phase 3 clinical study titled ‘TALAPRO-3: A Phase 3, Randomized, Double-Blind, Study of Talazoparib With Enzalutamide Versus Placebo With Enzalutamide in Men With DDR Gene Mutated Metastatic Castration-Sensitive Prostate Cancer.’ The study aims to evaluate the safety and efficacy of combining talazoparib with enzalutamide compared to a placebo with enzalutamide in men with DDR-deficient metastatic castration-sensitive prostate cancer (mCSPC). This research is significant as it could lead to new treatment options for this patient group.
Pfizer Inc. is conducting a Phase 3 study titled ‘A Phase 3 Multi-Center, Long-Term Extension Study Investigating the Efficacy and Safety of Abrocitinib, With or Without Topical Medications, Administered to Subjects Aged 12 Years and Older With Moderate to Severe Atopic Dermatitis.’ The study aims to evaluate the efficacy and safety of Abrocitinib, an oral medication, in treating moderate to severe atopic dermatitis in patients aged 12 and older. This research is significant as it addresses a common and challenging skin condition, potentially offering a new treatment option.
Pfizer Inc. is conducting a Phase 2 clinical study titled ‘A PHASE 2, MULTICENTER, SINGLE-ARM STUDY TO EVALUATE THE SAFETY AND DYSTROPHIN EXPRESSION AFTER FORDADISTROGENE MOVAPARVOVEC (PF-06939926) ADMINISTRATION IN MALE PARTICIPANTS WITH EARLY STAGE DUCHENNE MUSCULAR DYSTROPHY.’ The study aims to assess the safety and dystrophin expression following the administration of the gene therapy fordadistrogene movaparvovec in young boys with Duchenne Muscular Dystrophy (DMD). This research is significant as it explores potential treatment options for this progressive genetic disorder.
Pfizer Inc. is conducting a retrospective cohort study titled ‘Retrospective Cohort Study of Pregnancy Outcomes in Women Exposed to Rimegepant During Pregnancy.’ The study aims to evaluate the risk of pregnancy and infant outcomes among women with migraines who were exposed to rimegepant during pregnancy, compared to two groups of women who were not exposed to rimegepant. This research is significant as it seeks to understand the safety and implications of using rimegepant, a migraine medication, during pregnancy.
Pfizer Inc. is conducting a Phase 3 clinical study titled A Phase 3, External and Synthetic Placebo-Controlled Randomized Study with Dose-Up for Non-Responders to Investigate Safety and Efficacy of Ritlecitinib 50 mg and 100 mg Once Daily in Adult and Adolescent Participants 12 Years of Age and Older with Alopecia Areata. The study aims to evaluate the safety and efficacy of two doses of Ritlecitinib, a drug approved for treating severe alopecia areata, a condition causing hair loss. This study is significant as it could offer new insights into effective treatment dosages for this condition.
Pfizer Inc. recently completed a clinical study titled ‘A Phase 1, Randomized, Open-Label, Single-Dose, Parallel-Group Study to Compare the Pharmacokinetics and Relative Bioavailability of Medroxyprogesterone Acetate in Healthy Female Participants Following Subcutaneous Injection of Sayana Press in the Upper Arm Relative to Anterior Thigh and Abdomen.’ The study aimed to evaluate the pharmacokinetics and bioavailability of medroxyprogesterone when injected in different body areas, which is significant for optimizing contraceptive delivery methods.
Pfizer Inc. is conducting a Phase 2, open-label, multicenter study titled ‘AN INTERVENTIONAL PHASE 2, OPEN-LABEL, MULTI-CENTER STUDY TO EVALUATE SAFETY AND EFFICACY OF PF-06835375 IN ADULT PARTICIPANTS WITH MODERATE TO SEVERE PRIMARY IMMUNE THROMBOCYTOPENIA.’ The study aims to assess the safety and efficacy of PF-06835375, a CXCR5 inhibitor, in increasing platelet counts in adults with moderate to severe primary immune thrombocytopenia (ITP). This research is significant as it could lead to improved treatment options for ITP patients.
Pfizer Inc. is conducting a Phase 3 clinical study titled ‘MagnetisMM-32’ to evaluate the efficacy of elranatamab, a novel treatment for relapsed or refractory multiple myeloma (MM). The study aims to compare elranatamab monotherapy against other established combination therapies in patients who have previously undergone anti-CD38 directed therapy. This research is significant as it seeks to provide new treatment options for MM patients whose cancer has returned or not responded to prior treatments.
Pfizer Inc. is conducting a Phase 3 clinical trial titled ‘Randomized Study in Children and Adolescents With Migraine: Acute Treatment.’ The study aims to evaluate the safety and efficacy of the drug Rimegepant (BHV-3000) compared to a placebo for treating moderate to severe migraines in children and adolescents aged 6 to 18. This research is significant as it could provide a new treatment option for a demographic that currently has limited choices.
Pfizer Inc. is currently conducting a Phase 3 clinical study titled ‘A Phase 3, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy and Safety of Rimegepant in Migraine Prevention in Children and Adolescents ≥ 6 to <18 Years of Age.' The study aims to assess the effectiveness and safety of rimegepant as a preventative treatment for migraines in young patients, highlighting its potential significance in addressing pediatric migraine management.
Pfizer Inc. is conducting a Phase 1 clinical study titled ‘A Phase 1, Randomized, Double-Blind, Third-Party-Unblinded Trial to Evaluate the Safety and Immunogenicity of 20-valent Pneumococcal Conjugate Vaccine (20vPnC) and 13-valent Pneumococcal Conjugate Vaccine (13vPnC) in Pneumococcal Vaccine-Naïve Adults 50 Years of Age and Older in China.’ The study aims to assess the safety and immune response of these vaccines in adults aged 50 and older who have not previously received pneumococcal vaccines. This research is significant as it could lead to improved vaccine options for preventing infections caused by Streptococcus pneumoniae in this demographic.
Pfizer Inc. is currently conducting a Phase 3 study titled ‘A PHASE 3, NON-INVESTIGATIONAL PRODUCT, MULTI COUNTRY COHORT STUDY TO DESCRIBE THE LONG-TERM SAFETY AND EFFECTIVENESS OF A PRIOR SINGLE-DOSE TREATMENT WITH INVESTIGATIVE GIROCTOCOGENE FITELPARVOVEC OR FIDANACOGENE ELAPARVOVEC IN PARTICIPANTS WITH HEMOPHILIA A OR HEMOPHILIA B, RESPECTIVELY.’ The study aims to assess the long-term safety and effectiveness of giroctocogene fitelparvovec and fidanacogene elaparvovec in patients with hemophilia A and B, respectively, who have previously participated in a Pfizer-sponsored clinical trial. This research is significant as it seeks to provide insights into the enduring impact of these treatments, potentially influencing future therapeutic strategies for hemophilia.
Pfizer Inc. is conducting a Phase 3 clinical study titled A RANDOMIZED, 2-ARM, PHASE 3 STUDY OF ELRANATAMAB (PF-06863135) VERSUS LENALIDOMIDE IN PATIENTS WITH NEWLY DIAGNOSED MULTIPLE MYELOMA AFTER UNDERGOING AUTOLOGOUS STEM-CELL TRANSPLANTATION. This study aims to assess the efficacy of elranatamab, a bispecific antibody, compared to lenalidomide in patients who have recently undergone stem-cell transplants for multiple myeloma. The significance of this study lies in its potential to offer a more effective treatment option for this patient group.
Pfizer Inc. is conducting a clinical study titled ‘Special Investigation for ABRYSVO Intramuscular Injection – Investigation in Pregnant Women and Infants.’ The study aims to confirm the safety of the RSVpreF vaccine, known as Abrysvo, in pregnant women and their infants under actual clinical practice conditions in Japan. This research is significant as it seeks to ensure the vaccine’s safety for both mothers and their newborns, potentially impacting public health positively.
Pfizer Inc. is conducting a clinical study titled ‘Special Investigation of TALZENNA Capsules – Study on BRCA Mutation-Positive Metastatic Castration-Resistant Prostate Cancer.’ The study aims to evaluate the safety of TALZENNA in patients with a specific type of prostate cancer that has spread and is resistant to hormone reduction therapies. This research is significant as it targets a challenging cancer type, potentially offering new treatment avenues for affected patients.
Pfizer Inc. is conducting a study titled ‘TALZENNA Capsules Special Investigation’ to evaluate the safety of TALZENNA in treating patients with BRCA mutation-positive and HER2-negative breast cancer that is unresectable or has recurred. The study aims to assess the safety profile of TALZENNA in patients who have previously undergone chemotherapy but have not used this medication before. The significance of this study lies in its potential to provide a new treatment option for a challenging subset of breast cancer patients.
Pfizer and Bristol-Myers Squibb are conducting a study titled A Phase 1B, Open-Label Study of Elranatamab in Combination with Iberdomide in Participants with Relapsed Refractory Multiple Myeloma. The study aims to evaluate the safety and tolerability of combining elranatamab and iberdomide for treating relapsed or refractory multiple myeloma, a challenging form of cancer that resists treatment or returns after improvement.
Pfizer Inc. is conducting a Phase 2 clinical study titled A PHASE 2, DOUBLE-BLIND, RANDOMIZED, PLACEBO-CONTROLLED, MULTICENTER STUDY TO EVALUATE THE CLINICAL EFFECT, PHARMACODYNAMIC, PHARMACOKINETIC AND SAFETY PROFILE OF PF 06823859 IN ADULT PARTICIPANTS WITH ACTIVE CLE OR SLE WITH CUTANEOUS MANIFESTATIONS. The study aims to assess the effects, safety, and processing of PF-06823859 in adults with cutaneous lupus erythematosus (CLE) or systemic lupus erythematosus (SLE) with skin symptoms. This research is significant as it seeks to improve treatment options for these conditions.
Pfizer Inc. is conducting a study titled ‘VICTORIE (VTE In Cancer – Treatment, Outcomes and Resource Use In Europe)’ to explore treatment patterns and healthcare resource utilization in patients with venous thromboembolism (VTE) and cancer. The study aims to analyze the effectiveness and safety of anticoagulant treatments in these patients, which is crucial for improving clinical outcomes and cost management in cancer care.
Pfizer Inc. is conducting a clinical study titled ‘A Phase 1, Randomized, Double Blind, Sponsor-Open, Placebo-Controlled, Single Dose Escalation Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Subcutaneous Administration of PF-07999415 in Healthy Adult Participants.’ The study aims to assess the safety and effects of PF-07999415, a new biological treatment, in healthy adults aged 18 to 65. This research is significant as it could lead to new therapeutic options if successful.
Pfizer Inc. is conducting a study titled ‘Korean Post Marketing Surveillance for ELREXFIO (Elranatamab),’ aimed at evaluating the safety and effectiveness of Elranatamab in treating multiple myeloma in real-world clinical settings in Korea. The study is significant as it seeks to confirm the drug’s performance outside of controlled clinical trials, ensuring it meets safety standards and effectiveness in general clinical practice.
