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10x Genomics Inc (TXG)
NASDAQ:TXG
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10x Genomics (TXG) AI Stock Analysis

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TXG

10x Genomics

(NASDAQ:TXG)

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Neutral 60 (OpenAI - 4o)
Rating:60Neutral
Price Target:
$18.00
▼(-1.85% Downside)
10x Genomics' stock score is primarily driven by strong technical momentum, despite weak financial performance and valuation metrics. The company's effective cash management and strong gross margins are positive, but ongoing profitability challenges and a negative P/E ratio weigh heavily. The earnings call highlights mixed results, with some growth in consumables but overall revenue declines.
Positive Factors
Strong Cash Position
A robust cash position enhances financial flexibility, allowing the company to invest in growth opportunities and weather economic uncertainties.
Product Innovation
Continuous product innovation strengthens competitive positioning and can drive future revenue growth by meeting evolving customer needs.
Partnership with Anthropic
Strategic partnerships can enhance product offerings and market reach, potentially leading to increased adoption and customer satisfaction.
Negative Factors
Decline in Overall Revenue
A decline in overall revenue indicates potential challenges in maintaining market share and pricing power, affecting long-term growth prospects.
Challenges in U.S. Market
Challenges in key markets like the U.S. can hinder revenue growth and reflect broader issues in customer demand and funding availability.
Decline in Instrument Revenue
Significant declines in instrument revenue suggest potential issues with product demand or market saturation, impacting future sales growth.

10x Genomics (TXG) vs. SPDR S&P 500 ETF (SPY)

10x Genomics Business Overview & Revenue Model

Company Description10x Genomics (TXG) is a biotechnology company that specializes in genomic sequencing and analysis technologies. Founded in 2012 and headquartered in Pleasanton, California, the company operates primarily in the life sciences sector, providing advanced solutions for single-cell analysis, spatial genomics, and immune profiling. 10x Genomics' core products include their Chromium platform and associated reagents, which enable researchers to conduct high-throughput genomic studies across various applications, including cancer research, immunology, and drug discovery.
How the Company Makes Money10x Genomics generates revenue primarily through the sale of its genomic analysis systems, consumables, and software. The company offers a range of products, including the Chromium Controller, Chromium Chips, and associated reagents, which represent a significant portion of its revenue. Additionally, 10x Genomics provides software tools and cloud-based solutions that facilitate data analysis and interpretation for researchers. The company benefits from ongoing partnerships with academic institutions, research organizations, and pharmaceutical companies, which often lead to bulk purchases of its products for large-scale genomic studies. Furthermore, the expanding applications of its technology in areas such as personalized medicine and drug development contribute to its growing customer base and revenue potential.

10x Genomics Key Performance Indicators (KPIs)

Any
Any
Revenue by Geography
Revenue by Geography
Breaks down revenue across different regions, revealing where 10x Genomics is strongest and where it may face risk or growth potential due to local economic conditions or market share shifts.
Chart Insights10x Genomics is experiencing mixed geographic performance. The Americas and APAC regions saw revenue declines in Q4 2024, with the Americas down 16% and APAC down 5%, reflecting broader market challenges and NIH funding uncertainties. In contrast, EMEA and China showed resilience, with EMEA maintaining steady growth. Despite these regional disparities, the company is optimistic about 2025, focusing on product innovation and expanding biopharma revenue. However, potential NIH funding cuts remain a significant risk, potentially impacting revenue by up to $15 million.
Data provided by:Main Street Data

