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Twist Bioscience Corp (TWST)
NASDAQ:TWST

Twist Bioscience (TWST) AI Stock Analysis

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TWST

Twist Bioscience

(NASDAQ:TWST)

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Neutral 43 (OpenAI - 4o)
Rating:43Neutral
Price Target:
$28.00
▲(7.69% Upside)
Twist Bioscience's overall stock score is primarily impacted by its financial performance and technical analysis. Despite revenue growth and margin improvements, significant profitability and cash flow challenges persist. The technical indicators suggest a bearish trend, and the valuation remains unattractive due to negative earnings. While the earnings call highlighted strong growth and future potential, the immediate financial and technical challenges weigh heavily on the score.

Twist Bioscience (TWST) vs. SPDR S&P 500 ETF (SPY)

Twist Bioscience Business Overview & Revenue Model

Company DescriptionTwist Bioscience is a biotechnology company that specializes in synthetic DNA production and gene synthesis. Founded in 2013 and headquartered in San Francisco, California, the company operates primarily in the life sciences sector and serves various industries including pharmaceuticals, agriculture, and industrial biotechnology. Twist Bioscience's core products include synthetic genes, gene fragments, and other DNA-based products, which are utilized in research, development, and manufacturing processes.
How the Company Makes MoneyTwist Bioscience generates revenue primarily through the sale of synthetic DNA products, which are utilized by customers in genetic research, drug development, and various industrial applications. The company's revenue model is based on a combination of direct product sales, service contracts, and partnerships with pharmaceutical and biotechnology companies. Key revenue streams include sales of custom gene synthesis, oligonucleotides, and other DNA-related products. Additionally, Twist has formed strategic collaborations with leading organizations in the life sciences sector to expand its market reach and enhance its product offerings, which further contributes to its earnings. The company's innovative approach and scalable technology platform enable it to meet the growing demand for synthetic biology solutions, positioning it for continued growth in the biotechnology market.

Twist Bioscience Earnings Call Summary

Earnings Call Date:Nov 14, 2025
(Q4-2025)
|
% Change Since: |
Next Earnings Date:Jan 30, 2026
Earnings Call Sentiment Positive
Twist Bioscience reported strong financial performance with record revenue and significant margin improvement, driven by growth in SynBio, Biopharma, and NGS segments. However, the transition of a major customer and moderate growth guidance for fiscal 2026 presents challenges. The company is optimistic about future growth driven by AI-enabled discovery and new product introductions.
Q4-2025 Updates
Positive Updates
Record Revenue Achievement
Twist Bioscience reported a record quarter with $99 million in revenue, exceeding guidance and marking a 17% year-over-year increase. For the fiscal year, revenue was $376.6 million, a growth of 20% over fiscal 2024.
Significant Gross Margin Improvement
Gross margin for the quarter was 51.3%, and for the year, it was 50.7%, up from 42.6% in fiscal 2024, marked by a nearly 20 margin points increase over the last two years.
Strong SynBio and Biopharma Growth
SynBio revenue was $39.5 million, up 17% year-over-year, driven by the Express portfolio. Biopharma revenue grew by 22% year-over-year to $6.4 million.
NGS Revenue Growth
NGS reported revenues of $53 million, representing a 16% year-over-year growth, driven by successful diagnostic customer assays.
AI-Enabled Discovery Growth
AI-enabled drug discovery projects grew more than $25 million versus fiscal 2024, highlighting significant growth potential in AI-driven drug discovery.
Negative Updates
Customer Transition Impact on NGS
A large cancer diagnostics customer is transitioning their assay from research to commercial, impacting Q4 and Q1 NGS revenue, with expected reacceleration in Q2 of fiscal 2026.
Moderate Revenue Growth Guidance
Guidance for fiscal 2026 indicates a revenue growth of 13% to 15.5%, which is slower compared to the previous year's growth rate.
Limited Contribution from MRD in Fiscal 2026
Only 1 to 2 points of overall growth for MRD products are assumed in fiscal 2026, with significant ramp expected later.
Company Guidance
During the Twist Bioscience's 2025 Fourth Quarter Financial Results Conference Call, the company reported a record quarterly revenue of $99 million, marking a 17% year-over-year increase and surpassing their guidance. For the entire fiscal year 2025, Twist Bioscience achieved $376.6 million in revenue, reflecting a 20% growth compared to fiscal 2024. The company's gross margin for the quarter was 51.3%, and for the year, it stood at 50.7%, up from 42.6% in the previous fiscal year. The SynBio segment reported $39.5 million in revenue, also a 17% year-over-year increase, while NGS revenue grew by 16% to $53 million. The Biopharma Services segment saw a 22% year-over-year revenue increase to $6.4 million. The company anticipates an adjusted EBITDA breakeven by the end of fiscal 2026, driven by robust growth from AI-enabled drug discovery projects, which contributed over $25 million more in orders compared to fiscal 2024. Looking ahead to fiscal 2026, Twist Bioscience projects total revenues between $425 million and $435 million, representing 13% to 15.5% growth, with a gross margin expected to exceed 52%.