Pfizer Inc. is conducting a clinical study titled ‘A PHASE 2, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY TO EVALUATE THE EFFICACY AND SAFETY OF AN ORAL BRANCHED-CHAIN KETOACID DEHYDROGENASE KINASE INHIBITOR, PF-07328948, IN ADULTS WITH HEART FAILURE (BRANCH-HF)’. The study aims to assess the safety and effectiveness of PF-07328948 in treating heart failure in adults, potentially offering a new therapeutic option for patients.
Pfizer Inc. is conducting a Phase 3 clinical study titled ‘An Interventional Efficacy and Safety, Phase 3, Double-Blind, Parallel Group Study to Investigate Intermittent Prevention of Menstrual Migraine with Rimegepant Compared with Placebo in Women Participants 18 to 45 Years of Age.’ The study aims to evaluate the efficacy and safety of rimegepant for the intermittent prevention of menstrual migraines in women, a significant concern for many affected by this condition.
Pfizer Inc. is conducting a study titled ‘Ngenla Subcutaneous Injection Special Investigation’ to evaluate the long-term safety and effects of Ngenla in treating Growth Hormone Deficiency (GHD) in children. The study focuses on patients who have not yet experienced epiphyseal closure and are receiving Ngenla for the first time. This investigation is significant as it aims to provide insights into the long-term use of Ngenla, potentially influencing treatment protocols for GHD.
The FLOTILLA Study, officially titled ‘ENCORAFENIB/BINIMETINIB MASTER PROTOCOL: AN OPEN-LABEL CONTINUATION STUDY FOR PARTICIPANTS CONTINUING FROM ENCORAFENIB/BINIMETINIB CLINICAL STUDIES,’ aims to provide continued access to the study medicines encorafenib and binimetinib for participants from prior clinical trials. This study is significant as it ensures ongoing treatment for those benefiting from these drugs, underlining Pfizer’s commitment to patient care.
Pfizer Inc. is conducting a Phase 1 study titled A Phase 1, Single-Arm Study to Evaluate the Safety and Tolerability of a 20-valent Pneumococcal Conjugate Vaccine in Healthy Chinese Adults, Children, and Infants. The study aims to assess the safety of the 20-valent pneumococcal conjugate vaccine (20vPnC) across five age groups in China, ranging from infants to adults. This research is significant as it seeks to ensure the vaccine’s safety for diverse age groups, potentially expanding its use and acceptance.
Study Overview: Pfizer Inc. is conducting a clinical study titled ‘Elranatamab Post Trial Access Study for Participants With Multiple Myeloma (MM).’ The study aims to provide continued access to elranatamab for participants with multiple myeloma who have shown clinical benefits from prior Pfizer-sponsored trials. This study is significant as it supports ongoing treatment for patients until elranatamab becomes commercially available in their country.
Pfizer, in collaboration with Eli Lilly and Company, ONO Pharmaceutical Co., and Merck KGaA, is conducting a Phase 3 clinical study titled ‘AN OPEN-LABEL, MULTICENTER, RANDOMIZED PHASE 3 STUDY OF FIRST-LINE ENCORAFENIB PLUS CETUXIMAB WITH OR WITHOUT CHEMOTHERAPY VERSUS STANDARD OF CARE THERAPY WITH A SAFETY LEAD-IN OF ENCORAFENIB AND CETUXIMAB PLUS CHEMOTHERAPY IN PARTICIPANTS WITH METASTATIC BRAF V600E-MUTANT COLORECTAL CANCER.’ The study aims to evaluate the efficacy of encorafenib plus cetuximab, with or without chemotherapy, compared to standard chemotherapy in patients with metastatic colorectal cancer with the BRAF V600E mutation. This study is significant as it explores new treatment combinations for a cancer type that has spread and has not been previously treated.
Pfizer Inc. is conducting a Phase 3, multicenter, open-label study to evaluate the long-term safety and tolerability of Rimegepant for the acute treatment of migraine in children and adolescents aged 6 to 18 years. This study aims to address the significant need for effective migraine treatments in younger populations, potentially offering a new therapeutic option for pediatric patients.
Pfizer Inc. is conducting a clinical study titled ‘A Phase 1B Open-Label Non-Randomized Study to Assess the Safety, Pharmacokinetics, and Pharmacodynamics of Marstacimab Treatment Following the Discontinuation of Emicizumab Therapy in Adolescent and Adult Participants with Severe Hemophilia A Without Inhibitors.’ The study aims to evaluate the safety and effectiveness of marstacimab in patients with severe hemophilia A, a rare bleeding disorder, who are transitioning from emicizumab treatment.
Pfizer Inc. is conducting a Phase 3 study titled ‘A Study to Evaluate the Safety and Immunogenicity of RSVpreF Coadministered With Herpes Zoster Vaccine in Adults.’ The study aims to assess the safety, tolerability, and immune response of the Respiratory Syncytial Virus Prefusion F Subunit Vaccine (RSVpreF) when administered alongside the Herpes Zoster Subunit Vaccine (HZ/su) in adults aged 50 and older. This research is significant as it explores the potential for simultaneous vaccination against two common viral infections in older adults.
Pfizer Inc. is currently conducting a Phase 3 clinical study titled ‘MAGNETISMM-6’ to evaluate the efficacy and safety of Elranatamab, a bispecific antibody, in combination with other drugs for patients with newly diagnosed multiple myeloma who are not candidates for transplant. The study aims to determine if Elranatamab, combined with Daratumumab and Lenalidomide, or with Lenalidomide alone, provides better clinical outcomes compared to the existing combination of Daratumumab, Lenalidomide, and Dexamethasone.
Pfizer Inc. is conducting a study titled ‘Real-world Effectiveness of the 20-valent Pneumococcal Conjugate Vaccine (PCV20) Among Medicare Fee-for-service Beneficiaries Aged ≥65 Years in the United States.’ The study aims to evaluate how effectively the Prevnar 20 vaccine prevents various forms of pneumonia and lower respiratory tract infections in individuals aged 65 and older. This research is significant as it seeks to provide real-world data on the vaccine’s effectiveness, potentially influencing public health strategies for older adults.
Pfizer Inc. is conducting a study titled Retrospective Study Evaluating ABRYSVO Vaccine Effectiveness Against Severe Lower Respiratory Tract Infection in Older Adults. The study aims to assess the effectiveness of the ABRYSVO vaccine in preventing severe respiratory syncytial virus (RSV) infections in adults aged 60 and older. This research is significant as RSV can lead to severe respiratory issues, particularly in older adults, and the study seeks to provide insights into the vaccine’s protective duration and effectiveness after revaccination.
Pfizer Inc. is conducting a clinical study titled A 16-WEEK, MULTICENTER, INTERVENTIONAL, PHASE 3, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, PARALLEL GROUP STUDY TO INVESTIGATE EFFICACY AND SAFETY OF ABROCITINIB IN CHILDREN 6 TO LESS THAN 12 YEARS OF AGE WITH MODERATE-TO-SEVERE ATOPIC DERMATITIS. The study aims to evaluate the effectiveness and safety of the drug Abrocitinib in treating moderate-to-severe eczema in children aged 6 to under 12 years. This research is significant as it addresses a common and challenging condition in pediatric dermatology.
Pfizer Inc., in collaboration with Merck Sharp & Dohme LLC, is conducting a Phase 3 clinical trial titled A Phase 3, Randomized, Double-Blind Study of Encorafenib and Binimetinib Plus Pembrolizumab Versus Placebo Plus Pembrolizumab in Participants with BRAF V600E/K Mutation-Positive Metastatic or Unresectable Locally Advanced Melanoma. The study aims to evaluate the efficacy, safety, and tolerability of a combination of three drugs—encorafenib, binimetinib, and pembrolizumab—in treating advanced melanoma with a specific genetic mutation.
Pfizer Inc. is conducting a clinical trial titled An Open-Label Study in Pediatric (<18 Years of Age), Severe Hemophilia A Participants (Coagulation Factor Activity <1%) With or Without Inhibitors or Moderately Severe to Severe Hemophilia B Participants (Coagulation Factor Activity =2%) With or Without Inhibitors Comparing 12 Months of Historical Standard Treatment to Marstacimab Prophylaxis. The study aims to evaluate the safety and effectiveness of marstacimab, a potential treatment for hemophilia in pediatric patients, by comparing it to historical standard treatments. This study is significant as it targets a vulnerable population with limited treatment options.
Pfizer Inc. is conducting a Phase 2 clinical study titled ‘A Study Comparing 3 Study Medicines (Encorafenib, Binimetinib, Pembrolizumab) to 2 Study Medicines (Ipilimumab and Nivolumab) in Patients With Advanced Melanoma.’ The study aims to evaluate the effectiveness of a combination of three drugs (encorafenib, binimetinib, and pembrolizumab) against two drugs (ipilimumab and nivolumab) in treating patients with advanced melanoma, specifically those with a BRAF V600E/K mutation who have previously undergone anti-PD-1 therapy.
Study Overview: Pfizer Inc. is conducting a post-marketing surveillance study titled ‘Post Marketing Surveillance (PMS) Study for Ngenla Prefilled Pen in Pediatric Patients Who Have Endogenous Growth Failure Due to an Inadequate Secretion of Endogenous Growth Hormone in Korea.’ The study aims to assess the safety and effectiveness of the Ngenla® pre-filled pen injection in treating children and adolescents with growth disturbances due to insufficient growth hormone secretion. This research is significant as it fulfills a regulatory requirement by the Ministry of Food and Drug Safety (MFDS) in Korea.
Pfizer Inc. is conducting a study titled ‘Korea Comirnaty Post-marketing Surveillance’ to assess the safety of the BNT162b2 vaccine in routine clinical practice in Korea. The study’s primary objective is to collect safety data on the vaccine, known as Tozinameran, and its variants, including Riltozinameran, Famtozinameran, and Raxtozinameran, across different age groups. This surveillance is significant as it aligns with the New Drug Re-Examination Guideline of the Ministry of Food and Drug Safety in Korea.
Pfizer Inc. is conducting a Phase 3 clinical study titled ‘An Interventional Efficacy and Safety, Phase 3, Double-Blind, 2-Arm Study to Investigate Orally Administered Ibuzatrelvir Compared with Placebo in Non-Hospitalized Symptomatic Adult and Adolescent Participants with COVID-19 Who Are at High Risk of Progressing to Severe Illness.’ The study aims to evaluate the efficacy and safety of ibuzatrelvir in preventing the progression of COVID-19 in non-hospitalized patients at high risk for severe disease.
Eli Lilly and Company, in collaboration with Pfizer Inc and other industry leaders, is conducting a Phase 2 clinical study titled A Study of Encorafenib Plus Cetuximab Taken Together With Pembrolizumab Compared to Pembrolizumab Alone in People With Previously Untreated Metastatic Colorectal Cancer. The study aims to evaluate the effectiveness of combining encorafenib and cetuximab with pembrolizumab versus using pembrolizumab alone in treating metastatic colorectal cancer with specific genetic mutations. This research is significant as it explores new treatment avenues for patients with limited options.
