OnKure Therapeutics (OKUR)
NASDAQ:OKUR
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OnKure Therapeutics
(NASDAQ:OKUR)
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Rating:47Neutral
Price Target:
$3.00
▼(-40.00% Downside)
Action:Reiterated
Date:05/09/26
The score is held down primarily by weak financial performance (pre-revenue, widening losses, and persistent cash burn) and bearish near-term technicals (below key moving averages with weak momentum). These are partially offset by a supportive corporate event (a sizable $150M financing that improves runway) and a low-debt balance sheet, while valuation metrics offer limited insight due to negative earnings and no dividend.
Positive Factors
Low financial leverage
Very low debt and materially improved equity (from negative to roughly $184M TTM) reduce refinancing risk and preserve strategic optionality. This balance-sheet strength provides durable flexibility to fund multi-stage clinical programs and absorb development timing variability common in biotech.
Negative Factors
Persistent cash burn
Sustained negative free cash flow near -$50M TTM indicates structural cash consumption tied to operations. Ongoing cash burn necessitates further financings or rapid milestone success to avoid runway compression, constraining strategic choices and raising execution risk over coming quarters.
Read all positive and negative factors
Positive Factors
Negative Factors
Low financial leverage
Very low debt and materially improved equity (from negative to roughly $184M TTM) reduce refinancing risk and preserve strategic optionality. This balance-sheet strength provides durable flexibility to fund multi-stage clinical programs and absorb development timing variability common in biotech.
Read all positive factors
OnKure Therapeutics (OKUR) vs. SPDR S&P 500 ETF (SPY)
Market Cap
$127.65M
Dividend YieldN/A
Average Volume (3M)86.56K
Price to Earnings (P/E)―
Beta (1Y)1.21
Revenue GrowthN/A
EPS Growth25.85%
CountryUS
Employees46
SectorHealthcare
Sector Strength45
IndustryBiotechnology
Share Statistics
EPS (TTM)-4.33
Shares Outstanding40,395,480
10 Day Avg. Volume131,167
30 Day Avg. Volume86,556
Financial Highlights & Ratios
PEG Ratio-0.06
Price to Book (P/B)0.70
Price to Sales (P/S)0.00
P/FCF Ratio-0.76
Enterprise Value/Market Cap-1.17
Enterprise Value/RevenueN/A
Enterprise Value/Gross Profit736.86
Enterprise Value/Ebitda2.56
Forecast
1Y Price Target
$24.33Price Target Upside386.67% Upside
Rating ConsensusStrong Buy
Number of Analyst Covering4
EPS Forecast (FY)-2.66
Revenue Forecast (FY)$666.67K
OnKure Therapeutics Business Overview & Revenue Model
Company Description
OnKure, Inc. engages in the discovery and development of oncology-precision medicines for the treatment of cancer. The company focuses on developing selective inhibitors of histone deacetylases. Its portfolio includes OKI-179, an inhibitor for the...
How the Company Makes Money
null...
OnKure Therapeutics Financial Statement Overview
Summary
Income Statement
12
Very Negative
Balance Sheet
62
Positive
Cash Flow
18
Very Negative
| Breakdown | TTM | Dec 2025 | Dec 2024 | Dec 2023 | Dec 2022 | Dec 2021 |
|---|---|---|---|---|---|---|
Income Statement | ||||||
| Total Revenue | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| Gross Profit | -203.00K | -830.00K | 0.00 | 0.00 | 0.00 | -50.00K |
| EBITDA | -58.38M | -62.12M | -51.71M | -34.75M | -29.38M | -39.72M |
| Net Income | -58.75M | -59.52M | -52.67M | -35.31M | -29.51M | -39.77M |
Balance Sheet | ||||||
| Total Assets | 198.69M | 62.12M | 114.91M | 35.73M | 16.00M | 154.02M |
| Cash, Cash Equivalents and Short-Term Investments | 192.11M | 59.05M | 110.76M | 29.88M | 11.54M | 147.67M |
| Total Debt | 409.00K | 549.00K | 1.08M | 674.00K | 637.00K | 0.00 |
| Total Liabilities | 14.34M | 5.93M | 11.08M | 137.58M | 70.42M | 6.81M |
| Stockholders Equity | 184.35M | 56.18M | 103.83M | -101.84M | -54.42M | 147.21M |
Cash Flow | ||||||
| Free Cash Flow | -50.79M | -51.87M | -51.17M | -34.79M | -28.09M | -38.18M |
| Operating Cash Flow | -50.76M | -51.83M | -51.12M | -34.55M | -26.95M | -37.98M |
| Investing Cash Flow | -33.00K | -46.00K | 15.87M | -246.00K | -1.13M | -23.38M |
| Financing Cash Flow | 146.24M | 163.00K | 116.13M | 53.13M | 26.46M | 132.41M |
OnKure Therapeutics Technical Analysis
Negative
5.00
Price Trends
4.21
Negative
3.49
Negative
3.15
Negative
Market Momentum
-0.32
Positive
26.68
Positive
2.41
Positive
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For OKUR, the sentiment is Negative. The current price of 5 is above the 20-day moving average (MA) of 4.29, above the 50-day MA of 4.21, and above the 200-day MA of 3.15, indicating a bearish trend. The MACD of -0.32 indicates Positive momentum. The RSI at 26.68 is Positive, neither overbought nor oversold. The STOCH value of 2.41 is Positive, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Negative sentiment for OKUR.
OnKure Therapeutics Risk Analysis
OnKure Therapeutics disclosed 71 risk factors in its most recent earnings report. OnKure Therapeutics reported the most risks in the "Tech & Innovation" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks
OnKure Therapeutics Peers Comparison
UnderperformOutperform
Sector (51)
Name | Overall Rating | Market Cap | P/E Ratio | ROE | Dividend Yield | Revenue Growth | EPS Growth |
|---|---|---|---|---|---|---|---|
51 Neutral | $7.86B | -0.30 | -43.30% | 2.27% | 22.53% | -2.21% | |
47 Neutral | $127.65M | -0.93 | -61.02% | ― | ― | 25.85% | |
47 Neutral | $133.69M | -4.70 | -245.46% | ― | 164.08% | 58.49% | |
46 Neutral | $45.53M | -1.51 | -225.83% | ― | -32.64% | 56.66% | |
42 Neutral | $28.26M | ― | -76.54% | ― | ― | ― |
* Healthcare Sector Average
OKUR
OnKure Therapeutics
3.08
0.76
32.76%
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OnKure Therapeutics Corporate Events
Business Operations and StrategyExecutive/Board ChangesPrivate Placements and Financing
OnKure Announces $150M Private Placement and Board Changes
Positive
Mar 30, 2026
On March 27, 2026, OnKure Therapeutics entered into a $150 million private placement with institutional investors to sell 26,713,636 shares of Class A common stock at $4.15 per share and pre-funded warrants for 9,430,959 additional shares, with cl...
Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
Disclaimer
This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.