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Viridian Therapeutics, Inc. (VRDN)
:VRDN

Viridian Therapeutics (VRDN) AI Stock Analysis

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Viridian Therapeutics

(NASDAQ:VRDN)

Rating:55Neutral
Price Target:
$15.50
▲(1.77%Upside)
Viridian Therapeutics faces financial challenges with declining revenues and negative profitability, significantly impacting its overall score. However, positive corporate events, including successful trial results and strategic board appointments, provide a potential path for future growth. Technical indicators suggest moderate bullish momentum, but valuation concerns persist due to ongoing losses.
Positive Factors
Market Positioning
Veligrotug offers enhanced convenience with fewer infusions and less time per infusion, compared to alternatives, which could improve patient adherence.
Product Efficacy
Veligrotug's efficacy includes rapid onset and favorable safety with lower rates of hearing impairment, which is likely to drive uptake in thyroid eye disease treatment.
Negative Factors
Financial Stability
Viridian is not yet profitable and will likely require additional funding for development and commercialization.
Regulatory Approval
Key risks include the need for regulatory approval and competition against larger organizations like Horizon.

Viridian Therapeutics (VRDN) vs. SPDR S&P 500 ETF (SPY)

Viridian Therapeutics Business Overview & Revenue Model

Company DescriptionViridian Therapeutics, Inc., a biotechnology company, develops treatments for patients suffering from serious diseases. It develops VRDN-001, a humanized monoclonal anti-IGF-1R antibody that is in Phase 1/2 clinical trial for the treatment of thyroid eye disease (TED); VRDN-002, an IGF-1R antibody, which is in Phase 1 clinical trial; and VRDN-003, a therapeutic antibody targeting IGF-1R for the treatment of TED. The company was formerly known as Miragen Therapeutics, Inc. and changed its name to Viridian Therapeutics, Inc. in January 2021. Viridian Therapeutics, Inc. was founded in 2006 and is headquartered in Waltham, Massachusetts.
How the Company Makes MoneyViridian Therapeutics makes money primarily through the development and commercialization of its proprietary therapeutics. The company generates revenue through partnerships, collaborations, and licensing agreements with other pharmaceutical companies. These partnerships often involve upfront payments, milestone payments based on development progress, and royalties on sales of successfully developed products. Viridian's focus on rare disease therapeutics also allows it to benefit from orphan drug designations, which can provide market exclusivity and potential tax incentives. Additionally, the company may receive funding from grants and research collaborations that support its innovative pipeline.

Viridian Therapeutics Earnings Call Summary

Earnings Call Date:May 06, 2025
(Q1-2024)
|
% Change Since: 16.08%|
Next Earnings Date:Aug 06, 2025
Earnings Call Sentiment Positive
The earnings call reflects significant progress and positive developments in the company's pipeline, particularly with the completion of enrollment in the THRIVE trial, a strong financial position, and positive regulatory interactions. However, there are challenges, such as the extended timeline for BLA submission and concerns about hearing impairment assessments in clinical trials.
Q1-2024 Updates
Positive Updates
Completion of THRIVE Phase III Enrollment
The THRIVE Phase III trial evaluating 001 in patients with active TED completed enrollment ahead of schedule with 113 patients, exceeding the target of 90 due to strong patient demand.
Strong Financial Position
Viridian ended the quarter with $613 million in cash, cash equivalents, and short-term investments, maintaining a cash runway into the second half of 2026.
Positive FDA Meeting for Subcutaneous 003 Program
The company completed a positive Type C meeting with the FDA for the subcutaneous 003 program and is on track to initiate pivotal clinical trials midyear.
Progress in FcRn Portfolio
Viridian is making progress with its FcRn portfolio, aiming to file an IND for 006 by the end of the year, and plans to share 008 nonhuman primate data in the second half of 2024.
Negative Updates
Extended Timeline for BLA Submission
The BLA submission for the 001 program is anticipated in the second half of 2025, driven primarily by the extended follow-up period in the THRIVE 2 trial.
Challenges in Hearing Impairment Assessment
There are concerns about controlling for hearing impairment events in the THRIVE study due to factors already present in TED patients.
Company Guidance
During Viridian Therapeutics' Q1 2024 earnings call, the company provided several updates on their pipeline and financial outlook. Viridian announced the completion of enrollment for their THRIVE Phase III trial for the 001 IV program, surpassing the target with 113 patients. They anticipate top-line results in September 2024 and plan a BLA submission for the 001 program in the second half of 2025. The company also highlighted progress in their FcRn portfolio, with an IND for 006 expected by the end of 2024 and 008 nonhuman primate data anticipated in the second half of 2024. Viridian ended the quarter with $613 million in cash, cash equivalents, and short-term investments, maintaining a cash runway into the second half of 2026.