Pfizer Inc. has completed a Phase 3 study titled ‘Efficacy and Safety Study of Rimegepant for Migraine Prevention in Japanese Subjects (Japan Only).’ The study aimed to evaluate the efficacy, safety, and tolerability of rimegepant, a drug intended for migraine prevention, in Japanese participants. This study is significant as it addresses a prevalent health issue, potentially offering a new preventive treatment option for migraines.
In an earlier published TipRanks article, it was incorrectly stated that the gene therapy was a ‘promising and ongoing program.’
Pfizer Inc. is conducting a clinical study titled ‘A Phase 1/2A Dose Escalation and Expansion Study to Evaluate Safety, Tolerability, Pharmacokinetic, Pharmacodynamic, and Anti-Tumor Activity of PF-07248144 in Participants with Advanced or Metastatic Solid Tumors.’ The study aims to assess the safety and effectiveness of PF-07248144, both as a standalone treatment and in combination with other drugs, for patients with advanced or metastatic solid tumors. This study is significant as it explores potential new treatments for difficult-to-treat cancers.
Pfizer Inc. is conducting a study titled ‘Real-world Clinical Outcomes of Tucatinib, Trastuzumab, and Capecitabine Following Trastuzumab Deruxtecan for the Treatment of HER2-positive Metastatic Breast Cancer.’ The study aims to evaluate the real-world outcomes of a specific drug combination in patients with HER2-positive metastatic breast cancer, focusing on metrics like time to next treatment and overall survival.
Study Overview: Pfizer Inc. recently completed a Phase 3 clinical study titled A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Parallel Group Study to Evaluate the Efficacy and Safety of Zavegepant Intranasal (IN) for the Acute Treatment of Migraine in Asian Adults. The study aimed to assess the safety and effectiveness of zavegepant, an intranasal treatment, compared to a placebo in treating migraines in Asian adults. This study is significant as it targets a prevalent condition that causes severe headaches and other symptoms like nausea and sensitivity to light and sound.
Pfizer Inc. is conducting a Phase 3 study titled ‘A Phase 3 Multi-Center, Long-Term Extension Study Investigating the Efficacy and Safety of Abrocitinib, With or Without Topical Medications, Administered to Subjects Aged 12 Years and Older With Moderate to Severe Atopic Dermatitis.’ The study aims to evaluate the efficacy and safety of Abrocitinib, an oral medication, in treating moderate to severe atopic dermatitis in patients aged 12 and older. This research is significant as it could offer a new long-term treatment option for those suffering from this chronic skin condition.
Pfizer Inc. and Astellas Pharma Inc. are conducting a significant clinical study titled ‘TALAPRO-3: A PHASE 3, RANDOMIZED, DOUBLE-BLIND, STUDY OF TALAZOPARIB WITH ENZALUTAMIDE VERSUS PLACEBO WITH ENZALUTAMIDE IN MEN WITH DDR GENE MUTATED METASTATIC CASTRATION-SENSITIVE PROSTATE CANCER.’ The study aims to evaluate the safety and efficacy of combining talazoparib with enzalutamide compared to a placebo with enzalutamide in treating men with DDR-deficient metastatic castration-sensitive prostate cancer (mCSPC). This research could have substantial implications for prostate cancer treatment.
Pfizer Inc. is conducting a Phase 2 clinical study titled A Prospective, Randomized, Open-Label Phase 2 Study to Evaluate the Superiority of Inotuzumab Ozogamicin Monotherapy Versus ALLR3 for Induction Treatment of Childhood High Risk First Relapse B-Cell Precursor Acute Lymphoblastic Leukemia. The study aims to assess the effectiveness and safety of Inotuzumab Ozogamicin (InO) compared to the ALLR3 regimen in children aged 1 to under 18 years with high-risk first relapse of B-cell precursor acute lymphoblastic leukemia (ALL). This research is significant as it explores potential advancements in treatment options for this vulnerable patient group.
Study Overview: Pfizer Inc. is conducting a study titled MagnetisMM-4: Umbrella Study of Elranatamab (PF-06863135) in Combination With Anti-Cancer Treatments in Multiple Myeloma. The study aims to determine the Recommended Phase 2 Dose and assess the clinical benefit of elranatamab, a BCMA-CD3 bispecific antibody, when combined with other anti-cancer therapies in patients with multiple myeloma. This research is significant as it explores new treatment combinations for a challenging cancer type.
Pfizer Inc. is conducting a Phase 2 study titled ‘A PHASE 2, MULTICENTER, SINGLE-ARM STUDY TO EVALUATE THE SAFETY AND DYSTROPHIN EXPRESSION AFTER FORDADISTROGENE MOVAPARVOVEC (PF-06939926) ADMINISTRATION IN MALE PARTICIPANTS WITH EARLY STAGE DUCHENNE MUSCULAR DYSTROPHY.’ The study aims to assess the safety and dystrophin expression following gene therapy in boys with early-stage Duchenne Muscular Dystrophy (DMD), highlighting its potential significance in advancing treatment options for this condition.
Pfizer Inc. is set to launch a clinical study titled ‘Zavicefta Combination for Intravenous Infusion Special Investigation’ in Japan, focusing on patients with sepsis or renal impairment. The study aims to evaluate the safety and effectiveness of Zavicefta, a combination of Avibactam sodium and Ceftazidime hydrate, under real-world clinical conditions. This research is significant as it targets serious health conditions like sepsis and kidney function loss, which require effective treatment options.
Study Overview: Pfizer Inc. is conducting a study titled ‘Long-term Follow-up Safety and Efficacy Study in Participants With Duchenne Muscular Dystrophy Who Have Received Fordadistrogene Movaparvovec in a Preceding Clinical Study.’ The study aims to understand the long-term safety and effects of an experimental gene therapy for Duchenne Muscular Dystrophy (DMD), a severe muscle-wasting disease. This research is significant as it could lead to breakthroughs in treating DMD, potentially improving the quality of life for affected individuals.
Pfizer Inc. is conducting a Phase 2A clinical study titled A Phase 2A Multicenter, Observer-Blinded, Randomized 2 Arm Study to Investigate Pharmacokinetics, Safety, Tolerability and Efficacy of Intravenous Aztreonam-Avibactam ± Metronidazole Compared to Best Available Therapy (BAT) in Pediatric Participants 9 Months to Less Than 18 Years of Age with Serious Gram-Negative Bacterial Infections Including Complicated Intra-Abdominal Infection. The study aims to evaluate the pharmacokinetics, safety, and efficacy of Aztreonam and Avibactam in pediatric patients with serious gram-negative infections, highlighting its significance in addressing antibiotic resistance in this vulnerable population.
Pfizer Inc. is conducting a study titled ‘Retrospective Cohort Study of Pregnancy Outcomes in Women Exposed to Rimegepant During Pregnancy.’ The study aims to assess the risk of pregnancy and infant outcomes in women with migraines who are exposed to rimegepant during pregnancy, compared to two unexposed groups. This research is significant as it seeks to understand the safety profile of rimegepant, a migraine medication, during pregnancy.
Pfizer Inc. is conducting a study titled ‘Real World Impact and Effectiveness of ABRYSVO® Vaccination During Pregnancy Against RSV Illness in Infants.’ The study aims to evaluate the effectiveness of the ABRYSVO vaccine administered during pregnancy in preventing RSV-related illnesses in infants. This research is significant as it assesses the vaccine’s impact in real-world settings across multiple seasons in Argentina and Uruguay.
Pfizer Inc. is conducting a non-interventional study titled ‘ELREXFIO SPECIAL INVESTIGATION- INVESTIGATION ON LONG-TERM TREATMENT’ to assess the safety and efficacy of elranatamab in patients with relapsed and refractory multiple myeloma (RRMM). The study aims to confirm the onset status of cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS) and evaluate adverse reactions and overall response rate (ORR) for long-term treatment.
Pfizer Inc. is conducting a study titled ‘Use and Effectiveness of COVID-19 Vaccines Using State Vaccine Registries and Insurance Claims Data.’ The study aims to evaluate the effectiveness of the Pfizer-BioNTech vaccine in preventing post-COVID conditions and to understand the characteristics of patients receiving COVID-19 vaccines. This research is significant as it leverages state vaccine registries and HealthVerity insurance claims data to provide insights into vaccine effectiveness and uptake.
Pfizer Inc. is conducting a Phase 3 study titled ‘Randomized Study in Children and Adolescents With Migraine: Acute Treatment’ to evaluate the efficacy and safety of Rimegepant (BHV-3000) for treating moderate to severe migraines in children and adolescents aged 6 to 18. This study aims to provide a new treatment option for young patients suffering from migraines, a condition that significantly impacts quality of life.
Pfizer Inc. is conducting a Phase 3 clinical study titled ‘An Interventional Efficacy and Safety, Phase 3, Double-Blind, Parallel Group Study to Investigate Intermittent Prevention of Menstrual Migraine with Rimegepant Compared with Placebo in Women Participants 18 to 45 Years of Age.’ The study aims to evaluate the efficacy and safety of the drug Rimegepant for the intermittent prevention of menstrual migraines in women. This research is significant as it addresses a common and debilitating condition affecting many women.
Study Overview: Pfizer Inc. is conducting a clinical study titled ‘ATGAM Intravenous Infusion 250mg General Investigation’ to confirm the safety of ATGAM in patients with moderate to severe aplastic anemia in Japan. The study aims to ensure the drug’s safety under actual use conditions, which is significant for patient safety and treatment efficacy.
Pfizer Inc. is conducting a Phase 1 clinical study titled ‘A PHASE 1, OPEN-LABEL, DOSE ESCALATION AND DOSE EXPANSION STUDY TO EVALUATE THE SAFETY, TOLERABILITY, PHARMACOKINETICS, AND ANTI TUMOR ACTIVITY OF PF-07799933 (ARRY-440) AS A SINGLE AGENT AND IN COMBINATION THERAPY IN PARTICIPANTS 16 YEARS AND OLDER WITH ADVANCED SOLID TUMORS WITH BRAF ALTERATIONS.’ The study aims to assess the safety and effectiveness of PF-07799933, alone and in combination with other treatments, in patients with advanced solid tumors featuring BRAF alterations. This research is significant as it targets a population with limited treatment options.
Pfizer Inc. is conducting a Phase 3 clinical study titled ‘A Phase 3, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy and Safety of Rimegepant in Migraine Prevention in Children and Adolescents ≥ 6 to <18 Years of Age.' The study aims to assess the effectiveness and safety of rimegepant as a preventative treatment for episodic migraines in children and adolescents, highlighting its potential to address a significant unmet medical need in this age group.
Pfizer Inc. is conducting a Phase 3 study titled ‘MagnetisMM-32’ to evaluate the efficacy of elranatamab, a new treatment for relapsed/refractory multiple myeloma (MM), against standard combination therapies. This study is significant as it targets patients who have previously undergone anti-CD38 antibody and lenalidomide treatments, aiming to provide an alternative for those with recurring or resistant MM.
