Spero Therapeutics (SPRO)
NASDAQ:SPRO
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Spero Therapeutics
(NASDAQ:SPRO)
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Rating:53Neutral
Price Target:
$3.00
▲(15.83% Upside)
Action:ReiteratedDate:03/27/26
The score is held back primarily by inconsistent earnings and ongoing negative operating/free cash flow despite a low-debt balance sheet. Technical indicators are broadly neutral with a slight positive tilt, valuation is only moderately supportive (P/E ~15) without dividend support, and corporate events provide a modest boost due to the removal of SEC-related overhang.
Positive Factors
Low leverage / strong balance sheet
Very low leverage and modest total debt reduce financial risk and preserve strategic optionality. With meaningful equity ($59.0M in 2025) the company can fund R&D or tolerate clinical setbacks longer, improving resilience and lowering the urgency of dilutive financing in the medium term.
Negative Factors
Persistent negative operating and free cash flow
Consistent operating and free cash flow deficits indicate the business is not self-funding and will need external capital to sustain development. This persistent cash burn elevates refinancing and dilution risk, constrains discretionary investment, and reduces the margin for error on clinical programs over the medium term.
Read all positive and negative factors
Positive Factors
Negative Factors
Low leverage / strong balance sheet
Very low leverage and modest total debt reduce financial risk and preserve strategic optionality. With meaningful equity ($59.0M in 2025) the company can fund R&D or tolerate clinical setbacks longer, improving resilience and lowering the urgency of dilutive financing in the medium term.
Read all positive factors
Spero Therapeutics (SPRO) vs. SPDR S&P 500 ETF (SPY)
Market Cap
$157.46M
Dividend YieldN/A
Average Volume (3M)320.86K
Price to Earnings (P/E)15.2
Beta (1Y)1.69
Revenue Growth-67.38%
EPS Growth-1076.54%
CountryUS
Employees32
SectorHealthcare
Sector Strength45
IndustryBiotechnology
Share Statistics
EPS (TTM)0.53
Shares Outstanding57,891,495
10 Day Avg. Volume375,043
30 Day Avg. Volume320,859
Financial Highlights & Ratios
PEG Ratio-0.14
Price to Book (P/B)2.21
Price to Sales (P/S)2.19
P/FCF Ratio-10.34
Enterprise Value/Market Cap0.76
Enterprise Value/Revenue1.99
Enterprise Value/Gross Profit2.57
Enterprise Value/Ebitda21.97
Forecast
1Y Price TargetN/A
Price Target UpsideN/A
Rating ConsensusN/A
Number of Analyst Covering0
EPS Forecast (FY)0.67
Revenue Forecast (FY)$800.00K
Spero Therapeutics Business Overview & Revenue Model
Company Description
Spero Therapeutics, Inc., a clinical-stage biopharmaceutical company, focuses on identifying, developing, and commercializing treatments for multi-drug resistant (MDR) bacterial infections and rare diseases in the United States. The company's prod...
How the Company Makes Money
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Spero Therapeutics Earnings Call Summary
Earnings Call Date:Aug 12, 2025
(Q2-2025)
| % Change Since: |
Next Earnings Date:May 19, 2026
Earnings Call Sentiment Positive
The earnings call reflected a positive outlook with significant achievements, particularly the successful Phase III trial for Tebipenem HBr and the improved financial metrics. However, challenges remain in the SPR720 program. Overall, the positive developments notably outweigh the negative aspects.Positive Updates
Successful Phase III PIVOT-PO Trial for Tebipenem HBr
The Phase III PIVOT-PO trial evaluating Tebipenem HBr for complicated urinary tract infections met its primary endpoint and was stopped early for efficacy, demonstrating non-inferiority to intravenous imipenem-cilastatin.
Negative Updates
SPR720 Trial Challenges
The Phase IIa proof-of-concept study for SPR720 did not meet its primary endpoint, and there were potential dose-limiting safety signals, including reversible grade 3 hepatotoxicity in the high-dose cohort.
Read all updates
Q2-2025 Updates
Positive
Negative
Successful Phase III PIVOT-PO Trial for Tebipenem HBr
The Phase III PIVOT-PO trial evaluating Tebipenem HBr for complicated urinary tract infections met its primary endpoint and was stopped early for efficacy, demonstrating non-inferiority to intravenous imipenem-cilastatin.
