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Zenas BioPharma, Inc. (ZBIO)
NASDAQ:ZBIO
US Market
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Zenas BioPharma, Inc. (ZBIO) AI Stock Analysis

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ZBIO

Zenas BioPharma, Inc.

(NASDAQ:ZBIO)

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Neutral 48 (OpenAI - 4o)
Rating:48Neutral
Price Target:
$22.00
▲(5.01% Upside)
The overall score is primarily impacted by the company's poor financial performance, with significant revenue decline and cash flow issues. Technical analysis provides some positive momentum, but the negative valuation metrics further weigh down the score.
Positive Factors
Strong Equity Position
A strong equity position with low financial leverage indicates financial stability and resilience, providing a solid foundation for future growth.
High Gross Profit Margin
A high gross profit margin suggests efficient operations and potential for profitability improvement if revenue growth resumes, supporting long-term viability.
Significant Stockholder's Equity Recovery
Significant recovery in stockholder's equity reflects improved financial health and investor confidence, enhancing the company's ability to fund growth initiatives.
Negative Factors
Revenue Decline
The drastic revenue decline indicates challenges in market demand or product adoption, potentially impacting long-term growth and sustainability.
Negative Cash Flow
Persistent negative cash flow suggests operational inefficiencies and financial strain, limiting the company's ability to invest in growth and innovation.
Operating Losses
Ongoing operating losses highlight profitability challenges, potentially affecting the company's ability to sustain operations and invest in future growth.

Zenas BioPharma, Inc. (ZBIO) vs. SPDR S&P 500 ETF (SPY)

Zenas BioPharma, Inc. Business Overview & Revenue Model

Company DescriptionZenas BioPharma, Inc., a clinical-stage biopharmaceutical company, engages in the development and commercialization of transformative immunology-based therapies. Its lead product candidate is obexelimab, a bifunctional monoclonal antibody for various indications, including immunoglobulin G4-related disease, multiple sclerosis, systemic lupus erythematosus, and warm autoimmune hemolytic anemia. The company also develops ZB002, an anti-TNFa monoclonal antibody; ZB004, a cytotoxic T-lymphocyte-associated antigen 4-immunoglobulin fusion; ZB001, an anti-insulin-like growth factor-1 receptor monoclonal antibody; and ZB005, an anti-active complement component 1s monoclonal antibody. Zenas BioPharma, Inc. was formerly known as Zenas BioPharma (Cayman) Limited and changed its name to Zenas BioPharma, Inc. in August 2023. The company was incorporated in 2019 and is based in Waltham, Massachusetts.
How the Company Makes MoneyZenas BioPharma generates revenue primarily through the development and commercialization of its proprietary therapies. The company earns money through multiple revenue streams, including product sales once therapies are approved and launched in the market, milestone payments from partnerships with larger pharmaceutical companies, and potential royalties on product sales from licensed technologies. Significant partnerships and collaborations with other biopharmaceutical firms and research institutions also contribute to its earnings by providing funding for research and development activities, as well as enhancing its market reach and distribution capabilities.

Zenas BioPharma, Inc. Financial Statement Overview

Summary
Zenas BioPharma is facing severe financial challenges, with a significant revenue decline, persistent operating losses, and negative cash flow, indicating substantial operational inefficiency despite a strong equity recovery.
Income Statement
30
Negative
Zenas BioPharma has shown a significant decline in revenue from $50 million in 2023 to $5 million in 2024, indicating a severe contraction. The gross profit margin remains high due to zero cost of goods sold, yet the company faces substantial operating losses with negative EBIT and net income, highlighting ongoing profitability challenges.
Balance Sheet
40
Negative
The company has a strong equity position with a debt-to-equity ratio of only 0.003, suggesting low financial leverage. However, the negative equity in previous years indicates past difficulties, although recent improvements in stockholder's equity to $312 million show significant recovery. The equity ratio of approximately 84% is a positive indicator of financial stability.
Cash Flow
35
Negative
Zenas BioPharma's free cash flow remains negative, with a decline in operating cash flow from -$30 million to -$120 million. While financing activities have injected significant cash, the operational cash burn is a concern. The operating cash flow to net income ratio is negative, reflecting inefficiency in converting income into cash.
BreakdownTTMDec 2024Dec 2023Dec 2022
Income Statement
Total Revenue15.00M5.00M50.00M0.00
Gross Profit14.95M5.00M50.00M-78.00K
EBITDA-185.46M-163.75M-27.03M-75.12M
Net Income-176.97M-156.99M-37.12M-119.28M
Balance Sheet
Total Assets293.08M369.97M68.18M74.58M
Cash, Cash Equivalents and Short-Term Investments273.28M350.77M56.86M67.21M
Total Debt1.01M1.00M21.11M1.53M
Total Liabilities53.46M57.51M293.90M266.87M
Stockholders Equity239.63M312.46M-225.72M-192.29M
Cash Flow
Free Cash Flow-148.50M-119.81M-30.55M-67.85M
Operating Cash Flow-148.41M-119.67M-30.53M-65.65M
Investing Cash Flow-229.06M-30.55M-17.00K-2.20M
Financing Cash Flow237.65M412.96M20.12M59.39M