Pfizer Inc. is conducting a study titled ‘An Open-label Extension Study to Evaluate the Long-term Safety of Inclacumab Administered to Participants With Sickle Cell Disease Who Have Participated in an Inclacumab Clinical Trial.’ The study aims to assess the long-term safety of inclacumab in individuals with sickle cell disease (SCD) who have previously participated in an inclacumab trial. This research is significant as it could provide insights into the prolonged use of inclacumab, potentially improving the quality of life for those with SCD.
Pfizer Inc. is conducting a study titled ‘Patient-Reported Outcomes Associated With COVID-19 and Influenza: A Prospective Survey Study on Outpatient Symptomatic Adults With Test-Confirmed Illness in the United States.’ The study aims to understand the symptoms and health outcomes of patients with COVID-19 and influenza, as well as the effects of COVID-19 vaccines. This research is significant as it seeks to provide insights into patient experiences and outcomes related to these illnesses.
Pfizer Inc. and AbbVie are conducting a clinical study titled ‘A PHASE 2A, 2-PART, OPEN-LABEL, NON-RANDOMIZED, MULTICENTER, SINGLE AND MULTIPLE DOSE TRIAL TO EVALUATE PHARMACOKINETICS, SAFETY AND TOLERABILITY OF AZTREONAM AND AVIBACTAM ± METRONIDAZOLE IN NEONATES AND INFANTS FROM BIRTH TO LESS THAN 9 MONTHS OF AGE WITH SUSPECTED OR CONFIRMED INFECTIONS DUE TO GRAM-NEGATIVE PATHOGENS REQUIRING INTRAVENOUS ANTIBIOTIC TREATMENT.’ The study aims to assess the safety and effects of the combination drug Aztreonam-Avibactam (ATM-AVI) in treating gram-negative bacterial infections in infants and newborns.
Pfizer Inc. is currently conducting the MUltiple Myeloma Italian ObServational sTudy (MUST) to understand how patients with Triple Class Refractory Multiple Myeloma (TCR-MM) are treated in Italian centers for blood-related diseases. The study aims to analyze current clinical practices and the standard of care provided to these patients, alongside treatment costs, across approximately 25 centers.
Pfizer Inc. is conducting a pivotal study titled MAGNETISMM-6 to evaluate the efficacy and safety of Elranatamab, a bispecific antibody, in combination with other drugs for treating newly diagnosed multiple myeloma patients who are not eligible for transplant. The study aims to determine if Elranatamab-based combinations offer superior clinical benefits compared to existing treatments.
Pfizer Inc. is conducting a Phase 3 clinical study titled ‘An Interventional Efficacy and Safety, Phase 3, Double-Blind, 2-Arm Study to Investigate Orally Administered Ibuzatrelvir Compared with Placebo in Non-Hospitalized Symptomatic Adult and Adolescent Participants with COVID-19 Who Are at High Risk of Progressing to Severe Illness.’ The study aims to evaluate the efficacy and safety of ibuzatrelvir in preventing severe COVID-19 in high-risk, non-hospitalized patients.
Pfizer Inc. is conducting a Phase 1b clinical trial titled A Clinical Trial of Four Medicines (Elranatamab Plus Carfilzomib and Dexamethasone or Maplirpacept) in People With Relapsed Refractory Multiple Myeloma. The study aims to evaluate the safety and tolerability of elranatamab in combination with other drugs for treating relapsed refractory multiple myeloma, a significant step in addressing this challenging condition.
Pfizer Inc. is conducting a clinical study titled AN OPEN-LABEL, 3-ARM, MULTICENTER, RANDOMIZED PHASE 3 STUDY TO EVALUATE THE EFFICACY AND SAFETY OF ELRANATAMAB (PF-06863135) MONOTHERAPY AND ELRANATAMAB + DARATUMUMAB VERSUS DARATUMUMAB + POMALIDOMIDE + DEXAMETHASONE IN PARTICIPANTS WITH RELAPSED/REFRACTORY MULTIPLE MYELOMA WHO HAVE RECEIVED AT LEAST 1 PRIOR LINE OF THERAPY INCLUDING LENALIDOMIDE AND A PROTEASOME INHIBITOR. The study aims to assess the efficacy and safety of elranatamab, both alone and in combination with daratumumab, compared to a standard treatment regimen in patients with relapsed or refractory multiple myeloma.
Pfizer Inc. is conducting a Phase 3 clinical study titled ‘Phase 3, Multicenter, Open-label Study to Assess the Long-term Safety and Tolerability of Rimegepant for the Acute Treatment of Migraine (With or Without Aura) in Children and Adolescents ≥ 6 to < 18 Years of Age.' The study aims to evaluate the long-term safety of rimegepant, a drug intended for the acute treatment of migraines in pediatric patients. This research is significant as it could provide a new treatment option for young migraine sufferers.
Pfizer Inc., in collaboration with Astellas Pharma Global Development, Inc., is conducting a Phase 4 clinical study titled ‘A Safety Study of Enfortumab Vedotin in Indian Adults With Urothelial Cancer.’ The study aims to confirm the safety of enfortumab vedotin, a treatment for advanced or metastatic urothelial cancer, in Indian adults. This research is significant as it addresses the need for safe and effective cancer treatments in this demographic.
Pfizer Inc. is conducting a study titled ‘Estimated Vaccine Effectiveness and Durability of Pfizer/BioNTech 2024-2025 COVID-19 Vaccine’ to evaluate the real-world effectiveness of its updated COVID-19 vaccine formulation. The study aims to assess the vaccine’s effectiveness against symptomatic SARS-CoV-2 infections across various age groups and during different variant circulations.
Pfizer Inc. is conducting a clinical study titled ‘Low Interventional Cohort Study of Myocarditis/Pericarditis Associated With COMIRNATY in Persons Less Than 21 Years of Age.’ The study aims to evaluate the safety and effects of the COMIRNATY vaccine in preventing COVID-19 among individuals under 21, focusing on potential myocarditis/pericarditis associations. This research is significant as it seeks to understand long-term cardiac outcomes in young vaccine recipients.
Pfizer Inc. is currently conducting a Phase 3 clinical study titled A RANDOMIZED, 2-ARM, PHASE 3 STUDY OF ELRANATAMAB (PF-06863135) VERSUS LENALIDOMIDE IN PATIENTS WITH NEWLY DIAGNOSED MULTIPLE MYELOMA AFTER UNDERGOING AUTOLOGOUS STEM-CELL TRANSPLANTATION. The study aims to evaluate the efficacy of elranatamab compared to lenalidomide in patients with newly diagnosed multiple myeloma who have undergone stem cell transplantation. This research is significant as it explores potential improvements in treatment options for this patient group.
Pfizer Inc. is conducting a study titled ‘A Multicenter, Non-interventional Prospective Active Surveillance Study Among Participants Receiving Somatrogon Under Routine Clinical Care in India.’ The study aims to evaluate the safety of Somatrogon, a long-acting growth hormone, in treating pediatric growth hormone deficiency (p GHD) in India. This condition is characterized by insufficient growth hormone production, leading to short stature in children. The study’s significance lies in its potential to confirm the safety of Somatrogon for this condition.
Pfizer Inc. is conducting a Phase 3 clinical study titled An Interventional, Efficacy, and Safety, Phase 3 Randomized, Double-Blind, Placebo-Controlled Study with an Open-Label Extension to Investigate Rimegepant in Migraine Prevention in Adolescents 12 to Less Than 18 Years of Age with Chronic Migraine. The study aims to evaluate the effectiveness and safety of rimegepant, a dissolvable tablet, in preventing migraines in adolescents experiencing frequent migraine attacks.
Pfizer Inc. is conducting a Phase I study titled ‘A Phase I Dose Escalation and Expanded Cohort Study Of PF-06821497 (Mevrometostat) in the Treatment of Adult Patients with Relapsed/Refractory Small Cell Lung Cancer (SCLC), Castration Resistant Prostate Cancer (CRPC), and Follicular Lymphoma (FL).’ The study aims to evaluate the safety and efficacy of Mevrometostat, a new drug designed to treat these challenging cancer types. This study is significant as it targets cancers that are often resistant to conventional treatments, potentially offering new hope for patients.
Pfizer Inc. is conducting a Phase 3 study titled ‘A Phase 3 Study to Investigate the Safety, Tolerability, and Immunogenicity of Revaccinating Pregnant Participants During Subsequent Pregnancies and Persistence of Immunity of a Single Dose of a Bivalent Respiratory Syncytial Virus (RSV) Vaccine.’ The study aims to evaluate the safety and immune response of a second dose of the RSVpreF vaccine in pregnant women and the duration of immunity from a single dose given in a previous pregnancy. This research is significant as it could enhance maternal and infant health by providing insights into long-term vaccine efficacy.
Pfizer Inc. has announced a new clinical study titled ‘CORRELATE-UK: Consistency of Response With Rimegepant Oral Lyophilisate in Acute Treatment of Migraine in the United Kingdom.’ The study aims to assess the consistency of response to rimegepant, a drug used for acute migraine treatment, by enrolling participants in the UK who are currently using the medication. This study is significant as it seeks to provide real-world data on the effectiveness of rimegepant, potentially influencing treatment protocols for migraine sufferers.
Pfizer Inc. and BioNTech SE are conducting a clinical study titled ‘A Phase 1/2 Randomized, Observer-Blind Study to Evaluate the Safety, Tolerability, and Immunogenicity of a Modified RNA Vaccine Against Varicella Zoster Virus in Healthy Individuals.’ This study aims to assess the safety and immune response of a new modified RNA vaccine for shingles in adults aged 50 to 85, which could offer a significant advancement in preventing this common viral infection.
Pfizer Inc. is conducting a clinical study titled ‘Special Investigation for Abrysvo Intramuscular Injection – Investigation in Individuals Aged 60 Years or Older’. The study aims to confirm the safety of the Abrysvo RSV vaccine in individuals aged 60 and older under real-world clinical settings in Japan. This investigation is significant as it seeks to ensure the vaccine’s safety profile in a vulnerable population.
Pfizer Inc recently updated its clinical study titled ‘A Phase 1, Open-Label, Fixed-Sequence Study to Evaluate the Pharmacokinetic Interactions Between PF-07976016 and PF-06882961 in Otherwise Healthy Adult Participants With Overweight or Obesity.’ The study aimed to understand how these two drugs interact when taken together, focusing on their absorption and processing in the body. This research is significant as it could inform future treatments for overweight and obesity.
Pfizer Inc. has announced a new clinical study titled ‘A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study of Mevrometostat (PF-06821497) With Enzalutamide in Metastatic Castration-Sensitive Prostate Cancer (MEVPRO-3).’ The study aims to determine if the combination of the investigational drug Mevrometostat and Enzalutamide is more effective than Enzalutamide alone in treating patients with metastatic castration-sensitive prostate cancer (mCSPC) who are androgen receptor pathway inhibitor (ARPI) naïve. This study is significant as it explores a potential new treatment avenue for mCSPC, a condition with limited therapeutic options.
