Skye Bioscience (SKYE)
NASDAQ:SKYE
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Skye Bioscience (SKYE) AI Stock Analysis

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SKYE

Skye Bioscience

(NASDAQ:SKYE)

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Underperform 38 (OpenAI - 4o)
Rating:38Underperform
Price Target:
Skye Bioscience's overall stock score is primarily hindered by significant financial challenges, including zero revenue and continuous losses. Despite strong earnings call highlights and a substantial cash position, the bearish technical analysis and valuation difficulties weigh heavily on the score.
Positive Factors
Strong Financial Position
The reduction in net loss and substantial cash reserves provide Skye Bioscience with a stable financial foundation to support ongoing R&D and clinical trials, crucial for a biotech company in its developmental stage.
Clinical Trial Progress
Successful enrollment and earlier-than-expected data readouts from the CBeyond trial demonstrate Skye's capability to advance its drug pipeline efficiently, enhancing its potential market entry timeline.
Strategic Focus on Nimacimab
Focusing resources on nimacimab, which has shown promising preclinical results, aligns Skye's strategy with its strengths and market opportunities, potentially leading to a more successful product launch.
Negative Factors
Zero Revenue and Consistent Losses
The absence of revenue and ongoing losses highlight the financial risk associated with Skye's operations, emphasizing the need for successful commercialization of its drug candidates to achieve sustainability.
Increased R&D Expenses
Rising R&D costs, while necessary for drug development, strain financial resources and require careful management to ensure long-term viability without immediate revenue offsets.
High Liabilities Relative to Assets
High liabilities compared to assets can limit Skye's financial flexibility, posing a risk to its ability to invest in growth opportunities and manage operational costs effectively.

Skye Bioscience (SKYE) vs. SPDR S&P 500 ETF (SPY)

Skye Bioscience Business Overview & Revenue Model

Company DescriptionSkye Bioscience, Inc., a biopharmaceutical company, discovers, develops, and commercializes cannabinoid-based molecules for the treatment of infectious diseases. The company's lead product candidate is SBI-100, which is in Phase I trials for the treatment of glaucoma and ocular hypertension. It is also developing SBI-200 that is in preclinical trials to treat and manage various eye diseases, including uveitis, dry eye syndrome, macular degeneration and diabetic retinopathy. The company was formerly known as Emerald Bioscience, Inc. and changed its name to Skye Bioscience, Inc. in January 2021. Skye Bioscience, Inc. was founded in 2012 and is headquartered in San Diego, California.
How the Company Makes MoneySkye Bioscience generates revenue through the development and eventual commercialization of its pharmaceutical products, which are primarily aimed at treating ocular diseases. The company's revenue model is built on the successful advancement of its drug candidates through clinical trials, regulatory approvals, and subsequent market entry. Key revenue streams include potential milestone payments and royalties from partnerships with larger pharmaceutical companies, as well as direct sales of approved products. Strategic collaborations and licensing agreements also play a crucial role in funding research and development activities, which are critical to advancing the company's drug pipeline. However, as of the current data, Skye Bioscience may still be in the pre-revenue stage, focusing on research and development efforts to bring its drug candidates to market.

Skye Bioscience Earnings Call Summary

Earnings Call Date:Nov 10, 2025
(Q3-2025)
|
% Change Since: |
Next Earnings Date:Mar 19, 2026
Earnings Call Sentiment Neutral
The earnings call presented a mixed picture with strong financial health and promising Phase 2a study results highlighting the potential of Nimazumab in combination with semaglutide. However, increased R&D expenses, a larger net loss, concerns about monotherapy efficacy, and limited study enrollment were notable challenges.
Q3-2025 Updates
Positive Updates
Strong Financial Position
Skye Bioscience ended the third quarter with cash and cash equivalents totaling $35.3 million, which is expected to fund operations and key clinical milestones into 2027.
Successful Phase 2a Study Results
The Phase 2a CBEYOND study showed synergistic efficacy with Nimazumab plus semaglutide, achieving approximately 3% additional weight loss at 26 weeks with a p-value of 0.0372, nearly a 30% improvement.
Positive Safety Profile
Nimazumab demonstrated a positive safety signal with no neuropsychiatric signals or additive GI burden.
Durability of Weight Loss
In a 12-week post-treatment follow-up, Nimazumab plus semaglutide showed significantly less weight regain (18% vs. 50% in semaglutide alone), with a p-value of 0.006.
Encouraging KOL Feedback
Key opinion leaders have responded positively to the combination data, emphasizing the potential for dosing holidays without significant weight regain.
Negative Updates
Increased R&D Expenses
R&D expenses for Q3 2025 increased to $9.4 million from $4.9 million in Q3 2024, primarily due to contract manufacturing and clinical trial costs.
Net Loss Increase
Net loss for Q3 2025 was $12.8 million compared to $3.9 million in Q3 2024.
Monotherapy Efficacy Concerns
The Phase 2a study indicated that patients were underdosed at 200 mg, and higher doses are needed to achieve expected efficacy in monotherapy.
Limited Patient Enrollment in Extension Study
Concerns were raised about the ability to draw statistically significant insights from the 43 patients enrolled in the 26-week extension study.
Company Guidance
In the Skye Bioscience, Inc. third-quarter 2025 earnings call, the company provided detailed guidance on its financial and clinical development milestones. Key financial highlights included ending the quarter with $35.3 million in cash and equivalents, with expectations to fund operations into 2027. R&D expenses increased to $9.4 million from $4.9 million in the previous year due to ongoing clinical trials, including those for Nolasimab and Nimazumab. Notably, the company reported a net loss of $12.8 million, attributed partly to non-cash share-based compensation expenses. Clinical updates focused on the promising results from the Phase 2a CBEYOND study, showing a 3% additional weight loss with Nimazumab plus semaglutide compared to semaglutide alone, with a significant p-value of 0.0372. The study also demonstrated improvements in lean to fat mass ratio and reduced waist circumference, with retention strong in the extension study. The company is advancing Nimazumab's dose concentration strategy and plans to evaluate higher doses in future studies, keeping scalability and patient convenience in focus.