Read all positive updates
Company Guidance
During Spero Therapeutics' second quarter 2025 earnings call, significant progress was highlighted, particularly in their lead clinical program for Tebipenem HBr targeting complicated urinary tract infections (cUTIs). The Phase III PIVOT-PO trial was stopped early for efficacy, demonstrating Tebipenem HBr's non-inferiority to intravenous imipenem-cilastatin, with primary endpoint achievement noted in a test of cure visit. The trial's early conclusion resulted in cost savings, extending the company's cash runway into 2028. Financially, Spero reported a second-quarter revenue of $14.2 million, up from $10.2 million in the prior year, mainly due to collaboration revenue from GSK. R&D expenses decreased from $23.7 million to $10.7 million year-over-year, while G&A expenses slightly increased to $5.9 million. The net loss narrowed significantly to $1.7 million from $17.9 million in the previous year, with a diluted net loss per share of $0.03 compared to $0.33. Looking ahead, Spero focuses on regulatory approval of Tebipenem HBr, with FDA action anticipated in the second half of 2026, supported by contingent milestone opportunities with GSK, potentially totaling $351 million.Spero Therapeutics Financial Statement Overview
Summary
Income Statement
46
Neutral
Balance Sheet
78
Positive
Cash Flow
24
Negative
| Breakdown | Dec 2025 | Dec 2024 | Dec 2023 | Dec 2022 | Mar 2022 |
|---|---|---|---|---|---|
Income Statement | |||||
| Total Revenue | 59.62M | 47.98M | 103.78M | 48.58M | 3.07M |
| Gross Profit | 59.62M | -48.78M | 52.34M | 48.58M | 3.07M |
| EBITDA | -24.00K | -72.48M | 27.15M | -42.94M | -87.17M |
| Net Income | 8.57M | -68.57M | 22.81M | -46.41M | -89.76M |
Balance Sheet | |||||
| Total Assets | 68.92M | 110.54M | 182.39M | 124.80M | 171.07M |
| Cash, Cash Equivalents and Short-Term Investments | 40.27M | 52.89M | 76.33M | 109.11M | 146.40M |
| Total Debt | 2.90M | 4.30M | 5.54M | 6.65M | 7.33M |
| Total Liabilities | 9.90M | 64.42M | 75.50M | 48.87M | 82.78M |
| Stockholders Equity | 59.02M | 46.12M | 106.89M | 75.93M | 88.29M |
Cash Flow | |||||
| Free Cash Flow | -12.62M | -23.44M | -32.99M | -7.73M | 0.00 |
| Operating Cash Flow | -12.62M | -23.44M | -32.99M | -7.73M | -64.35M |
| Investing Cash Flow | 0.00 | 0.00 | 0.00 | 33.81M | 7.67M |
| Financing Cash Flow | 0.00 | 0.00 | 221.00K | -29.55M | 84.05M |
Spero Therapeutics Technical Analysis
Positive
2.59
Price Trends
2.37
Positive
2.37
Positive
2.32
Positive
Market Momentum
0.06
Negative
67.92
Neutral
96.83
Negative
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For SPRO, the sentiment is Positive. The current price of 2.59 is above the 20-day moving average (MA) of 2.48, above the 50-day MA of 2.37, and above the 200-day MA of 2.32, indicating a bullish trend. The MACD of 0.06 indicates Negative momentum. The RSI at 67.92 is Neutral, neither overbought nor oversold. The STOCH value of 96.83 is Negative, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Positive sentiment for SPRO.
Spero Therapeutics Risk Analysis
Spero Therapeutics disclosed 69 risk factors in its most recent earnings report. Spero Therapeutics reported the most risks in the "Finance & Corporate" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks
Spero Therapeutics Peers Comparison
UnderperformOutperform
Sector (51)
Name | Overall Rating | Market Cap | P/E Ratio | ROE | Dividend Yield | Revenue Growth | EPS Growth |
|---|---|---|---|---|---|---|---|
55 Neutral | $148.65M | -2.83 | ― | ― | ― | ― | |
53 Neutral | $157.46M | 15.23 | 22.53% | ― | -67.38% | -1076.54% | |
52 Neutral | $209.45M | -2.43 | -656.82% | ― | ― | 3.70% | |
51 Neutral | $7.86B | -0.30 | -43.30% | 2.27% | 22.53% | -2.21% | |
50 Neutral | $194.13M | -0.38 | -115.95% | ― | ― | 21.61% | |
50 Neutral | $495.70M | -5.28 | -30.40% | ― | ― | -100.71% | |
44 Neutral | $157.37M | -1.20 | -85.20% | ― | ― | 46.68% |
* Healthcare Sector Average
SPRO
Spero Therapeutics
2.72
2.14
371.40%
MIST
Milestone Pharmaceuticals
1.78
1.03
137.33%
KRRO
Korro Bio
13.46
0.49
3.78%
CNTB
Connect Biopharma Holdings
2.63
1.99
310.94%
TNYA
Tenaya Therapeutics
0.73
0.29
64.77%
CTNM
Contineum Therapeutics, Inc. Class A
12.79
8.66
209.69%
Spero Therapeutics Corporate Events
Executive/Board ChangesRegulatory Filings and Compliance
Spero Therapeutics Co-Founder Resigns From Board Roles
Positive
Jan 30, 2026
On January 30, 2026, Spero Therapeutics announced that co‑founder Ankit Mahadevia, MD resigned from its Board of Directors, its Development Committee, and all officer and director roles at its subsidiaries, citing other professional commitme...
Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
Disclaimer
This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.