Pfizer Inc. is conducting a study titled ‘Effectiveness of ABRYSVO® Maternal Respiratory Syncytial Virus (RSV) Vaccine Against RSV in Infants in Western Pennsylvania.’ The study aims to evaluate the effectiveness of the ABRYSVO vaccine, which is administered to pregnant individuals to protect infants from RSV-related lower respiratory tract diseases. The study is significant as RSV is a leading cause of such diseases in infants worldwide.
Pfizer Inc. is conducting a clinical study titled ‘TACTIVE-U: A Study to Learn About the Study Medicine (Vepdegestrant) When Given With Other Medicines in People With Advanced or Metastatic Breast Cancer (Sub-Study B)’. The study aims to evaluate the safety and efficacy of the drug ARV-471, in combination with ribociclib, for patients with estrogen receptor-positive advanced or metastatic breast cancer. This study is significant as it explores new treatment combinations for patients whose cancer has not responded to previous therapies.
Pfizer Inc. is conducting a Phase 3 study titled A PHASE 3, RANDOMIZED, DOUBLE BLIND, PLACEBO CONTROLLED STUDY OF PF-06821497 (MEVROMETOSTAT) WITH ENZALUTAMIDE IN METASTATIC CASTRATION RESISTANT PROSTATE CANCER (MEVPRO-2). The study aims to evaluate the efficacy of the investigational drug PF-06821497, combined with enzalutamide, compared to enzalutamide alone in men with metastatic castration-resistant prostate cancer (mCRPC) who have not previously received ARSi or abiraterone treatment. This research could potentially lead to more effective treatment options for this patient group.
Study Overview: Pfizer Inc. is conducting a study titled ‘Korean Post Marketing Surveillance for Comirnaty Injection’ to monitor the safety of the Comirnaty Injection (Bretovameran) during its post-marketing phase. The study aims to identify any safety concerns and questions related to the vaccine, ensuring it meets regulatory requirements and standard clinical practices in Korea.
Pfizer Inc. is conducting a Phase 3 clinical trial titled ‘A PHASE 3, RANDOMIZED, OPEN-LABEL STUDY OF PF-06821497 (MEVROMETOSTAT) IN COMBINATION WITH ENZALUTAMIDE COMPARED WITH ENZALUTAMIDE OR DOCETAXEL IN PARTICIPANTS WITH METASTATIC CASTRATION RESISTANT PROSTATE CANCER PREVIOUSLY TREATED WITH ABIRATERONE ACETATE (MEVPRO-1)’. The study aims to evaluate the safety and effectiveness of combining PF-06821497 with enzalutamide versus the physician’s choice of enzalutamide or docetaxel in treating metastatic castration-resistant prostate cancer (mCRPC) after prior treatment with abiraterone acetate. The primary objective is to assess radiographic progression-free survival (rPFS).
Pfizer Inc. is conducting a Phase 1A/B open-label study titled ‘A Study to Learn About the Study Medicine Called PF-07799544 in People With Advanced Solid Tumors.’ The study aims to evaluate the safety and effects of PF-07799544, administered alone and in combination with other targeted agents, in patients with advanced solid tumors that are unresponsive to existing treatments. This research is significant as it explores new treatment avenues for challenging cancer cases.
Pfizer Inc. is currently conducting a post-marketing surveillance study titled ‘Korean Post-marketing Surveillance for Xeljanz® 5 mg Film-coated Tablets and Xeljanz® 1 mg/mL Oral Solution in Patients With Active pJIA and jPsA.’ The study aims to evaluate the safety and effectiveness of Xeljanz, a JAK inhibitor, in treating Juvenile Idiopathic Arthritis (JIA) in routine clinical practice in Korea. This is significant as it helps ensure the ongoing safety of Xeljanz in a younger population.
Pfizer Inc. has announced a new clinical study titled ‘A Phase 2b/3, Randomized, Double-Blind Study to Investigate the Efficacy, Safety, and Tolerability of Ponsegromab (PF-06946860) Compared with Placebo Both with Background First-Line Chemotherapy in Adult Participants with Cachexia and Metastatic Pancreatic Ductal Adenocarcinoma.’ The study aims to evaluate the effectiveness of ponsegromab, a new drug, in treating patients suffering from significant weight loss and fatigue due to metastatic pancreatic cancer. This research is significant as it targets a challenging aspect of cancer treatment, potentially improving patient quality of life.
Pfizer Inc., a leading global biopharmaceutical company, specializes in the discovery, development, and distribution of healthcare products, with a focus on innovative medicines and vaccines. The company operates in the pharmaceutical industry and is known for its extensive R&D pipeline and strategic partnerships.
Pfizer’s recent earnings call painted a picture of strong financial and operational performance in the second quarter of 2025. The company reported significant revenue growth, driven by key products and advancements in research and development. Despite these positive developments, Pfizer acknowledged challenges in certain product lines and potential impacts from ongoing policy discussions. The overall sentiment was optimistic, but tempered by uncertainties related to COVID-19 revenues and geopolitical factors.
Study Overview: Pfizer Inc. is conducting a study titled Real World Impact and Effectiveness of ABRYSVO® Vaccination During Pregnancy Against RSV Illness in Infants. The study aims to evaluate the effectiveness of the ABRYSVO vaccine administered during pregnancy in preventing RSV-related illnesses in infants. This research is significant as it seeks to provide real-world evidence of the vaccine’s impact across multiple seasons in Argentina and Uruguay.
Pfizer Inc. is conducting a non-interventional study titled ‘ELREXFIO SPECIAL INVESTIGATION- INVESTIGATION ON LONG-TERM TREATMENT’ to evaluate the safety and effectiveness of elranatamab in patients with relapsed and refractory multiple myeloma (RRMM). The study aims to compare the onset status of cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS) in real-world settings to previous clinical trials, and to assess any adverse reactions and overall response rates.
Pfizer Inc. is conducting an observational study titled ‘Use and Effectiveness of COVID-19 Vaccines Using State Vaccine Registries and Insurance Claims Data.’ The study aims to evaluate the effectiveness of the Pfizer-BioNTech COVID-19 vaccine in preventing post-COVID conditions and to understand the characteristics of patients receiving the vaccine. This research is significant as it leverages state vaccine registries and HealthVerity insurance claims data to provide insights into vaccine efficacy and patient demographics.
Pfizer Inc. is conducting a Phase 2A clinical study titled A PHASE 2A MULTICENTER, OBSERVER-BLINDED, RANDOMIZED 2 ARM STUDY TO INVESTIGATE PHARMACOKINETICS, SAFETY, TOLERABILITY AND EFFICACY OF INTRAVENOUS AZTREONAM-AVIBACTAM ± METRONIDAZOLE COMPARED TO BEST AVAILABLE THERAPY (BAT) IN PEDIATRIC PARTICIPANTS 9 MONTHS TO LESS THAN 18 YEARS OF AGE WITH SERIOUS GRAM-NEGATIVE BACTERIAL INFECTIONS INCLUDING COMPLICATED INTRA-ABDOMINAL INFECTION. The study aims to evaluate the pharmacokinetics, safety, and efficacy of Aztreonam-Avibactam (ATM-AVI) in pediatric patients with serious gram-negative infections, offering insights into potential treatment improvements for this vulnerable population.
Pfizer Inc. is conducting a clinical study titled ‘A Phase 3, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy and Safety of Rimegepant in Migraine Prevention in Children and Adolescents ≥ 6 to <18 Years of Age.' The study aims to assess the effectiveness and safety of rimegepant as a preventative treatment for migraines in young patients, a significant step in addressing a common and debilitating condition in this age group.
Pfizer Inc. is conducting a study titled ‘Retrospective Cohort Study of Pregnancy Outcomes in Women Exposed to Rimegepant During Pregnancy.’ This research aims to assess the risk of pregnancy and infant outcomes in women with migraines who are exposed to rimegepant during pregnancy, compared to two groups not exposed to the drug. The study is significant as it seeks to provide insights into the safety of rimegepant, a medication used for treating migraines, during pregnancy.
Pfizer Inc. is conducting a study titled ‘An Open-label Extension Study to Evaluate the Long-term Safety of Inclacumab Administered to Participants With Sickle Cell Disease.’ The primary objective is to assess the safety of long-term use of inclacumab in individuals with sickle cell disease (SCD) who have completed a prior inclacumab trial. This study is significant as it aims to provide insights into the prolonged safety profile of inclacumab, potentially benefiting SCD patients.
Study Overview: Pfizer Inc. is conducting a study titled A Multicenter, Non-interventional Prospective Active Surveillance Study Among Participants Receiving Somatrogon Under Routine Clinical Care in India. The study aims to evaluate the safety of Somatrogon, a treatment for pediatric growth hormone deficiency (p GHD), a condition characterized by insufficient growth hormone production leading to short stature in children. This study is significant as it seeks to ensure the safety of Somatrogon in routine clinical settings in India.
Pfizer Inc. is conducting a Phase 3 clinical study titled An Interventional, Efficacy, and Safety, Phase 3 Randomized, Double-Blind, Placebo-Controlled Study with an Open-Label Extension to Investigate Rimegepant in Migraine Prevention in Adolescents 12 to Less Than 18 Years of Age with Chronic Migraine. The study aims to evaluate the efficacy and safety of rimegepant, a dissolvable tablet, in adolescents suffering from frequent migraines. This research is significant as it targets a younger demographic often affected by chronic migraines, potentially offering a new preventive treatment option.
Pfizer and AbbVie are collaborating on a clinical study titled ‘A PHASE 2A, 2-PART, OPEN-LABEL, NON-RANDOMIZED, MULTICENTER, SINGLE AND MULTIPLE DOSE TRIAL TO EVALUATE PHARMACOKINETICS, SAFETY AND TOLERABILITY OF AZTREONAM AND AVIBACTAM ± METRONIDAZOLE IN NEONATES AND INFANTS FROM BIRTH TO LESS THAN 9 MONTHS OF AGE WITH SUSPECTED OR CONFIRMED INFECTIONS DUE TO GRAM-NEGATIVE PATHOGENS REQUIRING INTRAVENOUS ANTIBIOTIC TREATMENT.’ The study aims to assess the safety and effects of the combination drug aztreonam-avibactam (ATM-AVI) in treating bacterial infections in infants, a significant step in addressing antibiotic resistance.
Pfizer Inc. is conducting the MUltiple Myeloma Italian ObServational sTudy (MUST) to understand the treatment landscape for patients with Triple Class Refractory Multiple Myeloma (TCR-MM) in Italy. The study aims to describe the standard of care and treatment costs for TCR-MM patients across 25 Italian centers specializing in blood diseases. This research is significant as it addresses the challenges faced by patients whose cancer does not respond to the three main classes of MM treatments.