Skye Bioscience Financial Statement Overview

Summary
Skye Bioscience faces significant financial challenges typical of a biotech firm in its early stages, with zero revenue and consistent losses. Recent financing efforts have improved cash reserves, but the company's long-term success relies on revenue generation and cost management.
Income Statement
10
Very Negative
Skye Bioscience exhibits significant challenges in its income statement, primarily due to consistently zero revenue and substantial net losses over recent years. The lack of revenue growth and negative profit margins highlight the financial stresses typical in the biotechnology industry, especially for companies in the developmental stage.
Balance Sheet
30
Negative
The balance sheet shows a positive trend with significant growth in stockholders' equity in the latest year, driven by substantial financing activities. However, the company still faces high liabilities relative to its assets, as evidenced by the historical negative equity until the most recent year. The low debt level and increasing cash position are positives, providing some financial stability.
Cash Flow
20
Very Negative
Cash flow performance is weak, with consistently negative operating and free cash flows. However, the company has managed to secure substantial financing, which has improved its cash position. The free cash flow remains negative, indicating ongoing operational challenges.
BreakdownTTMDec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income Statement
Total Revenue0.000.000.000.000.000.00
Gross Profit0.000.000.000.000.00-1.87K
EBITDA-50.55M-25.29M-36.62M-18.70M-7.72M-5.85M
Net Income-51.23M-26.57M-37.64M-19.48M-8.52M-6.56M
Balance Sheet
Total Assets41.32M72.76M11.94M9.11M9.86M2.67M
Cash, Cash Equivalents and Short-Term Investments35.31M68.42M1.26M1.24M8.98M2.47M
Total Debt321.85K455.59K4.62M1.98M2.14M1.50M
Total Liabilities8.49M4.61M14.07M12.12M3.99M2.22M
Stockholders Equity32.84M68.15M-2.13M-3.01M5.86M450.79K
Cash Flow
Free Cash Flow-9.22B-26.84M-13.96M-12.77M-6.57M-6.06M
Operating Cash Flow-9.22B-25.24M-13.95M-12.74M-6.47M-6.05M
Investing Cash Flow-12.81B-245.62K6.60M5.21M-90.87K-7.23K
Financing Cash Flow23.78K83.56M16.44M-208.79K13.08M6.70M

Skye Bioscience Technical Analysis

Technical Analysis Sentiment
Negative
Last Price1.30
Price Trends
50DMA
2.53
Negative
100DMA
3.13
Negative
200DMA
2.69
Negative
Market Momentum
MACD
-0.26
Negative
RSI
33.19
Neutral
STOCH
21.67
Neutral
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For SKYE, the sentiment is Negative. The current price of 1.3 is below the 20-day moving average (MA) of 1.48, below the 50-day MA of 2.53, and below the 200-day MA of 2.69, indicating a bearish trend. The MACD of -0.26 indicates Negative momentum. The RSI at 33.19 is Neutral, neither overbought nor oversold. The STOCH value of 21.67 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Negative sentiment for SKYE.

Skye Bioscience Risk Analysis

Skye Bioscience disclosed 51 risk factors in its most recent earnings report. Skye Bioscience reported the most risks in the "Finance & Corporate" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 3 New Risks
1.
We may face risks related to the wind-down of EHT's operations. Q4, 2022
2.
Government authorities extensively regulate our activities. Q4, 2022
3.
Recently enacted legislation, future legislation and healthcare reform measures may increase the difficulty and cost for us to obtain marketing approval for and commercialize our product candidates and may affect the prices we may set. Q4, 2022

Skye Bioscience Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
52
Neutral
$37.75M-155.77%19.05%2.01%
51
Neutral
$7.86B-0.30-43.30%2.27%22.53%-2.21%
45
Neutral
$39.20M-2.03-104.58%1.18%
41
Neutral
$42.11M-1.03-130.59%-100.00%13.14%
38
Underperform
$41.67M-94.31%-53.18%
38
Underperform
$69.74M86.28%
37
Underperform
$36.54M-0.15-66.96%71.83%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
SKYE
Skye Bioscience
1.30
-3.26
-71.49%
ATNM
Actinium Pharmaceuticals
1.27
-0.15
-10.56%
OTLK
Outlook Therapeutics
1.57
-3.59
-69.57%
BTAI
Bioxcel Therapeutics
1.63
-7.65
-82.44%
INMB
Inmune Bio
1.42
-3.45
-70.84%
LTRN
Lantern Pharma
3.38
0.22
6.96%

Skye Bioscience Corporate Events

Business Operations and Strategy
Skye Bioscience Updates Inducement Equity Incentive Plan
Neutral
Feb 26, 2025

On February 24, 2025, Skye Bioscience, Inc.’s Board of Directors approved an Amended and Restated 2024 Inducement Equity Incentive Plan. This plan provides the Administrator with broader authority over equity awards in the event of a Change in Control, allowing for actions such as cancellation, substitution, or replacement with cash incentives, while maintaining most terms from the previous plan.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Apr 24, 2025