10x Genomics Earnings Call Summary

Earnings Call Date:Nov 06, 2025
(Q3-2025)
|
% Change Since: |
Next Earnings Date:Feb 18, 2026
Earnings Call Sentiment Neutral
The earnings call presented a mixed picture, with strong performance in spatial consumables and successful new product launches offset by declines in overall revenue and instrument sales. Ongoing macroeconomic challenges and funding uncertainties continue to pose challenges.
Q3-2025 Updates
Positive Updates
Exceeded Revenue Guidance
10X Genomics reported total revenue of $149 million for the third quarter, exceeding the top end of their guidance range.
Strong Performance of Spatial Consumables
Spatial consumables revenue grew by 19% year-over-year, driven by strong demand for Xenium consumables.
Launch of Next-Generation Chromium Flex
10X Genomics began shipping the next generation of Chromium Flex, which offers improved sensitivity, robustness, scalability, and cost-effectiveness.
Partnership with Anthropic for Data Analysis
The partnership with Anthropic aims to address the data analysis bottleneck by integrating with Claude for Life Sciences, making data analysis more accessible.
Successful Balance Sheet Management
The company ended the quarter with $482 million in cash, cash equivalents, and marketable securities, up $35 million from the prior quarter.
Negative Updates
Decline in Overall Revenue
Total revenue decreased by 2% year-over-year, primarily due to lower average selling prices for consumables and instruments.
Challenges in U.S. Market
Americas revenue was down 9% year-over-year, driven by continued uncertainty in the U.S. academic and government funding environment.
Decline in Instrument Revenue
Total instrument revenue was down 37%, with Chromium instrument revenue down 36% and spatial instrument revenue down 38%.
Single-Cell Consumable Revenue Decline
Chromium consumables revenue was down 4% year-over-year, primarily driven by lower average selling prices despite double-digit reaction growth.
Macro Challenges and Uncertainty
Ongoing macroeconomic challenges and policy uncertainties are affecting customer spending behavior, particularly for capital expenditures.
Company Guidance
During the third quarter of 2025, 10X Genomics exceeded the top end of its guidance range, achieving a total revenue of $149 million despite facing ongoing macroeconomic challenges. Spatial consumables experienced robust double-digit year-over-year revenue growth, driven by strong demand for Xenium consumables, which saw increased usage in both the number of runs and average spend per run. In contrast, single-cell consumable revenue declined year-over-year, although there was a double-digit growth in Chromium consumables reactions. The company ended the quarter with $482 million on the balance sheet, reflecting a commitment to cost management and cash generation. Looking forward, 10X Genomics anticipates fourth-quarter revenue in the range of $154 million to $158 million, with no significant change expected in customer purchasing behavior and ongoing cautious spending patterns, especially concerning capital expenditures.

10x Genomics Financial Statement Overview

Summary
10x Genomics demonstrates strong gross margins and effective cash management, but faces challenges with profitability and revenue growth. The balance sheet is stable with low leverage, yet the company struggles to generate positive returns on equity. Continued focus on improving operational efficiency and revenue growth is essential for future financial health.
Income Statement
45
Neutral
10x Genomics has shown a decline in revenue growth with a negative growth rate of -41.2% in the TTM period. The company maintains a relatively high gross profit margin of 68.8%, indicating strong cost management. However, the net profit margin is negative at -11.9%, reflecting ongoing losses. The EBIT and EBITDA margins are also negative, suggesting challenges in achieving operational profitability.
Balance Sheet
55
Neutral
The company maintains a low debt-to-equity ratio of 0.11, indicating conservative leverage. However, the return on equity is negative at -10.3%, reflecting challenges in generating returns for shareholders. The equity ratio is not explicitly calculated, but the balance sheet shows a strong equity base relative to total assets.
Cash Flow
60
Neutral
10x Genomics has improved its free cash flow, with a growth rate of 43.56% in the TTM period. The operating cash flow to net income ratio is 0.60, indicating some ability to convert earnings into cash. The free cash flow to net income ratio is high at 0.92, suggesting effective cash management despite net losses.
BreakdownTTMDec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income Statement
Total Revenue641.81M610.78M618.73M516.41M490.49M298.85M
Gross Profit441.79M414.48M409.31M396.02M416.40M240.38M
EBITDA-30.81M-133.99M-205.11M-128.49M-24.59M-513.77M
Net Income-76.32M-182.63M-255.10M-166.00M-58.22M-542.73M
Balance Sheet
Total Assets1.03B918.64M965.14M1.03B1.02B929.34M
Cash, Cash Equivalents and Short-Term Investments482.08M393.40M388.69M429.98M587.45M663.60M
Total Debt86.98M82.61M95.37M95.18M81.98M62.98M
Total Liabilities241.03M208.50M224.10M223.24M201.26M190.27M
Stockholders Equity785.12M710.13M741.04M805.74M817.57M739.07M
Cash Flow
Free Cash Flow81.65M-5.73M-64.72M-165.27M-122.65M-256.29M
Operating Cash Flow88.53M6.66M-15.20M-33.61M-21.37M-217.90M
Investing Cash Flow-63.23M-32.63M133.49M-350.89M-106.73M-38.39M
Financing Cash Flow9.08M10.91M13.67M15.82M35.30M468.91M