Pfizer Inc. is conducting a Phase 3 clinical study titled A Randomized, 2-Arm, Phase 3 Study of Elranatamab (PF-06863135) Versus Lenalidomide in Patients With Newly Diagnosed Multiple Myeloma After Undergoing Autologous Stem-Cell Transplantation. The study aims to evaluate the clinical benefits of elranatamab monotherapy compared to lenalidomide monotherapy in patients with newly diagnosed multiple myeloma post-transplant. This research is significant as it explores potential advancements in treatment options for this patient group.
Pfizer Inc. is conducting a Phase 3 clinical study titled MagnetisMM-32 to evaluate the effectiveness of the drug elranatamab in patients with relapsed or refractory multiple myeloma (MM) who have previously been treated with anti-CD38 antibodies and lenalidomide. The study aims to compare elranatamab monotherapy against combination therapies involving other drugs to determine its safety and efficacy.
Pfizer Inc. is conducting a Phase 3 clinical study titled ‘Randomized Study in Children and Adolescents With Migraine: Acute Treatment.’ The study aims to evaluate the safety and efficacy of Rimegepant (BHV-3000) compared to a placebo for treating moderate to severe migraines in children and adolescents aged 6 to 18. This research is significant as it could provide a new treatment option for a younger demographic suffering from migraines.
Pfizer Inc. is conducting a Phase 3 clinical study titled ‘Phase 3, Multicenter, Open-label Study to Assess the Long-term Safety and Tolerability of Rimegepant for the Acute Treatment of Migraine (With or Without Aura) in Children and Adolescents ≥ 6 to < 18 Years of Age.' The study aims to evaluate the long-term safety of rimegepant, a medication intended for the acute treatment of migraines in young patients. This study is significant as it addresses a critical need for effective migraine treatments in the pediatric population.
Pfizer Inc. is conducting a clinical study titled AN OPEN-LABEL, 3-ARM, MULTICENTER, RANDOMIZED PHASE 3 STUDY TO EVALUATE THE EFFICACY AND SAFETY OF ELRANATAMAB (PF-06863135) MONOTHERAPY AND ELRANATAMAB + DARATUMUMAB VERSUS DARATUMUMAB + POMALIDOMIDE + DEXAMETHASONE IN PARTICIPANTS WITH RELAPSED/REFRACTORY MULTIPLE MYELOMA WHO HAVE RECEIVED AT LEAST 1 PRIOR LINE OF THERAPY INCLUDING LENALIDOMIDE AND A PROTEASOME INHIBITOR. The study aims to assess the benefits and safety of elranatamab, alone and in combination with daratumumab, compared to a standard treatment regimen for patients with multiple myeloma who have undergone prior treatments.
Pfizer Inc, in collaboration with CVS Caremark, is conducting a study titled ‘Patient-Reported Outcomes Associated With COVID-19 and Influenza.’ The study aims to assess the health outcomes and symptoms of individuals with test-confirmed COVID-19 or influenza, focusing on the effects of COVID-19 vaccines. This research is significant as it seeks to provide insights into the health impacts of these illnesses and the role of vaccination in mitigating symptoms.
Pfizer Inc., in collaboration with Astellas Pharma Global Development, Inc., is conducting a Phase 4 clinical study titled ‘A Multicenter, Phase 4, Open-label, Single-arm, Safety Study of Enfortumab Vedotin in Adult Indian Participants With Previously Treated Locally Advanced or Metastatic Urothelial Cancer.’ The study aims to confirm the safety of enfortumab vedotin, a treatment for urothelial cancer, in Indian adults whose cancer is advanced or has spread.
Pfizer Inc. is conducting a Phase 1B clinical trial titled A PHASE 1B, OPEN-LABEL STUDY OF ELRANATAMAB IN COMBINATION WITH CARFILZOMIB PLUS DEXAMETHASONE AND ELRANATAMAB IN COMBINATION WITH PF-07901801 IN PARTICIPANTS WITH RELAPSED REFRACTORY MULTIPLE MYELOMA. The study aims to assess the safety and tolerability of combining elranatamab with other drugs in treating relapsed refractory multiple myeloma, a significant concern in oncology.
Pfizer Inc. is conducting a study titled ‘Low Interventional Cohort Study of Myocarditis/Pericarditis Associated With COMIRNATY in Persons Less Than 21 Years of Age.’ The study aims to assess the safety and effects of the COMIRNATY vaccine in preventing COVID-19, specifically examining potential long-term effects of myocarditis/pericarditis in individuals under 21. This research is significant as it seeks to determine the vaccine’s safety and any associations with myocarditis/pericarditis.
Pfizer Inc. is conducting a study titled ‘Estimated Vaccine Effectiveness and Durability of Pfizer/BioNTech 2024-2025 COVID-19 Vaccine’ to evaluate the real-world effectiveness of their updated COVID-19 vaccine formulation. The study aims to assess the vaccine’s effectiveness against symptomatic SARS-CoV-2 infections across different age groups and during various variant circulations.
Study Overview: Pfizer Inc. is conducting a study titled ‘ATGAM INTRAVENOUS INFUSION 250mg GENERAL INVESTIGATION’ to confirm the safety of ATGAM in patients with moderate to severe aplastic anemia in Japan. The study aims to observe the safety profile of ATGAM under actual use conditions, which is significant for ensuring patient safety and effective treatment outcomes.
Pfizer Inc. is conducting a Phase 3 clinical study titled ‘AN INTERVENTIONAL EFFICACY AND SAFETY, PHASE 3, DOUBLE-BLIND, 2-ARM STUDY TO INVESTIGATE ORALLY ADMINISTERED IBUZATRELVIR COMPARED WITH PLACEBO IN NON-HOSPITALIZED SYMPTOMATIC ADULT AND ADOLESCENT PARTICIPANTS WITH COVID-19 WHO ARE AT HIGH RISK OF PROGRESSING TO SEVERE ILLNESS.’ The study aims to assess the efficacy and safety of ibuzatrelvir in preventing severe COVID-19 in non-hospitalized patients at high risk of severe disease progression.
Pfizer Inc. is conducting a significant clinical study titled ‘MAGNETISMM-6’ to evaluate the efficacy and safety of Elranatamab in combination with other drugs for patients with newly diagnosed multiple myeloma who are not candidates for transplant. The study aims to determine if Elranatamab, when combined with Daratumumab and Lenalidomide, or with Lenalidomide alone, offers superior clinical benefits compared to the existing combination of Daratumumab, Lenalidomide, and Dexamethasone.
Pfizer Inc. is conducting a Phase 3 clinical study titled ‘An Interventional Efficacy and Safety, Phase 3, Double-Blind, Parallel Group Study to Investigate Intermittent Prevention of Menstrual Migraine with Rimegepant Compared with Placebo in Women Participants 18 to 45 Years of Age.’ The study aims to evaluate the efficacy and safety of rimegepant, a medication administered during the peri-menstrual period, for the intermittent prevention of menstrual migraine attacks in women.
Pfizer Inc. is conducting a Phase 1 clinical study titled A PHASE 1, OPEN-LABEL, DOSE ESCALATION AND DOSE EXPANSION STUDY TO EVALUATE THE SAFETY, TOLERABILITY, PHARMACOKINETICS, AND ANTI TUMOR ACTIVITY OF PF-07799933 (ARRY-440) AS A SINGLE AGENT AND IN COMBINATION THERAPY IN PARTICIPANTS 16 YEARS AND OLDER WITH ADVANCED SOLID TUMORS WITH BRAF ALTERATIONS. The study aims to assess the safety and effectiveness of PF-07799933, alone and in combination with other drugs, in treating advanced solid tumors with BRAF gene alterations.
Pfizer Inc. is conducting a long-term clinical study titled A Long-Term, Double-Blind Extension Study to Investigate the Safety and Efficacy of Ritlecitinib in Participants with Severe Alopecia Areata Who Previously Completed Studies B7981027 or B7981031. The study aims to evaluate the long-term safety and efficacy of ritlecitinib, a treatment for severe alopecia areata, a condition causing significant hair loss. This study is significant as it seeks to provide a viable treatment option for pediatric patients suffering from this condition.
Pfizer Inc. has completed a Phase 1 clinical study titled A Phase 1, Open-Label, Fixed-Sequence Study to Evaluate the Effect of Itraconazole and Cyclosporine on the Single-Dose Pharmacokinetics of Danuglipron in Healthy Adult Participants. The study aimed to understand how the drugs itraconazole and cyclosporine affect the levels of danuglipron in the blood, potentially guiding future use of danuglipron with these medications.
Study Overview: Pfizer Inc. has completed a Phase 1 clinical study titled ‘A Phase 1, Randomized, Double-Blind, Third-Party Open, Placebo-Controlled, Single-Dose Study to Evaluate the Pharmacokinetics, Safety, Tolerability, Immunogenicity, and Pharmacodynamics Following Intravenous Dose of PF-07275315 in Chinese Healthy Adult Participants.’ The study aimed to assess the safety and processing of the investigational drug PF-07275315 in healthy Chinese adults, providing critical insights into its potential therapeutic applications.
Pfizer Inc. recently completed a Phase 1 clinical study titled A PHASE 1, OPEN-LABEL, 2-PART STUDY TO ESTIMATE SEPARATELY THE EFFECT OF ITRACONAZOLE AND FOOD ON THE PHARMACOKINETICS OF PF-07258669 IN OLDER ADULT OR HEALTHY ADULT PARTICIPANTS. The study aimed to understand how itraconazole and food affect the body’s processing of PF-07258669, a drug developed to treat unintended weight loss in older adults. This condition often leads to poor nutrition and health outcomes, making the study significant for improving patient care.
Study Overview: Pfizer Inc. is conducting a post-marketing surveillance study titled Korean Post-marketing Surveillance for Xeljanz® 5 mg Film-coated Tablets and Xeljanz® 1 mg/mL Oral Solution in Patients With Active pJIA and jPsA. The study aims to assess the safety and effectiveness of Xeljanz in treating Juvenile Idiopathic Arthritis (JIA) in routine clinical practice in Korea, focusing on patients aged 2 to less than 18 years.
Pfizer Inc. is conducting a study titled ‘Special Investigation of TALZENNA Capsules – Study on BRCA Mutation-Positive Metastatic Castration-Resistant Prostate Cancer.’ The study aims to evaluate the safety of TALZENNA in patients with this specific type of prostate cancer, which continues to grow despite low levels of male hormones and has spread to other parts of the body. This research is significant as it targets a mutation that affects cancer progression, potentially offering new treatment avenues.
Pfizer Inc. has recently updated the results of its phase 3 clinical study titled ‘A Study of Avelumab With Axitinib Versus Sunitinib In Advanced Renal Cell Cancer (JAVELIN Renal 101)’. The study aims to assess the anti-tumor activity and safety of avelumab combined with axitinib compared to sunitinib monotherapy in patients with advanced renal cell carcinoma. This research is significant as it explores potential first-line treatments for this aggressive cancer type.
