Clinical Development MilestonesDosing has begun in HER2+ combination cohorts with trastuzumab and tucatinib, and initial cohort data anticipated in Q1 2026 could clarify OKI-219's competitive positioning.
PharmacokineticsSteady-state pharmacokinetic data show OKI-219 achieves exposures above levels linked to robust antitumor activity in preclinical models, supporting its biological rationale for clinical benefit.
Safety And TolerabilityOKI-219 was well tolerated across tested dose levels with no serious treatment-related adverse events reported, supporting its suitability for combination regimens.