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Skye Bioscience, Inc. (SKYE)
:SKYE
US Market

Skye Bioscience (SKYE) AI Stock Analysis

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Skye Bioscience

(NASDAQ:SKYE)

Rating:38Underperform
Price Target:
Skye Bioscience's overall stock score is primarily hindered by significant financial challenges, including zero revenue and continuous losses. Despite strong earnings call highlights and a substantial cash position, the bearish technical analysis and valuation difficulties weigh heavily on the score.
Positive Factors
Clinical Development
The collaboration with Arecor Therapeutics could enable testing higher doses of nimacimab, potentially allowing for once-monthly dosing during future clinical development.
Clinical Trials
Management noted that clinical engagement remained robust for the ongoing Phase IIa CBeyond trial and that the three safety reviews conducted by the Data Safety Monitoring Committee had not raised concerns.
Negative Factors
Data Release Schedule
The interim data from the Phase IIa CBeyond trial will no longer be released as initially planned.
Financial Performance
Skye reported a net loss of $9.7 million, which was in line with estimates but still represents a financial loss.

Skye Bioscience (SKYE) vs. SPDR S&P 500 ETF (SPY)

Skye Bioscience Business Overview & Revenue Model

Company DescriptionSkye Bioscience, Inc., a biopharmaceutical company, discovers, develops, and commercializes cannabinoid-based molecules for the treatment of infectious diseases. The company's lead product candidate is SBI-100, which is in Phase I trials for the treatment of glaucoma and ocular hypertension. It is also developing SBI-200 that is in preclinical trials to treat and manage various eye diseases, including uveitis, dry eye syndrome, macular degeneration and diabetic retinopathy. The company was formerly known as Emerald Bioscience, Inc. and changed its name to Skye Bioscience, Inc. in January 2021. Skye Bioscience, Inc. was founded in 2012 and is headquartered in San Diego, California.
How the Company Makes MoneySkye Bioscience generates revenue through the development and eventual commercialization of its pharmaceutical products, which are primarily aimed at treating ocular diseases. The company's revenue model is built on the successful advancement of its drug candidates through clinical trials, regulatory approvals, and subsequent market entry. Key revenue streams include potential milestone payments and royalties from partnerships with larger pharmaceutical companies, as well as direct sales of approved products. Strategic collaborations and licensing agreements also play a crucial role in funding research and development activities, which are critical to advancing the company's drug pipeline. However, as of the current data, Skye Bioscience may still be in the pre-revenue stage, focusing on research and development efforts to bring its drug candidates to market.

Skye Bioscience Financial Statement Overview

Summary
Skye Bioscience faces significant financial challenges typical of a biotech firm in its early stages. The absence of revenue and consistent losses underline the high-risk nature of its operations. While recent financing efforts have bolstered the balance sheet, improving cash reserves, the company's long-term success will heavily depend on its ability to generate revenue and manage costs effectively.
Income Statement
10
Very Negative
Skye Bioscience exhibits significant challenges in its income statement, primarily due to consistently zero revenue and substantial net losses over recent years. The lack of revenue growth and negative profit margins highlight the financial stresses typical in the biotechnology industry, especially for companies in the developmental stage.
Balance Sheet
30
Negative
The balance sheet shows a positive trend with significant growth in stockholders' equity in the latest year, driven by substantial financing activities. However, the company still faces high liabilities relative to its assets, as evidenced by the historical negative equity until the most recent year. The low debt level and increasing cash position are positives, providing some financial stability.
Cash Flow
20
Very Negative
Cash flow performance is weak, with consistently negative operating and free cash flows. However, the company has managed to secure substantial financing, which has improved its cash position. The free cash flow remains negative, indicating ongoing operational challenges.
Breakdown
Dec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income StatementTotal Revenue
0.000.000.000.000.00
Gross Profit
0.00-124.25K-115.00K-34.13K-1.87K
EBIT
0.00-13.67M-18.31M-7.85M-6.29M
EBITDA
0.00-13.55M-12.09M-7.81M-6.29M
Net Income Common Stockholders
-26.57M-37.64M-19.48M-8.52M-6.56M
Balance SheetCash, Cash Equivalents and Short-Term Investments
68.42M1.26M1.24M8.98M2.47M
Total Assets
72.76M11.94M9.11M9.86M2.67M
Total Debt
455.59K4.62M1.93M2.14M1.50M
Net Debt
-67.96M3.36M682.55K-6.85M-971.61K
Total Liabilities
4.61M14.07M12.12M3.99M2.22M
Stockholders Equity
68.15M-2.13M-3.01M5.86M450.79K
Cash FlowFree Cash Flow
-26.84M-13.96M-12.77M-6.57M-6.06M
Operating Cash Flow
-25.24M-13.95M-12.74M-6.47M-6.05M
Investing Cash Flow
-245.62K6.60M5.21M-90.87K-7.23K
Financing Cash Flow
83.56M16.44M-208.79K13.08M6.70M

Skye Bioscience Technical Analysis

Technical Analysis Sentiment
Negative
Last Price2.07
Price Trends
50DMA
1.85
Positive
100DMA
2.36
Negative
200DMA
3.49
Negative
Market Momentum
MACD
0.05
Negative
RSI
48.99
Neutral
STOCH
63.78
Neutral
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For SKYE, the sentiment is Negative. The current price of 2.07 is above the 20-day moving average (MA) of 1.98, above the 50-day MA of 1.85, and below the 200-day MA of 3.49, indicating a neutral trend. The MACD of 0.05 indicates Negative momentum. The RSI at 48.99 is Neutral, neither overbought nor oversold. The STOCH value of 63.78 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Negative sentiment for SKYE.