Pfizer Inc. is conducting a Phase 1 clinical study titled A Phase 1 Open-Label Study of PF-07934040 as a Single Agent and in Combination With Other Targeted Agents in Participants With Advanced Solid Tumors Harboring Mutations in the KRAS Gene. The study aims to evaluate the safety and efficacy of PF-07934040, a panKRAS inhibitor, alone and in combination with other anti-cancer therapies in patients with advanced solid tumors that have a KRAS gene mutation. This research is significant as it targets cancers like non-small cell lung cancer, colorectal cancer, and pancreatic ductal adenocarcinoma, which are often challenging to treat.
Pfizer Inc. is launching a new Phase 3 clinical study titled A Long-term Study of the Medicine Called Abrocitinib in Children Aged 2 Years and Older With Moderate to Severe Eczema. The study aims to evaluate the long-term safety and efficacy of abrocitinib, an oral suspension, in treating moderate-to-severe atopic dermatitis in children aged 2 years and older. This study is significant as it could potentially offer a new treatment option for pediatric eczema, a condition that affects many children worldwide.
Study Overview: Pfizer Inc. is conducting a study titled ‘Ngenla Subcutaneous Injection Special Investigation’ to evaluate the long-term safety and effects of Ngenla in treating Growth Hormone Deficiency (GHD) in children. This study is significant as it aims to provide insights into the long-term use of Ngenla, a treatment approved for GHD without epiphyseal closure.
Pfizer Inc. is conducting a study titled ‘Special Investigation for ABRYSVO Intramuscular Injection – Investigation in Pregnant Women and Infants.’ The primary objective is to assess the safety of the RSVpreF vaccine, known as Abrysvo, in pregnant women and their infants in Japan. This study is significant as it aims to confirm the vaccine’s safety in real-world clinical settings, potentially influencing public health strategies.
Pfizer Inc. is conducting a study titled ‘Korea Comirnaty Post-marketing Surveillance’ to assess the safety of the BNT162b2 vaccine in routine clinical practice in Korea. The study aims to collect safety data from subjects who have received the vaccine, following the New Drug Re-Examination Guideline of the Ministry of Food and Drug Safety (MFDS). This study is significant as it helps ensure the ongoing safety of the vaccine in a real-world setting.
Pfizer Inc. is conducting a study titled ‘Retrospective Study Evaluating ABRYSVO Vaccine Effectiveness Against Severe Lower Respiratory Tract Infection in Older Adults.’ The study aims to assess the effectiveness of the ABRYSVO vaccine in preventing severe respiratory syncytial virus (RSV) infections in adults aged 60 and older. This research is significant as RSV can lead to severe respiratory issues, especially in older populations.
Pfizer Inc. is conducting a Phase 3 study titled ‘A Study to Evaluate the Safety and Immunogenicity of RSVpreF Coadministered With Herpes Zoster Vaccine in Adults.’ This study aims to assess the safety, tolerability, and immune response of a Respiratory Syncytial Virus (RSV) prefusion F subunit vaccine when administered alongside a herpes zoster subunit vaccine in adults aged 50 and above. The significance of this study lies in its potential to enhance vaccine efficacy and convenience for older adults.
Pfizer Inc. is conducting a study titled ‘AN OPEN-LABEL PHASE 1 STUDY TO INVESTIGATE PF-08046031 IN ADULTS WITH ADVANCED MELANOMA AND OTHER SOLID TUMORS.’ The study aims to assess the safety and side effects of PF-08046031, a drug for treating advanced melanoma and other solid tumors that lack approved treatments or have metastasized. The study is significant as it explores potential new treatment avenues for these challenging conditions.
Pfizer Inc. is conducting an open-label Phase 1 study titled AN OPEN-LABEL PHASE 1 STUDY TO EVALUATE PF-08046037 AS MONOTHERAPY AND PART OF COMBINATION THERAPY IN PARTICIPANTS WITH ADVANCED MALIGNANCIES. The study aims to assess the safety and effects of PF-08046037 alone or combined with sasanlimab in patients with advanced or metastatic cancers, including non-small cell lung cancer, head and neck squamous cell carcinoma, melanoma, and pancreatic ductal adenocarcinoma. This research is significant as it explores potential new treatments for these challenging conditions.
Pfizer Inc. is conducting a study titled ‘Real-world Clinical Outcomes of Tucatinib, Trastuzumab, and Capecitabine Following Trastuzumab Deruxtecan for the Treatment of HER2-positive Metastatic Breast Cancer.’ The study aims to evaluate real-world outcomes such as time to next treatment, time to discontinuation, and overall survival for patients using the tucatinib-trastuzumab-capecitabine therapy after T-DXd therapy in the U.S. This research is significant as it provides insights into the effectiveness of these treatments in a real-world setting.
Pfizer Inc. is conducting a Phase 3 clinical study titled ‘MagnetisMM-32’ to evaluate the effectiveness of elranatamab in patients with relapsed or refractory multiple myeloma, a type of cancer that has returned after previous treatments. The study aims to compare elranatamab monotherapy against other established combination therapies to determine its safety and efficacy.
Pfizer Inc. recently completed a significant study titled ‘Pfizer-BioNTech COVID-19 Vaccine Effectiveness Study – Kaiser Permanente Southern California.’ The study aimed to assess the effectiveness of two doses of the Pfizer-BioNTech BNT162b2 vaccine in preventing COVID-19-related hospitalizations. This research is crucial as it provides insights into the vaccine’s performance in real-world settings, helping guide public health decisions.
Pfizer Inc. is conducting an Elranatamab Post Trial Access Study for participants with Multiple Myeloma, officially titled ‘ELRANATAMAB POST TRIAL ACCESS: AN OPEN-LABEL, SINGLE-ARM STUDY FOR PARTICIPANTS WITH MULTIPLE MYELOMA CONTINUING FROM PFIZER-SPONSORED ELRANATAMAB CLINICAL STUDIES’. The study aims to provide continued access to elranatamab for patients who have shown clinical benefit in previous trials. This is significant as it supports ongoing treatment for patients with limited options.
Pfizer Inc. and Bristol-Myers Squibb Company are conducting a Phase 1B study titled ‘A PHASE 1B, OPEN-LABEL STUDY OF ELRANATAMAB IN COMBINATION WITH IBERDOMIDE IN PARTICIPANTS WITH RELAPSED REFRACTORY MULTIPLE MYELOMA.’ The study aims to evaluate the safety and tolerability of combining elranatamab with iberdomide in patients with relapsed or refractory multiple myeloma, a cancer affecting plasma cells.
Pfizer Inc. is conducting a study titled ‘MAGNETISMM-6’ to evaluate the efficacy and safety of Elranatamab in combination with Daratumumab and Lenalidomide, or Elranatamab and Lenalidomide, compared to Daratumumab, Lenalidomide, and Dexamethasone in patients with newly diagnosed multiple myeloma who are not eligible for transplant. The study aims to determine if these combinations offer superior clinical benefits, focusing on safety, tolerability, and progression-free survival.
Pfizer Inc. is conducting a Phase 3 study titled A RANDOMIZED, 2-ARM, PHASE 3 STUDY OF ELRANATAMAB (PF-06863135) VERSUS LENALIDOMIDE IN PATIENTS WITH NEWLY DIAGNOSED MULTIPLE MYELOMA AFTER UNDERGOING AUTOLOGOUS STEM-CELL TRANSPLANTATION. The study aims to evaluate the effectiveness of elranatamab monotherapy compared to lenalidomide monotherapy in patients who have undergone autologous stem cell transplantation for newly diagnosed multiple myeloma.
Pfizer Inc. is conducting a Phase 3 multi-center, long-term extension study titled A PHASE 3 MULTI-CENTER, LONG-TERM EXTENSION STUDY INVESTIGATING THE EFFICACY AND SAFETY OF ABROCITINIB, WITH OR WITHOUT TOPICAL MEDICATIONS, ADMINISTERED TO SUBJECTS AGED 12 YEARS AND OLDER WITH MODERATE TO SEVERE ATOPIC DERMATITIS. The study aims to evaluate the efficacy and safety of Abrocitinib, an oral medication, in patients aged 12 and older with moderate to severe atopic dermatitis. This study is significant as it explores potential long-term treatment options for this chronic skin condition.
Pfizer Inc. and Astellas Pharma have announced a significant update in their ongoing clinical study titled TALAPRO-3: A PHASE 3, RANDOMIZED, DOUBLE-BLIND, STUDY OF TALAZOPARIB WITH ENZALUTAMIDE VERSUS PLACEBO WITH ENZALUTAMIDE IN MEN WITH DDR GENE MUTATED METASTATIC CASTRATION-SENSITIVE PROSTATE CANCER. The study aims to evaluate the safety and efficacy of combining talazoparib with enzalutamide, compared to a placebo with enzalutamide, in treating men with DDR-deficient metastatic castration-sensitive prostate cancer (mCSPC).
Pfizer Inc. and Genmab are conducting a Phase 4 clinical study titled ‘A Prospective Low-Interventional Phase 4 Single Arm Study of Ocular Assessments in Patients Treated With Tivdak® in Recurrent or Metastatic Cervical Cancer.’ The study aims to evaluate potential ocular side effects of Tivdak, a treatment for cervical cancer that has recurred or metastasized after chemotherapy. Understanding these side effects is crucial for improving patient care and treatment outcomes.
Pfizer Inc. has initiated a Phase 1 clinical study titled ‘A PHASE 1 OPEN-LABEL STUDY OF PF-07985045 AS A SINGLE-AGENT AND IN COMBINATION WITH OTHER ANTI-CANCER AGENTS IN PARTICIPANTS WITH ADVANCED SOLID TUMORS.’ The study aims to evaluate the safety and effectiveness of PF-07985045, a KRAS inhibitor, alone and in combination with other anti-cancer therapies in patients with advanced solid tumors that have a KRAS gene mutation. This study is significant as it targets difficult-to-treat cancers such as Non-Small Cell Lung Cancer, Colorectal Cancer, and Pancreatic ductal adenocarcinoma.
Pfizer Inc. is conducting a Phase 1 clinical study titled ‘An Open-Label Phase 1 Study to Evaluate PF-08046032 as Monotherapy and Part of Combination Therapy in Participants With Advanced Malignancies.’ The study aims to assess the effects of PF-08046032, both alone and in combination with sasanlimab, in treating advanced cancers, including certain lymphomas and solid tumors. The significance of this study lies in its potential to offer new treatment options for patients with advanced or metastatic cancers.
Pfizer Inc. is conducting a clinical study titled ‘A 16-WEEK, MULTICENTER, INTERVENTIONAL, PHASE 3, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, PARALLEL GROUP STUDY TO INVESTIGATE EFFICACY AND SAFETY OF ABROCITINIB IN CHILDREN 6 TO LESS THAN 12 YEARS OF AGE WITH MODERATE-TO-SEVERE ATOPIC DERMATITIS.’ The study aims to evaluate the effectiveness and safety of the drug Abrocitinib in treating moderate-to-severe eczema in children aged 6 to less than 12 years. This research is significant as it addresses a common and challenging condition in pediatric dermatology.