10x Genomics Technical Analysis

Technical Analysis Sentiment
Positive
Last Price18.34
Price Trends
50DMA
13.41
Positive
100DMA
13.30
Positive
200DMA
11.56
Positive
Market Momentum
MACD
1.06
Negative
RSI
72.07
Negative
STOCH
64.74
Neutral
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For TXG, the sentiment is Positive. The current price of 18.34 is above the 20-day moving average (MA) of 14.95, above the 50-day MA of 13.41, and above the 200-day MA of 11.56, indicating a bullish trend. The MACD of 1.06 indicates Negative momentum. The RSI at 72.07 is Negative, neither overbought nor oversold. The STOCH value of 64.74 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Positive sentiment for TXG.

10x Genomics Risk Analysis

10x Genomics disclosed 71 risk factors in its most recent earnings report. 10x Genomics reported the most risks in the "Tech & Innovation" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks

10x Genomics Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
69
Neutral
$1.62B84.431.62%10.67%
64
Neutral
$3.59B50.67%-578.00%
61
Neutral
$4.24B2,430.350.84%50.50%
60
Neutral
$2.32B-10.12%1.92%59.18%
51
Neutral
$7.86B-0.30-43.30%2.27%22.53%-2.21%
48
Neutral
$316.27M-4.26-86.09%13.66%-2.65%
44
Neutral
$1.21B-45.67%32.90%1.85%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
TXG
10x Genomics
18.34
3.04
19.87%
OMCL
Omnicell
36.00
-9.96
-21.67%
SDGR
Schrodinger
16.47
-5.83
-26.14%
WGS
GeneDx Holdings
146.55
66.09
82.14%
SOPH
SOPHiA GENETICS
4.54
1.39
44.13%
HNGE
Hinge Health, Inc. Class A
45.99
5.83
14.52%

10x Genomics Corporate Events

10X Genomics Earnings Call: Mixed Results Amid Challenges
Nov 8, 2025

The recent earnings call from 10X Genomics painted a mixed picture for investors and stakeholders. While the company showcased strong performance in spatial consumables and successful new product launches, these positives were somewhat overshadowed by declines in overall revenue and instrument sales. The ongoing macroeconomic challenges and funding uncertainties continue to pose significant hurdles for the company’s growth trajectory.

10x Genomics Reports Q3 2025 Financial Results
Nov 7, 2025

10x Genomics is a life science technology company specializing in single cell and spatial biology, providing integrated research solutions to advance human health.

10X Genomics Balances Growth and Challenges in Earnings Call
Aug 13, 2025

The recent earnings call of 10X Genomics painted a picture of cautious optimism. The company reported strong performances in China and spatial consumables, a favorable settlement with Bruker, and strategic acquisitions. However, these positive aspects were tempered by challenges in capital expenditure spending, decreased revenue in key regions, and uncertainties in academic funding. The overall sentiment was balanced, reflecting both positive achievements and significant hurdles.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Nov 22, 2025