Twist Bioscience Financial Statement Overview

Summary
Income Statement
45
Neutral
Balance Sheet
55
Neutral
Cash Flow
40
Negative
Breakdown
Income Statement
Total Revenue
Gross Profit
EBITDA
Net Income
Balance Sheet
Total Assets
Cash, Cash Equivalents and Short-Term Investments
Total Debt
Total Liabilities
Stockholders Equity
Cash Flow
Free Cash Flow
Operating Cash Flow
Investing Cash Flow
Financing Cash Flow

Twist Bioscience Technical Analysis

Technical Analysis Sentiment
Positive
Last Price26.00
Price Trends
50DMA
30.92
Positive
100DMA
29.42
Positive
200DMA
32.79
Negative
Market Momentum
MACD
0.45
Negative
RSI
55.18
Neutral
STOCH
43.04
Neutral
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For TWST, the sentiment is Positive. The current price of 26 is below the 20-day moving average (MA) of 30.70, below the 50-day MA of 30.92, and below the 200-day MA of 32.79, indicating a neutral trend. The MACD of 0.45 indicates Negative momentum. The RSI at 55.18 is Neutral, neither overbought nor oversold. The STOCH value of 43.04 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Positive sentiment for TWST.

Twist Bioscience Peers Comparison

Overall Rating
UnderperformOutperform
Sector (―)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
77
Outperform
$1.00B16.0924.11%14.46%
70
Outperform
$3.35B-7.61-16.83%20.53%82.91%
57
Neutral
$850.09M-20.02-3.80%13.60%74.64%
55
Neutral
$1.50B-13.16-12.99%10.10%-44.29%
49
Neutral
$647.84M-1.55-72.52%0.21%-233.51%
43
Neutral
$1.96B-24.38-16.43%20.32%63.81%
* Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
TWST
Twist Bioscience
31.92
-16.02
-33.42%
MYGN
Myriad Genetics
6.70
-6.66
-49.85%
NEO
NeoGenomics
11.68
-4.73
-28.82%
CDNA
CareDx
19.19
-1.42
-6.89%
FLGT
Fulgent Genetics
28.06
9.72
53.00%
GRAL
GRAIL Inc
88.32
69.97
381.28%

Twist Bioscience Corporate Events

Twist Bioscience Faces Scaling Challenges: Potential Impact on Future Demand and Financial Health
Nov 18, 2025

Twist Bioscience faces a significant risk in its ability to scale manufacturing capacity to meet future demand, which could adversely impact its business operations. Although the current capacity meets existing demand, the unpredictability of future demand poses a challenge, potentially leading to excess inventory and financial losses. The complexity of their technology and production processes may result in unforeseen difficulties, diverting resources from other product offerings. Failure to expand manufacturing capacity efficiently could materially harm their business, financial condition, and operational results.

Twist Bioscience Reports Record Revenue and Growth
Nov 16, 2025

Twist Bioscience’s recent earnings call conveyed a positive sentiment, highlighting strong financial performance with record revenues and significant margin improvements. The company’s growth in SynBio, Biopharma, and NGS segments contributed to this success. Despite challenges such as the transition of a major customer and moderate growth guidance for fiscal 2026, Twist Bioscience remains optimistic about future growth driven by AI-enabled discovery and new product introductions.

Twist Bioscience Achieves Record Revenue in Fiscal 2025
Nov 15, 2025

Twist Bioscience Corporation, a mid-cap biotech company, specializes in synthetic DNA tools for various sectors including medicine and agriculture, leveraging its innovative silicon-based DNA synthesis platform. The company reported a record revenue of $376.6 million for fiscal 2025, marking a 20% increase from the previous year, with significant growth across its SynBio, NGS, and Biopharma segments. The fourth quarter alone saw a 17% revenue increase to $99 million, continuing its streak of sequential growth. Key financial metrics include an improved gross margin of 50.7% for the year and a reduced net loss of $77.7 million, down from $208.7 million in fiscal 2024. The company also made strategic advancements, including launching new products and expanding its customer base. Looking ahead, Twist Bioscience anticipates continued growth with projected revenues between $425 million and $435 million for fiscal 2026, while maintaining a gross margin above 52% and achieving adjusted EBITDA breakeven by the fourth quarter.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Nov 25, 2025