Pfizer Inc. recently updated its clinical study focused on evaluating the effects of multiple doses of Sisunatovir (RV521) on individuals infected with Respiratory Syncytial Virus (RSV). Officially titled ‘A Randomised, Phase 2a, Double-Blind, Placebo-Controlled Study To Evaluate The Safety, Pharmacokinetics And Antiviral Activity Of Multiple Doses Of RV521 Against Respiratory Syncytial Virus Infection In The Virus Challenge Model,’ the study aims to assess the safety, pharmacokinetics, and antiviral activity of Sisunatovir, a potential treatment for RSV, a virus known for causing severe lung infections in vulnerable populations.
Pfizer Inc. is conducting a study titled ‘TALZENNA Capsules Special Investigation’ to evaluate the safety of TALZENNA for treating patients with BRCA mutation-positive and HER2-negative unresectable or recurrent breast cancer. The study aims to assess the safety profile of TALZENNA in patients who have previously undergone chemotherapy, highlighting its significance in potentially offering a new treatment avenue for this patient group.
Study Overview: Pfizer Inc. is conducting a Korean Post Marketing Surveillance study for ELREXFIO (Elranatamab) to assess its safety and effectiveness in treating multiple myeloma in real-world clinical settings. The study aims to evaluate Elranatamab’s performance under general clinical practice conditions in compliance with the MFDS regulations, providing significant insights into its practical application.
Pfizer Inc, in collaboration with Carrick Therapeutics Limited, is conducting a Phase 2 clinical study titled ‘An Open-label, Interventional, Multicenter, Randomized, Phase 2 Study of Fulvestrant With or Without Samuraciclib in Participants With Metastatic or Locally Advanced Hormone Receptor (HR) Positive and Human Epidermal Growth Factor Receptor (HER)2-Negative Breast Cancer (BC)’. The study aims to evaluate the safety and efficacy of combining samuraciclib with fulvestrant compared to fulvestrant alone in treating specific types of advanced breast cancer.
Pfizer Inc. is conducting a Phase 3 clinical study titled AN OPEN-LABEL, RANDOMIZED, CONTROLLED PHASE 3 STUDY OF SIGVOTATUG VEDOTIN IN COMBINATION WITH PEMBROLIZUMAB COMPARED WITH PEMBROLIZUMAB MONOTHERAPY AS FIRST-LINE TREATMENT IN PARTICIPANTS WITH PD-L1 HIGH (≥50% OF TUMOR CELLS EXPRESSING PD-L1), LOCALLY ADVANCED, UNRESECTABLE, OR METASTATIC NON-SMALL CELL LUNG CANCER (BE6A LUNG-02). The study aims to evaluate the efficacy of a combination treatment of Sigvotatug Vedotin and pembrolizumab against pembrolizumab alone in patients with non-small cell lung cancer (NSCLC) exhibiting high PD-L1 levels. This protein is crucial as it regulates immune responses, and the study’s findings could significantly impact treatment strategies for advanced NSCLC.
The clinical study titled A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study of Talazoparib with Enzalutamide in Metastatic Castration-Resistant Prostate Cancer aims to evaluate the efficacy of combining Talazoparib with Enzalutamide compared to Enzalutamide alone in treating metastatic castration-resistant prostate cancer (mCRPC). The study’s significance lies in its potential to improve treatment outcomes for men with mCRPC.
Pfizer Inc. is set to launch a pivotal Phase 3 clinical study titled ‘A Long-term Study of the Medicine Called Abrocitinib in Children Aged 2 Years and Older With Moderate to Severe Eczema.’ This research aims to evaluate the long-term safety and efficacy of abrocitinib, administered as a liquid oral suspension, in pediatric patients with moderate-to-severe atopic dermatitis. The study is significant as it targets a young demographic, potentially offering a new therapeutic option for a challenging condition.
Pfizer Inc. is conducting a Phase 1B clinical study titled A Study to Evaluate the Safety and Tolerability of PF-06939926 Gene Therapy in Duchenne Muscular Dystrophy. The study aims to assess the safety and tolerability of PF-06939926, a gene therapy for Duchenne Muscular Dystrophy (DMD), in both ambulatory and non-ambulatory patients. The significance of this study lies in its potential to address a critical unmet need in DMD treatment by evaluating the expression and distribution of dystrophin, a key protein missing in DMD patients.
Pfizer Inc. has launched a study titled ‘Special Investigation of TALZENNA Capsules – Study on BRCA Mutation-Positive Metastatic Castration-Resistant Prostate Cancer’ to evaluate the safety of TALZENNA in patients with a specific type of prostate cancer. The study focuses on individuals with BRCA mutation-positive metastatic castration-resistant prostate cancer, a condition where cancer persists despite low male hormone levels and has spread to other parts of the body. The significance of this study lies in its potential to offer a new treatment option for this challenging cancer type.
Pfizer Inc. recently completed a significant phase 3 clinical study titled A PHASE 3, MULTINATIONAL, RANDOMIZED, OPEN-LABEL, PARALLEL-ARM STUDY OF AVELUMAB (MSB0010718C) IN COMBINATION WITH AXITINIB (INLYTA(REGISTERED)) VERSUS SUNITINIB (SUTENT(REGISTERED)) MONOTHERAPY IN THE FIRST-LINE TREATMENT OF PATIENTS WITH ADVANCED RENAL CELL CARCINOMA. The study aimed to evaluate the anti-tumor activity and safety of avelumab combined with axitinib compared to sunitinib monotherapy in patients with advanced renal cell carcinoma, highlighting its potential to improve treatment outcomes.
Pfizer Inc. is currently conducting a Phase 1 clinical study titled A Phase 1 Open-Label Study of PF-07934040 as a Single Agent and in Combination With Other Targeted Agents in Participants With Advanced Solid Tumors Harboring Mutations in the KRAS Gene. The study aims to evaluate the safety and efficacy of PF-07934040, a panKRAS inhibitor, alone and in combination with other anti-cancer therapies in patients with advanced solid tumors, such as non-small cell lung cancer, colorectal cancer, and pancreatic ductal adenocarcinoma, that have a KRAS gene mutation. The primary goal is to determine the optimal dosage and assess the treatment’s effects on tumor growth.
Pfizer Inc. is conducting an open-label Phase 1 study titled ‘A Study to Learn About the Study Medicine Called PF-08046031 in Advanced Melanoma and Other Solid Tumors.’ The study aims to investigate the safety and side effects of PF-08046031 in adults with advanced melanoma and other solid tumors that have spread or lack approved treatments. The study is significant as it explores potential new treatment options for these challenging conditions.
Study Overview: Pfizer Inc. is conducting a Phase 1b/2 clinical study titled ‘A Study of Disitamab Vedotin in Adults With HER2 Expressing Advanced Breast Cancer.’ The study aims to evaluate the safety and efficacy of disitamab vedotin in treating advanced breast cancer that is difficult to manage and has spread. This research is significant as it targets patients with HER2-expressing tumors who have undergone previous treatments.
Study Overview: Bristol-Myers Squibb and Pfizer are conducting a Phase 1b study titled A PHASE 1B, OPEN-LABEL STUDY OF ELRANATAMAB IN COMBINATION WITH IBERDOMIDE IN PARTICIPANTS WITH RELAPSED REFRACTORY MULTIPLE MYELOMA. The study aims to evaluate the safety and tolerability of combining elranatamab and iberdomide in patients with relapsed or refractory multiple myeloma, a challenging form of cancer that returns after treatment or resists current therapies.
Pfizer Inc. is conducting a clinical trial titled ‘AN OPEN-LABEL PHASE 1 STUDY TO EVALUATE PF-08046037 AS MONOTHERAPY AND PART OF COMBINATION THERAPY IN PARTICIPANTS WITH ADVANCED MALIGNANCIES.’ The study aims to assess the safety and effects of PF-08046037 alone or in combination with sasanlimab in treating advanced or metastatic malignancies, including non-small cell lung cancer, head and neck squamous cell carcinoma, melanoma, and pancreatic ductal adenocarcinoma. This research is significant as it explores new treatment avenues for these challenging conditions.
Pfizer Inc. has initiated a Phase 3 clinical study titled ‘MagnetisMM-32’ to evaluate the effectiveness of elranatamab in patients with relapsed or refractory multiple myeloma, a type of cancer that has returned after prior treatments. The study aims to compare elranatamab monotherapy against established combination therapies, providing insights into its safety and efficacy.
Pfizer Inc. is conducting a Phase 3 clinical study titled ‘A Randomized, 2-Arm, Phase 3 Study of Elranatamab (PF-06863135) Versus Lenalidomide in Patients with Newly Diagnosed Multiple Myeloma After Undergoing Autologous Stem-Cell Transplantation.’ The study aims to assess the clinical benefits of elranatamab monotherapy compared to lenalidomide monotherapy in patients with newly diagnosed multiple myeloma post-transplant. This study is significant as it explores potential advancements in treatment options for multiple myeloma, a challenging cancer to treat.
Pfizer Inc. has completed a study titled ‘Pfizer-BioNTech COVID-19 Vaccine Effectiveness Study – Kaiser Permanente Southern California.’ The study aimed to evaluate the effectiveness of two doses of the Pfizer-BioNTech BNT162b2 vaccine in preventing COVID-19-associated hospitalizations. This large-scale retrospective study is significant as it provides insights into vaccine performance against various COVID-19 strains and patient demographics.
Pfizer Inc. is conducting a study titled ‘Elranatamab Post Trial Access Study for Participants With Multiple Myeloma (MM).’ The study aims to provide continued access to elranatamab for participants who have benefited from previous Pfizer-sponsored trials. This study is significant as it supports ongoing treatment for multiple myeloma patients who have shown positive responses to elranatamab.
Pfizer Inc. is conducting a study titled ‘Real-world Clinical Outcomes of Tucatinib, Trastuzumab, and Capecitabine Following Trastuzumab Deruxtecan for the Treatment of HER2-positive Metastatic Breast Cancer.’ The study aims to evaluate the real-world outcomes of a specific drug combination in patients with HER2-positive metastatic breast cancer, focusing on metrics such as time to next treatment and overall survival.
Pfizer Inc. is conducting a Phase 3 study titled ‘A Phase 3 Multi-Center, Long-Term Extension Study Investigating the Efficacy and Safety of Abrocitinib, With or Without Topical Medications, Administered to Subjects Aged 12 Years and Older With Moderate to Severe Atopic Dermatitis.’ The study aims to evaluate the efficacy and safety of Abrocitinib, an oral medication, in treating moderate to severe atopic dermatitis in patients aged 12 and older. This study is significant as it explores long-term treatment options for a chronic skin condition that affects a significant portion of the population.
Pfizer Inc. is conducting a clinical study titled ‘MAGNETISMM-6’ to evaluate the efficacy and safety of Elranatamab in combination with other drugs for patients with newly diagnosed multiple myeloma who are not eligible for transplant. The study aims to determine if Elranatamab, combined with Daratumumab and Lenalidomide, or with Lenalidomide alone, provides better clinical outcomes compared to the existing combination of Daratumumab, Lenalidomide, and Dexamethasone.