Viridian Therapeutics Financial Statement Overview

Summary
Viridian Therapeutics faces significant financial challenges with declining revenues and persistent losses. The balance sheet shows moderate leverage and a strong equity ratio, but negative cash flow trends and profitability issues pose financial risks.
Income Statement
25
Negative
Viridian Therapeutics exhibits declining revenue with negative gross and net profit margins, indicative of significant operational challenges. The company has consistently reported negative EBIT and EBITDA margins, reflecting ongoing losses and high operating costs relative to revenue. Revenue growth is negative, suggesting the company is struggling to increase its top line.
Balance Sheet
45
Neutral
The balance sheet shows moderate leverage with a manageable debt-to-equity ratio. The equity ratio is strong, indicating a solid capital structure. However, the company reports negative return on equity due to persistent losses. The asset base is largely supported by equity, providing some financial stability despite ongoing losses.
Cash Flow
30
Negative
Operating and free cash flows are consistently negative, highlighting cash burn issues. The company's free cash flow growth rate is negative, indicating deteriorating cash flow performance. However, the company has managed to maintain liquidity through financing activities. The operating cash flow to net income ratio is unfavorable, illustrating cash flow challenges.
BreakdownTTMDec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income Statement
Total Revenue302.00K302.00K314.00K1.77M2.96M1.05M
Gross Profit-5.61M-938.00K-1.01M1.02M2.34M-27.25M
EBITDA-304.36M-265.66M-234.56M-128.63M-78.79M-109.67M
Net Income-308.32M-269.95M-237.73M-125.44M-79.42M-110.98M
Balance Sheet
Total Assets660.98M742.40M490.42M435.09M203.71M131.25M
Cash, Cash Equivalents and Short-Term Investments636.63M717.58M477.37M424.55M196.97M127.64M
Total Debt21.22M21.09M21.05M5.26M520.00K455.00K
Total Liabilities56.51M70.76M48.40M40.03M15.99M11.22M
Stockholders Equity604.47M671.64M442.02M395.06M187.72M120.04M
Cash Flow
Free Cash Flow-280.35M-232.83M-185.07M-94.64M-54.92M-29.82M
Operating Cash Flow-279.75M-232.32M-184.17M-93.84M-54.58M-29.78M
Investing Cash Flow14.46M-228.65M-94.25M-115.13M-74.29M-50.48M
Financing Cash Flow289.87M457.74M225.67M322.24M125.28M101.31M

Viridian Therapeutics Technical Analysis

Technical Analysis Sentiment
Positive
Last Price15.23
Price Trends
50DMA
13.96
Positive
100DMA
14.40
Positive
200DMA
17.74
Negative
Market Momentum
MACD
0.16
Positive
RSI
58.07
Neutral
STOCH
41.47
Neutral
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For VRDN, the sentiment is Positive. The current price of 15.23 is above the 20-day moving average (MA) of 14.91, above the 50-day MA of 13.96, and below the 200-day MA of 17.74, indicating a neutral trend. The MACD of 0.16 indicates Positive momentum. The RSI at 58.07 is Neutral, neither overbought nor oversold. The STOCH value of 41.47 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Positive sentiment for VRDN.

Viridian Therapeutics Risk Analysis

Viridian Therapeutics disclosed 67 risk factors in its most recent earnings report. Viridian Therapeutics reported the most risks in the "Tech & Innovation" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks

Viridian Therapeutics Peers Comparison

Overall Rating
UnderperformOutperform
Sector (46)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
69
Neutral
$1.01B27.1211.23%29.20%
55
Neutral
$1.18B-49.41%4.86%10.13%
WVWVE
50
Neutral
$1.01B-105.50%-7.06%-57.17%
48
Neutral
$758.94M-93.70%-25.83%
48
Neutral
$581.05M-51.85%11070.12%32.07%
46
Neutral
C$192.85M-4.28-8.56%2.83%13.52%-1.74%
45
Neutral
$878.95M-45.35%22264.23%39.09%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
VRDN
Viridian Therapeutics
15.23
2.91
23.62%
GERN
Geron
1.40
-3.13
-69.09%
IOVA
Iovance Biotherapeutics
1.75
-5.53
-75.96%
AUPH
Aurinia Pharmaceuticals
7.49
1.88
33.51%
WVE
Wave Life Sciences
6.75
1.28
23.40%
SNDX
Syndax Pharmaceuticals
9.00
-11.93
-57.00%

Viridian Therapeutics Corporate Events

Executive/Board ChangesShareholder Meetings
Viridian Therapeutics Stockholders Approve Key Proposals
Neutral
Jun 24, 2025

At the Annual Meeting, Viridian Therapeutics‘ stockholders approved several key proposals, including an amendment to the 2016 Equity Incentive Plan, increasing available shares by 8,000,000. Additionally, all director nominees were elected, and KPMG LLP was ratified as the independent auditor for the fiscal year ending December 31, 2025. The approval of the 2025 Employee Stock Purchase Plan was also confirmed.

The most recent analyst rating on (VRDN) stock is a Buy with a $45.00 price target. To see the full list of analyst forecasts on Viridian Therapeutics stock, see the VRDN Stock Forecast page.

Product-Related AnnouncementsBusiness Operations and Strategy
Viridian Reports Positive Phase 3 Trial Results
Positive
May 20, 2025

On May 20, 2025, Viridian Therapeutics announced positive long-term durability data from its THRIVE phase 3 clinical trial for veligrotug, an anti-IGF-1R antibody for thyroid eye disease (TED). The trial showed that 70% of patients maintained their response at week 52, with no changes in safety profile. Veligrotug has received Breakthrough Therapy Designation, and the company plans a Biologics License Application submission in the second half of 2025, with a commercial launch anticipated in 2026.

The most recent analyst rating on (VRDN) stock is a Buy with a $45.00 price target. To see the full list of analyst forecasts on Viridian Therapeutics stock, see the VRDN Stock Forecast page.

Executive/Board ChangesBusiness Operations and Strategy
Viridian Therapeutics Appoints Jeff Ajer to Board
Positive
Apr 7, 2025

On April 7, 2025, Viridian Therapeutics announced the appointment of Jeff Ajer to its Board of Directors. Mr. Ajer brings over 25 years of experience in commercialization for rare diseases, having previously served as Chief Commercial Officer at BioMarin Pharmaceutical. His expertise is expected to bolster Viridian’s commercial strategy as the company advances its pipeline, including veligrotug for thyroid eye disease. Additionally, Viridian announced inducement grants of stock options to new employees, aligning with its growth and recruitment strategies.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Jul 03, 2025