Skye Bioscience Risk Analysis

Skye Bioscience disclosed 51 risk factors in its most recent earnings report. Skye Bioscience reported the most risks in the “Finance & Corporate” category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 3 New Risks
1.
We may face risks related to the wind-down of EHT's operations. Q4, 2022
2.
Recently enacted legislation, future legislation and healthcare reform measures may increase the difficulty and cost for us to obtain marketing approval for and commercialize our product candidates and may affect the prices we may set. Q4, 2022
3.
Government authorities extensively regulate our activities. Q4, 2022

Skye Bioscience Peers Comparison

Overall Rating
UnderperformOutperform
Sector (53)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
54
Neutral
$64.40M-154.88%20.25%
53
Neutral
$5.14B3.03-43.89%2.83%16.75%-0.06%
45
Neutral
$59.63M-232.51%138.11%76.60%
43
Neutral
$48.61M-505.14%-11.21%47.20%
42
Neutral
$29.05M-70.01%71.57%
41
Neutral
$53.03M-130.87%-100.00%30.65%
38
Underperform
$64.14M-47.27%87.22%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
SKYE
Skye Bioscience
1.90
-10.16
-84.25%
ATHE
Alterity Therapeutics
4.25
2.25
112.50%
ATNM
Actinium Pharmaceuticals
1.64
-6.86
-80.71%
MRSN
Mersana Therapeutics
0.35
-2.03
-85.29%
CELU
Celularity
2.29
-1.17
-33.82%
OKUR
OnKure Therapeutics
2.15
-14.45
-87.05%

Skye Bioscience Earnings Call Summary

Earnings Call Date:May 08, 2025
(Q4-2024)
|
% Change Since: 15.64%|
Next Earnings Date:Aug 08, 2025
Earnings Call Sentiment Positive
The earnings call was predominantly positive, with significant achievements in clinical and manufacturing milestones for nimacimab, a strong financial position, and a positive safety profile. However, the increase in expenses and the discontinuation of SBI-100 were noted as challenges. Overall, the highlights significantly outweighed the lowlights.
Q4-2024 Updates
Positive Updates
Successful $90 Million Investment
In early 2024, Skye Bioscience secured a $90 million investment from top life science institutional investors, which enabled the company to execute its clinical and operational goals for the year.
Accelerated Clinical Trial Enrollment
The CBeyond clinical trial for nimacimab exceeded expectations with an over-enrollment of 136 patients, compared to the originally planned 120. The trial is expected to yield data 3 months earlier than initially planned.
Positive Safety Profile
The independent Data Safety Monitoring Board (DSMB) held two meetings for nimacimab's Phase IIa trial and recommended continuing the study as planned, indicating a favorable safety profile.
Manufacturing Process Advancements
Skye successfully transferred the manufacturing process for nimacimab to a partner and began GMP manufacturing runs, preparing for scale-up and commercialization.
Strategic Focus on Nimacimab
The company decided to discontinue SBI-100 development to focus resources on nimacimab, which demonstrated significant weight loss in preclinical studies without crossing the blood-brain barrier.
Financial Improvements
Skye reported a decrease in net loss from $37.6 million in 2023 to $26.6 million in 2024, and maintained cash and cash equivalents of $68.4 million at the end of 2024.
Negative Updates
Increased Expenses
Research and development expenses increased significantly from $5.8 million in 2023 to $18.7 million in 2024, driven by clinical and manufacturing costs for nimacimab.
Discontinuation of SBI-100
The strategic decision to discontinue SBI-100 development was made to reallocate resources to nimacimab, indicating a narrowing of Skye's pipeline.
Company Guidance
In the Skye Bioscience Year-End 2024 Earnings Call, the company provided substantial guidance for its ongoing clinical efforts and financial outlook. Skye reported that it completed enrollment in its CBeyond clinical trial with 136 patients, exceeding the originally planned 120, and anticipates topline data by late Q3 or early Q4 2025, three months earlier than initially guided. The company successfully raised $90 million from institutional investors in early 2024, which fueled its clinical operations, including the initiation of the CBeyond trial. Skye also announced a protocol extension allowing all treatment arms to continue receiving therapy for an additional 26 weeks, totaling a 52-week treatment period. Financially, Skye reported a net loss of $26.6 million for the year, with research and development expenses increasing to $18.7 million, primarily driven by costs associated with the Phase IIa CBeyond study. Skye ended 2024 with $68.4 million in cash and cash equivalents, expecting this to fund operations through Q1 2027. The company remains focused on nimacimab's potential as a differentiated treatment for obesity and is preparing for its Phase IIb study by Q2 2026, while also working on manufacturing optimizations.

Skye Bioscience Corporate Events

Business Operations and Strategy
Skye Bioscience Updates Inducement Equity Incentive Plan
Neutral
Feb 26, 2025

On February 24, 2025, Skye Bioscience, Inc.’s Board of Directors approved an Amended and Restated 2024 Inducement Equity Incentive Plan. This plan provides the Administrator with broader authority over equity awards in the event of a Change in Control, allowing for actions such as cancellation, substitution, or replacement with cash incentives, while maintaining most terms from the previous plan.

Glossary
OutperformA stock rated as "Outperform" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests that the stock is likely to deliver higher returns compared to the average returns of other stocks in the same sector or market index. Investors might consider this stock a good buying opportunity.
NeutralA stock rated as "Neutral" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly attractive nor unattractive for investment. Investors may consider holding onto the stock, as it is not expected to either significantly outperform or underperform the market.
UnderperformA stock rated as "Underperform" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests that the stock may deliver lower returns compared to the average returns of other stocks in the same sector or market index. Investors might consider selling the stock or avoiding it as an investment.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.