OnKure Therapeutics (OKUR) AI Stock Analysis

• Market Cap: $36.40M
• Dividend Yield: N/A
• Average Volume (3M): 105.42K
• Price to Earnings (P/E): ―
• Beta (1Y): 0.49
• Revenue Growth: N/A
• EPS Growth: 68.13%
• Country: US
• Employees: 46
• Sector: Healthcare
• Sector Strength: 53
• Industry: Biotechnology
• EPS (TTM): -1.19
• Shares Outstanding: 12,843,434
• 10 Day Avg. Volume: 52,582
• 30 Day Avg. Volume: 105,421
• PEG Ratio: N/A
• Price to Book (P/B): N/A
• Price to Sales (P/S): N/A
• P/FCF Ratio: N/A
• Enterprise Value/Market Cap: -1.38
• Enterprise Value/Revenue: N/A
• Enterprise Value/Gross Profit: 78.17
• Enterprise Value/Ebitda: 0.84
• 1Y Price Target: $30.00
• Price Target Upside: 990.91% Upside
• Rating Consensus: Strong Buy
• Number of Analyst Covering: 5

• Rating: 42 Neutral
• Price Target: ―

OnKure Therapeutics is experiencing significant financial challenges with no revenue and persistent losses, impacting its financial performance score. The technical analysis indicates a bearish trend, compounded by a negative MACD and oversold RSI and Stochastic levels, suggesting caution. Valuation is weak due to a negative P/E ratio, highlighting the need for substantial operational improvements. Overall, the company's stock presents high risk, requiring strategic shifts to enhance financial health and investor appeal.

Positive Factors

Drug Development

OnKure Therapeutics has initiated two expansion arms in their Phase 1 study, showing progress in their development efforts.

Earnings

OnKure Therapeutics, Inc. has received a 'Buy' rating, indicating a positive outlook on the company's stock.

Financial Performance

The company's cash position is approximately $83.4 million, which is expected to provide a cash runway into the fourth quarter of 2026.

Negative Factors

Clinical Trial Progress

No objective responses have been seen to date in patients treated at the 900mg dose level.

Market Competition

The rapid development of next-gen drugs in the treatment of HR+/HER2- breast cancer may pose challenges for OnKure's existing drug combinations, as newer drugs are seen as more advanced.

Regulatory and Safety Concerns

Oncologists express concerns about balancing cancer treatment with managing side effects like hyperglycemia, highlighting a need for more selective drugs, which could impact OnKure's approach.

OnKure Therapeutics Business Overview & Revenue Model

Company Description

OnKure Therapeutics (OKUR) is a clinical-stage biopharmaceutical company specializing in the discovery and development of targeted oncology therapies. The company focuses on creating innovative small molecule inhibitors that modulate key oncogenic pathways, aiming to provide effective treatments for cancer patients. OnKure's core products are primarily centered around its proprietary drug candidates designed to address unmet medical needs in oncology.

How the Company Makes Money

OnKure Therapeutics generates revenue primarily through partnerships, collaborations, and licensing agreements with larger pharmaceutical companies. These agreements often include upfront payments, milestone payments based on the achievement of specific development or regulatory objectives, and royalties on future sales of successfully commercialized drugs. Additionally, OnKure may receive funding from government grants or research institutions to support its R&D activities. The company's revenue model is highly dependent on the progress and success of its clinical trials and the ability to secure strategic partnerships.

OnKure Therapeutics Financial Statement Overview

Summary

OnKure Therapeutics faces considerable financial management challenges, with persistent losses and no revenue. While recent improvements in equity and financing activity are positive signals, the company needs to focus on revenue generation and operational efficiency to achieve sustainable growth.

Income Statement

OnKure Therapeutics has not generated any revenue over the past three years, resulting in negative EBIT and net income figures. The lack of revenue and high operational losses indicate significant financial challenges and a need for strategic shifts to achieve profitability.

Balance Sheet

The company shows improvement in its equity position with positive stockholders' equity in the latest year, reversing the negative equity from previous years. However, the low debt levels relative to equity indicate limited leverage risk, albeit with significant liabilities. The equity ratio shows a strong position in total assets.

Cash Flow

The company exhibits strong cash flow management, with significant financing inflows enhancing cash reserves. Despite negative operating cash flow, the increase in cash and equivalents signals effective capital sourcing. However, substantial free cash outflows continue to reflect operational challenges.

Breakdown	TTM	Dec 2024	Dec 2023	Dec 2022
Income Statement
Total Revenue	0.00	0.00	0.00	0.00
Gross Profit	-643.00K	0.00	-560.00K	-529.00K
EBITDA	-60.03M	-51.71M	-34.75M	-29.38M
Net Income	-70.20M	-52.67M	-35.31M	-29.51M
Balance Sheet
Total Assets	86.07M	114.91M	35.73M	16.00M
Cash, Cash Equivalents and Short-Term Investments	83.37M	110.76M	29.88M	11.54M
Total Debt	823.00K	1.08M	674.00K	637.00K
Total Liabilities	7.90M	11.08M	137.58M	70.42M
Stockholders Equity	78.17M	103.83M	-101.84M	-54.42M
Cash Flow
Free Cash Flow	-61.36M	-51.17M	-34.79M	-28.09M
Operating Cash Flow	-61.29M	-51.12M	-34.55M	-26.95M
Investing Cash Flow	-20.41M	15.87M	-246.00K	-1.13M
Financing Cash Flow	116.14M	116.13M	53.13M	26.46M

OnKure Therapeutics Technical Analysis

• Technical Analysis Sentiment: Neutral
• Last Price: 2.75
• 50DMA: Positive
• 100DMA: Positive
• 200DMA: Negative
• MACD: Negative
• RSI: Neutral
• STOCH: Neutral

Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For OKUR, the sentiment is Neutral. The current price of 2.75 is above the 20-day moving average (MA) of 2.62, above the 50-day MA of 2.46, and below the 200-day MA of 4.99, indicating a neutral trend. The MACD of 0.11 indicates Negative momentum. The RSI at 57.67 is Neutral, neither overbought nor oversold. The STOCH value of 45.57 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Neutral sentiment for OKUR.

OnKure Therapeutics Peers Comparison

Name	Overall Rating	Market Cap	P/E Ratio	ROE	Dividend Yield	Revenue Growth	EPS Growth
RPTX	60 Neutral	$72.60M	―	-69.96%	―	-99.64%	-59.17%
STTK	55 Neutral	$72.33M	―	-73.39%	―	-27.33%	34.66%
Sector *	51 Neutral	$7.92B	-0.43	-41.67%	2.21%	22.29%	-1.85%
SPRO	48 Neutral	$120.43M	10.83	-94.59%	―	-67.67%	-390.60%
OKUR	42 Neutral	$36.40M	―	-90.56%	―	―	68.13%
MRSN	42 Neutral	$35.53M	―	-505.14%	―	16.14%	31.01%
PRLD	35 Underperform	$64.52M	―	-96.33%	―	―	7.72%

OnKure Therapeutics Corporate Events

OnKure Therapeutics Advances Cancer Drug Trials

OnKure Therapeutics has released promising early data from its PIKture-01 trial, showcasing the safety and efficacy of OKI-219, a selective PI3KαH1047R inhibitor, in treating various cancers. The drug demonstrated excellent tolerability and robust anti-tumor activity, with plans to advance its combination trials with fulvestrant. Investors can expect further insights and combination data by late 2025, positioning OnKure as a potential leader in precision oncology therapies.