Zenas BioPharma, Inc. Technical Analysis

Technical Analysis Sentiment
Positive
Last Price20.95
Price Trends
50DMA
17.85
Positive
100DMA
14.33
Positive
200DMA
11.35
Positive
Market Momentum
MACD
1.00
Negative
RSI
56.81
Neutral
STOCH
79.51
Neutral
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For ZBIO, the sentiment is Positive. The current price of 20.95 is above the 20-day moving average (MA) of 20.22, above the 50-day MA of 17.85, and above the 200-day MA of 11.35, indicating a bullish trend. The MACD of 1.00 indicates Negative momentum. The RSI at 56.81 is Neutral, neither overbought nor oversold. The STOCH value of 79.51 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Positive sentiment for ZBIO.

Zenas BioPharma, Inc. Risk Analysis

Zenas BioPharma, Inc. disclosed 78 risk factors in its most recent earnings report. Zenas BioPharma, Inc. reported the most risks in the "Tech & Innovation" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks

Zenas BioPharma, Inc. Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
60
Neutral
$871.90M-2.50131.84%1049.81%7.85%
55
Neutral
$1.03B-12.85-35.96%30.95%-78.41%
54
Neutral
$824.20M-5.15165.96%10.85%-1.41%
53
Neutral
$856.35M-9.4426.68%
51
Neutral
$860.73M-15.71-71.81%53.23%35.32%
48
Neutral
$931.48M-88.40%
51
Neutral
$7.86B-0.30-43.30%2.27%22.53%-2.21%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
ZBIO
Zenas BioPharma, Inc.
20.95
2.14
11.38%
ABUS
Arbutus Biopharma
4.49
0.65
16.93%
RZLT
Rezolute
9.10
4.17
84.58%
URGN
Urogen Pharma
17.40
4.70
37.01%
PHAT
Phathom Pharmaceuticals
12.21
-5.04
-29.22%
VALN
Valneva
11.39
5.58
96.04%

Zenas BioPharma, Inc. Corporate Events

Private Placements and Financing
Zenas BioPharma Secures $300M Funding for Obexelimab
Positive
Sep 2, 2025

On September 2, 2025, Zenas BioPharma entered into a $300 million funding agreement with Royalty Pharma, granting them rights to revenue streams from the sales of obexelimab. This deal provides Zenas with financial support to advance obexelimab’s development and potential commercial launch, particularly for treating IgG4-Related Disease, and underscores the drug’s potential as a significant player in the autoimmune disease market.

Executive/Board ChangesShareholder Meetings
Zenas BioPharma Announces Board Changes at Annual Meeting
Neutral
Jun 12, 2025

On June 10, 2025, Zenas BioPharma, Inc. held its 2025 Annual Meeting of Stockholders. During this meeting, Ting (Tim) Xiao resigned from the Board of Directors, reducing the board size from nine to eight. Stockholders elected Leon O. Moulder, Jr. and Hongbo Lu, Ph.D. as Class I directors for a three-year term and ratified Ernst & Young LLP as the independent registered public accounting firm for the fiscal year ending December 31, 2025.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Oct 01, 2025