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OnKure Therapeutics
(NASDAQ:OKUR)
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Rating:49Neutral
Price Target:
$4.00
▼(-2.91% Downside)
Action:Reiterated
Date:08/05/26
OKUR scores below average primarily due to persistent zero revenue, sizable losses, and ongoing cash burn (raising financing/dilution risk), partially offset by a strong low-debt balance sheet. Technical indicators are broadly neutral with mild weakness, and valuation is constrained by negative earnings and no dividend.
Positive Factors
Low leverage and sizable asset base
Very low reported debt and a materially larger equity and asset base provide financial flexibility for a development-stage biotech. A strong balance sheet supports continued R&D investment, reduces near-term refinancing pressure, and lengthens the runway versus peers reliant on high leverage.
Negative Factors
No product revenue; widening net losses
The company remains pre‑revenue with widening annual losses, meaning value is entirely contingent on future clinical success. Continued negative earnings erode equity over time and require sustained external financing to fund development, heightening execution and dilution risk if trials falter.
Read all positive and negative factors
Positive Factors
Negative Factors
Low leverage and sizable asset base
Very low reported debt and a materially larger equity and asset base provide financial flexibility for a development-stage biotech. A strong balance sheet supports continued R&D investment, reduces near-term refinancing pressure, and lengthens the runway versus peers reliant on high leverage.
Read all positive factors
OnKure Therapeutics (OKUR) vs. SPDR S&P 500 ETF (SPY)
Market Cap
$154.31M
Dividend YieldN/A
Average Volume (3M)86.56K
Price to Earnings (P/E)―
Beta (1Y)1.23
Revenue GrowthN/A
EPS Growth25.85%
CountryUS
Employees45
SectorHealthcare
Sector Strength45
IndustryBiotechnology
Share Statistics
EPS (TTM)-3.50
Shares Outstanding40,395,480
10 Day Avg. Volume131,167
30 Day Avg. Volume86,556
Financial Highlights & Ratios
PEG Ratio-0.06
Price to Book (P/B)0.70
Price to Sales (P/S)0.00
P/FCF Ratio-0.76
Enterprise Value/Market Cap<0.01
Enterprise Value/RevenueN/A
Enterprise Value/Gross Profit>-0.01
Enterprise Value/Ebitda>-0.01
Forecast
1Y Price Target
$22.33Price Target Upside442.07% Upside
Rating ConsensusStrong Buy
Number of Analyst Covering4
EPS Forecast (FY)-2.36
Revenue Forecast (FY)$500.00K
OnKure Therapeutics Business Overview & Revenue Model
Company Description
OnKure, Inc., established in 2011 and based in Boulder, Colorado, operates as a biopharmaceutical company primarily engaged in the creation and advancement of precise therapeutic agents for cancer. A core area of their research centers on developi...
How the Company Makes Money
null...
OnKure Therapeutics Financial Statement Overview
Summary
Income Statement
12
Very Negative
Balance Sheet
68
Positive
Cash Flow
22
Negative
| Breakdown | TTM | Dec 2025 | Dec 2024 | Dec 2023 | Dec 2022 | Dec 2021 |
|---|---|---|---|---|---|---|
Income Statement | ||||||
| Total Revenue | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| Gross Profit | -203.00K | -830.00K | 0.00 | 0.00 | 0.00 | -50.00K |
| EBITDA | -58.09M | -58.69M | -51.71M | -34.75M | -29.13M | -39.72M |
| Net Income | -58.70M | -59.52M | -52.67M | -35.31M | -29.51M | -39.77M |
Balance Sheet | ||||||
| Total Assets | 179.35M | 62.12M | 114.91M | 35.73M | 16.00M | 154.02M |
| Cash, Cash Equivalents and Short-Term Investments | 176.39M | 59.05M | 110.76M | 29.88M | 11.54M | 147.67M |
| Total Debt | 926.00K | 549.00K | 1.08M | 674.00K | 637.00K | 0.00 |
| Total Liabilities | 7.25M | 5.93M | 11.08M | 137.58M | 70.42M | 6.81M |
| Stockholders Equity | 172.11M | 56.18M | 103.83M | -101.84M | -54.42M | 147.21M |
Cash Flow | ||||||
| Free Cash Flow | -47.86M | -51.87M | -51.17M | -34.79M | -28.09M | -38.18M |
| Operating Cash Flow | -47.84M | -51.83M | -51.12M | -34.55M | -26.95M | -37.98M |
| Investing Cash Flow | -9.89M | -46.00K | 15.87M | -246.00K | -1.13M | -23.38M |
| Financing Cash Flow | 140.86M | 163.00K | 116.13M | 53.13M | 26.46M | 132.41M |
OnKure Therapeutics Technical Analysis
Positive
4.12
Price Trends
4.24
Negative
4.24
Negative
3.59
Positive
Market Momentum
-0.05
Negative
49.59
Neutral
55.84
Neutral
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For OKUR, the sentiment is Positive. The current price of 4.12 is above the 20-day moving average (MA) of 4.11, below the 50-day MA of 4.24, and above the 200-day MA of 3.59, indicating a neutral trend. The MACD of -0.05 indicates Negative momentum. The RSI at 49.59 is Neutral, neither overbought nor oversold. The STOCH value of 55.84 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Positive sentiment for OKUR.
OnKure Therapeutics Risk Analysis
OnKure Therapeutics disclosed 71 risk factors in its most recent earnings report. OnKure Therapeutics reported the most risks in the "Tech & Innovation" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks
OnKure Therapeutics Peers Comparison
UnderperformOutperform
Sector (51)
Name | Overall Rating | Market Cap | P/E Ratio | ROE | Dividend Yield | Revenue Growth | EPS Growth |
|---|---|---|---|---|---|---|---|
51 Neutral | $7.86B | -0.30 | -43.30% | 2.27% | 22.53% | -2.21% | |
49 Neutral | $154.31M | -0.88 | -49.02% | ― | ― | 25.85% | |
48 Neutral | $105.56M | -1.89 | -245.45% | ― | 164.08% | 58.49% | |
45 Neutral | $37.88M | 0.68 | -560.64% | ― | -32.64% | 56.66% | |
44 Neutral | $24.92M | -3.44 | -94.51% | ― | ― | ― |
* Healthcare Sector Average
OKUR
OnKure Therapeutics
4.14
2.11
103.94%
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OnKure Therapeutics Corporate Events
Business Operations and StrategyExecutive/Board ChangesShareholder Meetings
OnKure Shareholders Approve Amended 2024 Equity Incentive Plan
Positive
Jun 4, 2026
On June 3, 2026, OnKure Therapeutics, Inc. stockholders approved an amended and restated 2024 Equity Incentive Plan that increases the share reserve by 3,231,638 shares, removes the fixed numerical cap in the annual “evergreen” provisi...
Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
Disclaimer
This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.