SPR720 Clinical Development Progress
Spero Therapeutics is advancing SPR720 as a first-line oral agent for nontuberculous mycobacterial pulmonary disease (NTM-PD). They expect to share comprehensive data from ongoing and completed clinical studies in Q4, including data from a Phase IIa proof of concept study and two supportive Phase I studies.
Tebipenem HBr Phase III Enrollment on Track
Enrollment for the Phase III PIVOT-PO trial for tebipenem HBr, developing as the first potential oral carbapenem antibiotic for cUTI, is on track with completion expected in the second half of 2025.
Strong Financial Position and Revenue Growth
Ended Q2 2024 with $63.5 million in cash and equivalents. Total revenue for Q2 2024 was $10.2 million, a significant increase from $2.7 million in Q2 2023, primarily due to increased collaboration and grant revenue.
Partnerships and Funding
Spero has ongoing partnerships with GSK and Pfizer, and anticipates receiving three remaining tranches of development milestone payments from GSK totaling approximately $24 million every six months.